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The Deep Thioredoxome in Chlamydomonas reinhardtii： New Insights into Redox Regulation

Molecular Plant 2017年第8期10卷 1107-1125页

作者： Maria Esther Perez-Perez Adeline Mauries alexandre Maes Nicolas J. Tourasse Marion Hamon Stephane D. Lemaire christophe H. Marchand Institut de Biologie Physico-Chimique UMR8226 CNRS Sorbonne Universit6s UPMC Univ Paris 06 13 rue Pierre et Marie Curie 75005 Paris France Institut de Biologie Physico-Chimique Plateforme de Proteomique FRC550 CNRS 13 rue Pierre et Marie Curie 75005 Paris France Instituto de Bioquimica Vegetal y Fotosintesis Consejo Superior de Investigaciones Cientificas (CSIC)-Universidad de Sevilla Seville Spain ARNA Laboratory INSERM U1212 CNRS UMR5320 Universite Bordeaux 2 Bordeaux France

Thiol-based redox post-translational modifications have emerged as important mechanisms of signaling and regulation in all organisms, and thioredoxin plays a key role by controlling the thiol-disulfide status of target proteins. Recent redox proteomic studies revealed hundreds of proteins regulated by glutathio- nylation and nitrosylation in the unicellular green alga Chlamydomonas reinhardtii, while much less is known about the thioredoxin interactome in this organism. By combining qualitative and quantitative proteomic analyses, we have comprehensively investigated the Chlamydomonas thioredoxome and 1188 targets have been identified. They participate in a wide range of metabolic pathways and cellular pro- cesses. This study broadens not only the redox regulation to new enzymes involved in well-known thiore- doxin-regulated metabolic pathways but also sheds light on cellular processes for which data supporting redox regulation are scarce （aromatic amino acid biosynthesis, nuclear transport, etc）. Moreover, we char- acterized 1052 thioredoxin-dependent regulatory sites and showed that these data constitute a valuable resource for future functional studies in Chlamydomonas. By comparing this thioredoxome with proteomic data for glutathionylation and nitrosylation at the protein and cysteine levels, this work confirms the existence of a complex redox regulation network in Chlamydomonas and provides evidence of a tremendous selectivity of redox post-translational modifications for specific cysteine residues.

关键词： Chlamydomonas reinhardtii disulfide bond isotope-coded affinity tag redox proteomics redox regulation thioredoxin targets

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Research and development of VUV optical coatings for micro mirror applications

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光学精密工程 2005年第4期13卷 465-470页

作者： alexandre Gatto Norbert Kaiser Fraunhofer IOF Albert-Einstein-Str. 7 D-07745 Jena GermanyFraunhofer IOF Albert-Einstein-Str. 7 D-07745 Jena Germany

This paper deals with vacuum UV optical coatings for micro mirror applications. High reflecting low-stress optical coatings have been developed for the next-generation of micro mechanical mirrors. The optimized metal systems are applicable in the VUV spectral region and can be integrated in the technology of MOEMS, such as spatial light modulators (SLM) and micro scanning mirrors.

关键词： VUV 光学涂覆技术微镜技术薄膜调节器

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Phytochemical Composition and Insecticidal Property of Native Plants against the Cowpea Weevil Callosobruchus maculatus Fab. (Coleoptera: Bruchidae) for Natural Preservation of Cowpea Seeds

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Advances in Entomology 2024年第1期12卷 56-66页

作者： Elias Mano Rabièta Simde Koï Wenceslas Kam Nadjatou Ouédraogo Désiré Dramane Abdoul Khader Sanou Rasmané Abdou Ouédraogo Boubakar Ouattara Pierre alexandre Eric Djifaby Sombié Souleymane Nacro Laboratory of Natural Substances and Technologies of Natural Products and the Environment (LABTECH-PRONE) Institute of Research in Applied Sciences and Technologies (IRSAT) Ouagadougou Burkina Faso Central Horticulture Laboratory of the Regional Center of Excellence in Fruits and Vegetables of Bobo-Dioulasso Institute of Environment and Agricultural Research (INERA) Bobo Dioulasso Burkina Faso Department of Animal Biology and Physiology University Joseph Ki-Zerbo Ouagadougou Burkina Faso National Agricultural Training School of Matourkou (ENAFA) Bobo Dioulasso Burkina Faso Institute of Rural Development (IDR) Nazi Boni University Bobo Dioulasso Burkina Faso

