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Absent MicroRNAs in Different Tissues of Patients with Acquired Cardiomyopathy

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Genomics, Proteomics & Bioinformatics 2016年第4期14卷 224-234页

作者： christine s. siegismund Maria Rohde Uwe Kiihl Felicitas Escher Heinz Peter schultheiss Dirk Lassner Institute for Cardiac Diagnostics and Therapy(IKDT) 12203 BerlinGermany Department of Cardiology Campus VirchowCharite-University Hospital Berlin13353 BerlinGermany

MicroRNAs （miRNAs） can be found in a wide range of tissues and body fluids, and their specific signatures can be used to determine diseases or predict clinical courses. The miRNA profiles in biological samples （tissue, serum, peripheral blood mononuelear cells or other body fluids） differ significantly even in the same patient and therefore have their own specificity for the presented condition. Complex profiles of deregulated miRNAs are of high interest, whereas the importance of non-expressed miRNAs was ignored. since miRNAs regulate gene expression rather negatively, absent miRNAs could indicate genes with unaltered expression that therefore are normally expressed in specific compartments or under specific disease situations. For the first time, non-detectable miRNAs in different tissues and body fluids from patients with different diseases （cardiomyopathies, Alzheimer＇s disease, bladder cancer, and ocular cancer） were analyzed and compared in this study, miRNA expression data were generated by microarray or TaqMan PCR-based platforms. Lists of absent miRNAs of primarily cardiac patients （myocardium, blood cells, and serum） were clustered and analyzed for potentially involved pathways using two prediction platforms, i.e., miRNA enrichment analysis and annotation tool （miEAA） and DIANA miRPath. Extensive search in biomedical publication databases for the relevance of non-expressed miRNAs in predicted pathways revealed no evidence for their involvement in heart-related pathways as indicated by software tools, confirming proposed approach.

关键词： Cardiomyopathy Heart muscle biopsy Absent mi RNAs Peripheral blood mononuclear cell serum

Risk stratification for malignant progression in Barrett's esophagus: Gender, age, duration and year of surveillance

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World Journal of Gastroenterology 2016年第48期22卷 10592-10600页

作者： Piers Gatenby santanu Bhattacharjee christine Wall christine Caygill Anthony Watson United Kingdom Barrett’s Oesophagus Registry UCL Regional Oesophagogastric Unit Royal Surrey County Hospital Department of Clinical and Experimental Medicine University of Surrey Division of surgery and Interventional science UCL Royal Free Campus

AIM To clarify risk based upon segment length, diagnostic histological findings, patient age and year of surveillance, duration of surveillance and *** Patients registered with the United Kingdom Barrett's Oesophagus Registry from 9 United Kingdom centers were included. The outcome measures were(1) development of all grades of dysplasia;(2) development of high-grade of dysplasia or adenocarcinoma; and(3) development of adenocarcinoma. Prevalent cases and subjects with s examined were segment length, previous biopsy findings, age at surveillance, duration of surveillance, year of surveillance and *** One thousand and one hundred thirty six patients were included(total 6474 patient-years). Fifty-four patients developed adenocarcinoma(0.83% per annum), 70 developed high-grade dysplasia/adenocarcinoma(1.1% per annum) and 190 developed any grade of dysplasia(3.5% per annum). High grade dysplasia and adenocarcinoma increased with age and duration of surveillance. The risk of low-grade dysplasia development was not dependent on age at surveillance. segment length and previous biopsy findings were also significant factors for development of dysplasia and *** The risk of development of low-grade dysplasia is independent of age at surveillance, but high-grade dysplasia and adenocarcinoma were more commonly found at older age. segment length and previous biopsy findings are also markers of risk. This study did not demonstrate stabilisation of the metaplastic segment with prolonged surveillance.

