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Programmed cell death-1 inhibitor combination treatment for recurrent proficient mismatch repair/miscrosatellite-stable type endometrial cancer:A case report

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World Journal of Clinical Cases 2022年第21期10卷 7474-7482页

作者： chong-ya zhai Lu-Xi Yin Wei-Dong Han Department of Medical Oncology Xiasha CampusSir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhou 310020Zhejiang ProvinceChina Department of Medical Oncology Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhou 310020Zhejiang ProvinceChina

BACKGROUND Endometrial cancer(EC)is one of the most common cancers of the female reproductive tract,and the incidence is increasing *** using programmed cell death-1(PD-1)inhibitors is an emerging research topic and treatment strategy for refractory gynecological ***,clinical management of EC with checkpoint inhibitors requires ***,we discuss a case of refractory proficient mismatch repair(pMMR)/miscrosatellitestable(MSS)EC treated with a combination of PD-1 and angiogenesis inhibitors and offer a review of the pathophysiology and clinical outcomes based on previous *** SUMMARY A 62-year-old woman diagnosed with invasive or metastatic EC in 2015 was treated with six courses of chemotherapy and refused further *** years later,she developed chest pain,and lung biopsy indicated thyroid transcription factor-1(-),Napsin A(-),estrogen receptor(+),progesterone receptor(+),anaplastic lymphoma kinase(D5F3)(-),and receptor tyrosine kinase(D4D6)(-)metastatic *** testing results showed low tumor mutation burden,pMMR,PD ligand 1(-),MSS,and HLA-class 1 heterogeneous *** patient was started on toripalimab combined with nab-paclitaxel for seven cycles(every 3 wk),but this regimen was terminated because of an intolerable chemotherapy adverse *** disease progressed in 2020,and the patient’s treatment was switched from nab-paclitaxel to anlotinib,while immunotherapy using toripalimab was *** patient achieved a major partial response with well-tolerated toxicities,and treatment is *** Molecular testing is advised for clinical classifications of EC owing to its high *** this case,the patient had pMMR/MSS EC and achieved a positive outcome with combination PD-1 inhibitor *** results warrant further clinical exploration.

关键词： Refractory endometrial cancer Proficient mismatch repair Miscrosatellite-stable Immunotherapy Case report

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Covalently Bonded Ni Sites in Black Phosphorene with Electron Redistribution for Efficient Metal‑Lightweighted Water Electrolysis

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Nano-Micro Letters 2024年第6期16卷 233-245页

作者： Wenfang zhai ya Chen yaoda Liu Yuanyuan Ma Paranthaman Vijayakumar Yuanbin Qin Yongquan Qu Zhengfei Dai State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049People’s Republic of China School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China SSN Research Centre SSN College of EngineeringChennaiTamil Nadu 603110India

The metal-lightweighted electrocatalysts for water splitting are highly desired for sustainable and economic hydrogen energy deployments,but *** this work,a low-content Ni-functionalized approach triggers the high capability of black phosphorene(BP)with hydrogen and oxygen evolution reaction(HER/OER)*** a facile in situ electro-exfoliation route,the ionized Ni sites are covalently functionalized in BP nanosheets with electron redistribution and controllable metal *** is found that the as-fabricated Ni-BP electrocatalysts can drive the water splitting with much enhanced HER and OER *** 1.0 M KOH electrolyte,the optimized 1.5 wt%Nifunctionalized BP nanosheets have readily achieved low overpotentials of 136 mV for HER and 230 mV for OER at 10 mA cm^(−2).Moreover,the covalently bonding between Ni and P has also strengthened the catalytic stability of the Ni-functionalized BP electrocatalyst,stably delivering the overall water splitting for 50 h at 20 mA cm^(−2).Theoretical calculations have revealed that Ni–P covalent binding can regulate the electronic structure and optimize the reaction energy barrier to improve the catalytic activity *** work confirms that Ni-functionalized BP is a suitable candidate for electrocatalytic overall water splitting,and provides effective strategies for constructing metal-lightweighted economic electrocatalysts.

