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Management of patients with stercoral perforation of the sigmoid colon:Report of five cases

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World Journal of Gastroenterology 2006年第3期12卷 500-503页

作者： Wen-Shih Huang Chia-Siu Wang ching-Chuan hsieh Paul Y Lin Chih-Chien Chin Jeng-Yi Wang Divisionof Colon and Rectal Surgery Chang Gung Memorial Hospital Putzu 613 Taiwan China Division of GeneralSurgery Chang Gung Memorial Hospital Pu-tzu 613 TaiwanChina Division of Anatomical Pathology Chang GungMemorial Hospital Pu-tzu 613 Taiwan China Graduate Institute of Clinical Medicine Chang Gung University Kwei-Shan Taiwan China

到我们的知识，冒号的粪的穿孔很少比 90 个案例在文学报导到日期为止与少数被看见。我们探索了管理的原则与这个条件在五个病人阻止逼近的死亡。五个病人，二男性和三女性，其中部的年龄是 64 年，支撑了 S 字形的冒号的粪的穿孔。长... 详细信息

到我们的知识，冒号的粪的穿孔很少比 90 个案例在文学报导到日期为止与少数被看见。我们探索了管理的原则与这个条件在五个病人阻止逼近的死亡。五个病人，二男性和三女性，其中部的年龄是 64 年，支撑了 S 字形的冒号的粪的穿孔。长期的便秘是在这些病人之中的普通症状。三个病人经历了一个 Hartmannos 过程和另外一个二与吻合和转移结肠开口术与部分结肠切除术被对待。有一外科的死亡，另外的病人让一所平静医院留下来。与广泛的腹洗室年龄一起阻止或对待任何联系败血的及时干预和在主要粪的溃疡地点的结肠的织物结合了移开 diseased 的外科的干预为腹膜炎的好攻击的治疗是在抢救与冒号的粪的穿孔介绍的病人的关键治疗形式。

关键词：大便检查乙状结肠检验方法细菌感染

Aberrant activation of nuclear factor of activated T cell 2 in lamina propria mononuclear cells in ulcerative colitis

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World Journal of Gastroenterology 2008年第11期14卷 1759-1767页

作者： Tsung-Chieh Shih Sen-Yung hsieh Yi-Yueh hsieh Tse-Chin Chen Chien-Yu Yeh Chun-Jung Lin Deng-Yn Lin Cheng-tang Chiu Clinical Proteomics Center Chang Gung Memorial HospitalTaoyuan 333Taiwan Clinical Proteomics Center Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of Hepato-GastroenterologyChang Gung Memorial HospitalChang Gung University School of Medicine Taoyuan 333Taiwan Department of Anatomic Pathology Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of Colorecto-Surgery Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of Hepato-Gastroenterology Chang Gung Memorial HospitalChang Gung University School of Medicine Taoyuan 333Taiwan

AIM:To investigate the role of nuclear factor of activated T cell 2(NFAT2),the major NFAT protein in peripheral T cells,in sustained T cell activation and intractable inflammation in human ulcerative colitis(UC). METHODS:We used two-dimensional gel-electrophoresis, immunohistochemistry,double immunohistochemical staining,and confocal microscopy to inspect the expression of NFAT2 in 107,15,48 and 5 cases of UC, Crohn's disease(CD),non-specific colitis,and 5 healthy individuals,respectively. RESULTS:Up-regulation with profound nucleo- translocation/activation of NFAT2 of lamina propria mononuclear cells(LPMC)of colonic mucosa was found specifically in the affected colonic mucosa from patients with UC,as compared to CD or NC(P<0.001,Kruskal- Wallis test).Nucleo-translocation/activation of NFAT2 primarily occurred in CD8+T,but was less prominent in CD4+T cells or CD20+B *** was strongly associated with the disease activity,including endoscopic stage (τ=0.2145,P=0.0281)and histologic grade(τ=0.4167, P<0.001). CONCLUSION:We disclose for the first time the nucleo-translocation/activatin of NFAT2 in lamina propria mononuclear cells in ulcerative *** of NFAT2 was specific for ulcerative colitis and highly associated with disease *** activation of NFAT2is implicated in an auto-regulatory positive feedback loop of sustained T-cell activation and NFAT proteins play key roles in the calcium/calcineurin signaling pathways,our results not only provide new insights into the mechanism for sustained intractable inflammation,but also suggest the calcium-calcineurin/NFAT pathway as a new therapeutic target for ulcerative colitis.

