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A family of explicit algorithms for general pseudodynamic testing

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Earthquake Engineering and Engineering Vibration 2011年第1期10卷 51-64页

作者： Shuenn-Yih Chang Chi-Wei hsu Department of Civil Engineering Taipei University of Technology (NTUT) NTUT Box 2653

A new family of explicit pseudodynamic algorithms is proposed for general pseudodynamic testing. One particular subfamily seems very promising for use in general pseudodynamic testing since the stability problem for a structure does not need to be considered. This is because this subfamily is unconditionally stable for any instantaneous stiffness softening system, linear elastic system and instantaneous stiffness hardening system that might occur in the pseudodynamic testing of a real structure. In addition, it also offers good accuracy when compared to a general second-order accurate method for both linear elastic and nonlinear systems.

关键词： pseudodynamic test explicit method unconditional stability dominant mode structural dynamics instantaneous degree of nonlinearity

Botulinum toxin injection for Cockayne syndrome with muscle spasticity over bilateral lower limbs:A case report

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World Journal of Clinical Cases 2021年第18期9卷 4728-4733页

作者： Lin-Chieh hsu Po-Ying Chiang Wei-Pin Lin Yao-Hong Guo Pei-Chun Hsieh Ta-Shen Kuan Wei-Chih Lien Yu-ching Lin Department of Physical Medicine and Rehabilitation National Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainan 704Taiwan Department of Physical Medicine and Rehabilitation College of MedicineNational Cheng Kung UniversityTainan 704Taiwan Medical Device Innovation Center National Cheng Kung UniversityTainan 704Taiwan

BACKGROUND Cockayne syndrome(CS)is a rare inherited disease characterized by progressive motor symptoms including muscle weakness,joint contracture,ataxia,and *** neurotoxin type A has been used for conditions such as dystonia and spasticity,but it has rarely been used in patients with *** SUMMARY We report a 6-year-and-9-mo old girl diagnosed with CS who received an injection of botulinum neurotoxin type A to manage her difficulty with walking.A total dose of 210 units of botulinum neurotoxin type A was administered into the bilateral tibialis posterior and gastrocnemius *** evaluate the treatment effects on spasticity,joint contracture,pain,and ataxia,measurement tools including the Modified Ashworth Scale,the passive range of motion,the Faces Pain Scale-Revised,and the Scale for the Assessment and Rating of Ataxia,were *** first week after the injection,the Modified Ashworth Scale score for the plantar flexors and foot invertors improved bilaterally,along with advancements in the passive range of motion of the bilateral ankles and a lower score for the Faces Pain *** treatment effects persisted to the 8th week post-injection,but returned to baseline values at the 12th week post-injection,except for the pain *** Botulinum toxin injection can thus be considered as a treatment option for lower extremity spasticity,joint contracture,and pain derived from CS.

关键词： Cockayne syndrome Botulinum toxin Spasticity Pain Ataxia Case report

Comparison of capability of time integration methods in capturing dynamic loading

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Earthquake Engineering and Engineering Vibration 2010年第3期9卷 409-423页

作者： Shuenn-Yih Chang Chi-Wei hsu Department of Civil Engineering Taipei University of Technology

Numerical properties of the time integration method proposed by the first author of this paper in 2007 are the same as those of the constant average acceleration method （AAM） for linear elastic systems, except that the capability to capture dynamic loading was not explored. It was found that there were different quadrature equations to predict the next step displacement increment. A modified quadrature equation of this method was derived so that the equation to determine the next step displacement was numerically equivalent to the equation used in the constant AAM. It was verified that the original form of this method, in general, had a better capability to capture dynamic loadings than the constant AAM. This excellent property, in addition to computational efficiency, will help to make this method competitive with general secondorder accurate integration methods.

