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World Journal of Clinical Cases 2022年第7期10卷 2351-2356页

作者： Youngbeom Seo Jonghoon kim Min Cheol Chang Hyungkyu Huh Eun-hee Lee Department of Neurosurgery College of MedicineYeungnam UniversityDaegu 42415South Korea Department of Rehabilitation Medicine College of MedicineYeungnam UniversityDaegu 42415South Korea Medical Interdisciplinary Team Medical Device Development CenterDaegu-Gyeongbuk Medical Innovation FoundationDaegu 41061South Korea

BACKGROUND Blood-brain barrier(BBB)disruption plays an important role in the development of neurological dysfunction in ischemic ***,diagnostic modalities that can clearly diagnose the degree of BBB disruption in ischemic stroke are ***,we describe two cases in which the usefulness of dynamic contrastenhanced magnetic resonance imaging(DCE-MRI)in detecting BBB disruption was evaluated after treatment of acute ischemic stroke using two different *** SUMMARY The two patients of similar age and relatively similar cerebral infarction locations were treated conservatively or with thrombectomy,although their sex was *** a result of analysis by performing DCE-MRI,it was confirmed that BBB disruption was significantly less severe in the patient who underwent thrombectomy(P=3.3×10^(-7)),whereas the average Ktrans of the contralateral hemisphere in both patients was similar(2.4×10^(-5)min^(-1) and 2.0×10^(-5)min^(-1)).If reperfusion is achieved through thrombectomy,it may indicate that the penumbra can be saved and BBB recovery can be *** Our cases suggest that BBB disruption could be important if BBB permeability is used to guide clinical treatment.

关键词： Blood-brain barrier Ischemic stroke Dynamic contrast-enhanced magnetic resonance imaging Thrombectomy Penumbra Case report

Role of adjuvant chemoradiotherapy and chemotherapy in patients with resected gallbladder carcinoma: a multiinstitutional analysis (KROG 19-04)

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Cancer Biology & Medicine 2022年第6期19卷 931-944页

作者： Sung Uk Lee Jinsil Seong Tae Hyun kim Jung Ho Im Woo Chul kim Kyubo kim Hae Jin Park Tae Gyu kim Youngkyong kim Bae Kwon Jeong Jin hee kim Byoung Hyuck kim Taek-Keun Nam Center for Proton Therapy and Center for Liver and Pancreatobiliary Cancer National Cancer CenterGoyang 10408Korea Department of Radiation Oncology Yonsei Cancer CenterYonsei University College of MedicineSeoul 03722Korea Department of Radiation Oncology CHA Bundang Medical CenterCHA University School of MedicineSeongnam 13497Korea Department of Radiation Oncology Inha University HospitalInha University School of MedicineIncheon 22332Korea Department of Radiation Oncology Ewha Womans University Mokdong HospitalEwha Womans University College of MedicineSeoul 07985Korea Department of Radiation Oncology Hanyang University Medical CenterHanyang University College of MedicineSeoul 04763Korea Department of Radiation Oncology Samsung Changwon HospitalSungkyunkwan University School of MedicineChangwon 51353Korea Department of Radiation Oncology Kyung Hee University HospitalKyung Hee University College of MedicineSeoul 02447Korea Department of Radiation Oncology Gyeongsang National University HospitalGyeongsang National University College of MedicineJinju 52727Korea Department of Radiation Oncology Dongsan Medical CenterKeimyung University School of MedicineDaegu 41931Korea Department of Radiation Oncology Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 07061Korea Department of Radiation Oncology Chonnam National University Hwasun HospitalChonnam National University College of MedicineHwasun 58128Korea

Objective:The effectiveness of adjuvant treatments for resected gallbladder carcinoma(GBC)has remained unclear due to lack of randomized controlled trials;thus,the aim of present study was to evaluate the role of adjuvant treatments,including chemoradiotherapy(CRT)and/or chemotherapy(CTx),in patients with resected ***:A total of 733 GBC patients who received curative-intent surgical resection were identified in a multi-institutional *** 733 patients,372(50.8%)did not receive adjuvant treatment,whereas 215(29.3%)and 146(19.9%)received adjuvant CTx and CRT,*** locoregional recurrence-free survival(LRFS),recurrence-free survival(RFS),and overall survival(OS)of the adjuvant treatment groups were compared according to tumor stage(stage II *** III–IV).Results:In stage II disease(n=381),the 5-year LRFS,RFS,and OS were not significantly different among the no-adjuvant therapy,CTx,and CRT groups,and positive resection margin,presence of perineural invasion,and Nx classification were consistently associated with worse LRFS,RFS,and OS in the multivariate analysis(P<0.05).For stage III–IV(n=352),the CRT group had significantly higher 5-year LRFS,RFS,and OS than the no-adjuvant therapy and CTx groups(67.8%,45.2%,and 56.9%;37.9%,28.8%,and 35.4%;and 45.0%,30.0%,and 45.7%,respectively)(P<0.05).Conclusions:CRT has value as adjuvant treatment for resected GBC with stage III–IV *** study is needed for stage II disease with high-risk features.