关键词： T细胞大肠炎核因子蛋白质

A modified protocol for <i>in vitro</i>maturation of mouse oocytes from secondary preantral follicles

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Advances in Bioscience and Biotechnology 2012年第1期3卷 57-74页

作者： Weidong Wang Yaxu tang Lujuan Ni Theerayut Jongwutiwes Hung-ching Liu Zev Rosenwaks The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine Weill Medical College of Cornell University New York USA

A 2-step culture system was designed and tested for the in vitro maturation efficiency of oocytes from pre-puberty preantral follicles of FVB/N inbred mice. The following modifications were made: 1) The concentration of ITS was reduced by half in the basal MIF medium to minimize uncoordinated growth between oocyte and GC cells;2) Heterogeneous preantral follicles were cultured in groups of 3 - 5 follicles in hanging drops of medium with reduced concentration of ITS for six days to induction follicular aggregation. This hanging drop method mimics a 3-D IVM culture system at the early stage of cultivation in which the sphere structure of each follicle is well maintained. It also enables follicles in each aggregate to communicate with each other, synchronize their growth, and thus prevent immature follicular rupture. 3) Medium was further supplemented with retinoic acid to enhance developmental capacity of meiotically arrested oocytes. After a 14-day culture in vitro, ~37% of the collected inbred preantral follicles completed nuclear maturation. Approximately 94% of the mature oocytes tested were able to be fertilized;and 77% of them developed into healthy embryos. These results demonstrate that our IVM system is reliable to produce a satisfactory number of high quality oocytes. In addition, multiple cytoplasmic parameters, including gene expression of key regulators, chromosome/spindle organization, mitochondrial proliferation and distribution, and total ATP content were explored to characterize the supportive and limiting components of our IVM system so that the culture system can be further optimized.

关键词： Follicle Oocyte In Vitro Maturation In Vitro Fertilization Hanging Drops Fertility Spindle Mitochondrion and ATP Content

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岩石变形记忆效应:应用、试验与理论

岩土工程学报 2018年第9期40卷 1571-1583页

作者：王海军汤雷任旭华钟凌伟司富安 hsieh Ariel 南京水利科学研究院水文水资源与水利工程国家重点试验室江苏南京210029 河海大学江苏南京210098 水利部水利水电规划设计总院北京100120 TheUniversityofWesternAustralia Perth6009Australia

基于岩石变形记忆效应DME＆DRA法,为准确便捷测量初始地应力提供了全新的思路,国际上及中国台湾的一系列实践应用证明了其巨大的潜力。但是,岩石变形记忆效应的研究和工程应用在中国（除中国台湾外）刚起步,同时,试验及理论的系统性研... 详细信息

基于岩石变形记忆效应DME＆DRA法,为准确便捷测量初始地应力提供了全新的思路,国际上及中国台湾的一系列实践应用证明了其巨大的潜力。但是,岩石变形记忆效应的研究和工程应用在中国（除中国台湾外）刚起步,同时,试验及理论的系统性研究整体上落后于工程应用,成为制约DME＆DRA法成熟和普及的瓶颈问题。因此,开展岩石变形记忆效应的应用、试验、理论的研究进展综述具有重要意义。首先给出岩石DME＆DRA法的基本概念,然后给出在国际上的应用实践现状;从7个方面的内容对试验研究进展进行系统性评述：（1）岩石变形记忆DRA曲线特征;（2）岩石变形记忆效应的失忆性;（3）人工记忆与地应力记忆;（4）初始加载保持时间;（5）初始加载重复次数;（6）记忆存在应力区域;（7）三维应力记忆特征;详细探讨各方面成果及不足;探讨了岩石变形记忆效应形成机理的两种认识及相应的理论模型,深入剖析现有研究结论与进展揭示存在的挑战,最终给出研究方向与建议。为推动国内开始开展岩石变形记忆效应的研究与应用提供基础。

