The Role of Chromatin Modifications in Progression through Mouse Meiotic Prophase

作     者：James H.Crichton Christopher J.Playfoot Ian R.Adams 

作者机构：MRC Human Genetics UnitMRC Institute of Genetics and Molecular MedicineUniversity of EdinburghWestern General Hospital 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2014年第41卷第3期

页      面：97-106页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：supported by a Medical Research Council (MRC)intramural program grant to I.R.A.at the MRC Human Genetics Unit in UK 

主　　题：Mouse Meiosis Chromatin Chromosome Histone modification DNA methylation 

摘      要：Meiosis is a key event in gametogenesis that generates new combinations of genetic information and is required to reduce the chro- mosome content of the gametes. Meiotic chromosomes undergo a number of specialised events during prophase to allow meiotic recombination, homologous chromosome synapsis and reductional chromosome segregation to occur. In mammalian cells, DNA phys- ically associates with histones to form chromatin, which can be modified by methylation, phosphorylation, ubiquitination and acetylation to help regulate higher order chromatin structure, gene expression, and chromosome organisation. Recent studies have identified some of the enzymes responsible for generating chromatin modifications in meiotic mammalian cells, and shown that these chromatin modifying enzymes are required for key meiosis-specific events that occur during meiotic prophase. This review will discuss the role of chromatin modifications in meiotic recombination, homologous chromosome synapsis and regulation of meiotic gene expression in mammals.