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Higher consumption of animal organ meat is associated with a lower prevalence of nonalcoholic steatohepatitis

Hepatobiliary Surgery and Nutrition 2023年第5期12卷 645-657页

作者： Rui Zhang Huai Zhang Yi Wang Liang-Jie Tang Gang Li Ou-Yang Huang Sui-dan Chen Giovanni Targher christopher d.byrne Bin-Bin Gu Ming-Hua Zheng department of Nutrition the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Biostatistics and Medical Quality Management Office the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina MAFLd Research Center Department of Hepatologythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina department of Pathology the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly Southampton National Institute for Health Research Biomedical Research Centre University Hospital SouthamptonSouthampton General HospitalSouthamptonUK Institute of Hepatology Wenzhou Medical UniversityWenzhouChina Key Laboratory of diagnosis and Treatment for The development of Chronic Liver disease in Zhejiang Province WenzhouChina

Background:Animal organ meat(offal)is a food with high nutrient density that is popular in different parts of the world,but its relationship with nonalcoholic steatohepatitis(NASH)is *** aimed to examine whether daily animal organ meat consumption is associated with the presence of NASH in individuals with nonalcoholic fatty liver disease(NAFLd).Methods:A total of 136 Chinese adults with biopsy-proven NAFLd were *** NASH was defined as NAFLd activity score≥4 and at least one point for steatosis,ballooning,and lobular *** animal organ meat consumption was estimated using a self-administered validated food frequency *** regression analysis was performed to assess the association between animal organ meat intake and liver disease ***:The 136 participants(80.9%men)of the study had a mean±standard deviation(Sd)age of 39.0±12.5 years and body mass index of 27.4±3.6 kg/*** of definite NASH was 65.4%.daily median organ meat consumption was 1.30 g/1,000 *** organ meat consumption was inversely associated with the presence of NASH even after adjustment of demographics,lifestyle variables,metabolic and dietary factors,as well as liver fibrosis stage;adjusted-odds ratios(95%confidence intervals)for NASH were 0.15(0.03,0.69)for the highest tertile and 0.18(0.05,0.70)for the medium tertile,compared to the lowest(reference)tertile of animal organ meat intake(P value for trend=0.024).Conclusions:Our results suggest for the first time that higher animal organ meat consumption is associated with a lower prevalence of NASH in Chinese individuals with biopsy-proven NAFLd.

关键词： Nonalcoholic fatty liver disease(NAFLd) nonalcoholic steatohepatitis(NASH) diet organ meat red meat metabolic dysfunction-associated fatty liver disease(MAFLd)

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Portal hypertension in nonalcoholic fatty liver disease: Challenges and perspectives

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Portal Hypertension & Cirrhosis 2022年第1期1卷 57-65页

作者： Lei Miao Giovanni Targher christopher d.byrne Luca Valenti Xiaolong Qi Ming-Hua Zheng department of Gastroenterology The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly Southampton National Institute for Health Research Biomedical Research Centre Southampton General HospitalUniversity Hospital SouthamptonSouthamptonUK Translational Medicine Department of Transfusion Medicine and HematologyFondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca'Granda Ospedale Maggiore PoliclinicoMilanoItaly department of Pathophysiology and Transplantation Universitàdegli Studi di MilanoMilanoItaly CHESS Center Institute of Portal HypertensionThe First Hospital of Lanzhou UniversityLanzhouGansuChina department of Hepatology NAFLD Research CenterThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Key Laboratory of diagnosis and Treatment for the development of Chronic Liver disease in Zhejiang Province WenzhouZhejiangChina

Nonalcoholic fatty liver disease(NAFLd)has become the most common chronic liver disease ***‐related cirrhosis is often complicated by portal hypertension(PHT).Recent evidence showed that portal venous pressure(PVP)starts to rise in the early stages of NAFLd,even in absence of advanced fibrosis or ***,the precise pathological mechanisms of this process are still poorly *** accumulation,hepatocellular ballooning,sinusoidal endothelial cell dysfunction,capillarization,microthrombosis,increased angiogenesis,and pericellular fibrosis may all be involved in the early development of increased PVP in *** measurement of PHT is invasive and impractical in noncirrhotic NAFLd individuals and may also underestimate its ***,the development and validation of noninvasive and more accurate measurements,including new serum biomarkers,scoring models,and imaging techniques(such as ultrasonography,elastography,and magnetic resonance imaging),are urgently *** to the increasing morbidity,challenges in the prevention and management of PHT in NAFLd are *** review article aims to briefly discuss these challenges and summarizes the mechanisms,diagnosis,and emerging therapies for PHT in people with NAFLd.

