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Regulation of hepatic blood flow:The hepatic arterial buffer response revisited

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World Journal of Gastroenterology 2010年第48期16卷 6046-6057页

作者： christian Eipel Kerstin Abshagen Brigitte Vollmar Institute for Experimental Surgery Medical FacultyUniversity of Rostock

The interest in the liver dates back to ancient times when it was considered to be the seat of life processes. The liver is indeed essential to life,not only due to its complex functions in biosynthesis,metabolism and clearance,but also its dramatic role as the blood volume reservoir. Among parenchymal organs,blood flow to the liver is unique due to the dual supply from the portal vein and the hepatic artery. Knowledge of the mutual communication of both the hepatic artery and the portal vein is essential to understand hepatic physiology and pathophysiology. To distinguish the individual importance of each of these inflows in normal and abnormal states is still a challenging task and the subject of on-going research. A central mechanism that controls and allows constancy of hepatic blood flow is the hepatic arterial buffer response. The current paper reviews the relevance of this intimate hepatic blood flow regulatory system in health and disease. We exclusively focus on the endogenous interrelationship between the hepatic arterial and portal venous inflow circuits in liver resection and transplantation,as well as inflammatory and chronic liver diseases. We do not consider the hepatic microvascular anatomy,as this has been the subject of another recent review.

关键词： Hepatic blood flow Hepatic arterial buffer response Liver

On the Lorentz factor of superluminal sources

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Research in Astronomy and Astrophysics 2013年第5期13卷 509-516页

作者： Chika christian Onuchukwu Augustine A. Ubachukwu Department of Industrial Physics Anambra State University Uli Department of Physics and Astronomy University of Nigeria Nsukka

We investigate the properties of features seen within superluminal sources often referred to as components. Our result indicates a fairly strong correlation of r ～ 0.5 for quasars, r ～ 0.4 for galaxies and r ～ 0.7 for BL Lac objects in our sam- ple between component sizes and distances from the stationary core. The assumption of free adiabatic expanding plasma enables us to constrain the Lorentz factor for su- perluminal sources. Our estimated Lorentz factor of y ～ 9-13 for quasars, 7 ～ 7-11 for galaxies and y～ 4 - 9 for BL Lac objects indicates that BL Lacs have the lowest range of Lorentz factors.

关键词： galaxies: general -- galaxies: active -- galaxies: jets -- methods: ana-lytical -- methods: statistical -- methods: data analysis

Species concepts and biodiversity in Trichoderma and Hypocrea:from aggregate species to species clusters?

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2005年第2期6卷 100-112页

作者： DRUZHININA Irina KUBICEK christian P. Institute of Chemical Engineering Institute of Chemical Engineering Research Area Gene Technology and Applied Biochemistry Getreidemarkt 9/E1665 A-1060 Vienna Austria Research Area Gene Technology and Applied Biochemistry Getreidemarkt 9/E1665 A-1060 Vienna Austria

Trichoderma/Hypocrea is a genus of soil-borne or wood-decaying fungi containing members important to mankind as producers of industrial enzymes and biocontrol agents against plant pathogens, but also as opportunistic pathogens of immunocompromised humans. Species identification, while essential in view of the controversial properties of taxa ofthis genus, has been problematic by traditional methods. Here we will present a critical survey of the various identification methods in use. In addition,we will present an update on the taxonomy and phylogeny of the 88 taxa (which occur as 14 holomorphs, 49 teleomorphs and 25 anamorphs in nature) of Trichoderma/Hypocrea that have been confirmed by a combination of morphological, physiological and genetic approaches.

关键词： TrichodermalHypocrea Genus Molecular taxonomy-phylogeny

A Concise Review of Gold Nanoparticles-Based Photo-Responsive Liposomes for Controlled Drug Delivery

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Nano-Micro Letters 2018年第1期10卷 85-94页

作者： Malathi Mathiyazhakan christian Wiraja Chenjie Xu School of Chemical and Biomedical Engineering Nanyang Technological University

The focus of drug delivery is shifting toward smart drug carriers that release the cargo in response to a change in the microenvironment due to an internal or external trigger. As the most clinically successful nanosystem, liposomes naturally come under the spotlight of this trend. This review summarizes the latest development about the design and construction of photo-responsive liposomes with gold nanoparticles for the controlled drug release. Alongside, we overview the mechanism involved in this process and the representative applications.

关键词： Photo-responsive liposome Controlled release Drug delivery Gold nanoparticles

Secular dynamics of navigation satellites in the MEO and GSO regions

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Astrodynamics 2022年第4期6卷 357-374页

作者： Hanlun Lei Emiliano Ortore christian Circi School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Key Laboratory of Modern Astronomy and Astrophysics in Ministry of Education Nanjing UniversityNanjing 210023China Department of Astronautical Electrical and Energy EngineeringSapienza University of RomeVia Salaria 851Rome 00138Italy

In this study,a dynamical model is developed to describe the secular evolution of navigation satellites under the geocentric reference frame with the Laplace orbit as the fundamental *** disturbing function,involving the effects of Earth's oblateness and lunisolar gravitational attraction,is averaged over the orbital periods of both the satellite and the *** the regions of medium-Earth orbits and geosynchronous orbits,there are varieties of lunisolar resonances for governing the secular dynamics of navigation *** these resonances,we are interested in the ones occurring at the critical inclinations as well as the lunar node *** each resonance of interest,the resonant center and width are identified ***,dynamical maps are compared with the analytical results.

