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Commentary on impact of pulmonary function on robotic pulmonary resection

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Laparoscopic, Endoscopic and Robotic Surgery 2021年第3期4卷 93-94页

作者： Anthony Le Matheus Carelli Allen Guo christopher cao Department of Cardiothoracic Surgery Royal Prince Alfred HospitalSydney UniversitySydneyAustralia The Baird Institute for Applied Heart and Lung Surgical Research SydneyAustralia Chris O'Brien Lifehouse SydneyAustralia

Buitrago and colleagues should be commended on an excellent case report on the effective use of the robotic platform for a successful minimally invasive left lower lobectomy for a patient with biopsy proven squamous cell carcinoma.1 Despite a predicted postoperative forced expiratory volume in one second(ppoFEV1)of 23%and a preoperative diffusing capacity for carbon monoxide(DLCO)of 21%,the patient underwent a lobectomy without any intraoperative complications or evidence of disease at 15 months *** node sampling was performed from 5 *** postoperative length of staywas not clearly *** authors made several interesting points about the impact of pulmonary function on postoperative outcomes,the oncological efficacy of lobectomy versus sublobar resections,and merits of roboticassisted thoracoscopic surgery(RATS)versus thoracotomy and conventional video-assisted thoracoscopic surgery(VATS).We would like to discuss these points in further detail based on the available evidence in the current literature.

关键词： Pulmonary function Lung cancer Robot-assisted thoracoscopic surgery Lobectomy

Employment and Patient Satisfaction after Liver Transplantation

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Journal of Clinical and Translational Hepatology 2020年第3期8卷 299-303页

作者： christopher cao Dina Halegoua-DeMarzio Shady Guirguis Crystal Chen Jonathan M.Fenkel Steven Herrine Department of Gastroenterology and Hepatology Thomas Jefferson University HospitalsPhiladelphiaPAUSA

Background and Aims:This study serves to revisit the effects of liver transplantation(LT)on employment in an era of improving survival outcomes post-transplant,and to identify areas of improvement in the transplant process to better optimize post-LT employment and patient ***:Prospectively,patients who had undergone LT at a single tertiary LT center were surveyed in person and by *** outcomes included employment rate pre-and post-LT,annual salary,weekly hours worked,barriers to re-employment,and patient ***:Responses were collected and analyzed from 121 patients who underwent ***-LT,68(56.1%)reported full-time employment,13(10.7%)part-time employment,and 40(33.1%)***-LT,26(21.4%)reported continued full-time employment,18(14.9%)part-time employment,and 77(63.6%)*** weekly work hours decreased post-LT(16.1 h/week vs.39.9 h/week).Mean annual salaries decreased post-LT(17 earning salary≥$40,000 vs.56 earning salary≥$40,000).These outcomes differed from patient pre-LT expectations,with 81.0%of previously employed patients believing they would return to employment,resulting in decreased patient *** working physically demanding jobs pre-LT were less likely to return to *** cited for lack of return to full employment included early fatigue and difficulty regaining physical ***:Re-employment rates remain low post-LT,which is particularly true for patients working physically active *** is a significant barrier to re-employment and increased physical rehabilitation post-LT may prove to be *** should be given realistic expectations about return to employment prior to their LT.

关键词： Liver Transplant Liver transplant Employment Patient satisfaction

Malignant peritoneal mesothelioma

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World Journal of Gastrointestinal Surgery 2009年第1期1卷 38-48页

作者： Stine Munkholm-Larsen christopher Q cao Tristan D Yan University of Sydney Department of Cardiothoracic SurgeryRoyal Prince Alfred Hospital Baird Institute for Applied Heart and Lung Surgical

Malignant mesothelioma is a highly aggressive *** incidence of malignant mesothelioma is increasing *** malignant peritoneal mesothelioma(DMPM) represents one-fourth of all *** of asbestos exposure with DMPM has been observed,especially in *** great majority of patients present with abdominal pain and distension,caused by accumulation of tumors and ascitic ? *** the past,DMPM was considered a pre-terminal condition;therefore attracted little *** invariably died from their disease within a ***,several prospective trials have demonstrated a median survival of 40 to 90 mo and 5-year survival of 30% to 60% after combined treatment using cytoreductive surgery and perioperative intraperitoneal *** remarkable improvement in survival has prompted new search into the medical science related to DMPM,a disease previously ignored as *** review article focuses on the key advances in the epidemiology,diagnosis,staging,treatments and prognosis of DMPM that have occurred in the past decade.

关键词： Asbestos Cisplatin Cytoreductive surgery Doxorubicin Intraperitoneal chemotherapy Mesothelin Pemetrexed Peritoneal mesothelioma Peritonectomy

学术型外科医师如何撰写系统评价和Meta分析?

