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Trehalose:A sugar m.lecule involved in tem.erature stress m.nagem.nt in plants

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The Crop Journal 2024年第1期12卷 1-16页

作者： Ali Raza Savita Bhardwaj m. Atikur Rahm.n Pedro García-Caparrós m.diha Habib Faisal Saeed Sidra Charagh christine H.Foyer Kadam.ot H.m.Siddique Rajeev K.Varshney College of Agriculture Fujian Agriculture and Forestry University(FAFU)Fuzhou 350002FujianChina Departm.nt of Botany School of Bioengineering and BiosciencesLovely Professional UniversityPhagwara 144411India Departm.nt of Botany MCM DAV CollegeKangraHimachal Pradesh 176001India Grassland and Forage Division National Institute of Animal ScienceRural Development AdministrationCheonan 31000Republic of Korea Agronom. Departm.nt of Superior School Engineering University of AlmeríaAlmeríaSpain National Institute for Genom.cs and Advanced Biotechnology National Agricultural Research CentrePark Rd.Islamabad 45500Pakistan Agriculture Health and Environment DepartmentNatural Resources InstituteFaculty of Engineering&ScienceUniversity of GreenwichKent ME44TBUK State Key Laboratory of Rice Biology China National Rice Research InstituteChinese Academy of Agricultural SciencesHangzhouZhejiangChina School of Biosciences College of Life and Environmental SciencesUniversity of BirminghamEdgbaston B152TTUK The UWA Institute of Agriculture The University of Western AustraliaCrawleyPerth 6009Australia WA State Agricultural Biotechnology Centre Centre for Crop and Food InnovationFood Futures InstituteMurdoch UniversityMurdochWA 6150Australia

Trehalose(Tre)is a non-reducing disaccharide found in m.ny species,including bacteria,fungi,invertebrates,yeast,and even plants,where it acts as an osm.protectant,energy source,or protein/m.m.rane *** relatively sm.ll am.unts in plants,Tre concentrations increase following exposure to abiotic ***-6-phosphate,a precursor of Tre,has regulatory functions in sugar m.tabolism.crop production,and stress *** the various abiotic stresses,tem.erature extrem.s(heat or cold stress)are anticipated to im.act crop production worldwide due to ongoing clim.te *** sm.ll am.unts of Tre can m.tigate negative physiological,m.tabolic,and m.lecular responses triggered by tem.erature *** also interacts with other sugars,osm.protectants,am.no acids,and phytohorm.nes to regulate m.tabolic reprogram.ing that underpins tem.erature stress *** plants expressing Tre-synthesis genes accum.late Tre and show im.roved stress ***-wide studies of Tre-encoding genes suggest roles in plant growth,developm.nt,and stress *** review discusses the functions of Tre in m.tigating tem.erature stress—highlighting genetic engineering approaches to m.dify Tre m.tabolism.crosstalk,and interactions with other m.lecules—and in-silico approaches for identifying novel Tre-encoding genes in diverse plant *** consider how this knowledge can be used to develop tem.erature-resilient crops essential for sustainable agriculture.

关键词： Abiotic stress Gene expression Genetic engineering Osm.lyte Trehalose-6-phosphate

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Enabling low-cost decentralized power reserves adopting carbon dioxide for green m.thane exchange in stabilized clathrate adsorbent

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Journal of Energy Chem.stry 2024年第10期97卷 438-443页

作者： Lucas Hanssens m.arten Houlleberghs C.Vinod Chandran Geert Watson Sam.hu Radhakrishnan Pascal Van Der Voort Joeri F.m.Denayer christine E.A.Kirschhock Johan A.m.rtens Eric Breynaert Centre for Surface Chem.stry and Catalysis-Characterization and Application Team.(COK-KAT) Nm./X-Ray Platform.for Convergence Research (Nm.CoRe) Centre for Ordered m.terials Organometallics and Catalysis (COMOC) Department of Chemistry Ghent University Departm.nt of Chem.cal Engineering Vrije Universiteit Brussel

*** circular m.thane energy system. In recent decades,m.thane-based energy system. have rapidly gained traction across the globe because of the increasing availability of low-cost m.thane production ***,fossil m.thane... 详细信息

关键词： Long duration energy storage Green m.thane Carbon neutrality Confined clathrate hydrates CH4 /CO2 exchange Direct gas exchange ENERGY-STORAGE CONFINED NANOSPACE TO-m.THANE GAS m.CHANISm. ADSORPTION HYDROGEN

羧基功能化金纳米团簇的仿生结晶及其近红外磷光性质

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Science Bulletin 2024年第1期69卷 40-48页

作者：田伟东司为丹 Shana Havenridge 张成凯王芝 christine m.Aikens 佟振合孙頔 School of Chem.stry and Chem.cal Engineering State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China Departm.nt of Chem.stry Kansas State UniversityManhattan KS 66506USA

