Accuracy for cytological evaluation in the detection of breast cancer among patients with pathologic nipple discharge:a PRISMA-compliant meta-analysis

作     者：Xiao-Qian Li Feng Xu Chu-Qi Lei Jie Li Hong-Chuan Jiang Li Xiao-Qian;Xu Feng;Lei Chu-Qi;Li Jie;Jiang Hong-Chuan

作者机构：Department of General SurgeryBeijing Huai-Rou HospitalCapital Medical UniversityBeijing 101400China Department of Breast SurgeryBeijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2020年第133卷第4期

页      面：435-443页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This study was supported by a grant from the Science and Technology Commission of Beijing Municipality(No.D16110000816002) 

主　　题：Breast carcinoma Cytology Diagnosis Meta-analysis Nipple discharge 

摘      要：Background:Nipple discharge cytology is a simple non-invasive method that may provide valuable information for detecting underlying *** studies have investigated the diagnostic value of cytology in breast cancer patients with pathological nipple discharge,but the results have been highly *** we presented a systematic review and meta-analysis of published studies pertaining to the diagnostic capacity of nipple discharge cytology in patients with breast ***:A systematic literature search was performed(Medline/PubMed,Embase,Cochrane Library databases,and Google Scholar)to identify studies that investigated the diagnostic capacity of cytology with regard to breast cancer in patients with pathologic nipple *** independent researchers identified articles that assessed the sensitivity and specificity of cytological evaluation for breast cancer detection in patients with pathologic nipple discharge published between January 2000 and October *** were only included in the meta-analysis if they met predetermined *** characteristics of each study and the data they yielded were *** assessment of all articles included was performed using the Methodological Index for Non-randomized Studies Criteria(MINORS)and the Quality Assessment of Diagnostic Accuracy Study 2(QUADAS-2).Heterogeneity was tested via Cochran Q test and the I2 statistic using Stata 12.0 and Meta-DiSc 1.4 software,and meta-analysis was ***:A total of 286 articles were identified,of which 12 articles including a total of 1476 patients were deemed eligible for inclusion in the meta-analysis.A random-effects model assessing the capacity of nipple discharge cytology to predict breast cancer yielded pooled sensitivity 63%(95%confidence interval[CI]:53%-72%),specificity 95%(95%CI:87%-98%),positive likelihood ratio 12.35(95%CI:4.87-31.34),and negative likelihood ratio 0.39(95%CI:0.30-0.50).The diagnostic odds ratio was 31.88(95%