检索结果-南通市图书馆

Gingipain from Porphyromonas gingivalis causes insulin resistance by degrading insulin receptors through direct proteolytic effects

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Oral Science 2024年第3期16卷 539-552页

作者： Fen Liu Bofeng Zhu Ying An Zhifei Zhou Peiying Xiong Xuan Li Yang Mi Tongqiang He Faming chen Buling Wu Shenzhen Stomatology Hospital(Pingshan) Southern Medical UniversityShenzhenChina Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research Laboratory Center of StomatologyDepartment of Paediatric DentistryCollege of StomatologyXi’an Jiaotong UniversityXi’anChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi International Joint Research Center for Oral DiseasesDepartment of PeriodontologySchool of StomatologyThe Fourth Military Medical UniversityXi’anChina Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification School of Forensic MedicineSouthern Medical UniversityGuangzhouChina Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhouChina Department of Stomatology General Hospital of Tibetan Military CommandLhasaChina Department of Stomatology Center Shenzhen HospitalSouthern Medical UniversityShenzhenChina Department of Obstetrics Northwest Women’s and Children’s HospitalXi’anChina

Periodontitis is a critical risk factor for the occurrence and development of *** gingivalis may participate in insulin resistance(IR)caused by periodontal inflammation,but the functional role and specific mechanisms of *** in IR remain *** the present study,clinical samples were analysed to determine the statistical correlation between *** and IR *** culturing of hepatocytes,myocytes,and adipocytes,and feeding mice *** orally,the functional correlation between *** and IR occurrence was further studied both in vitro and in *** data suggested that the amount of *** isolated was correlated with the Homeostatic Model Assessment for IR *** vitro studies suggested that coculture with *** decreased glucose uptake and insulin receptor(INSR)protein expression in hepatocytes,myocytes,and *** fed *** tended to undergo *** was detectable in the liver,skeletal muscle,and adipose tissue of experimental *** distribution sites of gingipain coincided with the downregulation of *** proteolysed the functional insulin-binding region of *** with *** significantly decreased the INSR–insulin binding *** out gingipain from *** alleviated the negative effects of *** on IR in *** together,these findings indicate that distantly migrated *** may directly proteolytically degrade INSR through gingipain,thereby leading to *** results provide a new strategy for preventing diabetes by targeting periodontal pathogens and provide new ideas for exploring novel mechanisms by which periodontal inflammation affects the systemic metabolic state.

关键词： gingivalis inflammation resistance

在线全文

学校读者我要写书评

暂无评论

电感耦合等离子体质谱在核工业分析中的应用

冶金分析 2024年第5期44卷 54-61页

作者：武宝利薛向明曾志伟中国辐射防护研究院山西太原030006

电感耦合等离子体质谱(ICP-MS)因其分析速度快、检出限低、线性范围宽、多元素同时分析等特点在核工业分析中得到广泛应用。本文对核工业样品分解方法、分离技术、进样技术、干扰校正方法进行了介绍,总结并比较了各方法的优缺点;评述了... 详细信息

电感耦合等离子体质谱(ICP-MS)因其分析速度快、检出限低、线性范围宽、多元素同时分析等特点在核工业分析中得到广泛应用。本文对核工业样品分解方法、分离技术、进样技术、干扰校正方法进行了介绍,总结并比较了各方法的优缺点;评述了在传统四极杆ICP-MS基础上发展的多种质谱形式、联用技术及其在核工业分析中的应用;讨论了ICP-MS在核工业分析应用研究中的重点和难点,并对ICP-MS的发展前景进行了展望。

关键词：电感耦合等离子体质谱(ICP-MS) 核工业分析样品分解分离技术进样技术干扰校正

基于SEM与IPA分析的研学教育体验价值研究

在线全文

学校读者我要写书评

暂无评论

宿州教育学院学报 2024年第1期27卷 116-122页

作者：李志伟厦门城市职业学院国际旅游学院福建厦门361008 厦门城市职业学院闽台区域文化旅游研究中心福建厦门361008

体验价值是影响研学教育满意度的重要因素。此研究从体验视角出发,以厦门中小学生为问卷施测对象,首先采用SEM模型分析变项之间的因果关系,其次采用IPA分析法测量体验学习指标的重要性与满意度,从而构建研学教育体验模型。研究结果发现:... 详细信息

体验价值是影响研学教育满意度的重要因素。此研究从体验视角出发,以厦门中小学生为问卷施测对象,首先采用SEM模型分析变项之间的因果关系,其次采用IPA分析法测量体验学习指标的重要性与满意度,从而构建研学教育体验模型。研究结果发现:(1)研学体验模型整体适配度良好,研学认知、体验学习、学习成效对学习满意度皆有显著影响,学习成效具有明显中介作用;(2)中小学生研学体验期望值与满意度存在较大差异,据此提出研学体验提升策略与决策思考。

