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Type D personality negatively associated with self-care in Chinese heart failure patients

Journal of Geriatric Cardiology 2016年第5期13卷 401-407页

作者： Xi CAO Xiu-Hua WANG Eliza ML Wong choi kai chow Sek Ying Chair The Nethersole School of Nursing The Chinese University of Hong Kong Hong Kong China Nursing School Central South University Changsha China

Background Little is known about the association between type D personality and self-care behaviors in heart failure （HF） patients. We examined the effect of type D personality on self-care behaviors and self-efficacy among Chinese HF patients. Methods A cross-sectional study with a convenience sample was conducted. All participants completed the questionnaires of the self-care of HF index （V6） and type D personality scale. Demographic and clinical variables were obtained from medical records and patient interviews. The me- thods used for data analysis included descriptive analysis, independent-sample t-test, Z2 test, and multiple linear regression. Results A total of 127 HF patients were included and 61.4% of them were male. The average age for this study sample was 64.9± 12.34 years. The majority of the participants were in a New York Heart Association class III or IV （87%）, and the average length of living with HF was 38.24 ± 41.1 months. A total of 33.1% of the participants were identified as having type D personality. No significant differences were determined in the demographic and clinical variables between type D and non-type D patients, except for the mean age and the length of living with HF. Type D patients were younger and had a shorter time of living with HF than their non-type D counterparts. Multiple regression demonstrated significant associations between type D personality and self-care maintenance and self-efficacy after adjusting the demographic and clinical factors. However, type D personality was not significantly associated with self-care management behaviors. Conclusions Type D personality was negatively related to self-care maintenance and self-efficacy in Chinese HF patients. Future study is warranted to develop a tailored intervention to improve engagement in self-care behaviors in HF patients with type D personality.

关键词： Heart failure Self care Self-efficacy Type D personality

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Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law Chi Seng Leung Chun Yin Tong kai Kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

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Information needs of older people with heart failure： listening to their own voice

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Journal of Geriatric Cardiology 2016年第5期13卷 435-438页

作者： Ming-Ming YU Sek Ying Chair Carmen WH Chan kai chow choi School of Nursing Peking Union Medical College Beijing China Nethersole School of Nursing The Chinese University of Hong Kong Hong Kong China

According to a large-scale census in 2000, there were approximately 4,000,000 patients with heart failure （HF） aged between 35 and 74 years in China. Patient education shows its importance and essentiality in controlling the disease by improving the self-care abilities of patients,t21 However, a shortened period of hospitalization compromises the effectiveness and efficacy of the education. It is therefore suggested that the information needs of patients with HF should be simultaneously addressed to make education more appropriate and tailored.

关键词： Education Heart failure Information needs Qualitative study

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政府卫生支出能否影响患者就医选择?——基于北京市郊区的实证研究

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中国全科医学 2024年第4期27卷 420-426页

作者：吕博孟开首都医科大学公共卫生学院北京市100069 首都医科大学附属北京天坛医院高质量发展研究中心北京市100070

背景我国优质医疗资源集中在大城市的城区,患者倾向到大医院就医,产生了不合理就医现象。为此,近几年政府加大财政支出以加强基层医疗卫生机构的建设,旨在促进患者合理就医,实现分级诊疗。目的分析郊区政府卫生支出对郊区患者就医选择... 详细信息

背景我国优质医疗资源集中在大城市的城区,患者倾向到大医院就医,产生了不合理就医现象。为此,近几年政府加大财政支出以加强基层医疗卫生机构的建设,旨在促进患者合理就医,实现分级诊疗。目的分析郊区政府卫生支出对郊区患者就医选择的影响,为推进分级诊疗制度改革提供参考依据。方法于2022-02-10选取2015—2017年北京市10个郊区的患者到北京市属医院、郊区医院和郊区基层医疗卫生机构的门、急诊人次数及住院人次数作为被解释变量,选取人均政府卫生支出作为解释变量,选取各郊区常住人口数、人均国内生产总值(GDP)和每千人口卫生技术人数作为控制变量。采用chow检验和Hausman检验选择恰当的数据分析模型(混合回归模型、固定效应模型和随机效应模型),以探讨北京市郊区患者到市属医院、郊区医院、郊区基层医疗卫生机构就医的影响因素。结果固定效应模型分析北京市郊区患者到市属医院和郊区医院就医选择影响因素的结果显示,人均政府卫生支出、每千人口卫生技术人员数、人均GDP、常住人口数不是郊区患者到市属医院门、急诊和住院就医的影响因素(P>0.05),人均政府卫生支出和人均GDP是郊区患者到郊区医院门、急诊就医的影响因素(P<0.05);随机效应模型分析北京市郊区患者到郊区基层医疗卫生机构就医选择影响因素的结果显示,常住人口数、人均GDP和人均政府卫生支出是郊区患者到郊区基层医疗卫生机构门、急诊就医的影响因素(P<0.05)。结论目前大医院对患者的“虹吸”现象依然存在,政府卫生支出未对郊区患者到市属医院就医产生明显影响。但是增加政府卫生支出能够促进郊区患者在区域内就医,有助于实现分级诊疗。每千人口卫生技术人员数对患者就医选择未产生明显影响,建议进一步增加郊区政府卫生支出,提升郊区医务人员医疗服务能力,促进患者在区域内就医。

