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Cytokine release in sepsis

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Advances in Bioscience and Biotechnology 2013年第9期4卷 860-865页

作者： Ian Burkovskiy Joel Sardinha Juan Zhou christian lehmann Department of Anesthesia Dalhousie University Halifax Canada Department of Pharmacology Dalhousie University Halifax Canada

Despite the advances in the therapeutic approaches, health care protocols and policies, sepsis continues to be an important problem in clinical medicine. High lethality of sepsis cases calls for a detailed and critically important study of the pathophysiology of sepsis. In this review, we discuss pathomechanisms of sepsis and the role of cytokines that are released in sepsis. We propose that the systemic levels of cytokines are not always reflecting the pathological picture and the immune status of the patient. One of the emerging approaches which may bring an effective treatment strategy exploits the endocannabinoid system for its immunomodulatory properties. Following from that, the research in this particular field is very important as it can bring understanding behind the complicated pathophysiology of sepsis.

关键词： Sepsis Cytokine Inflammation Immunology

Cellular models of stress resistance may pave ways to fight neurodegenerative diseases

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Neural Regeneration Research 2025年第9期20卷 2579-2580页

作者： Thu Nguyen Minh Pham christian Behl Institute of Pathobiochemistry University Medical Center of the Johannes Gutenberg UniversityMainzGermany

Alzheimer's disease(AD),the most common form of neurodegeneration,is characterized by selective neuronal vulnerability and brain regionselective neuron *** entorhinal cortex and hippoc,ampal CA1 projection neurons are at greater risk in AD whereas other regions display resistance to ***,the cerebellum,a phylogenetically very old region,is affected only very late in the disease progression.

关键词： cortex resistance Alzheimer

Many faces of neuronal activity manipulation in Drosophila

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Neural Regeneration Research 2025年第9期20卷 2574-2576页

作者： Amber Krebs Steffen Kautzmann christian Klämbt Institut für Neuro-und Verhaltensbiologie MünsterGermany

Animals exhibit complex responses to external and internal *** information is computed by interconnected neurons that express numerous ion channels,which modulate the neuronal membrane *** can neuronal activity orchestrate complex motor patterns or allow learning from previous experience?To answer such questions,we need the ability not only to record,but also to modulate neuronal activity in both space(e.g.,neuronal subsets)and time.

关键词： manipulation potential. neuronal

基于高分辨率的X光衍射数据研究一维配位聚合物[MX2py2]∝的电子密度(M=Zn,Cd;X=Cl,Br;py=m-二卤代吡啶)

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基于高分辨率的X光衍射数据研究一维配位聚合物[MX2py2]∝的电子...

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

中国晶体学会第四届全国会员代表大会暨学术会议

作者：王瑞敏王炳武 Ulli Englert christian lehmann RWTH Aachen University 北京大学化学与分子工程学院国家分子科学实验室 Max-Planck-Institut für Kohlenforschung

为了更好地理解各种配位聚合物[MX2y](M=Zn,Cd:X=C1,Br:py=m二卤代吡啶)的电子结构差异,我们在100K收集了五个配位聚合物单晶(图1a)的高分辨率X光衍射数据,用Hansen-Coppens非球型对称的原子中心多极子电子密度模型进行了优化,以Bade的Q...

为了更好地理解各种配位聚合物[MX2y](M=Zn,Cd:X=C1,Br:py=m二卤代吡啶)的电子结构差异,我们在100K收集了五个配位聚合物单晶(图1a)的高分辨率X光衍射数据,用Hansen-Coppens非球型对称的原子中心多极子电子密度模型进行了优化,以Bade的QTAIM为工具作了拓扑分析。除了得到传统化学键的键临界点外,还观测到了弱相互作用的(3,-1)型临界点。例如,PY中的对位H原子与另一相邻MX链中的卤离子(图1c);相邻晶格的吡啶环上的卤代基R...R等。并用量子化学从头算方法计算了弱相互作用的强度。

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来源： cnki会议评论

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Schrodinger and Klein-Gordon theories of black holes from the quantization of the Oppenheimer and Snyder gravitational collapse

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Communications in Theoretical Physics 2023年第9期75卷 122-135页

作者： christian Corda SUNY Polytechnic Institute 13502 UticaNew YorkUSAIstituto Livi59100 PratoTuscanyItaly and International Institute for Applicable Mathematics and Information SciencesB M Birla Science CentreAdarshnagarHyderabad 500063India