关键词： metabolic dysfunction‐associated fatty liver disease nonalcoholic fatty liver disease novel noninvasive measurement portal hypertension

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Associations of Hydroxysteroid 17-beta dehydrogenase 13 Variants with Liver Histology in Chinese Patients with Metabolicassociated Fatty Liver disease

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Journal of Clinical and Translational Hepatology 2021年第2期9卷 194-202页

作者： Wen-Yue Liu Mohammed Eslam Kenneth I.Zheng Hong-Lei Ma Rafael S.Rios Min-Zhi Lv Gang Li Liang-Jie Tang Pei-Wu Zhu Xiao-dong Wang christopher d.byrne Giovanni Targher Jacob George Ming-Hua Zheng department of Endocrinology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneyWestmeadSydneyAustralia NAFLd Research Center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina department of Biostatistics Zhongshan HospitalFudan UniversityShanghaiChina department of Laboratory Medicine The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Institute of Hepatology Wenzhou Medical UniversityWenzhouZhejiangChina Southampton National Institute for Health Research Biomedical Research Centre University Hospital SouthamptonSouthampton General HospitalSouthamptonUK Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly Key Laboratory of diagnosis and Treatment for The development of Chronic Liver disease in Zhejiang Province WenzhouZhejiangChina

Background and Aims:In Europeans,variants in the hydroxysteroid 17-beta dehydrogenase 13(HSd17B13)gene impact liver histology in metabolic-associated fatty liver disease(MAFLd).The impact of these variants in ethnic Chinese is *** aim of this study was to investigate the potential associations in Chinese ***:In total,427 Han Chinese with biopsy-confirmed MAFLd were *** single nucleotide polymorphisms in HSd17B13 were genotyped:rs72613567 and *** regression was used to test the association between the single nucleotide polymorphisms and liver ***:In our cohort,the minor allele TA of the rs72613567 variant was related to an increased risk of fibrosis[odds ratio(OR):2.93(1.20–7.17),p=0.019 for the additive model;OR:3.32(1.39–7.91),p=0.007 for the recessive model],representing an inverse association as compared to the results from European *** contrast,we observed a protective effect on fibrosis for the minor A allele carriers of the HSd17B13 rs6531975 variant[OR:0.48(0.24–0.98),p=0.043 for the additive model;OR:0.62(0.40–0.94),p=0.025 for the dominant model].HSd17B13 variants were only associated with fibrosis but no other histological ***,HSd17B13 rs6531975 modulated the effect of PNPLA3 rs738409 on hepatic ***:HSd17B13 rs72613567 is a risk variant for fibrosis in a Han Chinese MAFLd population but with a different direction for allelic association to that seen in *** data exemplify the need for studying diverse populations in genetic studies in order to fine map genome-wide association studies signals.

关键词： Metabolic-associated fatty liver disease(MAFLd) Nonalcoholic fatty liver disease(NAFLd) Hydroxysteroid 17-beta dehydrogenase 13(HSd17B13) Single nucleotide polymorphism(SNP)

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A novel radiomics signature based on T2-weighted imaging accurately predicts hepatic inflammation in individuals with biopsy-proven nonalcoholic fatty liver disease:a derivation and independent validation study

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Hepatobiliary Surgery and Nutrition 2022年第2期11卷 212-226,I0008-I0010页

作者： Zhong-Wei Chen Huan-Ming Xiao Xinjian Ye Kun Liu Rafael S.Rios Kenneth I.Zheng Yi Jin Giovanni Targher christopher d.byrne Junping Shi Zhihan Yan Xiao-Ling Chi Ming-Hua Zheng department of Radiology the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina department of Hepatology Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhouChina department of Radiology the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouChina NAFLd Research Center Department of Hepatologythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina department of Pathology the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly Southampton National Institute for Health Research Biomedical Research Centre University Hospital SouthamptonSouthampton General HospitalSouthamptonUK department of Hepatology The Affiliated Hospital of Hangzhou Normal UniversityHangzhouChina Institute of Hepatology Wenzhou Medical UniversityWenzhouChina Key Laboratory of diagnosis and Treatment for The development of Chronic Liver disease in Zhejiang Province WenzhouChina

