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Alcohol drinking triggered decrease of oxidative balance score is associated with high all-cause and cardiovascular mortality in hypertensive individuals: findings from NHANES 1999-2014

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Journal of geriatric cardiology : JGC 2024年第8期21卷 779-790页

作者： Yu-Jun Zhang Jing-Jing Song Jian-Hao Zhan chu-lin zhou Ao Li Mao-Qi Wang Ben-Jie Li Cong-Cong Ding Yi-Wei Zhang Zi-Heng Tan Zai-Hua Cheng Xiao Huang Department of Cardiology the Second Affiliated Hospital Jiangxi Medical College Nanchang University Nanchang China. Huankui Academy Nanchang University Nanchang China. School of Ophthalmology and Optometry of Nanchang University Nanchang China. The Second Clinical Medical College Nanchang University Nanchang China. Queen Mary School Nanchang University Nanchang China. The First Clinical Medical College Nanchang University Nanchang China. Department of Cardiovascular Medicine Huzhou First People's Hospital Zhejiang China.

BACKGROUND:Oxidative stress is closely associated with hypertensive outcomes. The oxidative balance score (OBS) measures oxidative stress exposure from dietary and lifestyle elements. The objective of this study was to investigate the association between OBS and mortality in hypertensive patients.METHODS:This study included 7823 hypertensive patients from the National Health and Nutrition Examination Survey (NHANES) 1999-2014. Several models, including Cox regression, restricted cubic splines (RCS), Kaplan‒Meier survival analysis, subgroup, and sensitivity analyses, were exploited to investigate the relationship between OBS and the risk of mortality.RESULTS:Controlling for all potential confounders, a significantly inverse association was observed between elevated OBS and all-cause [hazard ratio (HR) = 0.90, 95% CI: 0.85-0.95] and cardiovascular mortality (HR = 0.85, 95% CI: 0.75-0.95). With adjustment for covariates, significant associations between lifestyle OBS and mortality risks diminished, whereas associations between dietary OBS and these mortality risks remained robust (all-cause mortality: HR = 0.91, 95% CI: 0.86-0.96; cardiovascular mortality: HR = 0.85, 95% CI: 0.76-0.96). RCS demonstrated a linear relationship between OBS and all-cause and cardiovascular mortality risk ( = 0.088 and = 0.447, respectively). Kaplan‒Meier curves demonstrated that the mortality rate was lower with a high OBS ( < 0.001). The consistency of the association was demonstrated in subgroup and sensitivity analyses. RCS after stratification showed that among current drinkers, those with higher OBS had a lower risk of mortality compared with former or never drinkers.CONCLUSIONS:In hypertensive individuals, there was a negative association between OBS and all-cause and cardiovascular mortality. Encouraging hypertensive individuals, especially those currently drinking, to maintain high levels of OBS may be beneficial in improving their prognosis.

关键词： high finding Alcohol

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Alcohol drinking triggered decrease of oxidative balance score is associated with high all-cause and cardiovascular mortality in hypertensive individuals: findings from NHANES 1999–2014

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Journal of Geriatric Cardiology 2024年第08期 779-790页

作者： Yu-Jun ZHANG Jing-Jing SONG Jian-Hao ZHAN chu-lin zhou Ao LI Mao-Qi WANG Ben-Jie LI Cong-Cong DING Yi-Wei ZHANG Zi-Heng TAN Zai-Hua CHENG Xiao HUANG Department of Cardiology the Second Affiliated Hospital Jiangxi Medical College Nanchang University Huankui Academy Nanchang University School of Ophthalmology and Optometry of Nanchang University The Second Clinical Medical College Nanchang University Queen Mary School Nanchang University The First Clinical Medical College Nanchang University Department of Cardiovascular Medicine Huzhou First People's Hospital

