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Highly N-doped carbon with low graphitic-N content as anode material for enhanced initial Coulombic efficiency of lithium-ion batteries

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Carbon Energy 2023年第2期5卷 236-249页

作者： Yihua Tang Jingjing Chen Zhiyong Mao christina Roth Dajian Wang Department of Electrochemical Process Engineering Universitat BayreuthBayreuthGermany Chair of Electrochemical Process Engineering Bavarian Center for Battery Technology(BayBatt)BayreuthGermany Tianjin Key Laboratory for Photoelectric Materials and Devices School of Materials Science and EngineeringTianjin University of TechnologyTianjinPR China

N-doped carbons as one of the most prominent anode materials to replace standard graphite exhibit outstanding Li+storage ***,N-doped carbon anodes still suffer from low N-doping levels and low initial Coulombic efficiency(ICE).In this study,high N-doped and low graphitic-N carbons(LGNCs)with enhanced ICE were synthesized by taking advantage of a denitrification strategy for graphitic carbon nitride(g-C_(3)N_(4)).In brief,more than 14.5 at%of N from g-C_(3)N_(4)(55.1 at%N)was retained by reacting graphitic-N with lithium,which was subsequently *** graphitic-N is largely responsible for the irreversible capacity,the anode's performance was significantly *** to general N-doped carbons with high graphitic-N proportion(>50%)and low N content(mal sample of LGNC(4:1).This study provides a facile strategy to control the N content and speciation,achieving both high Li+storage capacity and high ICE,and thus promoting research and application of N-doped carbon materials.

关键词： denitrification graphitic carbon nitride graphitic-N lithium-ion batteries N-doped carbon

In Silico and in Vitro Analysis of Pyrazolone Derivatives against Zika Virus and Identification of Potential NS5 Methyltransferase Inhibitors by Molecular Docking

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Journal of Biosciences and Medicines 2024年第7期12卷 214-229页

作者： Luciene Soares Silva Tiago Soares Barbosa Maria Leonisa Sanchez-Nuñez Aldenise Mont Serrat Rosa da Silva Vitor Won-Held Rabelo Leonardo dos Santos Corrêa Amorim Leonardo Alves Miceli Percilene Fazolin Vegi Alice Bernardino Helena Carla Castro Izabel christina Nunes de Palmer Paixão Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niteri Brazil Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Antibiotics Biochemistry Teaching and Molecular Modeling Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Organic Chemistry at the Institute of Chemistry Institute of Biology Fluminense Federal University Niterói Brazil

Zika virus (ZIKV), a mosquito-borne flavivirus, has been associated with benign infections for decades. However, it has become a public health concern due to its association with severe fetal and neurological complications. Although many efforts have been made to control ZIKV infection, approved vaccines or antiviral drugs are still lacking. Consequently, the development of new effective anti-ZIKV agents is urgently needed. In this context, we investigated the antiviral potential of pyrazolone derivatives against ZIKV replication using in silico and in vitro methods. The four pyrazolone derivatives evaluated (1a, 1b, 1c, and 1d) inhibited over 50% of ZIKV replication with low cytotoxicity. Among them, compound 1b exhibited the most potent activity (EC50 = 4.3 μM) and the highest selectivity (SI = 342). Mechanism of action studies indicated that these compounds act at early stages of virus replication, and compound 1b can also directly inactivate ZIKV particles. Molecular docking studies suggested that these compounds can bind to and block the activity of ZIKV NS5 methyltransferase. Finally, pharmacokinetic and toxicological predictions have reinforced the safety and drug-like profiles of these derivatives. In conclusion, the pyrazolone scaffold proved to be valuable for anti-ZIKV drug development, and the derivatives studied deserve further investigation.