About 80% of cowpea seeds are lost along with 30% of their weight after six months of unprotected storage due to attacks by Callosobruchus maculatus. This study aimed at evaluating the effect of applying bioinsecticides on the biological parameters of C. maculatus to reduce its damage to cowpea stocks. Four treatments including an untreated control and three doses of powdery extracts of C. nigricans, Z. zanthoxyloides and H. suaveolens, were compared in a Fischer block with four completely randomized repetitions. One hundred undamaged cowpea seeds were mixed with doses of each extract in Petri dishes and then fed as food substrates to ten pairs of C. maculatus for eight days. The extracts of H. suaveolens, C. nigricans and Z. zanthoxyloides all contain active ingredients including polyphenols, flavonoids, anthocyanins and alkaloids, etc. The extract of Z. zanthoxyloides was found to be more active on adults (100.00% mortality) followed by C. nigricans (98.75% mortality) and H. suaveolens (97.50% mortality) at 80 mg/g. Fecundity per female decreased significantly in the treated batches of 13.82 eggs for H. suaveolens at 10.12 eggs for C. nigricans at a dose of 80 mg/g. Germination rate of seeds was statistically raised to 100% at 60 and 80 mg/g by C. nigricans powder and lowered to 83.00% at 20 mg/g by Z. zanthoxyloides extracts. The application of Z. zanthoxyloides extract would be a less expensive alternative for the sustainable management of C. maculatus in cowpea stocks.

关键词： Cassia nigricans Hyptis suaveolens Zanthoxylum zanthoxyloides Biological Activities Vigna unguiculata Pest Burkina Faso

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连接中欧,塑造未来

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今日中国 2024年第10期73卷 22-23页

作者：邓敬熙瑞士德科集团

中欧双方强强联手,将培养面向未来、推动经济增长的人才队伍。备受期待的2024中欧人才论坛重点关注人才发展的未来,为进一步增进中欧关系、加强中欧交流提供了一个宝贵平台。长期以来,中欧交往一直注重相互尊重,并在贸易、科技、教育和... 详细信息

中欧双方强强联手,将培养面向未来、推动经济增长的人才队伍。备受期待的2024中欧人才论坛重点关注人才发展的未来,为进一步增进中欧关系、加强中欧交流提供了一个宝贵平台。长期以来,中欧交往一直注重相互尊重,并在贸易、科技、教育和文化等各领域开展深度合作。在中欧培养适应性强、创新水平高、有韧性的人才,对于推动中欧关系持续蓬勃发展至关重要。我们今天面临的全球性挑战—从科技的快速进步到环境问题的不断出现—都在告诉我们,人类需要一支技术娴熟、能够灵活适应环境变化的人才队伍。

关键词：人才队伍中欧关系深度合作全球性挑战相互尊重强强联手灵活适应面向未来

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Effects of Andrade and Burgers rheologies on glacial isostatic adjustment modeling in Antarctica

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Geodesy and Geodynamics 2024年第5期 429页

作者： alexandre Boughanemi Anthony Mémin

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Needs of thermodynamic properties measurements and modeling in the frame of new regulations on refrigerants

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第5期8卷 724-733页

作者： COQUELET christophe RICHON Dominique School of Mines of Paris CEP/TEPCNRS FRE 286135rue Saint HonoréFontainebleau 77305France

In 1987, the Montreal Protocol prohibited the worldwide use and production of chlorofluorocarbons (CFCs) and hydrochlorofluorocarbons (HCFCs) and hydro fluorocarbons (HFCs) were proposed as alternative refrigerants. Unfortunately, HFCs have non negligible global warning potential and therefore new refrigerants must be proposed or old refrigerants must be used associated with HFC. Accurate experimental thermodynamic data and predictive techniques are required for better under-standing of the performance of the newly proposed refrigerants. In this communication, experimental techniques based on either analytic or synthetic methods are first described. Data are reported. Then two newly developed predictive models based on thermodynamic approach with the isofugacity criterion and artificial neural network method are presented. The results can provide better evaluation of refrigerants, especially with the aim of studying global warning effects.

关键词： Refrigerants Experimental apparatus Thermodynamic Modeling Vapor-liquid equilibria (VLE) Phase diagram Density

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Towards a modular and scalable holographic display

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Light(Science & Applications) 2022年第5期11卷 739-740页

作者： Pierre-alexandre Blanche Wyant College of Optical Sciences University of ArizonaTucsonAZUSA

Holographic three-dimensional(3D)display can be made very large using a modular system that allows seamless spatial tiling of multiple coarse integral holographic images.