Background:Currently,there are no effective methods for assessing hepatic inflammation without resorting to histological examination of liver tissue obtained by biopsy.T2-weighted images(T2WI)are routinely obtained from liver magnetic resonance imaging(MRI)scan *** aimed to establish a radiomics signature based on T2WI(T2-RS)for assessment of hepatic inflammation in people with nonalcoholic fatty liver disease(NAFLd).Methods:A total of 203 individuals with biopsy-confirmed NAFLd from two independent Chinese cohorts with liver MRI examination were enrolled in this *** hepatic inflammatory activity score(IAS)was calculated by the unweighted sum of the histologic scores for lobular inflammation and *** thousand and thirty-two radiomics features were extracted from the localized region of interest(ROI)in the right liver lobe of T2WI and,subsequently,selected by minimum redundancy maximum relevance and least absolute shrinkage and selection operator(LASSO)*** T2-RS was calculated by adding the selected features weighted by their ***:Eighteen radiomics features from Laplacian of Gaussian,wavelet,and original images were selected for establishing *** T2-RS value differed significantly between groups with increasing grades of hepatic inflammation(Pded an area under the receiver operating characteristic(ROC)curve(AUROC)of 0.80[95%confidence interval(CI):0.71-0.89]for predicting hepatic inflammation in the training cohort with excellent *** AUROCs of T2-RS in the internal cohort and external validation cohorts were 0.77(0.61-0.93)and 0.75(0.63-0.84),***:The T2-RS derived from radiomics analysis of T2WI shows promising utility for predicting hepatic inflammation in individuals with NAFLd.

关键词： Nonalcoholic fatty liver disease(NAFLd) inflammation activity radiomics magnetic resonance imaging(MRI)

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Unraveling the epidemiology of metabolic dysfunction-associated liver cancer:Insights from mixed etiologies,regional variations,and gender disparities

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iLIVER 2024年第3期3卷 57-58页

作者： Gong Feng Ya-Fei Fan Ru-Xin Li Giovanni Targher christopher d.byrne Ming-Hua Zheng Institute of General Practice Xi'an Medical UniversityXi'an 710021China department of Infectious disease The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061China department of Health Management The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004China School of Clinical Medicine Xi'an Medical UniversityXi'an 710021China department of Medicine University of VeronaVerona 37126Italy Metabolic diseases Research Unit IRCCS Sacro Cuore-Don Calabria HospitalNegrar di Valpolicella 37024Italy Southampton National Institute for Health and Care Research Biomedical Research Centre University Hospital Southampton and University of SouthamptonSouthampton General HospitalSouthampton SO166YDUK MAFLd Research Center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Key Laboratory of diagnosis and Treatment for the development of Chronic Liver disease in Zhejiang Province Wenzhou 325000China

The Korean Republic nationwide cohort study by Yun et *** a stepwise increase in hepatocellular carcinoma(HCC)risk,progressing from“pure”metabolic dysfunction-associated steatotic liver disease(MASLd)to MASLd with increased alcohol intake(MetALd)and then to alcohol-associated liver disease[1].These data also highlight the significant impact of age and gender,underscoring the importance of tailoring prevention strategies to address not only metabolic dysfunction but also alcohol consumption in liver disease management[1].This Korean cohort study also illustrates the characteristics of MASLd-related HCC,providing new insights into the natural history of this liver disease.

关键词： epidemiology prevention gender

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基于PPARα基因为靶序列的RNA干涉作用

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基础医学与临床 2006年第7期26卷 761-765页

作者：王海彬 Zhang Jun-long 王军舰 Wang Chun-li Mark Hanson christopher d.byrne 广州中医药大学第一医院骨科广东广州510405 Endocrinology & Metabolism Unit FOAD DivisionSchool of MedicineUniversity of SouthamptonLD66South BlockSouthampton General HospitalSouthamptonSO16 6YDUK 中山大学生命科学学院广东广州510275 FOAd division School of MedicineUniversity of SouthamptonLevel F (887)Princess Ann HospitalCoxford RoadSouthamptonSO16 5YA

目的利用RNAi技术研究PPARα基因表达对骨骼肌脂代谢相关基因的表达的影响。方法设计合成针对过氧化物酶体增殖蛋白激活性受体α(PPARα)的dsRNA并将其转染到鼠骨骼肌C2C12细胞中,用RT-PCR测定PPARα及其应激基因mRNA水平的变化。结果ds... 详细信息