关键词： equations of motion quadrature equation constant average acceleration method integration methods

Traffic Shaping for TCP Networks: TCP Leaky Bucket

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Traffic Shaping for TCP Networks: TCP Leaky Bucket

PDGFRαreporter activity identifies periosteal progenitor cells critical for bone formation and fracture repair

2002年IEEE十区计算机、通信、控制和电机工程会议

作者： Ming-hsien hsu Kim-Joan Chen Department of Electrical Engineering National ChungCheng University 160 Ming-Hsiung Chia-Yi 6217 Taiwan China Department of Electrical Engineering National ChungCheng University 160 Ming-Hsiung Chia-Yi 6217 Taiwan China

-Because of the oscillation of window on TCPwindow control mechanism, Internet applications cannotget rate and burstiness guaranteed through TCP even ifthe network layer provides guaranteed service or explicitnetwork available service rates. Therefore,in this paperwe present a new technique, called TCP Leaky Bucket(TCPLB), to realize not only rate but also burstinessguarantees for the TCP Internet applications. Instead ofadding an independent leaky bucket shaper on the outputof TCP, the proposed method adapts the window size inTCP widow to regulate the sending pattern of TCP output,Further, due to filter bank summation property undermin-plus algebra, the TCPLB is very easy to extend tomultiple leaky buckets so that further servicedifferentiation can be achieved.

关键词： TCP leaky bucket congestion control min-plus algebra QoS

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Bone Research 2022年第1期10卷 122-136页

作者： Jiajia Xu Yiyun Wang Zhu Li Ye Tian Zhao Li Amy Lu ching-Yun hsu Stefano Negri Cammy Tang Robert J.Tower Carol Morris Aaron W.James Departments of Pathology Johns Hopkins UniversityBaltimoreMD 21205USA Departments of Orthopedics Johns Hopkins UniversityBaltimoreMD 21205USA Department of Oral and Maxillofacial Surgery School of StomatologyChina Medical UniversityShenyangLiaoningPR China

The outer coverings of the skeleton,which is also known as the periosteum,are arranged in concentric layers and act as a reservoir for tissue-specific bone *** cellular heterogeneity within this tissue depot is being increasingly ***,inducible PDGFRαreporter animals were found to mark a population of cells within the periosteum that act as a stem cell reservoir for periosteal appositional bone formation and fracture *** these processes,PDGFRαreporter^(+)progenitors give rise to Nestin+periosteal cells before becoming osteoblasts and *** diphtheria toxin-mediated ablation of PDGFRαreporter^(+)cells led to deficits in cortical bone formation during homeostasis and a diminutive hard callus during fracture *** ossicle transplantation,both mouse PDGFRαreporter^(+)periosteal cells and human Pdgfrα+periosteal progenitors expand,ossify,and recruit marrow to a greater extent than their counterpart periosteal cells,whereas PDGFRαreporter^(−)periosteal cells exhibit a predisposition to chondrogenesis in *** RNA sequencing identified enrichment of the secreted factors Fermt3 and Ptpn6 within PDGFRαreporter^(+)periosteal cells,which partly underlie the osteoblastogenic features of this cell population.

关键词： progenitor fracture reservoir

Networking dual-surveillance/dual-pair-tele-paths for critical urban areas

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Journal of Southeast University(English Edition) 2008年第S1期24卷 114-119页

作者： hsu Li-Yen Department of Aviation Management China Institute of TechnologyHsinchu 31241

Providing a reliable and efficient communication infrastructure for critical regions is generally a strategy used to enhance regional safety or to sustain regional development. For such purposes, the spider-web network is prototyped as a cellular telecommunication infrastructure for its advantages including being interference-free, possessing fault-tolerance, having security management, and countering radio's multipath effects. Besides, it is used to develop area-based-street-SCADA (supervisory control and data acquisition) networks composed of regular optimal degree-3 prototyped sub-networks with the concepts of dual-surveillance, operational order and Hamiltonian laceability, and it flexibly fits various circulation configurations. Moreover, it can offer integrative response capabilities even after two paths' SCADA networks have been ruined.