关键词： Gallbladder cancer adjuvant treatment chemoradiotherapy locoregional recurrence-free survival overall survival

Development of acquired non-accommodative esotropia in a patient without a trochlear nerve

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International Journal of Ophthalmology(English edition) 2022年第6期15卷 1030-1031页

作者： hee Kyung Yang Jae Hyoung kim Jeong-Min Hwang Department of Ophthalmology Seoul National University College of MedicineSeoul National University Bundang HospitalSeongnam 13620Republic of Korea Department of Radiology Seoul National University College of MedicineSeoul National University Bundang HospitalSeongnam 13620Republic of Korea

Dear Editor,Congenital cranial dysinnervation disorders(CCDD) are neurodevelopmental diseases of the brainstem and cranial nerves;. Congenital superior oblique palsy(SOP) is one of the most representative CCDDs becaus... 详细信息

关键词： nerves diseases oblique

Gut microbiota as a potential key to modulating humoral immunogenicity of new platform COVID-19 vaccines

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2447-2450页

作者： Hye Seong Bo Kyu Choi Young-hee Han Jun Hyoung kim Jeong-An Gim Sooyeon Lim Ji Yun Noh hee Jin Cheong Woo Joo kim Joon Young Song Department of Internal Medicine Korea University College of MedicineSeoulRepublic of Korea Asia Pacific Influenza Institute Korea University College of MedicineSeoulRepublic of Korea Vaccine Innovation Center Korea University College of MedicineSeoulRepublic of Korea Department of Biomedical Systems Informatics Yonsei University College of MedicineSeoulRepublic of Korea Department of Food and Nutrition Chungbuk National UniversityCheongjuRepublic of Korea Department of Internal Medicine Chungbuk National University HospitalCheongjuRepublic of Korea Medical Science Research Center Korea University College of MedicineSeoulRepublic of Korea

Dear Editor,Coronavirus disease 2019(COVID-19)is a novel respiratory infectious disease,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which led to a global *** vaccination is the best measure to overcome a pandemic,the immunogenicity of vaccines can be influenced by diverse factors,including intrinsic(age,sex,genetics,and comorbidities),extrinsic(diet,nutrition,and behavior),and vaccine-associated characteristics.

关键词： vaccines respiratory acute

Development of a 3D subcutaneous construct containing insulin-producing beta cells using bioprinting

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Bio-Design and Manufacturing 2022年第2期5卷 265-276页

作者： Chi B.Ahn Ji-Hyun Lee Joo H.kim Tae H.kim hee-Sook Jun Kuk H.Son Jin W.Lee Department of Molecular Medicine College of MedicineGachon University155Gaetbeol-roYeonsu-kuIncheonRepublic of Korea Department of Health Sciences and Technology GAIHSTGachon University155Gaetbeol-roYeonsu-kuIncheonRepublic of Korea College of Pharmacy Gachon University191Hambangmoe-roYeonsu-kuIncheonRepublic of Korea Department Thoracic and Cardiovascular Surgery Gachon University Gil Medical CenterCollege of MedicineGachon University21Namdong-daero 774 beon-gilNamdong-guIncheonRepublic of Korea