关键词：卫生经费支出分级诊疗制度政府卫生支出就医选择影响因素分析

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Spectral Properties and Photochromic Characteristics of Spiropyran Dyes

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Chemical Research in Chinese Universities 2006年第4期22卷 505-509页

作者： SHEN kai-hua HAN Jian-guo ZHANG Gang choi Dong-hoon The State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116012 P. R. China The Key Laboratory of Cellulose and Lignocellulosics Chemistry Guangzhou Institute of Chemistry Chinese Academy of Sciences Guangzhou 510650 P. R. China Polymer and Fiber Material Engineering Kyunghee University Kyong Kido 449-701 Korea

A bis-benzospiropyran（BBSP） and nitro-substituted indoline spirobenzopyrans（SBP） were prepared by following a simple procedure. The reaction mechanism of synthesizing bis-benzospiropyran is discussed. A comparative analysis of the spectral and photochromic properties between SBP and BBSP was carried out with the aid of a PMMA film. The results indicate that chemical structures and UV irradiation played an important role in the spectral and photochromic properties of SBP and BBSP, which would readily affect λmax of the colored forms and the reversibility. The IR spectra and ^1H NMR spectra of these compounds are used to interpret the photochromic phenomena under different UV irradiation and determine the configurations of SBP and BBSP.

关键词： Photochromism Spiropyran UV radiation Protonation

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Safety evaluation of nanodiamond-doxorubicin complexes in a Naïve Beagle canine model using hematologic,histological,and urine analysis

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Nano Research 2022年第4期15卷 3356-3366页

作者： Liping Wang Wenqiong Su Khan Zara Ahmad Xin Wang Ting Zhang Youyi Yu Edward kai-Hua chow Dean Ho Xianting Ding State Key Laboratory of Oncogenes and Related Genes Institute for Personalized MedicineSchool of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200030China Cancer Science Institute of Singapore Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117599Singapore The N.1 Institute for Health(N.1) National University of SingaporeSingapore 117456Singapore The Institute for Digital Medicine(WisDM) National University of SingaporeSingapore 117456Singapore Department of Pharmacology National University of SingaporeSingapore 117597Singapore Department of Biomedical Engineering National University of SingaporeSingapore 117583Singapore

While doxorubicin(DOX)is one of the most common chemotherapeutic drugs for treating cancer,use of DOX must be managed carefully due to dose-related ***(ND)drug delivery system conjugated with DOX(NDX)has been reported to enhance treatment efficacy and attenuate toxicity in murine cancer *** addition,extensive biocompatibility studies indicate that NDs seem to be well tolerated in non-human *** the clinical translation of NDX,it is necessary to verify the safety of ND in large *** of nanomedicine drug safety for large animal are not commonly reported,and this work represents a key milestone in bridging earlier advances towards clinical ***,NDs’safety as a drug-delivery platform was evaluated in Naïve Beagle *** study is performed with DOX,ND,and NDX in a dual-gender animal model using intravenous(IV)injection and hepatic portal vein(HPV)injection *** dogs are monitored for their health phenotype changes in continuous 5 *** and urine obtained are for clinical pathology *** results indicate that ND drug delivery platform significantly relieves DOX toxicity for Naïve Beagle dog *** study provides guidance for the pre-clinical safety assessment of NDX therapy at large animal level.

