Role of Mdm2 and Mdmx in DNA repair

作     者：Christine M. Eischen 

作者机构：Department of Cancer Biology Sidney Kimmel Cancer Center Thomas Jefferson University Philadelphia PA 19107 USA 

出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)

年 卷 期：2017年第9卷第1期

页      面：69-73页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 

基　　金：supported by the grants NCI 

主　　题：Mdm2 Mdmx Nbsl DNA repair 

摘      要：Mdm2 and Mdmx are critical regulators of the p53 tumour suppressor and are overexpressed in many human malignancies. However, in recent years, their impact on genome instability was shown to be at least, in part, independent of p53. Both Mdm2 and Mdmx inhibit DNA break repair through their association with the Mrell/RadSO/Nbs1 DNA repair complex. Recent evidence indicates that harnessing Mdm2 and/or Mdmx-mediated inhibition of DNA break repair in cancer cells could provide a therapeutic opportunity, particularly for those malignancies that have lost functional p53.