Type 1 diabetes is caused by insulin deficiency due to the loss of beta cells in the islets of *** severe cases,islet transplantation into the portal vein is ***,due to the loss of transplanted islets and the failure of islet function,the 5-year insulin independence rate of these patients is<50%.In this study,we developed a long-term,insulin-secreting,3 Dbioprinted construct implanted subcutaneously with the aim of preventing islet *** bioprinted construct was fabricated by the multi-layer bioprinting of beta-cell(mouse insulinoma-6:MIN-6)-encapsulated alginate bioink and poly(caprolactone)biodegradable polymer.A glucose response assay revealed that the bioprinted constructs proliferated and released insulin normally during the 4-week in vitro *** MIN-6 generated clusters with a diameter of 100-200μm,similar to the original pancreatic islets in the *** an in vivo study using type 1 diabetes mice,animals implanted with bioprinted constructs showed three times higher insulin secretion and controlled glucose levels at 8 weeks after *** the implanted,bioprinted constructs had a positive effect on insulin secretion in the experimental animals,the survival rate of the implanted group(75%)was three times higher than that of the non-implanted group(25%).The results suggest that the proposed,3 D-bioprinted,subcutaneous construct can be a better alternative to portal vein islet transplantation.

关键词： 3D bioprinting Subcutaneous construct Type 1 diabetes Insulin Beta cells

High efficiency and stable solid-state fiber dye-sensitized solar cells obtained using TiO_(2) photoanodes enhanced with metal organic frameworks

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Journal of Energy Chemistry 2022年第4期31卷 458-466页

作者： Jae Ho kim Hyun Woo Park Sung-Jun Koo Daseul Lee Eunyeong Cho Yong-Ki kim Myunghun Shin Jin Woo Choi hee Jung Lee Myungkwan Song Department of Energy and Electronic Material Korea Institute of Materials Science(KIMS)797 Changwon-daeroSungsan-guChangwonGyeongsangnam-do 51508Republic of Korea Composites Research Division Korea Institute of Materials Science(KIMS)797 Changwon-daeroSungsan-GuChangwonGyeongsangnam-do 51508Republic of Korea School of Electronics and Information Engineering Korea Aerospace UniversityGoyang-cityGyeonggi-do 10540Republic of Korea

Solid-state fiber dye-sensitized solar cells(SS-FDSSCs) have been the subject of intensive attention and development in recent years. Although this field is only in its infancy, metal–organic frameworks(MOFs) are one such material that has been utilized to further improve the power conversion efficiency of solar cells. In this study, MOF-integrated DSSCs were shown to have potential in the development of solar cell devices with efficiency comparable to or better than that of conventional solar cells. The power conversion efficiency(PCE) of SS-FDSSCs was improved by embedding MOF-801 into a mesoporous-TiO_(2)(mp-TiO_(2)) layer, which was used as a photoanode in SS-FDSSCs, which are inherently flexible. The PCE of the MOF-integrated SS-FDSSCs was 6.50%, which is comparable to that of the reference devices(4.19%).The MOF-801 enhanced SS-FDSSCs decreased the series resistance(R_(s)) value, resulting in effective electron extraction with improved short-circuit current density(J_(SC)), while also increasing the shunt resistance(R_(sh)) value to prevent the recombination of photo-induced electrons. The result is an improved fill factor and, consequently, a higher value for the PCE.

关键词： Photoanode Metal organic frameworks Solid-state electrolyte Dye-sensitized solar cells Fiber-shaped solar cells

Flash‑Induced High‑Throughput Porous Graphene via Synergistic Photo‑Effects for Electromagnetic Interference Shielding

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纳微快报:英文版 2023年第11期15卷 1-18页

作者： Jin Soo Lee Jeong‑Wook kim Jae hee Lee Yong Koo Son Young Bin kim Kyoohee Woo Chanhee Lee Il‑Doo kim Jae Young Seok Jong Won Yu Jung Hwan Park Keon Jae Lee Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak‑roYuseong‑guDaejeon 34141Republic of Korea School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak‑roYuseong‑guDaejeon 34141Republic of Korea Department of Printed Electronics Nano‑Convergence Manufacturing Systems Research DivisionKorea Institute of Machinery and Materials(KIMM)156 Gajeongbuk‑RoYuseong‑GuDaejeon 34103Republic of Korea Department of Mechanical System Design Engineering Seoul National University of Science and Technology232 Gongneung‑roNowon‑guSeoul 01811Republic of Korea Department of Mechanical Engineering(Department of Aeronautics Mechanical and Electronic Convergence Engineering)Kumoh National Institute of Technology61 Daehak‑roGumiGyeongbuk 39177Republic of Korea