关键词： Black phosphorus Water electrolysis Electrocatalyst Electron redistribution Covalent functionalization

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Current and Potential Roles of Ferroptosis in Bladder Cancer

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Current Medical Science 2024年第1期44卷 51-63页

作者： Wen-xin AN Radheshyam Gupta Kun zhai ya-ru WANG Wan-hai XU yan CUI Department of Urology Harbin Medical University Cancer HospitalHarbin 150081China Department of Internal Medical Oncology Harbin Medical University Cancer HospitalHarbin 150081China

Ferroptosis,a type of regulated cell death driven by iron-dependent lipid peroxidation,is mainly initiated by extramitochondrial lipid peroxidation due to the accumulation of iron-dependent reactive oxygen *** is a prevalent and primitive form of cell *** cellular metabolic processes regulate ferroptosis,including redox homeostasis,iron regulation,mitochondrial activity,amino acid metabolism,lipid metabolism,and various disease-related signaling *** plays a pivotal role in cancer therapy,particularly in the eradication of aggressive malignancies resistant to conventional *** studies have explored the connection between ferroptosis and bladder cancer,focusing on its incidence and treatment *** biomolecules and tumor-associated signaling pathways,such as p53,heat shock protein 1,nuclear receptor coactivator 4,RAS-RAF-MEK,phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin,and the Hippo-tafazzin signaling system,exert a moderating influence on ferroptosis in bladder *** inducers,including erastin,artemisinin,conjugated polymer nanoparticles,and quinazolinyl-arylurea derivatives,hold promise for enhancing the effectiveness of conventional anticancer medications in bladder cancer *** conventional therapeutic drugs and treatment methods related to ferroptosis offers a promising approach for the treatment of bladder *** this review,we analyze the research on ferroptosis to augment the efficacy of bladder cancer treatment.

关键词： ferroptosis bladder cancer ferroptosis-associated tumor signaling pathway ferroptosis inducer

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ALTERNATING OPTIMIZATION METHOD FOR ISOGEOMETRIC TOPOLOGY OPTIMIZATION WITH STRESS CONSTRAINTS

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Journal of Computational Mathematics 2024年第1期42卷 134-155页

作者： Xiaoya zhai School of Mathematical Sciences University of Science and Technology of ChinaHefei 230071China

Topology optimization (TO) has developed rapidly recently. However, topology optimization with stress constraints still faces many challenges due to its highly non-linear properties which will cause inefficient computation, iterative oscillation, and convergence guarantee problems. At the same time, isogeometric analysis (IGA) is accepted by more and more researchers, and it has become one important tool in the field of topology optimization because of its high fidelity. In this paper, we focus on topology optimization with stress constraints based on isogeometric analysis to improve computation efficiency and stability. A new hybrid solver combining the alternating direction method of multipliers and the method of moving asymptotes (ADMM-MMA) is proposed to solve this problem. We first generate an initial feasible point by alternating direction method of multipliers (ADMM) in virtue of the rapid initial descent property. After that, we adopt the method of moving asymptotes (MMA) to get the final results. Several benchmark examples are used to verify the proposed method, and the results show its feasibility and effectiveness.

关键词： Isogeometric topology optimization Stress constraints The ADMM-MMA solver

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DCVAE-adv:A Universal Adversarial Example Generation Method for White and Black Box Attacks

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Tsinghua Science and Technology 2024年第2期29卷 430-446页

作者： Lei Xu Junhai zhai College of Mathematics and Information Science Hebei UniversityBaoding 071002China

Deep neural network(DNN)has strong representation learning ability,but it is vulnerable and easy to be fooled by adversarial *** order to handle the vulnerability of DNN,many methods have been *** general idea of existing methods is to reduce the chance of DNN models being fooled by observing some designed adversarial examples,which are generated by adding perturbations to the original *** this paper,we propose a novel adversarial example generation method,called *** from the existing methods,DCVAE-adv constructs adversarial examples by mixing both explicit and implicit perturbations without using original ***,the proposed method can be applied to both white box and black box *** addition,in the inference stage,the adversarial examples can be generated without loading the original images into memory,which greatly reduces the memory *** compared DCVAE-adv with three most advanced adversarial attack algorithms:FGSM,AdvGAN,and AdvGAN++.The experimental results demonstrate that DCVAE-adv is superior to these state-of-the-art methods in terms of attack success rate and transfer ability for targeted *** code is available at https://***/xzforeverlove/DCVAE-adv.