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中国胸心血管外科临床杂志 2015年第5期22卷 409-417页

作者： Kevin Phan David H. Tian christopher cao Deborah Black Tristan D. Yan 毛智 The Collaborative Research (CORE) Group Macquarie University Sydney Australia 解放军总医院

随着外科学领域文献数量的快速增长,越来越需要对现有证据进行评价和总结,使其能够更适用于临床。当针对某一临床问题的高质量临床试验很少时,对系统评价的结果解释就比较困难。若坚持使用严格的评价方法 (包括全面的文献检索、主要研... 详细信息

随着外科学领域文献数量的快速增长,越来越需要对现有证据进行评价和总结,使其能够更适用于临床。当针对某一临床问题的高质量临床试验很少时,对系统评价的结果解释就比较困难。若坚持使用严格的评价方法 (包括全面的文献检索、主要研究的质量评价、恰当的统计学方法、对估计值和偏倚风险的信度评估等),就可以将偏倚风险降到最低,并可能得出有用结论。因此,本文的目的是:(1)总结外科学领域全面严格的系统评价和meta分析的重要特征;(2)强调几个未广泛应用的统计学方法 ,相对于传统的两两对照数据合成,这些方法可能会开拓更广泛有趣的视野;(3)为全面分析和结果撰写提供一个指南。

关键词：系统评价 Meta分析外科结局森林图网络Meta分析 Meta回归

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全电视辅助胸腔镜手术治疗早期非小细胞肺癌

中国肺癌杂志 2010年第3期13卷 242-246页

作者： christopher Q. cao Stine MUNKHOLM-LARSEN Tristan D. YAN 王炜(翻译) 邵文龙(翻译) 何建行(校对) From Department of Cardiothoracic Surgery Royal Prince Alfred Hospital and the Baird Institute for Applied Heart and Lung Surgical University of Sydney Sydney NSW Australia 广州医学院第一附属医院胸外科广州呼吸疾病研究所

从出现至今,微创手术对所有的外科分支学科均产生了巨大影响。电视辅助胸腔镜(VATS)肺叶切除术治疗早期非小细胞肺癌于20世纪90年代早期被首次报道,自此在许多医疗中心中逐渐普及。这项较新的技术的支持者列举了该技术在围手术期可能获... 详细信息

从出现至今,微创手术对所有的外科分支学科均产生了巨大影响。电视辅助胸腔镜(VATS)肺叶切除术治疗早期非小细胞肺癌于20世纪90年代早期被首次报道,自此在许多医疗中心中逐渐普及。这项较新的技术的支持者列举了该技术在围手术期可能获得的许多有利结果,可能主要是因为该技术可减少手术创伤和应激反应。然而,由于仍缺乏有关长期生存和复发率的详实的临床数据,大部分胸心外科医生仍然持怀疑态度。"全"VATS的定义目前仍不明确,之前的许多研究将其视为"小切口开胸肺叶切除术",而非VATS肺叶切除术。在此,我们复习了有关全VATS肺叶切除术的文献,特别关注了直接对比VATS肺叶切除术和传统开胸肺叶切除术的比较研究。

关键词：电视辅助胸腔镜手术 VATS 非小细胞肺癌肺叶切除术

Amalgamated gold-nanoalloys with enhanced catalytic activity for the detection of mercury ions(Hg^2+)in seawater samples

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Nano Research 2020年第4期13卷 989-998页

作者： Natasha Logan Claire McVey christopher Elliott Cuong cao Institute for Global Food Security School of Biological SciencesQueens University Belfast19 Chlorine GardensBelfastBT95DLUK Material and Advanced Technologies for Healthcare Queens University Belfast18-30 Malone RoadBelfastBT95BNUK

Mercury(Hg)is extremely toxic,and continues to cause major threats to aquatic life,human health and the ***^2+mainly derives from seawater as a product of atmospheric deposition,therefore there is great demand for sensing approaches that can detect Hg^2+in seawater ***,we demonstrate that the peroxidase-mimicking activity of gold nanoparticles(AuNPs)or so-called nanozymes,can be exploited for the detection of Hg^2+ions in various water *** a high electrolyte environment,the catalytic activity for the oxidation of 3,3’,5,5’-tetramethylbenzidine(TMB)was significantly diminished due to poor stability of the *** activity was reduced by-73.7%when the NaCl concentration was higher than 1.168%,which is much lower than that of seawater(-3.5%),thus presenting its unsuitability for detecting Hg^2+in harsh water *** overcome this limitation,AuNPs were first functionalized with oligo-ethylene glycol(OEG),of which their colloidal form presented high stability in NaCl concentrations up to 20%and across a wide range of pHs from ***,the catalytic activity of OEG-AuNPs for the oxidation of TMB was strongly suppressed by the coating,but enhanced upon formation of Au-Hg *** novel finding underlies a straightforward,sensitive,and highly selective detection platform for Hg^2+in water *** approach could detect the exposure limit level for Hg^2+in drinking water(i.e.,2 ppb for tap and bottled water)as set by the United States Environmental Protection Agency(EPA)and the World Health Organization(WHO).When Hg^2+was spiked into a 3.5%saline solution and a coastal seawater certified reference material(CRM),the detection limits were found to be 10 ancM 3 ppb,respectively,which exceed the Hg^2+concentrations commonly found within seawater(-60-80 ppb).The whole procedure takes less than 45 min to conduct,providing a highly innovative,rapid and low-cost approach for detecting Hg^2+in complex water matrices.