关键词： Dysplasia Barrett’s esophagus Esophageal neoplasms Public health Epidemiology surveillance

Cryptanalysis and improvement of controlled secure direct communication

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Chinese Physics B 2013年第6期22卷 203-205页

作者： Kao shih-Hung hwang Tzonelih National Cheng Kung University Institute of Computer Science and Information Engineering

This paper points out that, due to a flaw in the sender＇s encoding, the receiver in Gao et al.＇s controlled quantum secret direct communication （CQsDC） protocol [Chin. Phys. 14 （2005）, No. 5, p. 893] can reveal ... 详细信息

关键词： quantum cryptography quantum communication

Brazilin and Caesalpinia sappan L. extract protect epidermal keratinocytes from oxidative stress by inducing the expression of GPX7

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Chinese Journal of Natural Medicines 2018年第3期16卷 203-209页

作者： Hyung seo hwang Joong Hyun shim Department of Oriental Cosmetic science Semyung University

Caesalpinia sappan L., belonging to the family Leguminosae, is a medicinal plant that is distributed in southeast Asia. The dried heartwood of this plant is used as a traditional ingredient of food, red dyes, and folk medicines in the treatment of diarrhea, dysentery, tuberculosis, skin infections, and inflammation. Brazilin is the major active compound, which has exhibited various phar- macological effects, including anti-platelet activity, anti-hepatotoxicity, induction of immunological tolerance, and anti-inflammatory and antioxidant activities. The present study aimed to evaluate the antioxidant activity and expression of antioxidant enzymes of C. sappan L. extract and its major compound, brazilin, in human epidermal keratinocytes exposed to UVA irradiation. Our results indi- cated that C. sappan L. extract reduced UVA-induced H202 production via GPX7 activation. Moreover, brazilin exhibited anfioxidant effects that were similar to those of C. sappan L. via glutathione peroxidase 7 （GPX7）, suggesting that C. sappan L. extract and its natural compound represent potential treatments for oxidative stress-induced photoaging of skin.

关键词： Caesalpinia sappan L. Brazilin Ultraviolet GPX7 Antioxidative

surgery for inflammatory bowel disease

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World Journal of Gastroenterology 2008年第17期14卷 2678-2690页

作者： John M hwang Madhulika G Varma Center for Colorectal surgery Department of Surgery University of California San Francisco

Despite the new and ever expanding array of medications for the treatment of inflammatory bowel disease (IBD), there are still clear indications for operative management of IBD and its complications. We present an ove... 详细信息

关键词： Crohn's disease Ulcerative colitis Operation surgical treatment Ileal pouch

Teleportation of three-dimensional single particle state in noninertial frames

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Chinese Physics B 2014年第2期23卷 74-79页

作者：吴奇成文晶姬计新 Yeon Kyu-hwang Department of Physics College of ScienceYanbian University Department of Physics College of Natural ScienceChungbuk National University

Considering the spin degree of freedom of the Dirac field, we study the entanglement behavior of a different class of communication channel and teleportation of three-dimensional single particle state in noninertial frames. Numerical analysis shows that the communication channel in our scheme can offer enough distillable entanglement for the teleportation protocol. Moreover, the teleportation protocol could work well if Rob＇s acceleration is not very big, but the fidelity of the teleportation is still reduced due to the Unruh effect.

关键词： three-dimensional entangled states noninertial frames teleportation Unruh effect

Estimation of plasma parameters of X-pinch with time-resolved x-ray spectroscopy

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Matter and Radiation at Extremes 2023年第3期8卷 34-46页

作者： seunggi Ham Jonghyeon Ryu Hakmin Lee sungbin Park Y.-C.Ghim Y.s.hwang Kyoung-Jae Chung Department of Energy systems Engineering Seoul National UniversitySeoul 08826South Korea Department of Nuclear and Quantum Engineering KAISTDaejeon 34141South Korea