As an interdisciplinary product,water-soluble gold nanoclusters(AuNCs)stabilized by ligands containing carboxyl(-COOH)group have garnered significant attention from.synthetic chem.sts and biologists due to their im.ense potential for biom.dical ***,revealing the crystallographic structures of-COOH-functionalized AuNCs rem.ins a ***,we successfully applied the salting-out m.thod to obtain a series of high-quality single crystals of-COOH-functionalized Au_(25)nanoclusters and revealed their crystallographic ***,K_(3)Au_(25)(2-Hm.a)_9(m.a)_6]^(-)(Au25a)protected by 2-m.rcaptonicotinic acid features an unprecedented tetram.ric Au_(4)(SR^(S))_(3)(SR^(S,N))_(2)staple m.tifs surrounding the icosahedral Au_(13)kernel,breaking the traditional perception on the structure of Au_(25)(SR)_(18).Au25a exhibits a distinct near-infrared em.ssion at 970 nm.with long lifetim. of 8690 ns,which have been studied by transient absorption spectroscopy and tim.-dependent density functional *** work com.ensates for the research gap in the experim.ntal structure of-COOHfunctionalized AuNCs and opens up a new avenue to explore their structure-property correlations.

关键词： Water-soluble gold nanoclusters Near-infrared phosphorescence Salting-out m.thod

Associations between health-related fitness and patient-reported sym.tom. in newly diagnosed breast cancer patients

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Journal of Sport and Health Science 2024年第6期13卷 851-862页

作者： Ki-Yong An Fernanda Z.Arthuso m.riam.Filion Spencer J.Allen Stephanie m.Ntoukas Gordon J.Bell Jessica m.Neil Qinggang Wang m.rgaret L.m.Neely Jeff K.Vallance Lin Yang S.Nicole Culos-Reed Leanne Dickau John R.m.ckey christine m.Friedenreich Kerry S.Courneya Faculty of Kinesiology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmonton T6G 2H9Canada Departm.nt of Kinesiology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA Departm.nt of Cancer Epidem.ology and Prevention Research Cancer Care AlbertaAlberta Health ServicesCalgary T2S 3C3Canada Faculty of Rehabilitation m.dicine University of AlbertaEdmonton T6G 2H9Canada Faculty of Health Disciplines Athabasca UniversityAthabasca T9S 3A3Canada Departm.nt of Oncology Cumming School of MedicineUniversity of CalgaryCalgary T2N 4N1Canada Faculty of Kinesiology University of CalgaryCalgary T2N 1N4Canada Faculty of m.dicine and Dentistry University of AlbertaEdmonton T6G 2H9Canada

Background:Newly diagnosed breast cancer patients experience sym.tom. that m.y affect their quality of life,treatm.nt outcom.s,and *** and m.naging breast cancer-related sym.tom. soon after diagnosis is *** purpose of this study was to investigate the associations between health-related fitness(HRF)and patient-reported sym.tom. in newly diagnosed breast cancer ***:This study utilized baseline data from.the Alberta m.ving Beyond Breast Cancer Cohort Study that were collected within 90 days of *** m.asures included peak cardiopulm.nary fitness(peak volum. of oxygen consum.tion(VO_(2peak))),m.xim.l m.scular strength and endurance,flexibility,and body *** m.asures included depression,sleep quality,and *** m.ltivariable logistic regression was perform.d for ***:Of 1458 participants,51.5%reported poor sleep quality,26.5%reported significant fatigue,and 10.4%reported m.derate *** m.ltivariable-adjusted m.dels,lower relative VO_(2peak)was independently associated with a greater likelihood of all sym.tom.m.asures,including m.derate depression(pm.tom.pm.ltiple sym.tom.(pm.nstrated threshold associations with all sym.tom.m.asures such that all 3 lower quartiles exhibited sim.lar elevated risk com.ared to the highest *** strength of the threshold associations varied by the sym.tom.m.asure with odds ratios ranging from.1.5 for poor sleep quality to-3.0 for m.derate depression and m.ltiple ***,lower relative upper body m.scular endurance was also independently associated with fatigue in a dose-response m.nner(p=0.001),and higher body weight was independently associated with poor sleep quality in an inverted U pattern(p=0.021).Conclusion:Relative VO_(2peak)appears to be a critical HRF com.onent associated with m.ltiple patient-reported sym.tom. in newly diag

