检索结果-南通市图书馆

Short-course or long-course radiation therapy as a part of a neoadjuvant regimen for stage Ⅱ & Ⅲ rectal adenocarcinoma?

在线全文

学校读者我要写书评

暂无评论

Chinese journal of Cancer Research 2019年第6期31卷 849-852页

作者： Nan Zhao christopher j Lin Fei Wang Chi Lin Department of Radiation Oncology University of Nebraska Medical Center OmahaNE 68198USA University of Southern California Los Angeles CA 90007USA

The aim of this mini-review is to compare and contrast the pros and cons of short-course and long-course neoadjuvant chemoradiation therapy regimens for stageⅡ&Ⅲrectal *** trials have demonstrated the equal efficacy and safety of short-course and long-course radiation therapy as a part of neoadjuvant *** data also shows that total neoadjuvant therapy could be more successful than neoadjuvant chemoradiation followed by adjuvant *** review points out future research directions for patients with locally advanced rectal adenocarcinoma such as comparing total neoadjuvant therapy that contains a short-course of radiation therapy to the standard of care,and evaluating how the sequence of short-course radiation therapy and chemotherapy in the total neoadjuvant therapy impacts the pathological complete response(pCR)rate,local control,and survival outcomes.

关键词： Short-course long-course radiation therapy rectal cancer

Expression of octopaminergic receptor genes in 4 nonneural tissues in female Nicrophorus vespilloides beetles

在线全文

学校读者我要写书评

暂无评论

Insect Science 2015年第4期22卷 495-502页

作者： christopher B. Cunningham Mary K. Douthit Allen j. Moore Department of Genetics University of Georgia Athens GA 30602 USA

Octopamine regulates the function of many tissues and physiological processes in invertebrates. The expression of octopamine receptor genes has been examined in multiple tissue types in several different insect orders. However, little work has addressed this issue in Coleoptera. Most studies characterize individual genes in different tissue types, but here we describe the expression of 6 octopamine receptor genes in thoracic musculature, oviducts, Malpighian tubules, and fat body of female Nicrophorus vespilloides beetles to characterize both different genes and different tissues within a single study. We then compare the gene expression profiles found in this beetle to other insects to examine the extent to which expression profiles are conserved across insects. We also examine the relative involvement of octopamine verses octopamine/tyramine receptors based on receptor gene expression in each tissue to help elucidate if tyramine plays a role in the regulation of these tissues. We find a high degree of overlap in the expression profile of the 6 genes examined in the thoracic muscula^tre, a moderate amount for the oviducts, and divergent profiles for Malpighian tubules and fat body. Based on expression difference in receptor subtypes, our results also support the suggestion that tyramine is a biogenic amine with physiological actions separate from octopamine.

关键词： biogenic amines Coleoptera G-protein coupled receptors quantitative real-time PCR

Biological and cultural diversity in the context of botanic garden conservation strategies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant Diversity 2017年第6期39卷 396-401页

作者： christopher P.Dunn Cornell Botanic Gardens 124 Comstock Knoll Drive Cornell University

Impacts of global climate change, habitat loss, and other environmental changes on the world's biota and peoples continue to increase, especially on islands and in high elevation areas. just as floristic diversity is affected by environmental change, so too are cultural and linguistic diversity. Of the approximately 7000 extant languages in the world, fully 50% are considered to be at risk of extinction, which is considerably higher than most estimates of extinction risks to plants and animals. To maintain the integrity of plant life, it is not enough for botanic gardens to consider solely the effects of environmental change on plants within the context of major conservation strategies such as the Global Strategy for Plant Conservation and the Convention on Biological Diversity. Rather, botanic gardens should actively engage in understanding and communicating the broader impacts of environmental change to biological and cultural diversity.