关键词： deep neural network adversarial examples white box attack black box attack robustness

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Mechanism of microarc oxidation on AZ91D Mg alloy induced byβ-Mg_(17)Al_(12) phase

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 712-724页

作者： Dajun zhai Xiaoping Li Jun Shen College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

This work proposed a strategy of indirectly inducing uniform microarc discharge by controlling the content and distribution ofβ-Mg_(17)Al_(12)phase in AZ91D Mg *** kinds of nano-particles(ZrO_(2)and TiO_(2))were designed to be added into the substrate of Mg alloy by friction stir processing(FSP).Then,Mg alloy sample designed with different precipitated morphology ofβ-Mg_(17)Al_(12)phase was treated by microarc oxidation(MAO)in Na_(3)PO_(4)/*** characteristics and performance of the MAO coating was analyzed using scanning electron microscopy(SEM),energy dispersive spectrometer(EDS),X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),contact angle meter,and potentiodynamic *** was found that the coarseα-Mg grains in extruded AZ91D Mg alloy were refined by FSP,and theβ-Mg_(17)Al_(12)phase with reticular structure was broken and *** nano-ZrO_(2)particles were pinned at the grain boundary by FSP,which refined theα-Mg grain and promoted the precipitation ofβ-Mg_(17)Al_(12)phase in *** effectively inhibited the“cascade”phenomenon of microarcs,which induced the uniform distribution of discharge *** MAO coating on Zr-FSP sample had good wettability and corrosion ***,TiO_(2)particles were hardly detected in the coating on TiFSP sample.

关键词： AZ91D Mg alloy microarc oxidation friction stir processing ZrO_(2) TiO_(2) β-Mg_(17)Al_(12)

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In-phase and out-of-phase spin pumping effects in Py/Ru/Pysynthetic antiferromagnetic structures

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Chinese Physics B 2024年第9期33卷 541-545页

作者： Zhaocong Huang Xuejian Tang Qian Chen Wei Jiang Qingjie Guo Milad Jalali Jun Du ya zhai Key Laboratory of Quantum Materials and Devices of Ministry of Education School of PhysicsSoutheast UniversityNanjing 211189China National Laboratory of Solid Microstructures Nanjing UniversityNanjing 210093China

The spin pumping effect in magnetic heterostructures and multilayers is a highly effective method for the generationand transmission of spin currents. In the increasingly prominent synthetic antiferromagnetic structures, the two ferromagneticlayers demonstrate in-phase and out-of-phase states, corresponding to acoustic and optical precession modes. Withinthis context, our study explores the spin pumping effect in Py/Ru/Py synthetic antiferromagnetic structures across differentmodes. The heightened magnetic damping resulting from the spin pumping effect in the in-phase state initially decreaseswith increasing Py thickness before stabilizing. Conversely, in the out-of-phase state, the amplified damping exceeds thatof the in-phase state, suggesting a greater spin relaxation within this configuration, which demonstrates sensitivity to alterationsin static exchange interactions. These findings contribute to advancing the application of synthetic antiferromagneticstructures in magnonic devices.