BACKGROUND Oxidative stress is closely associated with hypertensive *** oxidative balance score （OBS） measures oxidative stress exposure from dietary and lifestyle *** objective of this study was to investigate the association between OBS and mortality in hypertensive *** This study included 7823 hypertensive patients from the National Health and Nutrition Examination Survey （NHA-NES） *** models,including Cox regression,restricted cubic splines （RCS）,Kaplan-Meier survival analysis,subgroup,and sensitivity analyses,were exploited to investigate the relationship between OBS and the risk of *** Controlling for all potential confounders,a significantly inverse association was observed between elevated OBS and all-cause[hazard ratio （HR）=0.90,95%CI:0.85-0.95]and cardiovascular mortality （HR=0.85,95%CI:0.75-0.95）.With adjustment for covariates,significant associations between lifestyle OBS and mortality risks diminished,whereas associations between dietary OBS and these mortality risks remained robust （all-cause mortality:HR=0.91,95%CI:0.86-0.96;cardiovascular mortality:HR=0.85,95%CI:0.76-0.96）.RCS demonstrated a linear relationship between OBS and all-cause and cardiovascular mortality risk (Pnonlinear=0.088 and Pnonlinear=0.447,respectively).Kaplan-Meier curves demonstrated that the mortality rate was lower with a high OBS （P<0.001）.The consistency of the association was demonstrated in subgroup and sensitivity *** after stratification showed that among current drinkers,those with higher OBS had a lower risk of mortality compared with former or never *** In hypertensive individuals,there was a negative association between OBS and all-cause and cardiovascular *** hypertensive individuals,especially those currently drinking,to maintain high levels of OBS may be beneficial in improving their prognosis.

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Scalable synthesis of lipid nanoparticles for nucleic acid drug delivery using an isometric channel-size enlarging strategy

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Nano Research 2024年第4期17卷 2899-2907页

作者： Zesen Ma Haiyang Tong Sijin lin Li zhou Demeng Sun Baoqing Li Changlin Tian Jiaru chu Department of Precision Machinery and Precision Instrumentation University of Science and Technology of ChinaHefei 230027China Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes University of Science and Technology of ChinaHefei 230027China Science Island Branch Graduate SchoolUniversity of Science and Technology of ChinaHefei 230026China Anhui Provincial Key Laboratory of High Field Magnetic Resonance Imaging High Magnetic Field LaboratoryHefei Institute of Physical ScienceChinese Academy of SciencesHefei 230031China Anhui Provincial Engineering Laboratory of Peptide Drugs University of Science and Technology of ChinaHefei 230027China School of Biomedical Engineering Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaSuzhou 215127China

Lipid nanoparticles(LNPs)have emerged as highly effective delivery systems for nucleic acid-based ***,the broad clinical translation of LNP-based drugs is hampered by the lack of robust and scalable synthesis techniques that can consistently produce formulations from early development to clinical *** this work,we proposed a method to achieve scalable synthesis of LNPs by scaling inertial microfluidic mixers isometrically in three ***,a theoretical predictive method,which controls the mixing time to be equal across different chips,is developed to ensure consistent particle size and size distribution of the synthesized *** loaded with small interfering RNA(siRNA)were synthesized at different flow rates,exhibiting consistent physical properties,including particle size,size distribution and encapsulation *** work provides a practical approach for scalable synthesis of LNPs consistently,offering the potential to accelerate the transition of nucleic acid drug development into clinical application.

关键词： lipid nanoparticles nucleic acid delivery microfluidics scalable synthesis consistent particle size

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Accurate atomic scanning transmission electron microscopy analysis enabled by deep learning

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Nano Research 2024年第4期17卷 2971-2980页

作者： Tianshu chu Lei zhou Bowei Zhang Fu-Zhen Xuan Shanghai Key Laboratory of Intelligent Sensing and Detection Technology East China University of Science and TechnologyShanghai 200237China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Key Laboratory of Pressure Systems and Safety of Ministry of Education East China University of Science and TechnologyShanghai 200237China

Currently,the machine learning(ML)-based scanning transmission electron microscopy(STEM)analysis is limited in the simulative stage,its application in experimental STEM is needed but ***,we built up a universal model to analyze the vacancy defects and single atoms accurately and rapidly in experimental STEM images using a full convolution *** our model,the unavoidable interference factors of noise,aberration,and carbon contamination were fully considered during the training,which were difficult to be considered in the *** toward the simultaneous identification of various vacancy types and low-contrast single atoms in the low-quality STEM images,our model showed rapid process speed(45 images per second)and high accuracy(>95%).This work represents an improvement in experimental STEM image analysis by ML.

