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Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

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Science China Chemistry 2025年第01期 377-384页

作者： Shiwen Liu Xuerui wan Meng Zhao Jiaqi wang Weilan wu Linlin You Yonggui Yuan Qian Xu Rong Gao Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University Key Laboratory of Modern Toxicology of Ministry of Education Department of Hygienic Analysis and Detection School of Public HealthNanjing Medical University Department of Psychosomatics and Psychiatry Zhongda Hospital School of Medicine Southeast University

The measurement of amino acid and monoamine neurotransmitters（NTs） in serum plays a central role in the identification and monitoring of clinical panic disorder（PD）. However, the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely challenging. Herein, we developed a strategy that integrated solid phase extraction based on magnetic Fe3O4coated with polydopamine（Fe3O4@PDA） and direct analysis of mass spectrometry in real time（DART-MS） for quantification of 10 NTs. We systematically investigated the optimal conditions of this strategy to achieve good accuracy and precision. Compared with existing magnetic solid phase extraction methods for NTs detection in biological samples, this strategy could adsorb more targets while having similar adsorption efficiencies, and the total process time was reduced by an average of 69.42%. We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic accuracy. In addition, an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this strategy. Our results highlighted the potential ability of Fe3O4@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia wu Wei wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

Semi-supervised Software Defect Prediction Using Task-Driven Dictionary Learning

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Chinese Journal of Electronics 2016年第6期25卷 1089-1096页

作者： CHENG ming wu Guoqing YUAN Mengting wan Hongyan School of Computer Wuhan University State Key Laboratory of Software Engineering Wuhan University

We present a semi-supervised approach for software defect prediction. The proposed method is designed to address the special problematic characteristics of software defect datasets, namely, lack of labeled samples and class-imbalanced data. To alleviate these problems, the proposed method features the following components. Being a semi-supervised approach, it exploits the wealth of unlabeled samples in software systems by evaluating the confidence probability of the predicted labels, for each unlabeled sample. And we propose to jointly optimize the classifier parameters and the dictionary by a task-driven formulation, to ensure that the learned features(sparse code) are optimal for the trained classifier. Finally, during the dictionary learning process we take the different misclassification costs into consideration to improve the prediction performance. Experimental results demonstrate that our method outperforms several representative stateof-the-art defect prediction methods.

关键词： Software defect prediction Task-driven dictionary learning Cost-sensitive Semi-supervised learning Sparse representation

Strong Mixing Subshift of Finite Type and Hausdorff Measure of Its Chaotic Set

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Acta Mathematica Sinica,English Series 2011年第4期27卷 789-798页

作者： wan Gan SONG Zhi HU Hua ming wu School of Mathematical Science Peking University Beijing 100871 P. R. China School of Computer Science and Technology Huaibei Coal Industry Teachers Huaibei 235000 P. R. China School of Mathematical and Computer Science Zhanjiang Teachers College Zhanjiang 524048 P. R. China

We present a sufficient and necessary condition for the subshift of finite type to be a measure-preserving transformation or to be a strong mixing measure-preserving transformation with respect to the Hausdorff measur... 详细信息

关键词： Symbolic space a finite subshift chaotic set Hausdorff measure

Three-Dimensional Morphology and Growth Behavior of Ferrite Allotriomorphs Formed at Grain Boundary Edges

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Journal of Iron and Steel Research International 2010年第11期17卷 49-53页

作者： wan Xiang-liang CHENG Lin wu Kai-ming International Research Institute of Steel Technology Wuhan University of Science and Technology Wuhan 430081 Hubei China

Three-dimensional morphology of ferrite allotriomorphs nucleated at grain boundary edges in low carbon steel was revealed by means of serial sectioning in conjunction with computer-aided three-dimensional reconstruction techniques. The typical morphology of them was of an elongated triangular pyramid. The length, width and thickness of ferrite allotriomorphs were measured on the basis of three-dimensional reconstructed images. The aspect ratio （length/width） of them was 4.5 on an average and scattered from 3 to 6. The measured sizes were smaller than calculated ones, which was probably attributed to solute drag-like effect of manganese in the alloy.

关键词： steels ferrite allotriomorph three-dimensional morphology growth kinetics

Improved side information generation algorithm for Wyner-Ziv video coding

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The Journal of China Universities of Posts and Telecommunications 2014年第1期21卷 109-115页

作者： ZHANG Deng-yin wu Yuan-yuan wan ming-xiang Sci-Tech Park of Internet of Things Nanjing University of Posts and Telecommunication Key Laboratory of Broadband Wireless Communication and Sensor Network Technology Nanjing University of Posts and Telecommunication

Side information has a significant influence on the rate-distortion（RD） performance of distributed video coding（DVC）. In the conventional motion compensated frame interpolation scheme, all blocks adopt the same side-information generation method regardless of the motion intensity inequality at different regions. In this paper, an improved method is proposed. The image blocks are classified into two modes, fast motion and slow motion, by simply computing the discrete cosine transformation（DCT） coefficients at the encoder. On the decoder, it chooses the direct interpolation and refined motion compensated interpolation correspondingly to generate side information. Experimental results show that the proposed method, without increasing the encoder complexity, can increase the average peak signal-to-noise ratio（PSNR） by up to 1~ 2 dB compared with the existing algorithm. Meanwhile, the proposed algorithm significantly improves the subjective quality of the side information.

