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Many faces of neuronal activity manipulation in Drosophila

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Neural Regeneration Research 2025年第9期20卷 2574-2576页

作者： Amber Krebs Steffen Kautzmann christian Klämbt Institut für Neuro-und Verhaltensbiologie MünsterGermany

Animals exhibit complex responses to external and internal *** information is computed by interconnected neurons that express numerous ion channels,which modulate the neuronal membrane *** can neuronal activity orchestrate complex motor patterns or allow learning from previous experience?To answer such questions,we need the ability not only to record,but also to modulate neuronal activity in both space(e.g.,neuronal subsets)and time.

关键词： manipulation potential. neuronal

Efficient determination of stability lobe diagrams by in-process varying of spindle speed and cutting depth

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Advances in Manufacturing 2018年第3期6卷 272-279页

作者： christian.brecher Prateek Chavan Alexander Epple Laboratory for Machine Tools and Production Engineering(WZL) RWTH Aachen University Campus-Boulevard 3052074 Aachen Germany

The experimental determination of stability lobediagrams （SLDs） in milling can be realized by eithercontinuously varying the spindle speed or by varying thedepth of cut. In this paper, a method for combining boththese methods along with an online chatter detectionalgorithm is proposed for efficient determination of *** accomplish this, communication between the machinecontrol and chatter detection algorithm is established, andthe machine axes are controlled to change the spindle speedor depth of cut. The efficiency of the proposed method isanalyzed in this paper.

关键词： Chatter detection Poincaré Cutting depthvariation Spindle speed

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Thermal Behavior of Externally Driven Spindle: Experimental Study and Modelling

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Engineering（科研） 2015年第2期7卷 73-92页

作者： christian.brecher Yair Shneor Stephan Neus Kolja Bakarinow Marcel Fey RWTH Aachen University Laboratory for Machine Tools and Production Engineering Chair of Machine Tools Aachen Germany CAMT Center for Advanced Manufacturing Technologies Rotem Industries Rotem Industrial Park Mishor Yamin D.N. Arava Israel

This paper focuses on model development for computer analysis of the thermal behavior of an externally driven spindle. The aim of the developed model is to enable efficient quantitative estimation of the thermal characteristics of the main spindle unit in an early stage of the development process. The presented work includes an experimental validation of the simulation model using a custom-built test rig. Specifically, the effects of the heat generated in the bearings and the heat flux from the bearing to the adjacent spindle system elements are investigated. Simulation and experimental results are compared and demonstrate good accordance. The proposed model is a useful, efficient and validated tool for quantitative simulation of thermal behavior of a main spindle system.

关键词： Machine Tool Thermal Behavior Heat Transfer Spindle Modelling

Schrodinger and Klein-Gordon theories of black holes from the quantization of the Oppenheimer and Snyder gravitational collapse

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Communications in Theoretical Physics 2023年第9期75卷 122-135页

作者： christian Corda SUNY Polytechnic Institute 13502 UticaNew YorkUSAIstituto Livi59100 PratoTuscanyItaly and International Institute for Applicable Mathematics and Information SciencesB M Birla Science CentreAdarshnagarHyderabad 500063India

The Schrodinger equation of the Schwarzschild black hole(BH) has been recently derived by the author and collaborators. The BH is composed of a particle, the 'electron', interacting with a central field, the 'nucleus'. Via de Broglie's hypothesis, one interprets the 'electron' in terms of BH horizon's modes. Quantum gravity effects modify the BH semi-classical structure at the Schwarzschild scale rather than at the Planck scale. The analogy between this BH Schrodinger equation and the Schrodinger equation of the s states of the hydrogen atom permits us to solve the same equation. The quantum gravitational quantities analogous of the fine structure constant and of the Rydberg constant are not constants, but the dynamical quantities have well-defined discrete spectra. The spectrum of the 'gravitational fine structure constant' is the set of non-zero natural numbers. Therefore, BHs are well-defined quantum gravitational systems obeying Schrodinger's theory: the 'gravitational hydrogen atoms'. By identifying the potential energy in the BH Schrodinger equation as being the gravitational energy of a spherically symmetric shell, a different nature of the quantum BH seems to surface. BHs are self-interacting, highly excited,spherically symmetric, massive quantum shells generated by matter condensing on the apparent horizon, concretely realizing the membrane paradigm. The quantum BH described as a'gravitational hydrogen atom' is a fictitious mathematical representation of the real, quantum BH, a quantum massive shell having a radius equal to the oscillating gravitational *** consequences emerge from this result:(i) BHs have neither horizons nor singularities;(ii) there is neither information loss in BH evaporation, nor BH complementarity, nor firewall paradox. These results are consistent with previous ones by Hawking, Vaz, Mitra and ***, the special relativistic corrections to the BH Schrodinger equation give the BH Klein–Gordon equation and the cor

