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Photodynamic therapy of cancer-Challenges of multidrug resistance

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Journal of Innovative Optical Health Sciences 2015年第1期8卷 14-26页

作者： Zheng Huang Yih-Chih Hsu Li-Bo Li Luo-Wei Wang Xiao-Dong Song Christine m.N.Yow Xia Lei Ali I.musani Rong-Cheng Luo Brian J.Day mOE Key Laboratory of OptoElectronic Science and Technology for medicine Fujian Normal University FuzhouP.R.China College of Engineering and Applied Science University of Colorado Denver COUSA Department of medicine National Jewish Health COUSA Department of Bioscience Technology Center for Nanotechnology and Institute of Biomedical Technology Chung Yuan christian University TaoyuanTaiwan TCm-Integrated Cancer Center Southern medical University GuangzhouP.R.China Department of Gastroenterology&Endoscopy Changhai Hospital Second Military Medical University ShanghaiP.R.China Department of Urologic Surgery Tongji Medical College of Huazhong University of Science&TechnologyWuhanP.R.China Department of Health Technology Informatics Hong Kong Polytechnic University Hong Kong SARP.R.China Department of Dermatology Daping Hospital Third Military Medical UniversityChongqingP.R.China

Photodynamic therapy(PDT)of cancer is a two-step drug device combination modality,which involves the topical or systemie administration of a photosensitizer followed by light ilumnination of cancer *** the presence of oxygen molecules,the light illmnination of photosensitizer(PS)can lead to the generation of cytotoxic reactive oxygen species(ROS)and consequently destroy *** to many other anticancer therapies,PDT is also subject to intrinsic cancer resistance mediated by mutidrug resistance(mDR)*** paper will review the recent progress in understanding the interaction between mDR transporters and PS *** strategies that can be used in a clinical setting to owercome or bypass mDR will also be discussed.

关键词： Photodynamic therapy photosensitizer multidrug resistance cancer

Phytochemical Profile, Antioxidant, and Anti-Inflammatory Activities, Safety of Use and Spasmolytic Effects of Aqueous Decoction Extract of Diospyros mespiliformis Leaves Hochst. ex A. DC. (Ebenaceae) on the Isolated Duodenum of Rat

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Pharmacology & Pharmacy 2023年第12期14卷 513-529页

作者： mathieu Nitiéma Pegdwendé Esther Ouédraogo Tata Kadiatou Traoré Oumarou maman Noura Boukaré Kaboré Wendkouni Leila marie Esther Bélem-Kabré Windingoudi Rimwagna christian Ouédraogo moumouni Koala Bruno Nébié Abdel magid Arsène Ouoba makumbu Joseph makaya Sylvain Ilboudo Lazare Belemnaba Noufou Ouédraogo Sylvin Ouédraogo Laboratoire de Recherche-Développement des Phytomédicaments et médicaments (LR-D/Pm) Institut de Recherche en Sciences de la Santé/Centre National de la Recherche Scientifique et Technologique (IRSS/CNRST) Ouagadougou Burkina Faso Initiative Pour la Résilience et la Gouvernance (IRG) Ouagadougou Burkina Faso International Research Laboratory 3189 Environnement Santé Sociétés (IRL 3189 ESS) Centre National de la Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso UFR/Science et Technologie Université Aube Nouvelle Ouagadougou Burkina Faso Laboratoire du Développement du médicament (LADmE) école Doctorale Sciences et Santé Université Joseph KI-ZERBO Ouagadougou Burkina Faso Ecole Doctorale Sciences et Techniques Laboratoire de Biochimie et Chimie Appliquées (LABIOCA) Université Joseph KI-ZERBO Ouagadougou Burkina Faso