关键词：研学旅游体验价值学习成效结构方程模型 IPA分析

Osteoarthritis versus psoriasis arthritis: Physiopathology, cellular signaling, and therapeutic strategies

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第3期11卷 232-247页

作者： Salma Nassor Juma Junguang Liao Yuping Huang Rexhina Vlashi Qingwan Wang Bocong Wu Dan Wang Mengrui Wu Guiqian chen College of Life Science and Medicine Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and BiomedicineZhejiang Sci-Tech UniversityHangzhouZhejiang 310018China Department of Cell and Developmental Biology College of Life SciencesZhejiang UniversityHangzhouZhejiang 310058China

Osteoarthritis and psoriasis arthritis are two degenerative forms of arthritis that share similar yet also different manifestations at the histological,cellular,and clinical *** have marked them as two entirely distinct *** recent dis-coveries in disease initiation and progression,potential mechanisms,cellular signaling path-ways,and ongoing clinical therapeutics,there are now more opportunities for discovering osteoarthritis *** review summarized the osteoarthritis and psoriasis arthritis signaling pathways,crosstalk between BMP,WNT,TGF-β,VEGF,TLR,and FGF signaling pathways,bio-markers,and anatomical *** bench research,we demonstrated that regen-erative medicine is a promising alternative for treating osteoarthritis by highlighting significant scientific discoveries on entheses,multiple signaling blockers,and novel molecules such as immunoglobulin new antigen receptors targeted for potential drug ***,we offered valuable therapeutic approaches with a multidisciplinary strategy to treat patients with osteoarthritis or psoriasis arthritis in the coming future in the clinic.

关键词： Newantigen receptor Osteoarthritis Physiopathology Psoriasisarthritis Signaling pathway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

汉字熵值计算及其科学意义

北华大学学报（社会科学版） 2024年第1期25卷 17-25,150页

作者：冯志伟教育部语言文字应用研究所北京100010

汉字的熵值计算是确定计算机汉字编码形式的前提和基础。汉字熵值计算是交叉学科性质的研究。字符的熵值计算需要借助信息论理论、概率理论和香农推导出的计算英文字母熵的公式。汉字编码的依据是“信道编码定理”。世界首次计算出汉字... 详细信息

汉字的熵值计算是确定计算机汉字编码形式的前提和基础。汉字熵值计算是交叉学科性质的研究。字符的熵值计算需要借助信息论理论、概率理论和香农推导出的计算英文字母熵的公式。汉字编码的依据是“信道编码定理”。世界首次计算出汉字的熵值是在20世纪70年代中期,由中国学者冯志伟通过手工操作完成的。该研究具有重要的科学意义。为后来的多八位双字节汉字编码提供了语言学理据,为中国的计算机中文信息处理技术的飞速发展作出了重要贡献。

关键词：信息论信道编码定理汉字的熵值汉字编码

以流域综合治理筑牢长江经济带高质量发展水安全底线

在线全文

学校读者我要写书评

暂无评论

水利发展研究 2024年第2期24卷 76-81页

作者：廖志伟湖北省水利厅湖北武汉430064

长江是中华民族的生命河,也是中华民族发展的重要支撑。长江经济带横跨我国东中西三大区域,是我国经济稳增长的重要支撑。推动长江经济带高质量发展是党中央作出的重大决策,是关系国家发展全局的重大战略。文章总结了湖北省关于统筹绿... 详细信息

长江是中华民族的生命河,也是中华民族发展的重要支撑。长江经济带横跨我国东中西三大区域,是我国经济稳增长的重要支撑。推动长江经济带高质量发展是党中央作出的重大决策,是关系国家发展全局的重大战略。文章总结了湖北省关于统筹绿色与发展两大任务的顶层设计,守牢水安全底线的具体措施,介绍了推进国家水网建设的工作方向。

关键词：高质量发展流域长江经济带国家水网水安全

基于单细胞组学预测肝内胆管癌根治性切除患者预后的研究

在线全文

学校读者我要写书评

暂无评论

中华外科杂志 2024年第4期62卷 316-323页

作者：陈家璐唐玥覃德龙李宗龙汤朝晖全志伟上海交通大学医学院附属新华医院普外科上海200092

目的:基于单细胞组学分析肝内胆管癌(ICC)根治性切除术后患者的生存获益。方法:本研究为回顾性病例系列研究。整合基因表达综合数据库中4个数据集的ICC单细胞测序结果,共获得46例患者根治性切除样本,探索ICC微环境的特征。同时分析附有... 详细信息