关键词： supervisory control and data acquisition (SCADA) telecommunication transportation

Differential DNA methylation analysis of SUMF2,ADAMTS5,and PXDN provides novel insights into colorectal cancer prognosis prediction in Taiwan

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World Journal of Gastroenterology 2022年第8期28卷 825-839页

作者： Jing-Quan Su Pin-Yu Lai Pei-hsuan Hu Je-Ming Hu Pi-Kai Chang Chao-Yang Chen Jia-Jheng Wu Yu-Jyun Lin Chien-An Sun Tsan Yang Chih-Hsiung hsu Hua-ching Lin Yu-ching Chou School of Medicine National Defense Medical CenterTaipei 114TaiwanChina School of Public Health National Defense Medical CenterTaipei 114TaiwanChina Division of Colorectal Surgery Department of surgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Graduate Institute of Medical Sciences National Defense Medical CenterTaipei 114TaiwanChina Department of Public Health College of MedicineFu-Jen Catholic UniversityNew Taipei City 242TaiwanChina Big Data Research Center College of MedicineFu-Jen Catholic UniversityNew Taipei City 242TaiwanChina Department of Health Business Administration Meiho UniversityPingtung County 912TaiwanChina Division of Colorectal Surgery Department of SurgeryCheng-Hsin General HospitalTaipei 112TaiwanChina

BACKGROUND Patients with colorectal cancer(CRC)undergo surgery,as well as perioperative chemoradiation or adjuvant chemotherapy primarily based on the tumor–node–metastasis(TNM)cancer staging ***,treatment responses and prognostic outcomes of patients within the same stage vary *** potential use of novel biomarkers can improve prognostication and shared decision making before implementation into certain *** To investigate whether SUMF2,ADAMTS5,and PXDN methylation status could be associated with CRC *** We conducted a Taiwan region cohort study involving 208 patients with CRC recruited from TriService General Hospital and applied the candidate gene approach to identify three genes involved in oncogenesis pathways.A methylation-specific polymerase chain reaction(MS-PCR)and Epi TYPER DNA methylation analysis were employed to detect methylation status and to quantify the methylation level of candidate genes in tumor tissue and adjacent normal tissue from *** evaluated SUMF2,ADAMTS5,and PXDN methylation as predictors of prognosis,including recurrence-free survival(RFS),progression-free survival(PFS),and overall survival(OS),using a Cox regression model and Kaplan–Meier *** We revealed various outcomes related to methylation and *** shorter PFS and OS were associated with the CpG_3+CpG_7 hypermethylation of SUMF2 from tumor tissue compared with CpG_3+CpG_7 hypomethylation[hazard ratio(HR)=2.24,95%confidence interval(CI)=1.03-4.85 for PFS,HR=2.56 and 95%CI=1.08-6.04 for OS].By contrast,a significantly longer RFS was associated with CpG_2 and CpG_13 hypermethylation of ADAMTS5 from normal tissue compared with CpG_2 and CpG_13 hypomethylation[HR(95%CI)=0.15(0.03-0.71)for CpG_2 and 0.20(0.04-0.97)for CpG_13].The relationship between the methylation status of PXDN and the prognosis of CRC did not reach statistical *** Our study found that CpG_3+CpG_7 hypermethylation o

关键词： DNA methylation Biomarkers Tumor tissue Adjacent normal tissue Prognosis prediction Colorectal cancer

Employment of Two-Stage Oxygen Feeding to Control Temperature in a Downdraft Entrained-Flow Coal Gasifier

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International Journal of Clean Coal and Energy 2014年第3期3卷 29-45页

作者： Ting Wang Xijia Lu Heng-Wen hsu Cheng-hsien Shen Energy Conversion & Conservation Center University of New Orleans New Orleans LA USA Green Energy and Environment Research Laboratory Industrial Technology Research Institute Hsinchu City Taiwan