关键词： deep learning low-dimensional materials atomic defects single atoms

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A review of CFD simulation in pressure driven membrane with fouling model and anti-fouling strategy

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Frontiers of Environmental Science & Engineering 2024年第8期18卷 1-29页

作者： Shiyong Miao Jiaying Ma Xuefei zhou Yalei Zhang Huaqiang chu State Key Laboratory of Pollution Control and Resource Reuse Tongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Tongji UniversityShanghai 200092China

Pressure-driven membrane filtration systems are widely utilized in wastewater treatment,desalination,and water reclamation and have received extensive attention from *** fluid dynamics(CFD)offers a convenient approach for conducting mechanistic studies of flow and mass transfer characteristics in pressure-driven *** a signature phenomenon in membrane systems,the concentration polarization that accompanies the permeation process is a key factor in membrane performance degradation and membrane fouling *** fouling models(scaling,biofouling and colloidal particle fouling)based on CFD theory have been constructed,and considerable research has been *** representative antifouling strategies with special simulation methods,including patterned membranes,vibration membranes,rotation membranes,and pulsatile flows,have also been *** studies should focus on refining fouling models while considering local hydrodynamic characteristics;experimental observation tools focusing on the internal structure of inhomogeneous fouling layers;techno-economic model of antifouling strategies such as vibrational,rotational and pulsatile flows;and unfavorable hydraulic phenomena induced by rapidly changing flows in simulations.

关键词： Computational fluid dynamics Membrane Fouling model Concentration polarization

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Improved catalytic performance of CO_(2) electrochemical reduction reaction towards ethanol on chlorine-modified Cu-based electrocatalyst

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Nano Research 2024年第5期17卷 3761-3768页

作者： Yifan Liu Hehua Tang Yitian zhou Bo-lin lin School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China

Effective electrochemical conversion of CO_(2) to value-added liquid multi-carbon products driven by renewable energy is a promising approach to alleviate excessive CO_(2) emission and achieve large-scale renewable energy ***,the selectivity and catalytic activity towards liquid multi-carbon products of CO_(2) electroreduction reaction are still unsatisfactory due to the sluggish C-C coupling process and the formation of complex oxygen-containing ***,designing and fabricating highly effective electrocatalysts is crucial for practical applications in this ***,we developed Cl-modified Cu catalyst(Cu-Cl)for efficient electrochemical reduction of CO_(2) to *** optimal Faradaic efficiency and partial current density of ethanol on the Cu-Cl sample reached 26.2%and 343.2 mA·cm^(-2) at-0.74 V(*** hydrogen electrode(RHE)),which were 1.66 and 1.76 times higher than those of the catalyst without Cl decoration,outperforming those in most previously reported *** functional theory(DFT)calculations revealed that the Cl-modified Cu surface suppressed the parasitic hydrogen evolution reaction(HER)and reduced the energy barrier for the C-C coupling process,making the formation of key intermediates favorable for ethanol ***,the decoration of Cl on the Cu surface facilitated ethanol formation.

关键词： CO_(2)electrochemical reduction halogen chlorine Cu-based catalysts ethanol multi-carbon products

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Ordered Bicontinuous Network Structures Regulated by Orientational Interactions in a Rod-Coil Block Copolymer

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Chinese Journal of Polymer Science 2024年第5期42卷 636-642,I0008页

作者： Xiao-lin Lyu Shi-chu Yang An-Qi Xiao Ping-Ping Hou Wei Zhang Hong-Bing Pan Zhi-Hao Shen Xing-He Fan Qi-Feng zhou Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China Key Laboratory of Advanced Materials Technologies International(HongKong Macao and Taiwan)Joint Laboratory on Advanced Materials TechnologiesCollege of Materials Science and EngineeringFuzhou UniversityFuzhou350108China

The rich phase behavior of block copolymers(BCPs)has drawn great attention in recent ***,the double diamond(DD)phase is rarely obtained because of the competition between the minimization of interfacial energy and packing ***,a rod-coil BCP containing mesogen-jacketed liquid crystalline polymer is designed to acquire ordered bicontinuous network *** reduction of internal energy originating from the orientational interaction among the rod blocks can compensate for the free energy penalty of packing frustration to stabilize the DD *** resulting BCP can also experience lamellae-to-DD and double gyroid-to-lamellae transitions by changing the annealing *** results make the rod-coil BCP an excellent candidate for the self-assembly of ordered network structures,demonstrating great potential in nanopatterning and metamaterials.