关键词： secular resonances Laplace plane navigation satellites dynamical maps

Diabetes and pulmonary infection:how hyperglycaemia shapes the immune system

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1245-1246页

作者： christian Herder Michael Roden Nicolas Venteclef Institute for Clinical Diabetology German Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf40225DüsseldorfGermany German Center for Diabetes Research(DZD) Partner Düsseldorf85764München-NeuherbergGermany Department of Endocrinology and Diabetology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University Düsseldorf40225DüsseldorfGermany Institut Necker-Enfants Malades(INEM) UniversitéParis CitéINSERM UMR-S1151CNRS UMR-S8253ParisFrance

In a recent study published in Nature,Nobs and colleagues aimed to identify novel mechanisms that may explain why diabetes is associated with an increased susceptibility to viral respiratory *** analyses revealed a central role of lung dendritic cells(DC)which exhibited several functional defects induced by hyperglycaemia and consequently result in impaired antiviral immune responses.

关键词： impaired lung respiratory

Predictors of first-pass success intubations in the emergency departments in Germany:analysis of the German Airway Registry between 2015 and 2022

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World Journal of Emergency Medicine 2024年第6期15卷 490-493页

作者： christian Hohenstein Lucas Rudnik Frank Bloos Department of Emergency Medicine Zentralklinik Bad BerkaAffiliation University of MarburgFaculty of MedicineBad Berka 99437Germany University of Jena Faculty of MedicineJena 07747Germany Department of Anaesthesiology and Intensive Care Medicine University Hospital JenaJena 07747Germany

In the field of airway management,there is no national registry in Germany that captures data on emergency airway *** improve quality,one needs to know the data *** include gender,age,indications for emergency airway management,level of education,the intubating department,the intubation method,and other factors that can serve as a basis for quality improvement changes.

关键词： intubation airway education

Post-orogenic transients and relict landforms of the Bafoussam–Mamfe region(West-Cameroon Highland margin)

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Journal of Mountain Science 2022年第8期19卷 2180-2201页

作者： Pascal Landry WABO DEFO Sébastien OWONA Moussa NSANGOU NGAPNA christian BALLA ATEBA christian MWABANUA MUTABI The University of Douala Faculty of ScienceDepartment of Earth SciencesDouala 24157Cameroon The University of Lubumbashi Faculty of ScienceDepartment of GeologyLubumbashi 1825Democratic Republic of Congo

The Bafoussam-Mamfe Region(BMR)belongs to the Western Cameroon Highland margin,an amalgam of transient landscape that evolved from the interactions between tectonics,lithology and climate *** area is tectonically active and shows differential tectonic uplift,contrasting relief,variations in erosion rates,in river incision,and in channel *** order to appraise the BMR tectono-geomorphic evolution,it is essential to understand relationships between internal and external processes and their geomorphic expression at a river basin *** this purpose,we use drainage texture(Dt),stream frequency(Fs),drainage density(Dd),asymmetry factor(AF),the transverse topographic symmetry factor(TTSF),the mean of mountain front sinuosity per unit(Smf),concavity factor(Cf),hypsometry integral(HI)and streamlength gradient index(SL-index)based on 30 m Digital Elevation Models(DEM)and field *** results reveal considerable variations in geology,relief,topography and geomorphic indices values differentiated into three geomorphic units;the Mamfe unit developed on the Mamfe Cretaceous basin,the Nguti and Bafoussam high plateau units build up on the Precambrian granito-gneissic basement overlaid by a volcanic *** stepped(longitudinal and normalized)river profiles and complex hypsometric curves show the lithostructural control of the hydrographic ***(from~1.21 to~4.59),Fs(from~0.26 to~1.91),Dd(from~0.66 to~1.71)geomorphic indice values indicate a part of lithologic control on this morphology while the AF(from~1.16to~24.91),TTSF(from~0.20 to~0.71),Smf(U2=1.11 and U3=1.19),Cf(from~-20.91 to~78.93),HI(from~0.12 to~0.52)and SL-index designate the active tectonics as the main factor that had controlled the morphology of this same *** results pinpoint the combined post-Pan-African to Recent tectonic features,lithologic heterogeneities and the differential erosion processes as main factors that have controlled the BMR *** results highlight how

关键词： Geomorphic indices Tectonic,Lithology Differential erosion Bafoussam-Mamfe Cameroon

Is serine racemase(SRR) a second hit target for LRRK2-G2019S induced Parkinson's disease?

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Neural Regeneration Research 2021年第3期16卷 498-499页

作者： Sarah Louise Nickels Jens christian Schwamborn Luxembourg Centre for Systems Biomedicine(LCSB) University of LuxembourgBelvauxLuxembourg Riken Institute for Medical Sciences(IMS) KanagawaJapan

To date,at least 7 million people are suffering from Parkinson's disease(PD)worldwide,which is the second most prevalent,age-associated,and progressive neurodegenerative disorder(Tysnes and Storstein,2017).Given the accelerated global pace of aging,it becomes of fundamental importance that we start understanding the origins of neurodegeneration in order to develop effective disease modifying *** PD patients suffer from a combination of motor and nonmotor disabilities.

关键词： second patients suffering