关键词： Biocultural diversity Botanic gardens Linguistic diversity Plant diversity

Unanticipated multiple seam stresses from pillar systems behaving as pseudo gob–case histories

在线全文

学校读者我要写书评

暂无评论

International journal of Mining Science and Technology 2017年第1期27卷 131-137页

作者： Gauna Michael Mark christopher Pittsburgh Safety and Health Technology Center Mine Safety and Health Administration(MSHA)PittsburghPA 15236USA

Underground coal mining in the U.S. is conducted in numerous regions where previous workings exist above and/or below an actively mined seam. Miners know that overlying or underlying fully extracted coal areas, also known as gob regions, can result in abutment stresses that affect the active mining. If there was no full extraction, and the past mining consists entirely of intact pillars, the stresses on the active seam are usually minimal. However, experience has shown that in some situations there has been sufficient yielding in overlying or underlying pillar systems to cause stress transfer to the adjoining larger pillars or barriers, which in turn, transfer significant stresses onto the workings of the active seam. In other words, the overlying or underlying pillar system behaves as a ‘‘pseudo gob." The presence of a pseudo gob is often unexpected, and the consequences can be severe. This paper presents several case histories, summarized briefly below, that illustrate pseudo gob phenomenon:(1) pillar rib degradation at a West Virginia mine at 335 m depth that contributed to a rib roll fatality,(2) pillar rib deterioration at a Western Kentucky mine at 175 m depth that required pillar size adjustment and installation of supplemental bolting,(3) roof deterioration at an eastern Kentucky mine at 400 m depth that stopped mine advance and required redirecting the section development,(4) coal burst on development at an eastern Kentucky mine at 520 m depth that had no nearby pillar recovery, and(5) coal burst on development at a West Virginia mine at the relatively shallow depth of 335 m that also had no nearby pillar recovery. The paper provides guidance so that when an operation encounters a potential pseudo gob stress interaction the hazard can be mitigated based on an understanding of the mechanism encountered.

关键词： Underground mining Coal Multiple seam Gob Ground control

Preventing roof fall fatalities during pillar recovery:A ground control success story

在线全文

学校读者我要写书评

暂无评论

International journal of Mining Science and Technology 2017年第1期27卷 107-113页

作者： Mark christopher Gauna Michael MSHA Pittsburgh Safety and Health Technology CenterPittsburghPA 15236USA

For decades, pillar recovery accounted for a quarter of all roof fall fatalities in underground coal *** showed that a miner on a pillar recovery section was at least three times more likely to be killed by a roof fall than other coal miners. Since 2007, however, there has been just one fatal roof fall on a pillar line. This paper describes the process that resulted in this historic achievement. It covers both the key research findings and the ways in which those insights, beginning in the early 2000 s, were implemented in mining practice. One key finding was that safe pillar recovery requires both global and local *** stability is addressed primarily through proper pillar design, and became a major focus after the2007 Crandall Canyon mine disaster. But the most significant improvements resulted from detailed studies that showed that local stability, defined as roof control in the immediate work area, could be achieved with three interventions:(1) leaving an engineered final stump, rather than extracting the entire pillar,(2) enhancing roof bolt support, particularly in intersections, and(3) increasing the use of mobile roof supports(MRS). A final component was an emphasis on better management of pillar recovery *** included a focus on worker positioning, as well as on the pillar and lift sequences, MRS operations,and hazard identification. As retreat mines have incorporated these elements into their roof control plans,it has become clear that pillar recovery is not ‘‘inherently unsafe." The paper concludes with a discussion of the challenges that remain, including the problems of rib falls and coal bursts.

关键词： Retreat mining Roof support Room-and-pillar Ground control

Rhythms of chloroplast magnesium import contribute to daily metabolic feedback

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2022年第11期15卷 1659-1661页

作者： Xiang Li christopher R.Buckley Michael j.Haydon School of BioSciences University of MelbourneParkvilleVIC 3010Australia

Organisms have evolved stable yet dynamic circadian systems to coordinate biological rhythms that contribute to *** oscillators generate rhythms via transcriptional and post-transcriptional control of key cellular processes such as metabolism and nutrient transport that fluctuate across the course of the *** addition,intracellular ions and metabolites can act as signaling molecules and protein cofactors that provide feedback to fine-tune biological timekeeping(Haydon et al.,2013).

