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哈佛大学教育研究生院的学位发展与启迪

清华大学教育研究 2013年第6期34卷 84-90页

作者：姜川哈佛大学教育研究生院

美国哈佛大学教育研究生院2010年开设了"教育领导博士学位"(Ed.L.D),并与哈佛文理学院在2014年联合成立哲学博士(Ph.D)学位,代替了存在将近90年的教育博士学位(Ed.D),将单一的学科转化为跨学科的学习,运用跨学院的学术优势和资源,培养... 详细信息

美国哈佛大学教育研究生院2010年开设了"教育领导博士学位"(Ed.L.D),并与哈佛文理学院在2014年联合成立哲学博士(Ph.D)学位,代替了存在将近90年的教育博士学位(Ed.D),将单一的学科转化为跨学科的学习,运用跨学院的学术优势和资源,培养未来卓越的教育领导人才,继续哈佛大学博雅教育的精神和传统。哈佛大学跨学院合作及授予学位的经验值得我国高等教育院校借鉴。

关键词：哈佛大学本科教育教育领导博士学位哲学博士学位

Comparative Analysis on Rice Plant Type of Two Super Hybrids and Shanyou63

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Agricultural Sciences in China 2003年第5期2卷 513-520页

作者： LU chuan-gen and ZOU jiang-shijiangsu Academy of Agricultural Sciences, Nanjing 210014 , P.R. China jiangsu Academy of Agricultural Sciences Nanjing 210014 P. R. China

The characteristics of plant type and physiological indices for photosynthesis were analyzed using two super hybrid rices, Liangyoupeijiu and LiangyouE32 as materials, and an indica hybrid, Shan-you63 as a control. Based on the present analysis and various theories and breeding practices on rice plant type, a model of plant ideotype for super hybrid rice (indica) in the lower reaches of Yangtze River Valley was proposed. This was: a length of 35 - 40 cm for top leaf with a width of 2 cm, and that of 50 - 55 cm and 55-60 cm, respectively, for the second and third leaves from top, meanwhile, having a leaf angle of 5°, 10°and 15° respectively, and a curvature of 1 - 1. 5 cm-1for the leaf face at heading stage; the uppermost three leaves keeping their activities for as long as 70 d, which could lead a LAI of 3 at full ripeness; loose plant type with thin (SLW=2.5-3 g cm-2, dry weight) and curve-slant leaves during early growing stage, and compact plant type by thick (SLW=4 - 5 g cm-2) and erect leaves during the middle and late growing stages; with a coefficient of light extinction of 0. 3 - 0. 4, which allowed for an optimal LAI high of 8-10 during the middle growth period; plant height of 110-120 cm, with 2 - 4 cm basal internode and a long uppermost internode occupying 45% of total stem length; 25 - 28 cm panicle with 8-10 spikelets per centimeter showing bend-type in ripening; a rich chlorophyll which led to a high net photosynthetic rate, and tolerance to light shading and photooxidation which is of benefit to increasing the adaptability to varying light conditions.

关键词： Super hybrid rice Plant type Physiology Ecology

Glucocorticoid receptor regulates expression of microRNA-22 and downstream signaling pathway in apoptosis of pancreatic acinar cells

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World Journal of Gastroenterology 2018年第45期24卷 5120-5130页

作者： Qiang Fu chuan-jiang Liu Xu Zhang Zhen-Sheng Zhai Yu-Zhu Wang Ming-Xing Hu Xian-Ling Xu Hong-Wei Zhang Tao Qin Department of Hepatobiliary and Pancreatic Surgery People’s Hospital of Zhengzhou University (Henan Provincial People’s Hospital) School of Medicine Zhengzhou University

AIM To elucidate the underlying mechanism that microRNA-22(miR-22) promotes the apoptosis of rat pancreatic acinar cells(AR42 J) and the elements that regulate the expression of *** One hundred nanomoles per liter of caerulein(Cae)was administrated to induce the apoptosis of AR42 J cells and the apoptosis rate was detected by flow cytometry analysis. An amylase assay kit was used to measure the amylase expression level in the supernatant. Quantitative real-time PCR(qRT-PCR)was adopted to measure miR-22 expression. We used online tools to predict the potential transcription promoter of miR-22 and the binding sites, which was further identified by using luciferase reporter analysis,chromatin immunoprecipitation(ChIP) and ChIPqP CR assays. Then, a mimic of miR-22, Nr3 c1 plasmid encoding the glucocorticoid receptor(GR), and siNr3 c1 were used to transfect AR42 J cells, *** mRNA expression of miR-22, Nr3 c1, and Erb-b2 receptor tyrosine kinase 3(ErbB3) was confirmed by qRT-PCR and the apoptosis rate of AR42 J cells was detected by flow cytometry analysis. Western blot was used to detect the expression of ErbB3, GR, PI3 k, PI3 kp85α, Akt, p-Akt, Bad, Bax, Bcl-xl, Bcl-2, and cleaved *** After inducing apoptosis of AR42 J cells in vitro, the expression of miR-22 was significantly increased by2.20 ± 0.26 and 4.19 ± 0.54 times, respectively, at3 h and 6 h in comparison with the control *** revealed by qRT-PCR assay, the expression of miR-22 was 78.25 ± 6.61 times higher in the miR-22 mimic group relative to the miRNA control group,accompanied with an obviously increased acinar cell apoptosis rate(32.53 ± 1.15 vs 18.07 ± 0.89, P =0.0006). The upregulation of miR-22 could suppress its target gene, ErbB3, and the phosphorylation of PI3 k and Akt. Furthermore, we predicted the potential transcription promoter of miR-22 and the binding sites using online tools. Luciferase reporter analysis and sitedirected mutagenesis indicated that the b