目的:基于单细胞组学分析肝内胆管癌(ICC)根治性切除术后患者的生存获益。方法:本研究为回顾性病例系列研究。整合基因表达综合数据库中4个数据集的ICC单细胞测序结果,共获得46例患者根治性切除样本,探索ICC微环境的特征。同时分析附有生存数据的EMBI数据库共100例ICC组织芯片数据,通过ssGSEA算法计算芯片数据每个样本中各个上皮细胞亚群的浸润丰度,探索与患者较差预后相关的关键上皮细胞亚群,并研究该亚群关键标志(marker)基因的临床价值。通过单因素与多因素 Cox 比例风险模型筛选预后相关marker基因,使用目标基因构建 Cox比例风险模型并绘制列线图,使用Kaplan-Meier 生存分析验证评分与患者预后的关系,通过受试者工作特征(ROC)曲线、校准曲线及决策曲线(DCA)对模型预测效能进行评估。结果:上皮细胞亚群几乎仅在肿瘤组织中浸润。表达 MT2A的上皮细胞亚群与患者更差的预后相关且浸润丰度很高,以该亚群浸润为特征的患者被定义为抗氧化型。经单因素与多因素Cox比例风险模型筛选该亚群的marker基因,其中 FILPIL、 NAKBIA、 PEG10、 SERPINB5是患者的独立预后因素。用这4个基因表达量构建Cox比例风险模型,根据该模型所区分的高风险组患者的术后1、3、5年总体生存率均低于低风险组患者( P值均<0.05);所构建的列线图具有较好的区分度及有效性。ROC曲线显示,模型1、3、5年预测的曲线下面积分别为0.779、0.844、0.845;经校准曲线与DCA检验,对比临床指标,该模型具有较好的预测效能。结论:MT2A阳性上皮细胞亚群与ICC患者根治性切除术后的生存获益相关,可将ICC组织分为抗氧化型与非抗氧化型,抗氧化型预示患者预后较差,可考虑通过术后辅助治疗等手段改善生存。

关键词：肝肿瘤外科手术单细胞组学预后模型抗氧化型

Electrochemical Reduction of Benzo[b]thiophene 1,1-Dioxides with HFIP as Hydrogen Donor

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2024年第6期42卷 585-591页

作者： Ming-Zhong Guo Mei-Jin Mou Zhuo chen Shao-Fei Ni Ming Li Li-Rong Wen Lin-Bao Zhang State Key Laboratory Base of Eco-Chemical Engineering College of Chemistry and Molecular EngineeringQingdao University of Science & TechnologyQingdaoShandong266042 China Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Shantou UniversityShantouGuangdong515063 China

A straightforward electrochemical reduction of benzo[b]thiophene 1,1-dioxides with HFIP as the hydrogen donor has been reported in an undivided cell under metal-free ***,the tolerance of various functional groups and ... 详细信息

关键词： Electrochemistry Reduction Benzo[b]thiophene 1,1-dioxides Deuterium Hydrogen source

Human Herpesvirus 6 Infection Complicated by Viral Encephalitis Following Liver Transplantation:A Case Report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Microbes & Diseases 2024年第3期6卷 158-161页

作者： Kai Kou Heyu Huang Wei Qiu Yuguo chen Xiaodong Sun Guoyue Lv General Surgery Center Department of Hepatobiliary and Pancreatic SurgeryThe First Hospital of Jilin University:Bethune First Hospital of Jilin UniversityChangchunChina

Human herpesvirus 6(HHV-6)is a significant pathogen following solid organ ***,we report a 64-year-old female with cirrhosis related to nonalcoholic fatty liver disease who underwent orthotopic allogeneic liver transplantation and was ultimately diagnosed with HHV-6 encephalitis through cerebrospinal fluid analysis and *** treatment with daily ganciclovir was initiated according to characteristics indicative of viral encephalitis 3 days before confirmed *** improvement in symptoms was observed,with clearance of HHV-6 from the *** complex diagnosis and management of this case accentuate the possibility of serious consequences of HHV-6 infection in postoperative liver transplant *** must maintain a high index of suspicion for HHV-6 reactivation,especially given its association with immunosuppressive drug *** recognition and initiation of antiviral therapy are paramount,particularly when patients present with fever or psychiatric symptoms,as these may indicate HHV-6 encephalitis.

关键词： human herpesvirus 6 viral encephalitis liver transplantation