关键词： quantum black holes information paradox quantum shells quantum levels Schrodinger and Klein-Gordon theories

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有针对性地优化和改善机床性能

现代制造 2017年第32期 28-30页

作者： christian.brecher

在对机床的静态和动态性能作出评判的同时，可以向机床制造厂家提供有针对性的支持，以实现设备潜能的最大发挥。

关键词：机床性能优化动态性能制造厂家

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对刀具接口弯曲性能的分析

现代制造 2016年第18期 36-36,38-40页

作者： christian.brecher

作为机床和刀具之间的直接连接环节，刃具接口会直接影响加工流程的效率与质量。形成加工力所需的传动力矩，可以通过刀具接口被传递到切削流程中去。由于存在生成的弯曲力矩和扭矩的影响，对接口系统具有很高的机械刚性要求。

关键词：接口系统弯曲性能刀具加工流程传动力矩弯曲力矩连接环加工力

Insensitive high explosives:Ⅳ. Nitroguanidine-Initiation & detonation

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Defence Technology（防务技术） 2019年第4期15卷 467-487页

作者： Ernst-christian Koch Lutradyn-Energetic Materials

This paper reviews the detonative properties of low bulk density(LBD),high bulk density(HBD)Nitroguanidine(NGu)(1),CAS-No:[556-88-7]and 82 explosive formulations based on NGu reported in the public *** rank the performance of those formulations they are compared with 15 reference compositions containing both standard high explosives such as octogen(HMX)(2),hexogen(RDX)(3),pentaerythritol tetranitrate(PETN)(4),2,4,6-trinitrotoluene(TNT)(5)as well as insensitive high explosives such as 3-nitro-1,2,4-triazolone(NTO)(6),1,3,5-triamino-2,4,6-trinitrobenzene(TATB)(7),1,1-diamino-2,2-dinitroethylene(FOX-7)(8)and N-Guanylurea dinitramide(FOX 12)(9).NGu based formulations are superior to those based on FOX-12 or TATB and are a close match with FOX-7 based explosives,the latter just having higher Gurney Energies(-10%)and slightly higher detonation pressure(+2%).NGu based explosives even reach up to 78% of the detonation pressure,82% Gurney energy and up to 95% of detonation velocity of ***-NGu dissolves in many melt cast eutectics forming dense charges thereby eliminating the need for costly High Bulk Density *** based formulations are at the rock bottom of sensitiveness among all the above-mentioned explosives which contributes to the safety of these *** review gives 132 references to the public *** a review on the synthesis spectroscopy and sensitiveness of Nitroguanidine see Ref.[1].

关键词： Cook-off Detonation Insensitive munitions Nitroguanidine Shock sensitvity

Special materials in pyrotechnics Ⅶ: Pyrotechnics used in thermal batteries

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Defence Technology（防务技术） 2019年第3期15卷 254-263页

作者： Ernst-christian Koch Lutradyn Energetic Materials Science & Technology

Thermal batteries are unique direct current(DC) electrical power sources with long shelf live, high reliability and higher power density than classical alkaline batteries. This paper gives a brief overview into the working principle of thermal batteries and reviews the properties of zirconium/barium chromate(Zr/BaCrO4) pyrolant previously used as first fire and iron/potassium perchlorate(Fe/KClO4) pyrolant(Heat), commonly applied as heating pellet in thermal batteries and its hazard properties. The review gives 64 references to the public domain. CAS-Nos. Zr: [7440-67-7], BaCrO4: [10294-40-3], Fe: [7439-89-6], KClO4: [7778-74-7], Viton: [9011-17-0].CAS-Nos. Zr: [7440-67-7], BaCrO4: [10294-40-3], Fe: [7439-89-6], KClO4: [7778-74-7], Viton: [9011-17-0].

关键词： Barium chromate Heat-powder Iron Lithium Molten salt Potassium perchlorate Pyrotechnics Thermal battery Zirconium