关键词： Zika Pyrazolone NS5 Methyltransferase Antivirals

Hidden diversity revealed in the freshwater snails,Bythinella and Pseudamnicola,in the Island of Crete

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Integrative Zoology 2022年第5期17卷 804-824页

作者： Paraskevi Niki LAMPRI christina BOURANTA Canella RADEA Aristeidis PARMAKELIS Section of Ecology and Taxonomy Department of BiologyNational and Kapodistrian University of AthensAthensGreece Institute of Marine Biological Resources and Inland Waters Hellenic Centre for Marine ResearchAnavyssos AtticaGreece

Crete with its complex geomorphological history is the island with the highest number of endemism observed in animal and plant taxa throughout the Aegean *** other groups of organisms within Crete are well-studied,the freshwater gastropod fauna still remains poorly *** and Pseudamnicola,are 2 genera of freshwater springsnails,both present on the island,inhabiting springs and other freshwater ***,we conduct a comprehensive study on the distribution of the different genetic lineages of the 2 gastropod genera in order to assess the mode of their differentiation on the island and infer the actual number of species present in the *** these aims,sequence data from the mitochondrial gene were used and analyzed within a phylogenetic *** Bythinella,our results strongly support at least 5 delineated Bythinella *** Crete,which correspond to the already described species from previous studies with the addition of a new *** analyses reveal an old time-frame of differentiation with vicariant phenomena being more likely the main drivers shaping the present-day distribution of the genus’genetic *** Pseudamnicola,our data indicate the presence of at least 2 delineated Pseudamnicola *** a differentiation more consistent to an isolation-by-distance pattern of a relatively recent *** processes followed by isolation of the populations and/or recent speciation,seem to be the underlying process for the current distribution of Pseudamnicola lineages.

关键词： Aegean biodiversity freshwater snails mtDNA species delimitation

UnDoing Buildings:Adaptive Reuse and Cultural Memory,by Sally ***,New York,*** 9781138226616

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Built Heritage 2022年第4期6卷 70-73页

作者： christina mal.thouni School of Architecture University of LiverpoolAbercromby SquareLiverpool L697ZNMerseysideUK

Published by Routledge in 2020,the monograph Undoing Buildings:Adaptive Reuse and Cultural Memory is written by architect and educator Sally *** the title suggests,the book aims to cover a very important and topical subject as it focuses on the reuse of existing buildings and therefore also relates to all the associated environmental and cultural benefts of such *** recent award of the 2021 Pritzker Architecture Prize–a prize often paralleled to a Nobel Prize for Architecture–to Anne Lacaton and Jean-Philippe Vassal in recognition of their‘commitment to a restorative architecture that is at once technological,innovative,and ecologically responsive’,and whose critical choices have prioritised reuse and transformation of existing structures‘instead of demolition and reconstruction’。

关键词： Adaptive Stone Buildings

Degradation of black tea theaflavin through C-ring cleavage by gut microbiota

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Food Science and Human Wellness 2022年第3期11卷 598-605页

作者： Shuwei Zhang christina Ohland Christian Jobin Shengmin Sang Laboratory for Functional Foods and Human Health Center for Excellence in Post-Harvest TechnologiesNorth Carolina Agricultural and Technical State UniversityNorth Carolina Research CampusKannapolisNorth Carolina 28081USA Department of Medicine University of FloridaGainesvilleFlorida 32611USA Department of Infectious Diseases and Immunology University of FloridaGainesvilleFlorida 32611USA

Increasing evidence has shown that gut microbiota plays important roles in metabolizing large molecular polyphenols to bioavailable and bioactive microbial ***(TF)is one of the major color compounds in black tea and has demonstrated anti-inflammation,antioxidant,and anticancer effects ***,little is known about the metabolism of TF by gut microbiota in *** this study,following the administration of TF to mice,the C-ring cleavage metabolites,dihydro-and tetrahydro-theaflavin(DH-TF and TH-TF)were detected in mouse feces by LC-MS and validated by authentic standards from in situ chemical *** observation of the C-ring cleavage metabolites in TF-treated conventionalized mice but not in germ-free(GF)mice confirmed the role of gut microbiota in cleaving the C-rings of *** detection of DH-TF from the anaerobic incubation of TF with catechin-converting gut bacteria,Eggerthella lenta(Eggerth),suggested that the microbes with the capacity to cleave the C-ring of catechins were able to metabolize TF following the same ***,three small phenolic metabolites were detected in mouse feces,and one of them was primarily detected in SPF mice not GF mice,which revealed that TF,subsequent to the cleaved C-ring,can be further metabolized into smaller phenolic metabolites by gut ***-dependent production of these metabolites were observed from the administration of 100 mg/kg to 400 mg/kg body weight of *** conclusion,gut microbiota can metabolize TF to the open-ring metabolites and the phenolic metabolites through the C-ring cleavage in mice.