目的利用RNAi技术研究PPARα基因表达对骨骼肌脂代谢相关基因的表达的影响。方法设计合成针对过氧化物酶体增殖蛋白激活性受体α(PPARα)的dsRNA并将其转染到鼠骨骼肌C2C12细胞中,用RT-PCR测定PPARα及其应激基因mRNA水平的变化。结果dsRNA浓度的升高和PPARαmRNA水平的降低之间存在剂量线性关系。PPARα应激基因(包括乙酰辅酶A氧化酶ACO;长链脂酞辅酶A合成酶LCAS;脂蛋白脂肪酶LPL;LdL受体)mRNA水平也随之降低,进一步证明PPARαRNAi可以特异性的降低PPARαmRNA水平。然而PPARγ和PPARδmRNA水平不受影响,而且PPARαRNAi不能降低GAPdHmRNA和18srRNA水平,说明PPARαRNAi并不诱导一般mRNA的降解。结论PPARαRNAi能够特异性的降低骨骼肌细胞中PPARα及其应激基因的mRNA水平。

关键词： PPARα RNAi C2C12细胞株应激基因转录因子

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Glycemic control predicts the risk of hepatic fibrosis in biopsy-proven NAFLd:a possible mediating role for leukemia inhibitory factor?

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iLIVER 2022年第1期1卷 30-34页

作者： Feng Gong Kenneth I.Zheng Liang-Jie Tang Gang Li Rafael S.Rios Ou-Yang Huang Yang-Yang Li christopher d.byrne Giovanni Targher Man Mi Na He Hong-Lei Ma Ming-Hua Zheng Xi'an Medical University China NAFLd Research Center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina department of Pathology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Southampton National Institute for Health Research Biomedical Research Centre University Hospital SouthamptonSouthampton General HospitalSouthamptonUK Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly The First Affiliated Hospital of Xi'an Medical University Xi'anChina Institute of Hepatology Wenzhou Medical UniversityWenzhouChina Key Laboratory of diagnosis and Treatment for the development of Chronic Liver disease in Zhejiang Province WenzhouChina

Background:despite the clear link between nonalcoholic fatty liver disease(NAFLd)and type 2 diabetes mellitus,little is understood about how glycemic control impacts histological *** aimed to investigate the deeper association between hemoglobin A1c(HbA1c)and the histologic severity of liver ***:A total of 568 adults with biopsy-proven NAFLd from the PERSONS cohort in Wenzhou were *** association between mean HbA1c and hepatic histological features was investigated with ordinal logistic *** additive models were used to identify the non-linear relationship between HbA1c and increased fibrosis stage(stage F3).Causal mediation analysis was performed to calculate the indirect effect of the relationship between HbA1c and hepatic fibrosis mediated by ***:Every 1%increase in mean HbA1c was associated with 16%higher odds of increased fibrosis stage(odds ratio 1.16,95%CI 1.04–1.30),even after adjustment for confounding *** was a non-linear association between HbA1c and increased fibrosis stage(stage F3),and the HbA1c inflection point was 9.2%.In particular,the ORs on the left and right sides of this inflection point were 2.1(95%CI 1.4–3.3)and 0.1(95%CI 0–4.8),respectively.7%of the association(OR 1.07,95%CI 1.01–1.12)between HbA1c and liver fibrosis was mediated by leukemia inhibitory ***:Glycemic control predicts severity of hepatic fibrosis and leukemia inhibitory factor plays an intermediary role between them,and thus optimizing glycemic control may be a means of modifying the risk of fibrosis progression in NAFLd.

关键词： NAFLd Leukemia inhibitory factor Hepatic fibrosis

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对中-高度心血管危险人群，他汀类药物治疗使新发糖尿病轻度增多，但收益可能超过任何副作用

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英国医学杂志中文版 2010年第5期13卷 307-308页

作者： Lokpal Bhatia christopher d byrne 范维琥(译) Institute of developmental Sciences University of SouthamptonSouthamptonUK 复旦大学附属华山医院心内科

他汀类药物是使用范围最广的一类药物，仅在2008年，英国就大约开出了5千万张他汀类药物的处方。他汀类药物能显著减少中-高危病人的心血管事件，其在一级和二级预防中的有效性和安全性已经确立。常见报道的不良反应包括肌痛和肝酶升高... 详细信息

他汀类药物是使用范围最广的一类药物，仅在2008年，英国就大约开出了5千万张他汀类药物的处方。他汀类药物能显著减少中-高危病人的心血管事件，其在一级和二级预防中的有效性和安全性已经确立。常见报道的不良反应包括肌痛和肝酶升高，但总体上他汀类药物治疗中不良反应的发生率甚低，其耐受性良好。不过，

关键词：他汀类药物心血管事件药物治疗危险人群糖尿病副作用不良反应高危病人

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Metabolic dysfunction-associated Fatty Liver disease is Associated with Greater Impairment of Lung Function than Nonalcoholic Fatty Liver disease