关键词： gold nanoparticles nanozyme peroxidase-like mercury detection w ater samples seawater

Gold Nanozymes:From Concept to Biomedical Applications

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Nano-Micro Letters 2021年第1期13卷 138-173页

作者： Javier Lou‑Franco Bhaskar Das christopher Elliott Cuong cao Institute for Global Food Security School of Biological SciencesQueen’s University of Belfast19 Chlorine GardensBelfast BT95DLUK Present Address:Department of Biotechnology and Medical Engineering National Institute of Technology RourkelaRourkelaIndia

In recent years,gold nanoparticles have demonstrated excellent enzyme-mimicking activities which resemble those of peroxidase,oxidase,catalase,superoxide dismutase or ***,merged with their ease of synthesis,tunability,biocompatibility and low cost,makes them excellent candidates when compared with biological enzymes for applications in biomedicine or biochemical ***,over 200 research papers have been systematically reviewed to present the recent progress on the fundamentals of gold nanozymes and their potential *** review reveals that the morphology and surface chemistry of the nanoparticles play an important role in their catalytic properties,as well as external parameters such as pH or ***,real applications often require specific biorecognition elements to be immobilized onto the nanozymes,leading to unexpected positive or negative effects on their ***,rational design of efficient nanozymes remains a challenge of paramount *** implementation paths have already been explored,including the application of peroxidase-like nanozymes for the development of clinical diagnostics or the regulation of oxidative stress within cells via their catalase and superoxide dismutase *** review also indicates that it is essential to understand how external parameters may boost or inhibit each of these activities,as more than one of them could ***,further toxicity studies are required to ensure the applicability of gold nanozymes in *** challenges and future prospects of gold nanozymes are discussed in this review,whose significance can be anticipated in a diverse range of fields beyond biomedicine,such as food safety,environmental analyses or the chemical industry.

关键词： Gold nanoparticles Catalysis Nanozymes Diagnosis Nanomedicine

Low ADAMTS-13 in plavix induced thrombotic thrombocytopenic purpura

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World Journal of Clinical Cases 2013年第1期1卷 31-33页

作者： Long Bao cao christopher Jones Assad Movahed Department of Cardiovascular Sciences Brody School of MedicineEast Carolina University Greenville NC 27834 United States

Thrombotic thrombocytopenia purpura(TTP) was fi rst described in 1924 as a "pathologic alteration of the microvasculature, with detachment or swelling of the endothelium, amorphous material in the sub-endothelial space, and luminal platelet aggregation leading to compromise of the microcirculation". Ticlopidine induced TTP has been highly associated with autoimmune induced reduction in ADAMTS-13 activity. These findings, to a lesser extent, have also been found in clopidogrel induced TTP. We report a case of clopidogrel associated TTP in a patient that presented with acute stroke, renal failure, and non-ST elevation myocardial infarction.

关键词： Plavix Thrombotic thrombocytopenic purpura Antiplatelet therapy

Unusual switchable peroxidase-mimicking nanozyme for the determination of proteolytic biomarker

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Nano Research 2019年第3期12卷 509-516页

作者： Claire McVey Natasha Logan Nguyen T. K. Thanh christopher Elliott Cuong cao Institute for Global Food Security School of Biological Sciences Queens University Belfast 18-30 Malone Road Belfast BT9 5BN UK Biophysics Group Department of Physics and Astronomy University College London London WC1E 6BT UK UCL Healthcare Biomagnetic and Nanomaterials Laboratories 21 Albemarle Street London W1S 4BS UK Material and Advanced Technologies for Healthcare Queens University Belfast 18-30 Malone Road Belfast BT9 5BN UK

Detection of enzyme biomarkers originating from either bio-fluids or contaminating microorganisms is of utmost importance in clinical diagnostics and food safety. Herein, we present a simple, low-cost and easy-to-use sensing approach based on the switchable peroxidase-mimicking activity of plasmonic gold nanoparticles (AuNPs) that can catalyse for the oxidation of 3,3’,5’5-tetramethylbenzidine (TMB) for the determination of protease enzyme. The AuNP surface is modified with casein, showing dual functionalities. The first function of the coating molecule is to suppress the intrinsic peroxidase-mimicking activity of AuNPs by up to 77.1%, due to surface shielding effects. Secondly, casein also functions as recognition sites for the enzyme biomarker. In the presence of protease, the enzyme binds to and catalyses the degradation of the coating layer on the AuNP surface, resulting in the recovery of peroxidase-mimicking activity. This is shown visually in the development of a blue colored product (oxidised TMB) or spectroscopically as an increase in absorbance at 370 and 650 nm. This mechanism allows for the detection of protease at 44 ng·mL^-1 in 90 min. The nanosensor circumvents issues associated with current methods of detection in terms of ease of use, compatibility with point-of-care testing, low-cost production and short analysis time. The sensing approach has also been applied for the detection of protease spiked in ultra-heat treated (UHT) milk and synthetic human urine samples at a limit of detection of 490 and 176 ng·mL^-1, respectively, showing great potential in clinical diagnostics, food safety and quality control.

关键词： gold nano particles peroxidase-mimicking nanozyme enzyme detection biomarkers