Diospyros mespiliformis Hochst. ex A. DC. (Ebenaceae) is a multi-use plant, including for therapeutic purposes. It is used in alternative medicine in Burkina Faso to treat conjunctivitis, menorrhagia, dysentery, and diarrhea. The aim of our study was to evaluate the chemical profile, antioxidant and anti-inflammatory activities, safety of use and spasmolytic effects of the aqueous decoction of Diospyros mespiliformis leaves. Phytochemical screening by HPTLC and assay of compounds of interest were carried out. Four methods were used to assess antioxidant activity. Inhibitory activity against 15-lipoxygenase and phospholipase A2 was assessed. Acute oral toxicity of the extract was tested on female mice (NmRI). Following these tests, the extract contained bioactive compounds of interest such as flavonoids, tannins, sterols, triterpenes, and saponosides. The total phenolic and flavonoid contents of the aqueous decoctate were 70.59 ± 3.20 mg EAT/g and 31.57 ± 0.78 mg EQ/g respectively. The extract was less active than Trolox with inhibitory concentrations of 50% (IC50) for the ABTS, DPPH, FRAP, and LPO tests of 7.53 ± 0.08 μg/mL, 29.47 ± 0.06 μg/mL, 1128.83 ± 4.82 mol EAA/g, and 32.30 ± 1.60 μg/mL respectively. The extract has an anti-inflammatory effect with inhibition of phospholipase A2 compared to betamethasone. In addition, the aqueous extract produced an antispasmodic effect with Emax of 70% and 80% respectively during contractions induced by BaCl2 and ACh. Finally, this study provided basic scientific data and could justify the use of D. mespiliformis leaves in the treatment of diarrhea.

关键词： Diospyros mespiliformis Phytoconstituents Antioxidants Acute Oral Toxicity Spasmolytic Leaves

Experimental Culture of the Giant Freshwater Prawn, macrobrachium vollenhovenii (Herklots, 1857) around the FUTO Axis of Otamiri River, Imo State, Nigeria

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Journal of Agricultural Science and Technology(B) 2019年第1期9卷 60-67页

作者： Daniel Chikere Njoku Chukwuma Ogueri christian Ngozichukwu Anyanwu Chukwuka Fabian Ezeafulukwe Chinyere Chikere Njoku Department of Fisheries and Aquaculture Technology Federal University of Technology Owerri 00176 Nigeria Department of Soil Science and Environment lmo State University Owerri 00176 Nigeria

Culture trial of 7,488 juveniles of the giant freshwater prawn, macrobrachium vollenhovenii (Herklots, 1857) was carried out for 180 d in concrete tanks to determine their adaptability, survival, feed utilization and growth performance under culture condition. Twelve experimental concrete tanks each measuring 10 m × 5 m × 1.0 m were used for the experiment from march to August 2016. The prawns were stocked two weeks after treatment of tanks with agricultural lime at the rate of 2,279 kg/ha and poultry manure at the rate of 114 kg/ha. Four experimental diets tested were designated as T1: powdered broiler starter, T2: commercial brine shrimp, T3: combination of broiler starter and brine shrimp and T4: mississippi Agricultural and Forestry Experimental Station (mAFES) diet formula. Diets were randomly assigned to the four treatment tanks and replicated three times in a 4 × 3 = 12 experimental units as a completely randomized design experiment (CRD). Each tank was stocked with 624 juvenile prawns with mean total length of 1.5 cm and body weight of 10.0 g. Prawns were fed at 5% body weight and twice at 0600 h and 1800 h. Sampling for growth was carried out bi-weekly while water quality was tested weekly. Results were statistically evaluated with one way analysis of variance (ANOVA). Water quality of the four tanks was not significantly different (p > 0.05) from one another throughout the culture period and conformed to recommended tolerable limits in prawn culture ponds. Growth performance was best in diet T4 (the mAFES formula), with a survival rate of 75%, mean weight gain (mWG) of 65 g, relative growth rate (RGR) of 650%, specific growth rate (SGR) of 1.12%, average daily growth (ADG) of 0.3 g/day and food conversion ratio (FCR) of 1.44. The above values differed quite significantly (p m growth responses of other diets. The computed gross ratio (GR) of 0.62 suggests that prawn culture is a highly lucrative business.

关键词： Culture trial macrobrachium vollenhovenii Otamiri River banks Nigeria

Sustainable management of semi-arid rangelands and optimal paddock size-An ecologicaleconomic modelling analysis

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Sustainable management of semi-arid rangelands and optimal p...