关键词：初始地应力岩石变形记忆效应(DME) 变形率分析法(DRA法) 岩石力学研究进展

Treatment efficacy for patients with chronic hepatitis C and preexisting hepatocellular carcinoma by directly acting antivirals

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Hepatoma Research 2020年第4期6卷 30-38页

作者： Chia-Yen Dai Chung-Feng Huang Meng-Hsuan hsieh ching-I Huang Ming-Lun Yeh Pei-ChienTsai ching-Chih Lin Meng-Szu Lee Jeng-Fu Yang Po-Yao Hsu Yu-Ju Wei Cheng-Ting Hsu Po-Cheng Liang Yi-Hung Lin Jee-Fu Huang Wan-Long Chuang Ming-Lung Yu Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiung 807Taiwan Health Management Center&Department of Community Medicine Kaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiung 807Taiwan Faculty of Internal Medicine College of MedicineKaohsiung Medical UniversityKaohsiung 807Taiwan Department of Biological Science and Technology College of Biological Science and TechnologyNational Chiao Tung UniversityHsin-ChuKaohsiung 807Taiwan

Aim:Despite the high cure rate of interferon-free directly acting antivirals(DAAs)for chronic hepatitis C(CHC)patients,the treatment efficacy for patients with preexisting hepatocellular carcinoma(HCC)remains *** aimed in the present study to address the issue by using novel DAAs in treating CHC patients who were adherent to treatment in ***:CHC patients with or without HCC were consecutively *** primary objective was sustained virological response(SVR)defined as undetectable HCV RNA throughout 12 weeks of a post-treatment follow-up period(SVR12).Only patients with available SVR12 were enrolled for final ***:A total of 1237 patients(1113 non-HCC,101 inactive HCC and 23 active HCC)were *** overall SVR12 rate was 98.9%,and was similar between HCV patients with and without pre-existing HCC(98.4%vs.98.9%,P=0.64).While HCC patients were classified as those who had active or inactive HCC,the SVR12 was also similar between patients with and without active HCC(95.7%vs.99.0%,P=0.34).Among the 101 patients without viable HCC at the time of DAA initiation,eighty-four patients exhibited curative therapy and the other 17 ;patients experienced HCC recurrence before *** the 23 patients with viable HCC at the time of DAA treatment,10 patients had received curative therapy for HCC whereas the remaining 13 patients had HCC that was never *** SVR12 rates were also similar among the four subpopulations,being 98.8%(83/84),100%(17/17),90%(9/10)and 100%(13/13)***:CHC patients with HCC who were adherent to potent DAAs achieved similar SVR12 rate compared to those without HCC and could be effectively treated.

关键词： Directly acting antiviral chronic hepatitis C hepatitis C virus hepatocellular carcinoma sustained virological response

Targeted Therapy in Metastatic Breast Cancer:Highlights from ASCO 2009

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中国肺癌杂志 2009年第6期 36-37页

作者： Shou-ching tang, MD, PhD, FACP, FRCPC Professor of Medicine, University of Colorado, USA

Background: Metastatic breast cancer (MBC) is an incurable disease. The medium survival of MBC is 2-3 years with the aim of treatment focusing on symptom control and quality of life (QOL). Despite the availability of ... 详细信息

关键词： ASCO Targeted Therapy in Metastatic Breast Cancer

Information Encryption Based on Using Arbitrary Two-Step Phase-Shift Interferometry

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Optics and Photonics Journal 2011年第4期1卷 204-215页

作者： Chi-ching Chang Wen-Ho Wu Min-Tzung Shiu Wang-Ta hsieh Je-Chung Wang Hon-Fai Yau 不详