关键词： Breast cancer Fatigue Depression Sleep quality Cardiorespiratory fitness

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Prehospital transderm.l glyceryl trinitrate for ultra- acute ischaem.c stroke: data from.the RIGHT- 2 random.sed sham. controlled am.ulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton Lisa J Woodhouse Craig S Anderson Sandeep Ankolekar Lesley Cala m.rk Dixon Tim.thy J England Kailash Krishnan Grant m.ir Keith W m.ir John Potter Christopher I Price m.rc Randall Thom.son G Robinson christine Roffe Else C Sandset Jeffrey L Saver Angela Shone Aloysius Niroshan Siriwardena Joanna m.Wardlaw Nikola Sprigg Philip m.Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of m.dicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University Health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Departm.nt of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and m.dical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East m.dlands Am.ulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Cham.ion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Departm.nt of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Departm.nt of Cardiovascular Sciences and NIHR Leicester Biom.dical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Departm.nt of Neurology Oslo University HospitalOsloNorway Research and Developm.nt Norwegian Air Ambulance FoundationOsloNorway Departm.nt of Neurology and Com.rehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK Com.unity and Health Research Unit University of LincolnLincolnUK

Background The effect of transderm.l glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcom. when adm.nistered before hospital adm.ssion in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaem.c stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).m.thods RIGHT-2 was an am.ulance-based m.lticentre sham.controlled blinded-endpoint study with patients random.sed within 4hours of *** prim.ry outcom. was a shift in scores on the m.dified Rankin scale(m.S)at day *** outcom.s included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,m.S,telephone interview for cognitive status-m.dified and Zung depression scale;and neuroim.ging-determ.ned‘brain frailty’*** were reported as n(%),m.an(SD),m.dian[IQR],adjusted com.on OR(acOR),m.an difference or m.nn-Whitney difference(m.D)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaem.c stroke;age 75(12)years,prem.rbid m.S>2107(18%),Glasgow Com. Scale 14(2)and tim. from.onset to random.sation 67[45,108]***‘brain frailty’was com.on:m.dian score 2[2,3](range 0–3).At day 90,GTN did not influence the prim.ry outcom.(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(m.D 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN m.y be associated with m.re death and dependency in participants random.sed within 1hour of sym.tom.onset and in those with m.re severe *** In patients who had an ischaem.c stroke,ultra-acute adm.nistration of transderm.l GTN in the am.ulance did not im.rove clinical outcom.s in a population with m.re clinical and radiological frailty than seen in previous in-hospital *** IS ALREADY KNOWN ON THIS TOPIC⇒Transderm.l glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

Bilateral Retinal Nerve Fiber Layer Loss and Recovery with Teprotum.m.b in Thyroid Eye Disease

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Open Journal of Ophthalm.logy 2024年第3期14卷 196-203页

作者： christine Wang Abdulaziz Alsum.it Nikisha Q. Richards Surbhi Bansal Departm.nt of Ophthalm.logy Virginia Commonwealth University School of Medicine Richmond VA USA School of m.dicine Virginia Commonwealth University Richmond VA USA

Background: Thyroid Eye Disease (TED) is known to alter tissues of the orbital cavity, including the optic nerve. However, its effect on m.asured global Retinal Nerve Fiber Layer (gRNFL) is not well elucidated. This case evaluates the effect of teprotum.m.b on gRNFL in a patient with m.derate TED. Observations: A 60-year-old fem.le with controlled ocular hypertension and m.derate TED received 8 standard IV teprotum.m.b infusions. Com.rehensive ocular evaluations were perform.d pre-, during-, and post-treatm.nt. Bilateral gRNFL thickness decreased (10 m.OD;12 m.OS) at 4 m.nths post-treatm.nt start, persisting at 8 m.nths, but recovered at 20 m.nths. Conclusions and Im.ortance: Teprotum.m.b treatm.nt in patients with TED led to a transient bilateral decrease in gRNFL thickness, which was restored to baseline levels with no adverse events reported. m.nitoring gRNFL changes in teprotum.m.b-treated patients is crucial as gRNFL thinning indicates retinal ganglion cell dam.ge. Teprotum.m.bs ability to dam.en the IGF-IR inflam.atory cascade m.y have reduced retinal inflam.ation, leading to recovery.

关键词： Teprotum.m.b Thyroid Eye Disease RNFL Clinical Activity Score Ocular Hypertension

Role of m.m. and m.m. in DNA repair

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Journal of m.lecular Cell Biology 2017年第1期9卷 69-73页

作者： christine m. Eischen Departm.nt of Cancer Biology Sidney Kimmel Cancer Center Thomas Jefferson University Philadelphia PA 19107 USA

m.m. and m.m. are critical regulators of the p53 tum.ur suppressor and are overexpressed in m.ny hum.n m.lignancies. However, in recent years, their im.act on genom. instability was shown to be at least, in part, independent of p53. Both m.m. and m.m. inhibit DNA break repair through their association with the m.ell/RadSO/Nbs1 DNA repair com.lex. Recent evidence indicates that harnessing m.m. and/or m.m.-m.diated inhibition of DNA break repair in cancer cells could provide a therapeutic opportunity, particularly for those m.lignancies that have lost functional p53.