关键词： Theaflavin Black tea C-ring cleavage Anaerobic incubation Germ-free mice

Progress towards dog-mediated rabies elimination in PR China:a scoping review

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Infectious Diseases of Poverty 2023年第2期12卷 19-35页

作者： Tianren Shen Susan christina Welburn Long Sun Guo-Jing Yang Key Laboratory of Tropical Translational Medicine of Ministry of Education The School of Tropical MedicineThe First Affiliated HospitalHainan Medical UniversityHaikou571199HainanPeople’s Republic of China Zhejiang University-University of Edinburgh Joint Institute Zhejiang UniversityInternational Campus718 East Haizhou RoadHaining314400People’s Republic of China Infection Medicine Deanery of Biomedical SciencesEdinburgh Medical SchoolCollege of Medicine and Veterinary MedicineThe University of Edinburgh1 George SquareEdinburghEH89JZScotlandUK Department of Infectious Diseases The First Affiliated Hospital of Hainan Medical UniversityHainan Medical UniversityHaikouHainanPeople’s Republic of China

Background Rabies continues to be a serious threat to global public health endangering people’s health and public health *** the People’s Republic of China,multi-sectoral and comprehensive prevention and control strategies have aimed to extensively curb human rabies ***,we examine the current state of rabies infection in China,explore strategic interventions put in place in response to WHO’s ambition of“Zero rabies deaths by 2030”and critically assess the constraints and feasibility of dog-mediated rabies elimination in *** This study analyzed and evaluated the process towards dog-mediated rabies elimination in China from five perspectives:namely,human,dog,policy,challenge,and ***-based data on progress of dog-mediated rabies elimination in China was derived from a number of sources;a literature search was undertaken using PubMed,Web of Science and CNKI databases,distribution data for human rabies cases as derived from the Data-center of the China Public Health Science and policy and document data were obtained from official websites of the relevant China ministries and *** The incidence of human rabies cases in China have shown a downward trend year-on-year since *** of a government-led,multi-sectoral“One Health”approach to combating rabies has driven down the total number of rabies deaths nationwide to around 200 in *** number of provincial-level administrative divisions(PLADs)reporting human cases of rabies has also decreased to 21 in 2020,13 of which reported less than 10 ***,the number of outpatient visits seeking rabies post-exposure prophylaxis has risen dramatically over the past two decades,with demand being 15 times higher than it was *** remain however,significant gaps in rabies elimination outcomes across the different regions of *** date the target of achieving a canine rabies vaccination rate of>75%has not been *** challenges of rabies i

关键词： Rabies Lyssavirus China Elimination Dog Epidemics One Health Neglected Tropical Underreporting

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小船在河上扬帆

初中生 2024年第6期 22-23页

作者：克里斯蒂娜·罗塞蒂不详

赏析克里斯蒂娜·罗塞蒂(christina Rosseti,1830-1894),英国女诗人。这是一首儿童诗,共两段,每双句押韵。全诗用词简单,每一句都是一幅清晰的简笔画。在每段结尾,诗人都表达了自己对大自然中美好事物的欣赏和赞叹。大小船只、修建的桥... 详细信息