关键词： nanomedicine doxorubicin nanodiamonds safety biodistribution

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Mean sea surface heights of the South and East China Seas from ocean circulation model and geodetic leveling

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Chinese Science Bulletin 2002年第4期47卷 326-329页

作者： FANG Guohong WEI Zexun FANG Yue WANG kai choi Byungho Institute of Oceanology Chinese Academy of SciencesQingdao 266071China Department of Oceanography Texas A&M UniversityCollege StationTX 77843-3146USA Department of Civil Engineering Sungkyunkwan UniversitySuwon440-746Korea

The mean sea surface heights (sea surface topography) of the South China, East China, Yellow and Bohai Seas are derived from an ocean general circulation model and surface air pressure. The circulation model covers the global oceans, with fine grid (1/6°)? covering the East Asian marginal seas and coarse grid (3°) covering the rest part of the global oceans. The result shows that the China 1985 Na-tional Altitude Datum is 24.7 cm above the mean sea surface height of the world oceans. The mean sea surface in the coastal ocean adjacent to China is higher in the south than in the north. Intercomparison of the model results with the geodetic leveling measurements at 28 coastal tidal stations shows a standard deviation of 4.8 cm and a fitting coefficient of 95.3%. After correction through linear regression, the standard deviation is reduced to 4.5 cm. This indicates that the accuracy of model results is sufficient for practical application. Based on the model results, the mean sea surface heights for the

关键词： mean sea surface height ocean circulation model land leveling South China Sea East China Sea Yellow Sea Bohai Sea.

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Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation

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Protein & Cell 2024年第7期15卷 512-529页

作者： kai-Hui Zhang Fei-Fei Zhang Zhi-Ling Zhang Ke-Fei Fang Wen-Xing Sun Na Kong Min Wu Hai-Ou Liu Yan Liu Zhi Li Qing-Qing Cai Yang Wang Quan-Wei Wei Peng-Cheng Lin Yan Lin Wei Xu Cong-Jian Xu Yi-Yuan Yuan Shi-Min Zhao The Obstetrics&Gynecology Hospital of Fudan University State Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200090China Shanghai Key Laboratory of Metabolic Remodeling and Children’s Hospital of Fudan UniversityShanghai 200032China School of Life Sciences and Institutes of Biomedical Sciences Fudan UniversityShanghai 200438China Department of Nutrition and Food Hygiene School of Public HealthNantong UniversityNantong 226019China Reproductive Medicine Center The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Shanghai Fifth People’s Hospital of Fudan University Fudan UniversityShanghai 200240China Department of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210014China Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province College of PharmacyQinghai University for NationalitiesXining 810007China Pediatric Research Institute Children’s Hospital Affiliated to Shandong University(Jinan Children’s Hospital)Jinan 250022China

Polycystic ovary syndrome(PCOS)is the leading cause of anovulatory *** understanding of the ovulation drivers hinders PCOS ***,we report that follicle stimulating hormone(FSH)controls follicular fluid(FF)glutamine levels to determine *** ovulation starts from FF-exposing granulosa cell(GC)*** glutamine,which decreases in pre-ovulation porcine FF,elevates in PCOS patients ***-glutamine chow to elevate FF glutamine inhibits mouse GC apoptosis and induces hormonal,metabolic,and morphologic PCOS ***,follicle-development-driving FSH promotes GC glutamine synthesis to elevate FF glutamine,which maintain follicle wall integrity by inhibiting GC apoptosis through inactivating ASK1-JNK apoptotic *** and glutamine inhibit the rapture of cultured murine *** removal or ASK1-JNK pathway activation with metformin or AT-101 reversed PCOS traits in PCOS models that are induced with either glutamine or *** suggest that glutamine,FSH,and ASK1-JNK pathway are targetable to alleviate PCOS.

关键词： ovulation glutamine granulosa cells PCOS FSH

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Ultrasonic Plasma Engineering Toward Facile Synthesis of Single-Atom M-N4/N-Doped Carbon(M=Fe,Co) as Superior Oxygen Electrocatalyst in Rechargeable Zinc-Air Batteries

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Nano-Micro Letters 2021年第4期13卷 76-95页

作者： kai Chen Seonghee Kim Minyeong Je Heechae choi Zhicong Shi Nikola Vladimir Kwang Ho Kim Oi Lun Li Department of Materials Science and Engineering Pusan National University30 Jangjeon‑dongGeumjeong‑guBusan 609‑735Republic of Korea Theoretical Materials and Chemistry Group Institute of Inorganic ChemistryUniversity of CologneGreinstr.650939 CologneGermany School of Materials and Energy Guangdong University of TechnologyGuangzhou 510006People’s Republic of China Faculty of Mechanical Engineering and Naval Architecture University of ZagrebIvana Lucica 510002 ZagrebCroatia Global Frontier R&D Center for Hybrid Interface Materials 30 Jangjeon‑dongGeumjeong‑guBusan 46241Republic of Korea