The Schrodinger equation of the Schwarzschild black hole(BH) has been recently derived by the author and collaborators. The BH is composed of a particle, the 'electron', interacting with a central field, the 'nucleus'. Via de Broglie's hypothesis, one interprets the 'electron' in terms of BH horizon's modes. Quantum gravity effects modify the BH semi-classical structure at the Schwarzschild scale rather than at the Planck scale. The analogy between this BH Schrodinger equation and the Schrodinger equation of the s states of the hydrogen atom permits us to solve the same equation. The quantum gravitational quantities analogous of the fine structure constant and of the Rydberg constant are not constants, but the dynamical quantities have well-defined discrete spectra. The spectrum of the 'gravitational fine structure constant' is the set of non-zero natural numbers. Therefore, BHs are well-defined quantum gravitational systems obeying Schrodinger's theory: the 'gravitational hydrogen atoms'. By identifying the potential energy in the BH Schrodinger equation as being the gravitational energy of a spherically symmetric shell, a different nature of the quantum BH seems to surface. BHs are self-interacting, highly excited,spherically symmetric, massive quantum shells generated by matter condensing on the apparent horizon, concretely realizing the membrane paradigm. The quantum BH described as a'gravitational hydrogen atom' is a fictitious mathematical representation of the real, quantum BH, a quantum massive shell having a radius equal to the oscillating gravitational *** consequences emerge from this result:(i) BHs have neither horizons nor singularities;(ii) there is neither information loss in BH evaporation, nor BH complementarity, nor firewall paradox. These results are consistent with previous ones by Hawking, Vaz, Mitra and ***, the special relativistic corrections to the BH Schrodinger equation give the BH Klein–Gordon equation and the cor

关键词： quantum black holes information paradox quantum shells quantum levels Schrodinger and Klein-Gordon theories

Insensitive high explosives:Ⅳ. Nitroguanidine-Initiation & detonation

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Defence Technology（防务技术） 2019年第4期15卷 467-487页

作者： Ernst-christian Koch Lutradyn-Energetic Materials

This paper reviews the detonative properties of low bulk density(LBD),high bulk density(HBD)Nitroguanidine(NGu)(1),CAS-No:[556-88-7]and 82 explosive formulations based on NGu reported in the public *** rank the performance of those formulations they are compared with 15 reference compositions containing both standard high explosives such as octogen(HMX)(2),hexogen(RDX)(3),pentaerythritol tetranitrate(PETN)(4),2,4,6-trinitrotoluene(TNT)(5)as well as insensitive high explosives such as 3-nitro-1,2,4-triazolone(NTO)(6),1,3,5-triamino-2,4,6-trinitrobenzene(TATB)(7),1,1-diamino-2,2-dinitroethylene(FOX-7)(8)and N-Guanylurea dinitramide(FOX 12)(9).NGu based formulations are superior to those based on FOX-12 or TATB and are a close match with FOX-7 based explosives,the latter just having higher Gurney Energies(-10%)and slightly higher detonation pressure(+2%).NGu based explosives even reach up to 78% of the detonation pressure,82% Gurney energy and up to 95% of detonation velocity of ***-NGu dissolves in many melt cast eutectics forming dense charges thereby eliminating the need for costly High Bulk Density *** based formulations are at the rock bottom of sensitiveness among all the above-mentioned explosives which contributes to the safety of these *** review gives 132 references to the public *** a review on the synthesis spectroscopy and sensitiveness of Nitroguanidine see Ref.[1].

关键词： Cook-off Detonation Insensitive munitions Nitroguanidine Shock sensitvity

Special materials in pyrotechnics Ⅶ: Pyrotechnics used in thermal batteries

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Defence Technology（防务技术） 2019年第3期15卷 254-263页

作者： Ernst-christian Koch Lutradyn Energetic Materials Science & Technology

Thermal batteries are unique direct current(DC) electrical power sources with long shelf live, high reliability and higher power density than classical alkaline batteries. This paper gives a brief overview into the working principle of thermal batteries and reviews the properties of zirconium/barium chromate(Zr/BaCrO4) pyrolant previously used as first fire and iron/potassium perchlorate(Fe/KClO4) pyrolant(Heat), commonly applied as heating pellet in thermal batteries and its hazard properties. The review gives 64 references to the public domain. CAS-Nos. Zr: [7440-67-7], BaCrO4: [10294-40-3], Fe: [7439-89-6], KClO4: [7778-74-7], Viton: [9011-17-0].CAS-Nos. Zr: [7440-67-7], BaCrO4: [10294-40-3], Fe: [7439-89-6], KClO4: [7778-74-7], Viton: [9011-17-0].

关键词： Barium chromate Heat-powder Iron Lithium Molten salt Potassium perchlorate Pyrotechnics Thermal battery Zirconium

Deep learning for geometric and semantic tasks in photogrammetry and remote sensing

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Geo-Spatial Information Science 2020年第1期23卷 10-19页

作者： christian Heipke Franz Rottensteiner Institute of Photogrammetry and GeoInformation(PI) Leibniz University HannoverHannoverGermany

During the last few years,artificial intelligence based on deep learning,and particularly based on convolutional neural networks,has acted as a game changer in just about all tasks related to photogrammetry and remote *** have shown partly significant improvements in many projects all across the photogrammetric processing chain from image orientation to surface reconstruction,scene classification as well as change detection,object extraction and object tracking and recognition in image *** paper summarizes the foundations of deep learning for photogrammetry and remote sensing before illustrating,by way of example,different projects being carried out at the Institute of Photogrammetry and GeoInformation,Leibniz University Hannover,in this exciting and fast moving field of research and development.

关键词： Deep learning machine learning convolutional neural networks(CNN) example project from IPI