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 230-237页

作者： Lei Miao Li Yang Li-Sha Guo Qiang-Qiang Shi Teng-Fei Zhou Yang Chen Huai Zhang Hui Cai Zhi-Wei Xu Shuan-Ying Yang Hai Lin Zhe Cheng Ming-Yang Zhu Xu Nan Shuai Huang Ya-Wen Zheng Giovanni Targher christopher d byrne Yu-Ping Li Ming-Hua Zheng Cheng-Shui Chen department of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina department of Gastroenterology The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina The Interventional Pulmonary Key Laboratory of Zhejiang Province WenzhouZhejiangChina NAFLd Research Center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZheji-angChina department of Biostatistics and Records Room Medical Quality Management OfficeThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina department of Respiratory Medicine Zhong Shan Hospital Affiliated to Shanghai Fudan UniversityShanghaiChina Clinical Research Service Center People’s Hospital of Henan ProvincialZhengzhouHenanChina department of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShanxiChina department of Pulmonary and Critical Care Medicine The Second Affili-ated Hospital of Fujian Medical UniversityQuanzhouFujianChina department of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly Southampton National Institute for Health Research Biomedical Research Center University Hospital SouthamptonSouth-ampton General HospitalSouthamptonUK Key Laboratory of diagnosis and Treatment for The development of Chronic Liver disease in Zhejiang Province WenzhouZhejiangChina

Background and Aims:We compared lung function parameters in nonalcoholic fatty liver disease(NAFLd)and metabolic dysfunction-associated fatty liver disease(MAFLd),and examined the association between lung function parameters and fibrosis severity in ***:In this cross-sectional study,we randomly recruited 2,543 middle-aged individuals from 25 communities across four cities in China during 2016 and *** participants received a health check-up including measurement of anthropometric parameters,biochemical variables,liver ultrasonography,and *** severity of liver disease was assessed by the fibrosis(FIB)-4 ***:The prevalence of MAFLd was 20.4%(n=519)and that of NAFLd was 18.4%(n=469).After adjusting for age,sex,adiposity measures,smoking status,and significant alco-hol intake,subjects with MAFLd had a significantly lower predicted forced vital capacity(FVC,88.27±17.60%vs.90.82±16.85%,pd lower 1 s forced expiratory volume(FEV1,79.89±17.34 vs.83.02±16.66%,pd FIB-4 score was significantly associated with decreased lung *** each 1-point increase in FIB-4,FVC was diminished by 0.507(95%CI:-0.840,-0.173,p=0.003),and FEV1 was diminished by 0.439(95%CI:-0.739,-0.140,p=0.004).The results remained unchanged when the statistical analyses was performed separately for men and ***:MAFLd was significantly asso-ciated with a greater impairment of lung function param-eters than NAFLd.

关键词： MAFLd NAFLd Lung function Liver fibrosis score

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成人非酒精性脂肪性肝病的诊断与监测

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英国医学杂志中文版 2020年第1期23卷 45-52页

作者： christopher d byrne Janisha Palel Eleonora Scorletti Giovanni Targher 张亚男(译) 范竹萍(审校) Nutrition and Metabolism Faculty of MedicineUniversity of SouthamptonUK Southampton National Institute for Health Research Biomedical Research Centre University Hospital SouthamptonSouthampton General HospitalSouthamptonUK department of Hepatology Southampton General HospitalSouthamptonUK department of Medicine Section of EndocrinologyDiabetes and MetabolismAzienda Ospedaliera Universitaria Integrata di VeronaVeronaItaly 上海交通大学医学院附属仁济医院健康保健中心

在一项常规体检中,一名52岁,经常久坐不动的电脑程序员发现其血清丙氨酸氨基转移酶(ALT)浓度为68 IU/L(正常0~40 IU/L),甘油三酯浓度为1.9 mmol/L。空腹血糖5.8 mmol/L,其他肝、肾、血脂基础检查正常。他没有什么重大疾病史,没有常规服... 详细信息

在一项常规体检中,一名52岁,经常久坐不动的电脑程序员发现其血清丙氨酸氨基转移酶(ALT)浓度为68 IU/L(正常0~40 IU/L),甘油三酯浓度为1.9 mmol/L。空腹血糖5.8 mmol/L,其他肝、肾、血脂基础检查正常。他没有什么重大疾病史,没有常规服用的药物,不吸烟,每周饮酒量少于7个单位。临床检查也没有什么异常发现。他的体质指数为29 kg/m^2,腰围102 cm,血压134/88 mmHg。几个月后复查的血清ALT仍然升高,为62 IU/L。

关键词：非酒精性脂肪性肝病常规体检饮酒量体质指数血清ALT 疾病史空腹血糖甘油三酯

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