The traditional practice of employing a two-stage coal-fed gasification process is to feed all of the oxygen to provide a vigorous amount of combustion in the first stage but only feed the coal without oxygen in the second stage to allow the endothermic gasification process to occur downstream of the second stage. One of the merits of this 2-stage practice is to keep the gasifier temperature low downstream from the 2nd stage. This helps to extend the life of refractory bricks, decrease gasifier shut-down frequency for scheduled maintenance, and reduce the maintenance costs. In this traditional 2-stage practice, the temperature reduction in the second stage is achieved at the expense of a higher than normal temperature in the first stage. This study investigates a concept totally opposite to the traditional two-stage coal feeding practices in which the injected oxygen is split between the two stages, while all the coal is fed into the first stage. The hypothesis of this two-stage oxygen injection is that a distributed oxygen injection scheme can also distribute the release of heat to a larger gasifier volume and, thus, reduce the peak temperature distribution in the gasifier. The increased life expectancy and reduced maintenance of the refractory bricks can prevail in the entire gasifier and not just downstream from the second stage. In this study, both experiments and computational simulations have been performed to verify the hypothesis. A series of experiments conducted at 2.5 - 3.0 bars shows that the peak temperature and temperature range in the gasifier do decrease from 600?C - 1550?C with one stage oxygen injection to 950?C - 1230?C with a 60 - 40 oxygen split-injection. The CFD results conducted at 2.5 bars show that 1) the carbon conversion ratio for different oxygen injection schemes are all above 95%;2) H2 (about 70% vol.) dominates the syngas composition at the exit;3) the 80% - 20% case yields the lowest peak temperature and the most uniform temperature

关键词： Two-Stage Oxygen Feeding Entrained-Flow Coal Gasification Gasification Simulation Syngas Composition Clean Coal Technology Multiphase Flow Simulation

Outpatient varicocelectomy performed under local anesthesia

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Asian Journal of Andrology 2005年第4期7卷 439-444,页

作者： Geng-Long hsu Pei-Ying Ling Cheng-Hsing Hsieh Chii-Jye Wang Cheng-Wen Chen hsien-Sheng Wen Hsiu-Mei Huang E.Ferdinand Einhorn Guo-Fang Tseng Microsurgical Potency Reconstruction and Research Center Taiwan Adventist HospitalTaipei Medical UniversityTaipei 110TaiwanChina Department of Anatomy and Cell Biology College of MedicineNational Taiwan UniversityTaipei 100TaiwanChina

Aim： To report a series of varicocelectomy performed under pure local anesthesia. Methods： From July 1988 to June 2003, a total of 575 patients, aged between 15 and 73 years, underwent high ligation of the internal spermatic vein for treatment of a varicocele testis under a regional block in which a precise injection of 0.8 % lidocaine solution was delivered to involved tissues after exact anatomical references were made. A 100-mm visual analog scale （VAS） was used to assess whether the pain level was acceptable. Results： The surgeries were bilateral in 52 cases, and unilateral in 523 cases. All were successfully performed on an outpatient basis except in the case of two patients, who were hospitalized because their surgeries required general anesthesia. Overall, 98.6 % （567/575） of men could go back to work by the end of the first post-operative week and only 8 （1.4 %） men reported feeling physical discomfort on the eighth day. The VAS scores varied from 11 mm to 41 mm with an average of （18.5 ± 11.3） mm that was regarded as tolerable. Conclusion： This study has shown varicocelectomy under local anesthesia to be possible, simple, effective, reliable and reproducible, and a safe method with minimal complications. It offers the advantages of more privacy, lower morbidity, with no notable adverse effects resulting from anesthesia, and a more rapid return to regular physical activity with minor complications.

关键词： anterior superior iliac spine spermatic cord aponeurosis umbilicus pubic symphysis varicocelectomy anesthesia