关键词： DVC side information motion estimation motion compensation

基于感性工学和模糊层次分析法的汽车皮革座椅肌理设计研究

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皮革科学与工程 2025年第1期35卷 98-106页

作者：万青蓝武月琴西华大学美术与设计学院四川成都610039

为深入了解消费者对汽车皮革座椅的感性需求,选取25~44岁消费者进行实验研究。首先通过调研、焦点小组等方法选取4对感性词汇:商务/运动、高端/经济、传统/现代、复杂/简约;借助形态分析法解构汽车皮革座椅肌理要素,获得色彩、光泽、纹... 详细信息

为深入了解消费者对汽车皮革座椅的感性需求,选取25~44岁消费者进行实验研究。首先通过调研、焦点小组等方法选取4对感性词汇:商务/运动、高端/经济、传统/现代、复杂/简约;借助形态分析法解构汽车皮革座椅肌理要素,获得色彩、光泽、纹理、图案、质感五类肌理形式;其次运用模糊层次分析法构建层次指标体系与模糊函数评价矩阵,量化消费者感性需求;进一步分析用户感性意向与肌理设计各元素之间的相关性,提出符合用户感性需求的汽车皮革座椅肌理设计元素组合。并将代表特殊感性意向的肌理元素运用到汽车皮革座椅设计中,以期为汽车座椅颜色、材料、表面处理提供参考。

关键词：皮革肌理汽车座椅产品设计感性工学模糊层次分析法

In situ observation of austenite grain growth behavior in the simulated coarse-grained heat-affected zone of Ti-microalloyed steels

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International Journal of Minerals,Metallurgy and Materials 2014年第9期21卷 878-885页

作者： Xiang-liang wan Kai-ming wu Gang Huang Ran Wei Lin Cheng The State Key Laboratory of Refractories and Metallurgy Hubei Collaborative Innovation Center for Advanced Steels Wuhan University of Science and Technology

The austenite grain growth behavior in a simulated coarse-grained heat-affected zone during thermal cycling was investigated via in situ observation. Austenite grains nucleated at ferrite grain boundaries and then grew in different directions through movement of grain boundaries into the ferrite phase. Subsequently, the adjacent austenite grains impinged against each other during the α→γtransformation. After the α→γ transformation, austenite grains coarsened via the coalescence of small grains and via boundary migration between grains. The growth process of austenite grains was a continuous process during heating, isothermal holding, and cooling in simulated thermal cycling. Abundant finely dispersed nanoscale TiN particles in a steel specimen containing 0.012wt% Ti effectively retarded the grain boundary migration, which resulted in refined austenite grains. When the Ti concentration in the steel was increased, the number of TiN particles de- creased and their size coarsened. The big particles were not effective in pinning the austenite grain boundary movement and resulted in coarse austenite grains.

关键词： alloy steel austenite grain growth heat-affected zone coarsening titanium nitride

Emergence,Mating and Oviposition Behavior of the Chinese Population in Pink Bollworm,Pectinophora gossypiella (Lepidoptera:Gelechiidae)

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Journal of Integrative Agriculture 2013年第4期12卷 653-662页

作者： wu Huai-heng HUANG Min-song wan Peng Kris A G Wyckhuys wu Kong-ming State Key Laboratory for Biology of Plant Diseases and Insect Pests/Institute of Plant Protection Chinese Academy of Agricultural Sciences Institute of Plant Protection and Soil Fertilizer Hubei Academy of Agricultural Sciences International Center for Tropical Agriculture CIAT-Asia

The pink bollworm, Pectinophora gossypiella （Lepidoptera： Gelechiidae） is one of the most serious lepidopteran pests of cotton in the world. This pest invaded China at the onset of the 20th century, possibly through repeated introductions from several different locations worldwide. In this paper, we describe different behavioral parameters of this Hubei P. gossypiella strain under laboratory and field conditions. Using an infra-red video recorder, we observed （nocturnal） emergence, flight and mating activities, and oviposition patterns. Moth emergence started from 13：00 and continued up till 23：00. Under laboratory and field conditions, 2-7-d-old moths initiated flight around sunset, peaked 50 rain later and gradually declined until 04：00. Although mating started immediately after darkness （i.e., 20：00）, mating behavior was most intense from 23：00 to 03：40. Oviposition also showed distinct time-related patterns, with approx. 70% eggs laid between 20：00 and 22：00. In the studies of the relationship between flight and oviposition, the duration of flight had an effect on oviposition. The 1-d-old moths flown for 6 and 12 h began oviposition earlier than the unflown ones, and the 6-h flight had no effect on the egg production. However, the longevity of the flown moths was shortened after flight. In addition, the peaks of oviposition for the flown moths were advanced 2-3 d. The age when the moths flied affected the oviposition of adult moths. The earlier the moths started to fly after emergence, the greater the fecundity they had. The average egg production of moths flown for 24 h was less than that of non-flown moths which were of the same age. Both flight and delay in mating could advance the oviposition peak. Our study provides detailed insights in nocturnal activities and the reproductive biology of local P. gossypiella populations, which could be employed to fine-tune current pest management programs in China.

关键词： Pectinophora gossypiella nocturnal activities emergence mating oviposition