Porous 2D materials with high conductivity and large surface area have been proposed for potential electromagnetic interference(EMI)shielding materials in future mobility and wearable applications to prevent signal noise,transmission inaccuracy,system malfunction,and health ***,we report on the synthesis of lightweight and flexible flash-induced porous graphene(FPG)with excellent EMI shielding *** broad spectrum of pulsed flashlight induces photo-chemical and photo-thermal reactions in polyimide films,forming 5×10 cm^(2)-size porous graphene with a hollow pillar structure in a few *** resulting material demonstrated low density(0.0354 g cm^(−3))and outstanding absolute EMI shielding effectiveness of 1.12×10^(5) dB cm^(2) g^(−1).The FPG was characterized via thorough material analyses,and its mechanical durability and flexibility were confirmed by a bending cycle ***,the FPG was utilized in drone and wearable applications,showing effective EMI shielding performance for internal/external EMI in a drone radar system and reducing the specific absorption rate in the human body.

关键词： Porous graphene Flash lamp Photo-pyrolysis High-throughput Electromagnetic interference shielding

Metabolomic and transcriptomic study to understand changes in metabolic and immune responses in steers under heat stress

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Animal Nutrition 2022年第4期11卷 87-101页

作者： Jun Sik Eom Da Som Park Sang Jin Lee Bon-hee Gu Shin Ja Lee Sang-Suk Lee Seon-Ho kim Byeong-Woo kim Sung Sill Lee Myunghoo kim Institute of Agriculture and Life Science Gyeongsang National UniversityJinju52828Republic of Korea Department of Animal Science College of Natural Resources&Life SciencePusan National UniversityMiryang50463Republic of Korea Life and Industry Convergence Research Institute Pusan National UniversityMiryang50463Republic of Korea University-Centered Labs Gyeongsang National UniversityJinju52828Republic of Korea Ruminant Nutrition and Anaerobe Laboratory Department of Animal Science and TechnologySunchon National UniversitySuncheon57922Republic of Korea Division of Applied Life Science(BK21) Gyeongsang National UniversityJinju52828Republic of Korea

Heat stress(HS)damages livestock by adversely affecting physiological and immunological ***,fundamental understanding of the metabolic and immunological mechanisms in animals under HS remains elusive,particularly in *** understand the changes on metabolic and immune responses in steers under HS condition,we performed RNA-sequencing and proton nuclear magnetic resonance spectroscopy-based metabolomics on HS-free(temperature humidity index[THI]value:64.92±0.56)and HS-exposed(THI value:79.13±0.56)Jersey steer(n=8,body weight:559.67±32.72 kg).This study clarifies the metabolic changes in 3 biofluids(rumen fluid,serum,and urine)and the immune responses observed in the peripheral blood mononuclear cells of HS-exposed *** integrated approach allowed the discovery of HS-sensitive metabolic and immunological *** metabolomic analysis indicated that HS-exposed steers showed potential HS biomarkers such as isocitrate,formate,creatine,and riboflavin(P<0.05).Among them,there were several integrative metabolic pathways between rumen fluid and ***,HS altered mRNA expression and immune-related signaling pathways.A meta-analysis revealed that HS decreased riboflavin metabolism and the expression of glyoxylate and dicarboxylate metabolism-related ***,metabolic pathways,such as the hypoxia-inducible factor-1 signaling pathway,were downregulated in immune cells by HS(P<0.05).These findings,along with the datasets of pathways and phenotypic differences as potential biomarkers in steers,can support more in-depth research to elucidate the interrelated metabolic and immunological *** would help suggest new strategies to ameliorate the effects of HS,including disease susceptibility and metabolic disorders,in Jersey steers.

关键词： Heat stress Jersey steer Metabolome Transcriptome Immunity Metabolism

Indigenous microbiota protects development of medication-related osteonecrosis induced by periapical disease in mice

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International Journal of Oral Science 2022年第2期14卷 156-163页

作者： Wen Du Mengyu Yang Terresa kim Sol kim Drake W.Williams Maryam Esmaeili Christine Hong Ki-Hyuk Shin Mo K.Kang No-hee Park Reuben H.kim State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Prosthodontics West China Hospital of StomatologySichuan UniversityChengduChina The Shapiro Family Laboratory of Viral Oncology and Aging Research Los AngelesUSA Section of Restorative Dentistry UCLA School of DentistryLos AngelesUSA Department of Orofacial Sciences UCSF School of DentistrySan FranciscoUSA UCLA Jonsson Comprehensive Cancer Center Los AngelesUSA David Geffen School of Medicine at UCLA Los AngelesUSA