关键词： Block copolymer Rod-coil Ordered bicontinuous phase Double diamond Double gyroid

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Constructing a fluorinated interface layer enriched with Ge nanoparticles and Li-Ge alloy for stable lithium metal anodes

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Nano Research 2024年第6期17卷 5148-5158页

作者： Fulu chu Jinwei zhou Jiamin Liu Fengcheng Tang Liubin Song Feixiang Wu School of Metallurgy and Environment Engineering Research Center of the Ministry of Education for Advanced Battery MaterialsHunan Provincial Key Laboratory of Nonferrous Value-added MetallurgyCentral South UniversityChangsha 410083China Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation School of Chemistry and Chemical EngineeringChangsha University of Science and TechnologyChangsha 410004China School of Materials Science&Engineering University of JinanJinan 250022China

Lithium metal batteries(LMBs)based on metallic Li exhibit high energy density to be competent for advanced energy storage ***,the unstable solid electrolyte interphase(SEI)layer due to continuous decomposition of electrolytes,and the attendant problem of Li dendrite growth frustrate their commercialization ***,a hybrid SEI comprising abundant LiF,lithiophilic Li-Ge alloy,and Ge nanoparticles is constructed via a simple brush coating *** fluorinated interface layer with embedded Ge-containing components isolates the Li anode from the corrosive electrolyte and facilitates homogenous Li nucleation as well as uniform ***,the modified Li anode exhibits remarkable stability without notorious Li dendrites,delivering stable cycling lives of more than 1000 h for symmetric Li||Li cells and over 600 cycles for Li||Cu cells at 1 mA·cm^(−2).Moreover,the reinforced Li anodes endow multiple full-cell architectures with dramatically improved cyclability under different test *** work provides rational guidance to design an artificial hybrid SEI layer and would stimulate more ideas to solve the dendrite issue and promote the further development of advanced LMBs.

关键词： lithium metal anode artificial solid electrolyte interphase(SEI) dendrite suppression lithium fluoride Li-Ge alloy

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Voltage-modulated polymer nanopore field-effect transistor for multi-sized nanoparticle detection

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NANOTECHNOLOGY AND PRECISION ENGINEERING 2024年第3期7卷 79-89页

作者： zhou, Feng Li, lin Xue, Qiannan Tianjin Univ Sch Precis Instruments & Optoelect Engn State Key Lab Precis Measurement Technol & Instrum Tianjin 300072 Peoples R China

Solid-state nanopores offer a range of distinct advantages over biological nanopores, such as structural diversity and greater stability and durability; this makes them highly promising for high-resolution nanoparticle sensing. Biological nanopores can exhibit gating characteristics with stress-responsive switches and can demonstrate specificity toward particular molecules. Drawing inspiration from biological nanopores, this paper introduces a novel polymer nanopore with field-effect characteristics, leveraging a conductive polymer in its construction to showcase intriguing gating behavior. Notably, in this device, the polymer layer serves as the gate, enabling precise control over the source-drain current response inside and outside the pore by simply adjusting the gate voltage. This unique feature allows fine-tuning of the nanopore's sensitivity to nanoparticles of varying sizes and facilitates its operation in multiple modes. Experimental results reveal that the developed polymer nanopore field-effect transistor demonstrates remarkable selectivity in detecting nanoparticles of various sizes under different applied voltages. The proposed single device demonstrates the exceptional ability to detect multiple types of nanoparticle, showcasing its immense potential for a wide range of applications in biological-particle analysis and medical diagnostics.

关键词： Nanopipette Polymer nanopore Voltage modulation Nanoparticle detection DNA

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Enhanced removal of antibiotic resistance genes during chicken manure composting after combined inoculation of Bacillus subtilis with biochar

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Journal of Environmental Sciences 2024年第1期135卷 274-284页

作者： Zewen Wu Luan Zhang Hao lin Shungui zhou Fujian Provincial Key Laboratory of Soil Environmental Health and Regulation College of Resources and EnvironmentFujian Agriculture and Forestry UniversityFuzhou 350002China School of Environmental Science and Engineering Hubei Key Laboratory of Mine Environmental Pollution Control and RemediationHubei Polytechnic UniversityHuangshi 435003China Fujian Provincial Key Laboratory of Eco-Industrial Green Technology Wuyi UniversityWuyishan 354300China

This study explored the combined effects of Bacillus subtilis inoculation with biochar on the evolution of bacterial communities,antibiotic resistance genes(ARGs),and mobile genetic elements(MGEs)during the composting of chicken *** results showed that *** inoculation combined with biochar increased bacterial abundance and diversity as well as prolonged the compost thermophilic *** organic matter biodegradation and facilitated the organic waste compost humification process,reduced the proliferation of ARGs by altering the bacterial *** and Actinobacteriota were the main resistant bacteria related to ARGs and *** decrease in ARGs and MGEs was associated with the reduction in the abundance of related host *** inoculation with *** and the addition of biochar could promote nutrient transformation,reduce the increase in ARGs and MGEs,and increase the abundance of beneficial soil taxa.

关键词： Antibiotic resistance gene Bacillus subtilis Bacterial community Biochar Composting

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