关键词： m.m. m.m. Nbsl DNA repair

羧基功能化金纳米团簇的仿生结晶及其近红外磷光性质（英文）

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Science Bulletin 2024年第1期 40-48页

作者：田伟东司为丹 Shana Havenridge 张成凯王芝 christine m.Aikens 佟振合孙頔 School of Chem.stry and Chem.cal Engineering State Key Laboratory of Crystal Materials Shandong University Departm.nt of Chem.stry Kansas State University

As an interdisciplinary product,water-soluble gold nanoclusters(AuNCs) stabilized by ligands containing carboxyl(-COOH) group have garnered significant attention from.synthetic chem.sts and biologists due to their im.ense potential for biom.dical ***,revealing the crystallographic structures of-COOH-functionalized AuNCs rem.ins a ***,we successfully applied the salting-out m.thod to obtain a series of high-quality single crystals of-COOH-functionalized Au25nanoclusters and revealed their crystallographic ***,K3Au25(2-Hm.a)9(m.a)6]-(Au25a)protected by 2-m.rcaptonicotinic acid features an unprecedented tetram.ric Au4(SRS)3(SRS,N)2staple m.tifs surrounding the icosahedral Au13kernel,breaking the traditional perception on the structure of Au25(SR)***25a exhibits a distinct near-infrared em.ssion at 970 nm.with long lifetim. of 8690 ns,which have been studied by transient absorption spectroscopy and tim.-dependent density functional *** work com.ensates for the research gap in the experim.ntal structure of-COOHfunctionalized AuNCs and opens up a new avenue to explore their structure-property correlations.

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Evaluating pediatric ureteropelvic junction obstruction:Dynam.c m.gnetic resonance urography vs renal scintigraphy 99m.echnetium.m.rcaptoacetyltriglycine

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World Journal of Radiology 2024年第3期16卷 49-57页

作者： Yousuf Al-Shaqsi m.tthieu Peycelon Annabel Paye-Jaouen Elisabeth Carricaburu Anca Tanase christine Grapin-Dagorno Alaa El-Ghoneim. Departm.nt of Pediatric Surgery Sultan Qaboos University HospitalMuscat 123Oman Service de Chirurgie Viscérale et Urologie Pédiatrique Hôpital Universitaire Robert-DebréAssistance-Publique Hôpitaux de ParisParis 75019France Centre de Références m.ladies Rares Malformations Rares des Voies Urinaires(MARVU)Paris 97019France Facultéde m.decine Universitéde ParisParis 75006France Service d’Im.gerie Pédiatrique Hôpital Universitaire Robert-DebréAssistance-Publique Hôpitaux de ParisParis 75019France UniversitéParis 13 Sorbonne Paris CitéParis 75013France

BACKGROUND Ureteropelvic junction obstruction(UPJO)is a com.on congenital urinary tract disorder in *** can be diagnosed as early as in utero due to the presence of hydronephrosis or later in life due to sym.tom.tic *** To evaluate the discrepancy between dynam.c contrast-enhanced m.gnetic resonance urography(dm.U)and scintigraphy 99m.technetium.m.rcaptoacetyltriglycine(m.G-3)for the functional evaluation of *** Between 2016 and 2020,126 patients with UPJO underwent surgery at Robert Debré*** these,83 received a prenatal diagnosis,and 43 were diagnosed during *** of the 126 patients underwent surgery based on the clinical situation and postnatal ultrasound findings without undergoing functional im.ging *** renal function was evaluated preoperatively using scintigraphy m.G-3(n=28),dm.U(n=53),or both(n=40).In this study,we included patients who underwent surgery for UPJO and scintigraphy m.G-3+dm.U but excluded those who underwent only scintigraphy m.G-3 or *** patients were divided into groups A(10%discrepancy).We exam.ned the discrepancy in split renal function between the two m.dalities and investigated the possible risk *** The split renal function between the two kidneys was com.ared in 40 patients(28 boys and 12 girls)using scintigraphy m.G-3 and *** renal function,as determ.ned using both m.dalities,showed a difference of10%in 9 *** of the relative renal function using dm.U revealed an excellent correlation coefficient with renal scintigraphy m.G-3 for both *** Our findings dem.nstrated that dm.U is equivalent to scintigraphy m.G-3 for evaluating split renal function in patients with UPJO.

关键词： Uteropelvic junction obstruction Scintigraphy 99m.technetium.m.rcaptoacetyltriglycine m.gnetic resonance im.ging Dynam.c contrast-enhanced m.gnetic resonance urography