Bacterial infection is a common finding in patients,who develop medication-related osteonecrosis of the jaw(MRONJ)by the longterm and/or high-dose use of anti-resorptive agents such as bisphosphonate(BPs).However,pathological role of bacteria in MRONJ development at the early stage remains ***,we demonstrated that commensal microbiota protects against MRONJ development in the pulp-exposed periapical periodontitis mouse model.C57/BL6 female mice were treated with intragastric broadspectrum antibiotics for 1 *** acid(ZOL)through intravenous injection and antibiotics in drinking water were administered for throughout the *** was exposed on the left maxillary first molar,then the mice were left for 5 weeks after which bilateral maxillary first molar was extracted and mice were left for additional 3 weeks to *** mice were harvested,and cecum,maxilla,and femurs were *** development was assessed usingμCT and histologic *** antibiotic was treated in mice,these mice had no weight changes,but developed significantly enlarged ceca compared to the control group(CTL mice).Periapical bone resorption prior to the tooth extraction was similarly prevented when treated with antibiotics,which was confirmed by decreased osteoclasts and *** treatment with pulp exposure significantly increased bone necrosis as determined by empty lacunae and necrotic bone ***,antibiotics treatment could further exacerbate bone necrosis,with increased osteoclast *** findings suggest that the commensal microbiome may play protective role,rather than pathological role,in the early stages of MRONJ development.

关键词： protective finding antibiotics

The spliceophilin CYP18-2 is mainly involved in the splicing of retained introns under heat stress in Arabidopsis

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Journal of Integrative Plant Biology 2023年第5期65卷 1113-1133页

作者： Areum Lee Hyun Ji Park Seung hee Jo Haemyeong Jung Hyun-Soon kim Hyo-Jun Lee Youn-Sung kim Choonkyun Jung Hye Sun Cho Plant Systems Engineering Research Center Korea Research Institute of Bioscience and Biotechnology(KRIBB)Daejeon 34141Korea Department of Biosystems and Bioengineering KRIBB School of BiotechnologyUniversity of Science and Technology(UST)Daejeon 34141Korea Department of Functional Genomics KRIBB School of BioscienceUSTDaejeon 34113Korea Department of Biotechnology NongWoo BioAnseong 17558Korea Department of International Agricultural Technology and Crop Biotechnology Institute/Green Bio Science and Technology Seoul National UniversityPyeongchang 25354Korea Department of Agriculture Forestryand Bioresources and Integrated Major in Global Smart FarmCollege of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Korea

Peptidyl-prolyl isomerase-like 1(PPIL1)is associated with the human spliceosome ***,its function in pre-mRNA splicing remains *** this study,we show that Arabidopsis thaliana CYCLOPHILIN 18-2(AtCYP18-2),a PPIL1 homolog,plays an essential role in heat tolerance by regulating pre-mRNA *** heat stress conditions,AtCYP18-2 expression was upregulated in mature plants and GFP-tagged AtCYP18-2 redistributed to nuclear and cytoplasmic *** determined that AtCYP18-2 interacts with several spliceosome complex B^(ACT)components in nuclear puncta and is primarily associated with the small nuclear RNAs U5 and U6 in response to heat *** AtCYP18-2 loss-of-function allele cyp18-2 engineered by CRISPR/Cas9-mediated gene editing exhibited a hypersensitive phenotype to heat stress relative to the wild ***,global transcriptome profiling showed that the cyp18-2 mutation affects alternative splicing of heat stress–responsive genes under heat stress conditions,particularly intron retention(IR).The abundance of most intron-containing transcripts of a subset of genes essential for thermotolerance decreased in cyp18-2 compared to the wild ***,the intron-containing transcripts of two heat stress-related genes,HEAT SHOCK PROTEIN 101(HSP101)and HEAT SHOCK FACTOR A2(HSFA2),produced functional ***101-IR-GFP localization was responsive to heat stress,and HSFA2-Ⅲ-IR interacted with HSF1 and HSP90.1 in plant *** findings reveal that CYP18-2 functions as a splicing factor within the B~(ACT)spliceosome complex and is crucial for ensuring the production of adequate levels of alternatively spliced transcripts to enhance thermotolerance.

关键词： alternative splicing CYP18-2 HSFA2-Ⅲ intron retention spliceophilin spliceosome complex B~(ACT) thermotolerance