The pursuit of transplantation tolerance:new mechanistic insights
作者机构：Department of MedicineThe University of ChicagoChicagoIL 60637USA Department of SurgeryThe University of ChicagoChicagoIL 60637USA
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2019年第16卷第4期
页 面：324-333页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：National Institute of Child Health and Human Development, NICHD, (T32HD007009) Division of Intramural Research, National Institute of Allergy and Infectious Diseases, (2P01AI097113)
主 题：tolerance TCR avidity Treg T cell dysfunction
摘 要：Donor-specific transplantation tolerance that enables weaning from immunosuppressive drugs but retains immune competence to non-graft antigens has been a lasting pursuit since the discovery of neonatal *** recently,efforts have been devoted not only to understanding how transplantation tolerance can be induced but also the mechanisms necessary to maintain it as well as how inflammatory exposure challenges its *** review focuses on recent advances regarding key peripheral mechanisms of T cell tolerance,with the underlying hypothesis that a combination of several of these mechanisms may afford a more robust and durable tolerance and that a better understanding of these individual pathways may permit longitudinal tracking of tolerance following clinical transplantation to serve as *** review may enable a personalized assessment of the degree of tolerance in individual patients and the opportunity to strengthen the robustness of peripheral tolerance.
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