关键词： MicroRNA-22 Apoptosis Pancreatic acinar cells Erb-b2 receptor tyrosine kinase 3 Glucocorticoid receptor

Accuracy for cytological evaluation in the detection of breast cancer among patients with pathologic nipple discharge:a PRISMA-compliant meta-analysis

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Chinese Medical Journal 2020年第4期133卷 435-443页

作者： Xiao-Qian Li Feng Xu Chu-Qi Lei Jie Li Hong-chuan jiang Department of General Surgery Beijing Huai-Rou HospitalCapital Medical UniversityBeijing 101400China Department of Breast Surgery Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China

Background:Nipple discharge cytology is a simple non-invasive method that may provide valuable information for detecting underlying *** studies have investigated the diagnostic value of cytology in breast cancer patients with pathological nipple discharge,but the results have been highly *** we presented a systematic review and meta-analysis of published studies pertaining to the diagnostic capacity of nipple discharge cytology in patients with breast ***:A systematic literature search was performed(Medline/PubMed,Embase,Cochrane Library databases,and Google Scholar)to identify studies that investigated the diagnostic capacity of cytology with regard to breast cancer in patients with pathologic nipple *** independent researchers identified articles that assessed the sensitivity and specificity of cytological evaluation for breast cancer detection in patients with pathologic nipple discharge published between January 2000 and October *** were only included in the meta-analysis if they met predetermined *** characteristics of each study and the data they yielded were *** assessment of all articles included was performed using the Methodological Index for Non-randomized Studies Criteria(MINORS)and the Quality Assessment of Diagnostic Accuracy Study 2(QUADAS-2).Heterogeneity was tested via Cochran Q test and the I2 statistic using Stata 12.0 and Meta-DiSc 1.4 software,and meta-analysis was ***:A total of 286 articles were identified,of which 12 articles including a total of 1476 patients were deemed eligible for inclusion in the meta-analysis.A random-effects model assessing the capacity of nipple discharge cytology to predict breast cancer yielded pooled sensitivity 63%(95%confidence interval[CI]:53%-72%),specificity 95%(95%CI:87%-98%),positive likelihood ratio 12.35(95%CI:4.87-31.34),and negative likelihood ratio 0.39(95%CI:0.30-0.50).The diagnostic odds ratio was 31.88(95%

关键词： Breast carcinoma Cytology Diagnosis Meta-analysis Nipple discharge

高效液相色谱-串联质谱法测定中药口服液中23种防腐剂

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药物分析杂志 2019年第9期39卷 1651-1659页

作者：马传江山东中医药大学附属医院

目的:建立同时测定中药口服液产品中苯甲酸、山梨酸、三氯卡班、4-羟基苯甲酸丙酯、4-羟基苯甲酸异丙酯等23种防腐剂的的高效液相色谱-串联质谱检测方法。方法:样品以甲醇为提取溶剂进行超声提取,离心后取上清液以Acquity UPLC BEH C18... 详细信息

目的:建立同时测定中药口服液产品中苯甲酸、山梨酸、三氯卡班、4-羟基苯甲酸丙酯、4-羟基苯甲酸异丙酯等23种防腐剂的的高效液相色谱-串联质谱检测方法。方法:样品以甲醇为提取溶剂进行超声提取,离心后取上清液以Acquity UPLC BEH C18色谱柱(2.1 mm×100 mm,1.7μm)进行分离,0.01mol·L-1醋酸铵溶液和甲醇为流动相梯度洗脱;流速为0.4 mL·min-1。结果:在相应的浓度范围内,23种防腐剂质量浓度与峰面积呈良好的线性关系(r≥0.99);检测下限在1~40 ng·m L-1间;平均回收率范围为75.1%~115.0%,日内精密度为0.92%~3.3%。结论:该方法分析速度快,准确度好,灵敏度高,可用于中药口服液中防腐剂的快速筛查。

关键词：高效液相色-串联质谱口服液高通量筛查防腐剂

Modulation of host N6-methyladenosine modification by gut microbiota in colorectal cancer

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World Journal of Gastroenterology 2024年第38期30卷 4175-4193页

