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Organization of future training in bariatric gastroenterology

World journal of Gastroenterology 2017年第35期23卷 6371-6378页

作者： Timothy R Koch Timothy R Shope christopher j Gostout Center for Advanced Laparoscopic General and Bariatric Surgery Med Star Washington Hospital Center and Georgetown University School of Medicine Division of Gastroenterology and Hepatology Mayo Clinic

A world-wide rise in the prevalence of obesity continues. This rise increases the occurrence of, risks of, and costs of treating obesity-related medical conditions. Diet and activity programs are largely inadequate for the long-term treatment of medically-complicated obesity. Physicians who deliver gastrointestinal care after completing traditional training programs, including gastroenterologists and general surgeons, are not uniformly trained in or familiar with available bariatric care. It is certain that gastrointestinal physicians will incorporate new endoscopic methods into their practice for the treatment of individuals with medically-complicated obesity, although the longterm impact of these endoscopic techniques remains under investigation. It is presently unclear whether gastrointestinal physicians will be able to provide or coordinate important allied services in bariatric surgery, endocrinology, nutrition, psychological evaluation and support, and social work. Obtaining longitudinal results examining the effectiveness of this ad hoc approach will likely be difficult, based on prior experience with other endoscopic measures, such as the adenoma detection rates from screening colonoscopy. As a longterm approach, development of a specific curriculum incorporating one year of subspecialty training in bariatrics to the present training of gastrointestinal fellows needs to be reconsidered. This approach should be facilitated by gastrointestinal trainees' prior residency training in subspecialties that provide care for individuals with medical complications of obesity, including endocrinology, cardiology, nephrology, and neurology. Such training could incorporate additional rotations with collaborating providers in bariatric surgery, nutrition, and psychiatry. Since such training would be provided in accredited programs, longitudinal studies could be developed to examine the potential impact on accepted measures of care, such as complication rates, outcomes, and

关键词： Obesity Bariatrics Bariatric surgery Intragastric balloon Endoscopic sleeve gastroplasty Nutrition Endoscopy Training

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High–Speed electron beam curing of thick electrode for high energy density Li-ion batteries

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Green Energy & Environment 2019年第4期4卷 375-381页

作者： Zhijia Du christopher j.janke jianlin Li David L.Wood III Energy and Transportation Science Division Oak Ridge National LaboratoryOak RidgeTN 37831USA Chemical Sciences Division Oak Ridge National LaboratoryOak RidgeTN 37831USA

Electron beam curing is demonstrated as a promising method for high speed,low cost and environmentally friendly battery electrode *** work reports transfer of this process to pilot scale equipment and evaluation of electrochemical performance in prototype 1.5 Ah pouch *** LiNi0.5Mn0.3Co0.2O2(NMC532)composite electrodes with an areal loading of 25 mg cm^-2(~4 mAh cm^-2)are successfully cured at a line speed of 500 feet per minute at 275 *** to the NMC532 cathode processed via a conventional coating method,the electron beam cured electrodes show higher capacity fade in the first 100 cycles,but similar fade rate *** improvement strategies are proposed and *** work demonstrates that electron beam curing is a promising method for manufacturing thick battery electrodes at high speeds and low capital/operation cost.

关键词： Electron beam curing Li-ion batteries Thick electrode

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What job can a bug give?A controversy over the arsenic-guzzling bacterium cultured by NASA

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Protein & Cell 2011年第4期2卷 261-263页

作者： Mingwei Sun christopher j.Vavricka Baoli Zhu CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CASPMI)Beijing 100101China College of Life Sciences University of Science and Technology of ChinaHefei 230027China

The mysteries of life’s evolution on our planet drive us to explore the limits of *** forms on Earth as we know are composed of six essential elements:carbon,hydrogen,oxygen,nitrogen,sulfur and ***,a recently published research work funded by the National Aeronautics and Space Administration(NASA),USA,has almost shaken the fundamental knowledge about what is life made of on *** research team led by NASA astrobiologist Felisa Wolfe-Simon described a microbe isolated from California’s Mono Lake that could sustain its growth by using toxic chemical arsenic(As)instead of phosphorus(P).This surprising discovery was published online by Science Express on December 2 last year(Wolfe-Simon et al.,2010,online).If the authors of the paper were right,we would have to expand our definition of life on this *** arsenic-bug they grew was dubbed GFAj-1,which interestingly stands for“Give Felisa A job.”

关键词： bug planet Express

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Synthesis and Bioassay of 4-Substituted 2-Oxoglutaric Acids

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Chinese Chemical Letters 2006年第2期17卷 156-158页

作者： Qiu Yun CHEN Qing Shan LIU christopher j. SCHOFIELD Department of Chemistry Huangshan University Tunxi 245021 Department of Chemistry University of Oxford South Park Road Oxford OX1 3TA UK

Three 2-oxoglutaric acid analogues were synthesized. Their interaction with factor- inhibiting hypoxia-inducible factor （FIH） was studied using LC-MS method. The results show that hydrophobic substitutes of 2-oxoglu... 详细信息

关键词： 2-Oxoglutatic acid analogues inhibitor.

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Live-cell fluorescence imaging of ciliary dynamics

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Biophysics Reports 2021年第2期7卷 101-110页

作者： Quanlong Lü Chuanmao Zhang christopher j.Westlake Laboratory of Cellular and Developmental Signaling Center for Cancer Research National Cancer Institute National Institutes of Health Ministry of Education Key Laboratory of Cell Proliferation and Differentiation College of Life Sciences Peking University

The cilium was one of the first organelles observed through a microscope. Motile cilia appear as oscillating cell appendages and have long been recognized to function in cell motility. In contrast, the far more widespread non-motile cilia, termed primary cilia, were thought to be vestigial and largely ignored following their initial description over a century ago. Only in the last two decades has the critical function of primary cilia been elucidated. Primary cilia play essential roles in signal transduction,chemical sensation, mechanosensation and light detection. Various microscopy approaches have been important for characterizing the structure, dynamics and function of the cilia. In this review, we discuss the application of live-cell imaging technologies and their contribution to our current understanding of ciliary processes.