An audit of Paediatric Orofacial Lesions at the Kilimanjaro christian medical Centre in moshi, Tanzania

ⅩⅪ International Grassland Congress and the Ⅷ International Rangeland Congress

作者： Jakoby O. Quaas m.F. HeLmholtz Centre for Environmental Research-UFZ Permoserstr.1504318 LeipzigGermany christian-Albrechts-Universitt KielGermany

＜正＞Introduction Livestock grazing is the most important form of land use in arid and semi-arid *** to harsh climatic conditions,rangeland management requires good ecological knowledge to maintain the pasture in a v... 详细信息

关键词： semi-arid rangeland simulation model rotational grazing management ecological-economic modelling

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Surgical Science 2011年第10期2卷 476-480页

作者： D. S. Rwakatema m. L. Chindia 不详

Objective: To audit and categorize pathological lesions and conditions that occurred in the orofacial region among children aged up to 15 yrs. Setting: Kilimanjaro christian medical Centre, moshi, Tanzania. Design: Retrospective cross-sectional audit based on archival records and material between 1985 to 2005. Results: Biopsy results were generated into 11 categories whence most common lesions encountered were in the categories of soft tissue benign neoplasms (35.1%) and soft tissue malignant neoplasms (21.8%). Remarkably, Burkitt’s lymphoma (BL) in the category of malignant soft tissue neoplasia constituted 11.8% of all the lesions biopsied while haemangiomas and tuberculous adenitis comprised 8.1% and 3.8% respectively. The age groups revealed the highest burden (37.1%) among the 0 to 5-year-olds followed by the 11 to 15-(34.5%) and 6 to 10-year-olds (28.4%). The orofacial site distribution among the 211 biopsied cases included 62.1% in the mandibular 29.9% in the maxillary region and 8% in the tongue areas. malignant neoplasms of the bone were rare and all were diagnosed in the mandible. Overall, malignant neoplasms of soft tissue were significantly more in the age group of 6 - 10 years as well as in males than females. On the other hand, significantly more benign soft tissue neoplasms occurred in females than in males. main Outcome measure: There is great diversity and preponderance of soft tissue than skeletal orofacial lesions on the present audit. Significantly, clinicians should maintain high index of suspicion regarding the remarkably high frequency of diagnosing BL and tuberculous lymphadenitis in such a population in this era of HIV infection/AIDS.

关键词： Orofacial Neoplasm Soft Tissue Tuberculous Lymphadenitis Lesion Children Burkitt Lymphoma Cross-Sectional Study Tanzania

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2013赛季motoGP下半程简略前瞻

摩托车 2013年第9期 93-93页

作者：王晓宇 christian

2013赛季motoGP下半程的比赛即将在美国传奇赛道“砖厂”印第安纳波利斯拉开帷幕。新秀车手马奎斯出人意料地在上半赛季领跑车手积分榜。其实这也不难理解，本田和雅马哈两家厂队占有绝对优势，车手总冠军基本只可能在这两家车队的4位... 详细信息

2013赛季motoGP下半程的比赛即将在美国传奇赛道“砖厂”印第安纳波利斯拉开帷幕。新秀车手马奎斯出人意料地在上半赛季领跑车手积分榜。其实这也不难理解，本田和雅马哈两家厂队占有绝对优势，车手总冠军基本只可能在这两家车队的4位车手中诞生，佩德罗萨和洛伦佐由于锁骨骨折，最近两三站的成绩受到影响，而回归雅马哈的罗西又一直与m1赛车不甚合拍，只能比较尴尬地占据着比上不足比下有余的老四的位置。

关键词：印第安纳雅马哈车手本田车队赛车

Cell:研究揭示SIRT3在调节线粒体健康中的关键作用

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现代生物医学进展 2017年第6期17卷 I0004-I0004页

作者： Wen Yang Koji Nagasawa christian münch Yingjie Xu Kyle Satterstrom Seungmin Jeong Sebastian D. Hayes mark P. Jedrychowski F. Sejal Vyas Elma Zaganjor Virginia Guarani Alison E. Ringel Steven P. Gygi J. Wade Harper marcia C. Haigis Vascular Biology Program Boston Children’s Hospital Harvard Medical School Boston MA 02115 USA