关键词： holographic system integral

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Pharmaceutical applications of spouted beds: A review on solid dosage forms

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Particuology 2019年第1期17卷 126-136页

作者： Luis alexandre Pedro de Freitas Faculdade de Ciencias Farmaceuticas de Ribeirao Preto University of Sao PauloVia do Cafe s/n. Campus USPRibeirao Preto14040-903Sao Paulo. Brazil

Spouted beds (SBs) have a long history of successful applications for preparation of solid dosage forms of pharmaceuticals. The well-known versatility of SBs, provided by different design and operational factors, and their efficient mixing of solids allow for engineering of technological characteristics of pharmaceutical solid forms. Particle properties like morphology, size, porosity, flowability, and dissolution rate can be improved by managing geometric and operational conditions for spouting. Drying is probably the most disseminated operation for pharmaceutical processing in SBs, and many studies have investigated drying of medicinal plant extracts such as achiote (Bixa orellana sp.), guarana (Paullinia cupana sp.), passion flower (Passiflora alata D.), and rosemary (Rosmarinus officinalis L.) with excellent pharmacotechnical and stability results. Another important application is coating of tablets and gelatin capsules, and previous studies have shown that SBs and spout–fluid beds may be advantageous over traditional pan coating, especially for polymeric film coating. Recently, an alternative process for improving drug bioavailability has involved preparation of β-cyclodextrin inclusion complexes in SBs. The first study to propose SBs for this pharmaceutical application explored the advantage of obtaining solid forms of inclusion complexes in just one step, and obtained expressive increases in drug solubility. The technique has been applied in subsequent studies on inclusion complexes of the medication carvedilol and uxi (Endopleura uchi L.) extracts.

关键词： Coating Drying Granulation Inclusion Microencapsulation

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A POSTERIORI ENERGY-NORM ERROR ESTIMATES FOR ADVECTION-DIFFUSION EQUATIONS APPROXIMATED BY WEIGHTED INTERIOR PENALTY METHODS

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Journal of Computational Mathematics 2008年第4期26卷 488-510页

作者： alexandre Ern AnnetteF.Stephansen Université Paris-Est CermicsEcole des Ponts6 et 8 avenue Blaise PascalChamps sur Marne77455 Marne la Vallée Cedex 2France Université Paris-Est CermicsEcole des Ponts6 et 8 avenue Blaise PascalChamps sur Marne77455 Marne la Vallée Cedex 2France AndraParc de la Croix-Blanche1-7 rue Jean Monnet92298 Ch■tenay-Malabry cedexFrance

We propose and analyze a posteriori energy-norm error estimates for weighted interior penalty discontinuous Galerkin approximations of advection-diffusion-reaction equations with heterogeneous and anisotropic diffusion. The weights, which play a key role in the analysis, depend on the diffusion tensor and are used to formulate the consistency terms in the discontinuous Galerkin method. The error upper bounds, in which all the constants are specified, consist of three terms： a residual estimator which depends only on the elementwise fluctuation of the discrete solution residual, a diffusive flux estimator where the weights used in the method enter explicitly, and a non-conforming estimator which is nonzero because of the use of discontinuous finite element spaces. The three estimators can be bounded locally by the approximation error. A particular attention is given to the dependency on problem parameters of the constants in the local lower error bounds. For moderate advection, it is shown that full robustness with respect to diffusion heterogeneities is achieved owing to the specific design of the weights in the discontinuous Galerkin method, while diffusion anisotropies remain purely local and impact the constants through the square root of the condition number of the diffusion tensor. For dominant advection, it is shown, in the spirit of previous work by Verfiirth on continuous finite elements, that the local lower error bounds can be written with constants involving a cut-off for the ratio of local mesh size to the reciprocal of the square root of the lowest local eignevalue of the diffusion tensor.

关键词： Discontinuous Galerkin Weighted interior penalty A posteriori error estimate,Heterogeneous diffusion Advection-diffusion.

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Colon mucus in colorectal neoplasia and beyond

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World Journal of Gastroenterology 2022年第32期28卷 4475-4492页

作者： alexandre Loktionov DiagNodus Ltd Cambridge CB40WSUnited Kingdom

Little was known about mammalian colon mucus(CM)until the beginning of the 21^(st) *** that time considerable progress has been made in basic research addressing CM structure and *** CM is formed by two distinct layers composed of gel-forming glycosylated mucins that are permanently secreted by goblet cells of the colonic *** inner layer is dense and impenetrable for bacteria,whereas the loose outer layer provides a habitat for abundant commensal *** barrier integrity is essential for preventing bacterial contact with the mucosal epithelium and maintaining homeostasis in the gut,but it can be impaired by a variety of factors,including CM-damaging switch of commensal bacteria to mucin glycan consumption due to dietary fiber *** is proven that impairments in CM structure and function can lead to colonic barrier deterioration that opens direct bacterial access to the ***-induced damage dysregulates epithelial proliferation and causes mucosal inflammatory responses that may expand to the loosened CM and eventually result in severe disorders,including colitis and neoplastic *** described formation of bacterial biofilms within the inner CM layer was shown to be associated with both inflammation and *** obvious gaps in our knowledge of human CM remain,its importance for the pathogenesis of major colorectal diseases,comprising inflammatory bowel disease and colorectal cancer,is already *** progress in CM exploration is likely to result in the development of a range of new useful clinical applications addressing colorectal disease diagnosis,prevention and therapy.

关键词： Colon Colon mucus Mucins Goblet cells Gut microbiota Inflammatory bowel disease Colorectal cancer

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