关键词： Cilia Ciliogenesis Ciliary dynamics Live-cell fluorescence imaging

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Engineering Novel Molecular Beacon Constructs to Study Intracellular RNA Dynamics and Localization

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Genomics, Proteomics & Bioinformatics 2017年第5期15卷 279-286页

作者： Zhao Ma Xiaotian Wu christopher j.Krueger Antony K.Chen Department of Biomedical Engineering College of Engineering Peking University Beijing 100871 China Wallace H Coulter Department of Biomedical Engineering Georgia Institute of Technology Atlanta GA 30332 USA

With numerous advancements in novel biochemical techniques, our knowledge of the role of RNAs in the regulation of cellular physiology and pathology has grown significantly over the past several decades. Nevertheless, detailed information regarding RNA processing, trafficking, and localization in living cells has been lacking due to technical limitations in imaging single RNA transcripts in living cells with high spatial and temporal resolution. In this review, we discuss tech- niques that have shown great promise for single RNA imaging, followed by highlights in our recent work in the development of molecular beacons （MBs）, a class of nanoscale oligonucleotide-probes, for detecting individual RNA transcripts in living cells. With further refinement of MB design and development of more sophisticated fluorescence microscopy techniques, we envision that MB-based approaches could promote new discoveries of RNA functions and activities.

关键词： Y-O-methyl RNA Phosphorothioate Molecular beacon RNA dynamics Single-molecule RNAimaging

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The Role of Chromatin Modifications in Progression through Mouse Meiotic Prophase

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journal of Genetics and Genomics 2014年第3期41卷 97-106页

作者： james H.Crichton christopher j.Playfoot Ian R.Adams MRC Human Genetics Unit MRC Institute of Genetics and Molecular MedicineUniversity of EdinburghWestern General Hospital

Meiosis is a key event in gametogenesis that generates new combinations of genetic information and is required to reduce the chro- mosome content of the gametes. Meiotic chromosomes undergo a number of specialised events during prophase to allow meiotic recombination, homologous chromosome synapsis and reductional chromosome segregation to occur. In mammalian cells, DNA phys- ically associates with histones to form chromatin, which can be modified by methylation, phosphorylation, ubiquitination and acetylation to help regulate higher order chromatin structure, gene expression, and chromosome organisation. Recent studies have identified some of the enzymes responsible for generating chromatin modifications in meiotic mammalian cells, and shown that these chromatin modifying enzymes are required for key meiosis-specific events that occur during meiotic prophase. This review will discuss the role of chromatin modifications in meiotic recombination, homologous chromosome synapsis and regulation of meiotic gene expression in mammals.

关键词： Mouse Meiosis Chromatin Chromosome Histone modification DNA methylation

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Featuring the Nd:YAG laser capsulotomy in the operating room

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International journal of Ophthalmology(English edition) 2020年第3期13卷 523-524页

作者： Veronique Promelle Sharon Armarnik christopher j Lyons Department of Ophthalmology and Visual Sciences University of British ColumbiaVancouver V5Z 3N9Canada

Dear Editor,We read with interest the article of Kinori et al[1]titled’Pediatric Nd:YAG laser capsulotomy in the operating room:review of 87 cases’.Facilities for laser capsulotomy under general anesthesia are essen... 详细信息

关键词： Featuring the Nd:YAG laser capsulotomy in the operating room YAG

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Effects of chemical and physical cues in enhancing neuritogenesis and peripheral nerve regeneration

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Neural Regeneration Research 2016年第2期11卷 220-221页

作者： CaseyD. Sigerson christopher j. Dipollina Michele Fornaro Department of Anatomy Midwestern University-Chicago College of Osteopathic MedicineDowners GroveILUSA Department of Biomedical Sciences Midwestern UniversityCollege of Health SciencesDowners GroveILUSA

Peripheral nerve injuries are most often a consequence of axonal damage leading to functional losses that may vary from lack of sensitivity distal to the site of injury to complete loss of motor *** consequences of such injuries are immense because of the high cost of health care,limited ability to work and emotional trauma that follows the *** spontaneous regrowth that the peripheral nervous system（PNS）.

关键词： neuritogenesis enhancing chemical

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Short-course or long-course radiation therapy as a part of a neoadjuvant regimen for stage Ⅱ & Ⅲ rectal adenocarcinoma?

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Chinese journal of Cancer Research 2019年第6期31卷 849-852页

作者： Nan Zhao christopher j Lin Fei Wang Chi Lin Department of Radiation Oncology University of Nebraska Medical Center OmahaNE 68198USA University of Southern California Los Angeles CA 90007USA

The aim of this mini-review is to compare and contrast the pros and cons of short-course and long-course neoadjuvant chemoradiation therapy regimens for stageⅡ&Ⅲrectal *** trials have demonstrated the equal efficacy and safety of short-course and long-course radiation therapy as a part of neoadjuvant *** data also shows that total neoadjuvant therapy could be more successful than neoadjuvant chemoradiation followed by adjuvant *** review points out future research directions for patients with locally advanced rectal adenocarcinoma such as comparing total neoadjuvant therapy that contains a short-course of radiation therapy to the standard of care,and evaluating how the sequence of short-course radiation therapy and chemotherapy in the total neoadjuvant therapy impacts the pathological complete response(pCR)rate,local control,and survival outcomes.

关键词： Short-course long-course radiation therapy rectal cancer

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