关键词： spin pumping spin transmission synthetic antiferromagnetic structures spin dynamics

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Friction and Deformation Behavior of Human Skin During Robotic Sliding Massage Operation

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Journal of Bionic Engineering 2024年第4期21卷 1892-1904页

作者： Jingmei zhai Rixing Li Ziqing Su School of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou510000China

This study investigates the friction and deformation behavior of the skin in contact with a rigid massage ball and its influencing *** and stretching experiments were conducted using a collaborative robot experimental *** experiments encompassed a loading normal force range of 2 N to 18 N and a sliding speed range of 10 mm/s to 20 mm/*** friction response curve exhibits two different stages:static stick state and dynamic stick-slip stage,both of which have been mathematically *** analyzing the experimental data,we analyzed the effects of elastic modulus,sliding speed and normal loading force on skin tangential friction and tensile *** results indicate that as the normal load increases,both friction and deformation exhibit an ***,they decrease with an increase in elastic ***,while deformation diminishes with higher sliding speed,friction force remains relatively unaffected by *** observation can be attributed to the strain rate sensitivity resulting from the viscoelastic characteristics of the skin under substantial *** study advances the understanding of friction and deformation behavior during skin friction,offering valuable insights to enhance the operational comfort of massage robots.

关键词： Human skin Friction sliding Deformation Robotic massage Stereo image

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Lead-free metal halide scintillator materials for imaging applications

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Science China(Information Sciences) 2024年第8期67卷 85-101页

作者： Junzhe LIN Dan GUO Tianrui zhai Department of Physics and Optoelectronic Engineering Beijing University of Technology

High-energy radiation detection and imaging technology has significant applications in highenergy physics research, medical imaging, and industrial monitoring. Lead-free metal halides exhibit exceptional potential for conducting indirect detection of high-energy radiation due to their characteristics of low toxicity, strong stability, high light yield, and large Stokes shift. This paper reviews the most recent advances in lead-free metal halide scintillator materials for X-ray imaging. Subsequently, it lists the most important parameters of scintillator performance and introduces the production procedures for single crystal, powder,and nanocrystal scintillators. Furthermore, it discusses the manufacturing of scintillator films with improved performance, focusing on large-area flexible scintillator films and the coupling with microstructures. Finally,it discusses current challenges and opportunities for enhancing X-ray imaging using lead-free metal halide scintillator materials.

关键词： lead-free metal halide scintillators imaging film luminescence

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Bivariate attribution of the compound hot and dry summer of 2022 on the Tibetan Plateau

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Science China Earth Sciences 2024年第7期67卷 2122-2136页

作者： Baiquan ZHOU Panmao zhai Zhen LIAO State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081China

The extraordinarily high temperatures experienced during the summer of 2022 on the Tibetan Plateau(TP)demand attention when compared with its typical climatic *** absence of precipitation alongside the elevated temperatures resulted in 2022 being the hottest and driest summer on record on the TP since at least *** the susceptibility of the TP to climate change,this study employed large-ensemble simulations from the HadGEM3-A-N216 attribution system,together with a copula-based joint probability distribution,to investigate the influence of anthropogenic forcing,primarily global greenhouse gas emissions,on this unprecedented compound hot and dry event(CHDE).Findings revealed that the return period for the 2022 CHDE on the TP exceeds 4000 years,as determined from the fitted joint distributions derived using observational data spanning *** CHDE was directly linked to large-scale circulation anomalies,including the control of equivalent-barotropic high-pressure anomalies and the northward displacement of the subtropical westerly jet ***,anthropogenic forcing has,to some extent,promoted the surface warming and increased variability in precipitation on the TP in summer,establishing conditions conducive for the 2022 CHDE from a long-term climate change *** return period for a 2022-like CHDE on the TP was estimated to be approximately 283 years(142-613 years)by the large ensemble forced by both anthropogenic activities and natural ***,ensemble simulations driven solely by natural forcing indicated that the likelihood of occurrence of a 2022-like CHDE was almost *** outcomes underscore that the contribution of anthropogenic forcing to the probability of a 2022-like CHDE was 100%,implying that without anthropogenically induced global warming,a comparable CHDE akin to that observed in 2022 on the TP would not be possible.

关键词： Compound hot and dry event Tibetan Plateau Bivariate event attribution Anthropogenic forcing

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