作者： Tian-Qi jiang Hao Wang Wang-XinJun Cheng chuan Xie Department of Gastroenterology Jiangxi Provincial Key Laboratory of Digestive DiseasesJiangxi Clinical Research Center for Department of GastroenterologyDigestive Disease HospitalThe First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The First Clinical Medical College Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Queen Mary College Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

As a research hotspot in the field of molecular biology,N6-methyladenosine(m6A)modification has made progress in the treatment of colorectal cancer(CRC),leukemia and other *** studies have demonstrated that the tumour microenvironment(TME)regulates the level of m6A modification in the host and activates a series of complex epigenetic signalling pathways through interactions with CRC cells,thus affecting the progression and prognosis of ***,with the diversity in the composition of TME factors,this action is reci-procal and ***,some studies have experimentally revealed that the intestinal flora can alter CRC cell proliferation by directly acting on m6A and thereby altering CRC cell *** review summarizes the data,supporting the idea that the intestinal flora can influence host m6A levels through pathways such as methyl donor metabolism and thus affect the progression of *** also review the role of m6A modification in the diagnosis,treatment,and prognostic assessment of CRC and discuss the current status,limitations,and potential clinical value of m6A modification in this *** propose that additional in-depth research on m6A alterations in CRC patients and their TME-related targeted therapeutic issues will lead to better therapeutic outcomes for CRC patients.

关键词： Colorectal cancer N6-methyladenosine Tumour microenvironment Gut microbiota Clinical application

当代中国宪政理论与实践的探索和发展——以1949年以来宪法的变迁为视角

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西南师范大学学报（人文社会科学版） 2005年第4期31卷 54-59页

作者：蒋传光上海师范大学法政学院上海市200234

新中国成立以来,我国的宪政理论与实践经历了从共同纲领到宪法、从1954年宪法经1975年宪法和1978年宪法到1982年宪法以及现行宪法(即1982年宪法)的4次修正案的曲折发展。这一发展历程表明,建构中国特色的社会主义宪政体制,就是要积极稳... 详细信息

新中国成立以来,我国的宪政理论与实践经历了从共同纲领到宪法、从1954年宪法经1975年宪法和1978年宪法到1982年宪法以及现行宪法(即1982年宪法)的4次修正案的曲折发展。这一发展历程表明,建构中国特色的社会主义宪政体制,就是要积极稳妥地推进政治体制改革,确立宪法至上观念,建设社会主义法治国家。就此而言,如何适应社会政治、经济和文化的发展需要,探讨政治体制改革、执政党的执政方式、完善宪法的监督和实施体制等重大问题,都是我国宪政理论和宪法内容发展与完善的方向。

关键词：宪政理论实践探索内容创新发展方向

公民社会与社会转型中法治秩序的构建--以公民责任意识为视角

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求是学刊 2009年第1期36卷 76-84页

作者：蒋传光上海师范大学法政学院上海200234

法治社会的建立,离不开公民社会的培育、公民文化的弘扬和公民意识的塑造。而在此过程中,塑造与法治社会相匹配的公民意识则是关键。公民意识的内涵非常丰富,其表现是多角度和多层次的,其中公民的责任意识是一个重要方面。公民责任意识... 详细信息

法治社会的建立,离不开公民社会的培育、公民文化的弘扬和公民意识的塑造。而在此过程中,塑造与法治社会相匹配的公民意识则是关键。公民意识的内涵非常丰富,其表现是多角度和多层次的,其中公民的责任意识是一个重要方面。公民责任意识包含着"公民"、"责任"、"公民责任"和"公民责任意识"等逻辑范畴。公民责任意识包括公民责任感、法律规则意识、理性意识和道德责任意识等要素,并具有主体性、公共性、民主性和权责统一性等特点。在社会转型时期,公民责任意识对当下法治秩序的构建具有重要的功能和意义。

关键词：公民社会公民责任意识社会转型法治秩序

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办公楼疏散演练综合评估方法研究

中国安全科学学报 2012年第5期22卷 170-176页

作者：姜传胜中国安全生产科学研究院公共安全研究所

我国每年进行数以万计的办公楼疏散演练,迫切需要科学有效的评估方法,以评估应急演练所体现出的应急准备能力,提高管理方和员工的疏散安全意识和能力。从疏散人员行为表现、组织实施疏散的指挥体系、疏散程序及相关保障条件等多方面综... 详细信息

我国每年进行数以万计的办公楼疏散演练,迫切需要科学有效的评估方法,以评估应急演练所体现出的应急准备能力,提高管理方和员工的疏散安全意识和能力。从疏散人员行为表现、组织实施疏散的指挥体系、疏散程序及相关保障条件等多方面综合考虑,将应急疏散组织体制机制分析、参演人员疏散行为观测及对其主观感受调查、计算机模拟分析三者有机结合,提出了一种办公楼疏散演练综合评估方法。运用该方法对一栋高层办公楼的疏散演练的策划、组织实施、疏散人员行为和主观感受等进行了全过程跟踪评估,系统描述了该方法的使用过程。

关键词：疏散演练评估办公楼行为应急预案