就蛋白而言，去乙酰化酶（sirtuin）是令人喜欢的，而且因它们与衰老和年龄相关疾病相关联而受到人们的广泛关注。作为去乙酰化酶的来源，线粒体，也因在健康和疾病中的作用而闻名于世。来自美国哈佛医学院的marcia Haigis和她的团队从... 详细信息

就蛋白而言，去乙酰化酶（sirtuin）是令人喜欢的，而且因它们与衰老和年龄相关疾病相关联而受到人们的广泛关注。作为去乙酰化酶的来源，线粒体，也因在健康和疾病中的作用而闻名于世。来自美国哈佛医学院的marcia Haigis和她的团队从事基础研究。提出了一个较为深刻的问题：在细胞中。哪些蛋白与去乙酰化酶进行交谈？

关键词：线粒体 Cell 健康去乙酰化酶相关疾病基础研究医学院蛋白

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World Journal of Gastroenterology 2014年第14期20卷 3986-4000页

作者： Bjarte Fosby Sigrid Nss Johannes R Hov James Traherne Kirsten m Boberg John Trowsdale Aksel Foss Pl-Dag Line Andre Franke Espen melum Helge Scott Tom H Karlsen Norwegian PSC Research Center Division of CancerSurgery and TransplantationOslo University Hospital Institute of Clinical medicine Faculty of MedicineUniversity of Oslo KG Jebsen Inflammation Research Centre Research Institute of Internal MedicineOslo University Hospital Department of Transplantation medicine Division of CancerSurgery and TransplantationOslo University Hospital Division of Immunology Department of PathologyUniversity of Cambridge and Cambridge Institute for Medical ResearchUniversity of Cambridge Institute of Clinical molecular Biology Christian-Albrechts-University Department of Pathology Divisoin of Diagnostics and InterventionInstitute of PathologyOslo University Hospital

AIm: To investigate influence of human leukocyte antigen (HLA) and killer immunoglobuline-like receptor (KIR) genotypes on risks of acute rejection (AR) after liver transplantation (LTX).

关键词： Liver transplantation Primary sclerosing cholangitis Acute rejection Human leukocyte antigen Killer immunoglobulin-like receptor

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大喇叭

住区 2014年第6期 81-85页

作者： Einar Bye Cyril Chabaud Pablo Fernndez Federica Frangipane Styrkaar Hustveit Fanny Jacquet christian O' Riordan Larsen Quentin Leroy mélanie mathevet Runar Nedregàrd Ines Rakow Kévin Sanouiller Valentina Serra Bergur Porsteinsson martin Bergsmark Vodde Henning Aschim Wien Geir Brendeland Bergur Briem Stig Arne Heltorp NTNU

这个建筑装置是由Brendeland和Kristoffersen指导,由来自挪威科技大学的一群国际硕士研究生建造完成的.它是一个纪念碑、雕塑、运动场、城市扩音器、扬声器、声音接收器、舞台、电影放映台、遮蔽物、共鸣箱、乐器、一种数学公式、一个... 详细信息

这个建筑装置是由Brendeland和Kristoffersen指导,由来自挪威科技大学的一群国际硕士研究生建造完成的.它是一个纪念碑、雕塑、运动场、城市扩音器、扬声器、声音接收器、舞台、电影放映台、遮蔽物、共鸣箱、乐器、一种数学公式、一个感性经验和科学实验的工具、一个再利用的机械零件.这是挪威科技大学送给特隆赫姆市的建校100周年的纪念礼物.地段位于特隆赫姆市历史中心的一个小公园里,旁边是一个中世纪教堂.百年纪念活动结束之后,它将会搬到峡湾一个美丽的、永久的地点,作为大学的百年纪念碑.这个由柱形钢结构支撑的截锥型构筑物,厚3mm,长18m,高6.5m,重达12吨.

关键词：喇叭科技大学百年纪念活动硕士研究生纪念碑电影放映数学公式科学实验