As bifunctional oxygen evolution/reduction electrocatalysts,transition-metal-based single-atom-doped nitrogen-carbon(NC)matrices are promising successors of the corresponding noblemetal-based catalysts,offering the advantages of ultrahigh atom utilization effciency and surface active ***,the fabrication of such matrices(e.g.,well-dispersed single-atom-doped M-N4/NCs)often requires numerous steps and tedious ***,ultrasonic plasma engineering allows direct carbonization in a precursor solution containing metal phthalocyanine and *** combining with the dispersion effect of ultrasonic waves,we successfully fabricated uniform single-atom M-N4(M=Fe,Co)carbon catalysts with a production rate as high as 10 mg *** Co-N4/NC presented a bifunctional potential drop ofΔE=0.79 V,outperforming the benchmark Pt/C-Ru/C catalyst(ΔE=0.88 V)at the same catalyst *** calculations revealed that Co-N4 was the major active site with superior O2 adsorption-desorption *** a practical Zn-air battery test,the air electrode coated with Co-N4/NC exhibited a specific capacity(762.8 mAh g(-1))and power density(101.62 mW cm^(-2)),exceeding those of Pt/C-Ru/C(700.8 mAh g^(-1) and 89.16 mW cm^(-2),respectively)at the same catalyst ***,for Co-N4/NC,the potential difference increased from 1.16 to 1.47 V after 100 charge-discharge *** proposed innovative and scalable strategy was concluded to be well suited for the fabrication of single-atom-doped carbons as promising bifunctional oxygen evolution/reduction electrocatalysts for metal-air batteries.

关键词： Single-atom-doped M-N4/NC catalyst Plasma engineering ORR/OER bifunctional activity DFT calculation Rechargeable Zn-air battery

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A Creation Model from the Gell-Mann Standard Model to the Creation of Bio Cells: Based on the Assumption of Homogeneous 5D Space-Time Universe

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Journal of Modern Physics 2020年第7期11卷 1058-1074页

作者： kai Wai Wong Wan Ki chow Department of Physics and Astronomy University of Kansas Lawrence USA Department of Building Services Engineering The Hong Kong Polytechnic University Hong Kong China

In this paper, we briefly go over the homogeneous 5D model field theory: from the 5D space-time inception, to its quantum field solutions given in terms of Higgs vacuum, filled with magnetic monopole bose fields of all energies. Then through the space dimension reduction projections, the Gell-Mann standard model was obtained as well as a quantum to Classical connection was made via introducing Bose distribution to the monopoles to obtain the Perelman entropy and Ricci Flow mappings. This provided us a picture to the creation of Astronomical objects, from galaxies to stars and planets. This method of splitting the monopole energy into ranges is extended to show that below the basic rest mass range of the electron and Quark, it still can be applied to explaining for the creation of the chemical elements periodic table. But perhaps the most interesting is in the lowest hundreds of Hz energy range, obtained from yet another 3 fold space symmetry breaking, into 2D × 1D, producing bio nitrogenous bases composed of 3 Carbon 12 in hexagon structures, due to preservation of the 1D monopole standing waves of this low frequencies. From that by imposing gauge changes the monopole states into DNA spectra. Since such spectra states retain the DLRO, it induces formation of charge carriers periodicity in a spherical bio cell.. It was then argued that due to cell’s surface proteins, the structure must contain partial filled VB, with “p” state hole density, and empty CB, separated from VB by a positive band gap. Such band structures resemble known HTC Cuprate ceramics. Since the HTC goes through a Superconductivity transition via the simultaneous bose exciton condensation, providing a Coulomb pressure, which reduces the band gap substantially, and induces the ODLRO transition of the hole density. The same obviously applies to the bio cells. Because of the near continuous exciton levels generated, a matching to the DNA spectra then can always occur by selective choices of proteins on

关键词： 5D Fermat’s Theorem Space Dimension Reduction Projections Perelman Mappings The Higgs Vacuum: A B.E. Condensed Monopole Bosons Realization of Excitonic Induced Superconducting “p” Valence Band Orbitals in Bio Cells The Final Coherent Building Block EMF Spectra: Water Carbon Hydrogen and Oxygen

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