关键词： magnesium metabolism coordinate

The effect of inlet conditions on the flow and heat transfer in multiple rotating cavity with axial throughflow

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

航空动力学报 2007年第5期22卷 683-693页

作者： christopher Long Peter Childs TFMRC Department of Engineering and Design University of Sussex Brighton BN1 9QT UK

This paper discusses experimental results from two different build configurations of a heated multiple rotating cavity test rig. Measurements of heat transfer from the discs and tangential velocities are presented. The test rig is a 70% full scale version of a high pressure compressor stack of an axial gas turbine engine. Of particular interest are the internal cylindrical cavities formed by adjacent discs and the interaction of these with a central axial throughflow of cooling air. Tests were carried out for a range of non-dimensional parameters representative of high pressure compressor internal air system flows (Reφup to 5×106 and ReΦup to 2×105).Two different builds have been tested. The most significant difference between these two build configurations is the size of the annular gap between the (non-rotating) drive shaft and the bores of the discs. The heat transfer data were obtained from thermocouple measurements of surface temperature and a conduction solution method. The velocity measurements were made using a two component, LDA system. The heat transfer results from the discs show differences between the two builds. This is attributed to the wider annular gap allowing more of the throughflow to penetrate into the cavity. There are also significant differences between the radial distributions of tangential velocity in the two builds of the test rig. For the narrow annular gap, there is an increase of non-dimensional tangential velocity Vφ/Ωr with radial location to solid body rotation Vφ/Ωr=*** the wider annular gap, the non-dimensional velocities show a decrease with radial location to solid body rotation.

关键词：轴向直流热转移旋转式孔进口接头

Current trends in urethral stricture management

在线全文

学校读者我要写书评

暂无评论

Asian journal of Urology 2014年第1期1卷 46-54页

作者： christopher j.Hillary Nadir I.Osman christopher R.Chapple Department of Urology Royal Hallamshire HospitalSheffieldUK

The recent International Consultation on Urological Disease(ICUD)panel 2010 confirmed that a urethral stricture is defined as a narrowing of the urethra consequent upon ischaemic spongiofibrosis,as distinct from sphincter stenoses and a urethral disruption *** possible,an anastomotic urethroplasty should be performed because of the higher success rate as compared to augmentation *** is some debate currently regarding the critical stricture length at which an anastomotic procedure can be used,but clearly the extent of the spongiofibrosis and individual anatomical factors(the length of the penis and urethra)are important,the limitation for this being extension of dissection beyond the peno-scrotal junction and the subsequent production of *** recently,there has been interest in whether to excise and anastomose or to carry out a stricturotomy and reanastomosis using a Heineke-Miculicz *** urethroplasty has evolved towards the more extensive use of oral mucosa grafts as compared to penile skin flaps,as both flaps and grafts have similar efficacy and certainly the use of either dorsal or ventral positioning seems to provide comparable *** is important that the reconstructive surgeon is well versed in the full range of available repair techniques,as no single method is suitable for all cases and will enable the management of any unexpected anatomical findings discovered intra-operatively.

关键词： Urethral stricture Stricture Lichen sclerosus Pelvic fracture Urethral injury Bladder outflow obstruction Urethroplasty Buccal mucosa graft

Formal methods, statistical debugging and exploratory analysis in support of system development: Towards a verification and validation calculator tool

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International journal of Modeling, Simulation, and Scientific Computing 2016年第1期7卷 120-141页

作者： Saikou Y.Diallo Ross Gore christopher j.Lynch jose j.Padilla Virginia Modeling Analysis and Simulation Center Old Dominion University 1030 University Blvd.SuffolkVA 23435USA

In this paper,we propose an approach to formally verify and rigorously validate a simulation system against the specification of the real *** implement the approach in a verification and validation calculator tool that takes as input a set of statements that capture the requirements,internal conditions of the system and expected outputs of the real system and produces as output whether the simulation satisfies the requirements,faithfully represents the internal conditions of the system and produces the expected *** provide a use case to show how subject matter experts can apply the tool.

关键词： Verification and validation formal methods modeling and simulation