We estimate the parameters of a Cu plasma generated by an X-pinch by comparing experimentally measured x-rays with synthetic data.A filtered absolute extreme ultraviolet diode array is used to measure time-resolved x-ray spectra with a spectral resolution of∼1 keV in the energy range of 1–10 *** synthetic spectra of Cu plasmas with different electron temperatures,electron densities,and fast electron fractions are calculated using the FLYCHK *** quantitative comparison with the measured spectrum,two x-ray power ratios with three different spectral ranges are *** observe three x-ray bursts in X-pinch experiments with two Cu wires conducted on the sNU X-pinch at a current rise rate of∼0.2 kA/*** of the spectra reveals that the first burst comprises x-rays emitted by hot spots and electron beams,with characteristics similar to those observed in other *** second and third bursts are both generated by longlived electron beams formed after the neck structure has been completely *** the second burst,the formation of the electron beam is accompanied by an increase in the electron density of the background ***,the long-lived electron beams generate the additional strong x-ray bursts while maintaining a plasma channel in the central region of the ***,they emit many hard x-rays(HXRs),enabling the sNU X-pinch to be used as an HXR *** study confirms that the generation of long-lived electron beams is crucial to the dynamics of X-pinches and the generation of strong HXRs.

关键词： resolved parameters absolute

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Remembering Ray

science China(Life sciences) 2009年第2期52卷 115-117页

作者： christine Wan Ming Wu 6296 Riviera Circle Long Beach Long Beach USA

Part one:The earlier years I am christine, Ray’s younger sister. The last time that I was in this auditorium (Kendal re-tirement community), about 7 years ago, Ray was giving a wonderful talk on 'CHINA'. Ray was always very proud of his Chinese heritage, especially since he was born and raised in China where he lived twenty years.

关键词： very Remembering Ray

Uncovering the effect of poly(ethylene-co-vinyl alcohol)molecular weight and vinyl alcohol content on morphology,antifouling,and permeation properties of polysulfone ultrafiltration membrane:thermodynamic and formation hydrodynamic behavior

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Frontiers of Chemical science and Engineering 2023年第10期17卷 1484-1502页

作者： sania Kadanyo christine N.Matindi Derrick s.Dlamini Nozipho N.Gumbi Yunxia Hu Zhenyu Cui Jianxin Li state Key Laboratory of separation Membranes and Membrane Processes National Center for International Joint Research on Membrane Science and TechnologyTiangong UniversityTianjin 300387China school of Materials science and Engineering Tiangong UniversityTianjin 300387China Institute for Nanotechnology and Water sustainability College of ScienceEngineering and TechnologyUniversity of South Africa Science CampusFlorida 1710South Africa University of California Los Angeles(UCLA)Department of Civil&Environmental EngineeringUCLA California NanoSystems Institute and UCLA Institute of the Environment&SustainabilityLos AngelesCA 90095USA

Various hydrophilic poly(ethylene-co-vinyl alcohol)(EVOH)were used herein to precisely control the structure and hydrodynamic properties of polysulfone(PsF)***,to prepare pristine PsF and PsF/EVOH blends with increasing vinyl alcohol(VOH:73%,68%,56%),the non-solvent-induced phase separation(NIPs)technique was *** glycol was used as a compatibilizer and as a porogen in N,*** and ultrasonic separation kinetic measurements were also carried out to develop an ultrafiltration membrane *** extracted membrane properties and filtration capabilities were systematically compared to the proposed ***,the addition of EVOH led to an increase in the rheology of the *** resulting membranes exhibited a microporous structure,while the finger-like structures became more evident with increasing VOH *** PsF/EVOH behavior was changed from immediate to delayed segregation due to a change in the hydrodynamic ***,the PsF/EVOH32 membranes showed high hydrophilicity and achieved a pure water permeability of 264 L·m^(–2)·h^(–1)·bar^(–1),which was higher than that of pure PsF membranes(171 L·m^(–2)·h^(–1)·bar^(–1)).In addition,PsF/EVOH32 rejected bovine serum albumin at a high rate(>90%)and achieved a significant restoration of ***,from the thermodynamic and hydrodynamic results,valuable insights into the selection of hydrophilic copolymers were provided to tailor the membrane structure while improving both the permeability and antifouling performance.

关键词： polysulfone blend modification ultrafiltration membrane formation hydrodynamics poly(ethyleneco-vinyl alcohol)copolymer

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