赏析克里斯蒂娜·罗塞蒂(christina Rosseti,1830-1894),英国女诗人。这是一首儿童诗,共两段,每双句押韵。全诗用词简单,每一句都是一幅清晰的简笔画。在每段结尾,诗人都表达了自己对大自然中美好事物的欣赏和赞叹。大小船只、修建的桥梁,无论在河面和大海之上组成多么令人愉悦的画面,它们都无法与自然万物的美相比。

关键词：简笔画儿童诗女诗人自然万物

Protocadherin gamma C3:a new player in regulating vascular barrier function

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Neural Regeneration Research 2023年第1期18卷 68-73页

作者： Victoria Kaupp Kinga G.Blecharz-Lang christina Dilling Patrick Meybohm malgorzata Burek Department of Anesthesiology Intensive CareEmergency and Pain MedicineUniversity of WürzburgUniversity Hospital WürzburgWürzburgGermany Department of Experimental Neurosurgery Charité-UniversitätsmedizinBerlinGermany

Defects in the endothelial cell barrier accompany diverse malfunctions of the central nervous system such as neurodegenerative diseases,stroke,traumatic brain injury,and systemic diseases such as sepsis,viral and bacterial infections,and *** endothelial sealing leads to leaking blood vessels,followed by vasogenic *** edema as the most common complication caused by stroke and traumatic brain injury is the leading cause of *** microvascular endothelial cells,together with astrocytes,pericytes,microglia,and neurons form a selective barrier,the so-called blood-brain barrier,which regulates the movement of molecules inside and outside of the *** that regulate blood-brain barrier permeability in health and disease are complex and not fully *** newly discovered molecules that are involved in the regulation of cellular processes in brain microvascular endothelial cells have been described in the literature in recent *** of these molecules that are highly expressed in brain microvascular endothelial cells is protocadherin gamma *** this review,we discuss recent evidence that protocadherin gamma C3 is a newly identified key player involved in the regulation of vascular barrier function.

关键词： blood-brain barrier brain microvascular endothelial cells permeability protein interaction protocadherin gamma C3 protocadherins tight junctions

Spinal cord infarction attributed to SARS-CoV-2, with post-acute sequelae of COVID-19: A case report

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World Journal of Clinical Cases 2023年第36期11卷 8542-8550页

作者： christina V Oleson Andrew C Olsen Suzanna Shermon Department of Physical Medicine and Rehabilitation Case Western Reserve UniversityMetroHealth Rehabilitation InstituteClevelandOH 44109United States

BACKGROUND While stroke and lower extremity venous thromboemboli have been commonly reported following acute infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),spinal cord infarction or ischemia has been extremely *** of long coronavirus disease(COVID)in this select population have not been *** SUMMARY We present the case of a 70-year-old female with sudden onset of trunk and lower extremity sensorimotor loss due to spinal cord infarction,attributed to acute infection with *** work up confirmed a T3 complete(ASIA impairment Scale A)paraplegia resulting from a thrombotic *** reported myalgias,neuropathic pain,spasticity,bladder spasms,and urinary tract infections exceeded the frequency and severity of many spinal cord injury(SCI)individuals of similar age and degree of neurologic *** her first year after contracting COVID-19,she underwent 2 separate inpatient rehabilitation courses,but also required acute hospitalization 6 additional times for subsequent infections or uncontrolled *** other complications of complete non-traumatic SCI(NTSCI),including neurogenic bowel and temperature hypersens-itivity,were mild,and pressure injuries were *** has now transitioned from the acute to chronic phase of spinal cord injury care,with subsequent development of post-acute sequelae of SARS-CoV-2 infection(PASC).CONCLUSION This individual experienced significant challenges with the combined effects of acute T3 NTSCI and acute COVID-19,with subsequent progression to *** Tip:Although stroke and venous thromboembolism have been frequently observed with acute coronavirus disease 2019(COVID-19),spinal cord infarction leading to paraplegia has rarely been *** report a case of spinal cord infarction shortly following infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Consequently,this individual has experienced severe neurologic disability,with subsequent developme

关键词： Spinal cord infarction Paraplegia COVID-19 SARS-CoV-2 Post-acute