A deterministic phase-encoded encryption system is proposed. A lenticular lens array (LLA) sheet with a particular LPI (lenticular per inch) number is chosen as a modulator (key) instead of the random phase molator. The suggested encryption scheme is based on arbitrary two-step phase-shift interferometry (PSI), using an unknown phase step. The encryption and decryption principle is based on an LLA in arbitrary unknown two-step PSI. Right key holograms can be used to theoretically show that the object wavefront is the only one left in the hologram plane and that all accompanying undesired terms are eliminated. The encrypted image can therefore be numerically and successfully decrypted with the right key in the image plane. The number of degrees of freedom of the encryption scheme increases with the distance from the object and the LLA to the CCD, and also with the unknown phase-step and the LLA LPI number. Computer simulations are performed to verify the encryption and decryption principles without a key, with the wrong key and with the right key. Optical experiments are also performed to validate them.

关键词： Deterministic Phase-Encoded Encryption Arbitrary Two-Step Phase-Shift Interferometry Lenticular Lens Array

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公路交通服务能力的绿色安全指标研究

交通运输系统工程与信息 2016年第2期16卷 92-97页

作者：张堂贤曾仁松谢东宏谢伯嘉国立台湾大学土木工程学研究所台湾台北10617

国际上公路交通服务能力皆以道路拥堵情况(V/C值)及行车顺畅程度为评估标准,缺乏对交通安全潜在社会成本、时间成本及环境保护的测量.根据国际社会对绿色经济、绿色交通运输的重视与发展趋势,本文以台湾电子收费系统的数据为基础,针对... 详细信息

国际上公路交通服务能力皆以道路拥堵情况(V/C值)及行车顺畅程度为评估标准,缺乏对交通安全潜在社会成本、时间成本及环境保护的测量.根据国际社会对绿色经济、绿色交通运输的重视与发展趋势,本文以台湾电子收费系统的数据为基础,针对不同交通流需求量、路段平均行驶速率衍生的时间成本与污染排放、交通安全等因子,分别构建出行时间延滞成本、碳排放增量成本、潜在肇事概率成本等3个参数指标,利用这3个指标构建综合型绿色安全交通服务指标(Green and Safety Index for traffic levels of service,GSI),作为划分交通服务水平的评估标准,并通过实时在线软件,提供出行者道路出行延滞、碳排放及安全等社会成本信息.

关键词：综合交通运输绿色交通指标延滞成本指标碳排放增量成本指标安全成本指标

Anti-Helicobacter pylori therapy significantly reduces Helicobacter py/ori-Induced gastric mucosal damage in Mongolian gerbils

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World Journal of Gastroenterology 2005年第7期11卷 982-985页

作者： Sheng-Hsuan Chen Gi-Shih Lien Yuarn-Jang Lee Horng-Yuan Lou ching-Ruey hsieh Chia-Lang Fang Shiann Pan Department of Internal Medicine

AIM: To investigate the effectiveness of 4 d' anti-Helicobacter pyloritherapy on the H pylori-infected Mongolian gerbils based on physiological and pathological ***: We used 6-wk-old male gerbils orally inoculated with H pylori (ATCC43504, 2x108 CFU/mL).Seven weeks after H pylori inoculation, the animals of study group received 4 d' anti-H pylori triple therapy (H pylorieradicated group). Seven days later, all animals of the H pylori-eradicated and control groups (H pylori-infected& H pylori-uninfected groups) were sacrificed. We examined gastric mucosal lesions macroscopically, studied gastritis microscopically and determined the stomach weight ratio, myeloperoxidase (MPO) activity and prostaglandin (PG) E2 ***: The results showed that both macroscopic and histological gastric damages were significantly less in H pylori-eradicated group than H pylori-infected *** weight ratio, MPO activity and PGE2 levels were significantly higher in H pylori-infected group than those in the other two ***: Four days' anti-H pylori therapy was effective in the improvement of H pylori-induced gastric lesions in Mongolian gerbils.

关键词：幽门螺杆菌胃黏膜损害小鼠动物模型治疗方法