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Genome-wide identification,expression and functional analysis of sugar transporters in sorghum(Sorghum bicolor L.)

Journal of Integrative Agriculture 2022年第10期21卷 2848-2864页

作者： XIAO Qian-lin LI Zhen WANG Ya-yun HOU Xian-bin WEI Xi-mei ZHAO Xiao HUANG Lei guo Yan-jun LIU Zhi-zhai College of Agronomy and Biotechnology Southwest UniversityChongqing 400715P.R.China State Key laboratory of Crop Gene Exploration and Utilization in Southwest china Sichuan Agricultural UniversityChengdu 611130P.R.China College of Agriculture and Food Engineering Baise UniversityBaise 533000P.R.China College of Animal Science and Technology Southwest UniversityChongqing 400715P.R.China

Sugar transporters are essential for osmotic process regulation,various signaling pathways and plant growth and ***,few studies are available on the function of sugar transporters in sorghum(Sorghum bicolor L.).In this study,we performed a genome-wide survey of sugar transporters in *** total,98 sorghum sugar transporters(SSTs)were identified via *** SSTs were classified into three families based on the phylogenetic and conserved domain analysis,including six sucrose transporters(SUTs),23 sugars will eventually be exported transporters(SWEETs),and 69 monosaccharide transporters(MSTs).The sorghum MSTs were further divided into seven subfamilies,including 24 STPs,23 PLTs,two VGTs,four INTs,three p Glc T/SBG1 s,five TMTs,and eight *** localization of the SST genes showed that they were randomly distributed on 10 chromosomes,and substantial clustering was evident on the specific ***-seven SST genes from the families of SWEET,ERD,STP,and PLT were found to cluster in eight tandem repeat event *** total,22 SSTs comprising 11 paralogous pairs and accounting for 22.4%of all the genes were located on the duplicated *** different subfamilies of SST proteins possessed the same conserved domain,but there were some differences in features of the motif and transmembrane helices(TMH).The publicly-accessible RNA-sequencing data and real-time PCR revealed that the SST genes exhibited distinctive tissue specific *** studies showed that seven SSTs were mainly located on the cell membrane and membrane organelles,and 14 of the SSTs could transport different types of monosaccharides in *** findings will help us to further elucidate their roles in the sorghum sugar transport and sugar signaling pathways.

关键词： sorghum(Sorghum bicolor L.) sugar transporter SUT SWEET MST phylogenetic analysis

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Particle suspension in sediment-laden flow

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Progress in Natural Science:Materials International 2002年第7期 3-14页

作者： NI Jinren(Center for Environmental Sciences, Peking University The Key laboratory of Water and Sediment Sciences, Ministry of Education, Beijing 100871, china) Center for Environmental Sciences Peking University The Key laboratory of Water and Sediment Sciences Ministry of Education Beijing 100871 China

Many theories have been developed for predicting the vertical profiles of suspended sediment concentration in sediment-laden flows. An overview of various recent investigations is given herein. The generalization of the existing formulas and the interpretation of the typical sediment distributions are discussed in terms of continuum and kinetic concepts. The continuum assumption, which has been proved very successful for descriptions of liquid fluid motion, seems insufficient to describe motions of discrete solid particles in two-phase flows. Stochastic models can be used to approach the motion of the individual particles in the fluid, but are unsuitable for simulating interactions between solid particles. The analogy of kinetic theory in sediment-laden flows offers a promising alternative approach, and is expected for the applications in hyper-concentrated flow studies.

关键词： sediment distribution suspension generalization continuum concept kinetic theory.

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HUITWU： An Efficient Algorithm for High-Utility Itemset Mining in Transaction Databases

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Journal of Computer Science & Technology 2016年第4期31卷 776-786页

作者： Shi-Ming guo Hong Gao School of Computer Science and Technology Harbin Institute of Technology Harbin 150001 China

Mining high-utility itemsets （HUIs） from a transaction database refers to the discovery of itemsets with high utilities like profits. Most of existing studies discover HUIs from a transaction database in two phases. In phase 1, different overestimation methods are applied to calculate the upper bounds of the utilities of itemsets. Since the overestimated utilities of itemsets are adopted, the itemsets whose overestimated utilities are no less than a user-specified threshold are selected as candidate HUIs, and they are verified by scanning the database one more time in phase 2. However, a large number of candidate HUIs incur two problems： 1） it requires excessive memory to store these candidates; 2） it needs a large amount of running time to calculate their exact utilities. Vertical data format has been applied to mine HUIs recently. However this kind of method cannot deal with transactions with the same items effectively so that the size of database cannot be reduced sufficiently. The overall performance of algorithms is degraded consequently. Thus an algorithm HUITWU is proposed in this paper for mining HUIs. A novel data structure HUITwu-Tree is adopted to efficiently calculate the utilities of itemsets in a database. Extensive studies with both sparse and dense datasets have demonstrated that our proposed algorithm is more than an order of magnitude faster and consumes less memory than the state-of-the-art algorithms.

关键词： data mining high-utility itemset pattern growth

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中国日语学习者协商互动特征研究——基于多语种日语学习者语料库的考察

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日语学习与研究 2024年第4期 55-63页

作者：蔡妍林子怡福建师范大学外国语学院广东外语外贸大学日语语言文化学院

日语学习者的协商互动研究依据多语种日语学习者语料库(I-JAS)分析了不同语言水平的中国日语学习者与日语母语者在协商类型和互动策略上的分布特点。结果显示,交际过程中学习者更加关注话语的形式与意义,而母语者的核心目的在于推动会... 详细信息

日语学习者的协商互动研究依据多语种日语学习者语料库(I-JAS)分析了不同语言水平的中国日语学习者与日语母语者在协商类型和互动策略上的分布特点。结果显示,交际过程中学习者更加关注话语的形式与意义,而母语者的核心目的在于推动会话进展以获取更多新信息。学习者倾向使用求助型策略,直接要求对方提供协助或单方面开启新话题,而母语者更加注重交际的互动性,通过“寻求同意”和“隐性求助”策略维持共情基调,期待双方协同推进会话发展。学习者的协商互动能力与语言水平大致呈线性发展趋势。随着语言水平的提高,学习者的交际重点逐渐由话语的形式和意义转向话语内容,互动意识明显提升,尝试将更多的话轮资源分配给听话人。

关键词：意义协商形式协商内容协商日语学习者语言水平

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谈非母语习得中“兴趣”因素的激发

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江苏教育学院学报（社会科学版） 2003年第6期19卷 101-103页

作者：高平陈浩东兰州大学外国语学院甘肃兰州730000

“兴趣”因素虽然属于个体的一种心理表征 ,但它在导致目标实现过程中有着不可低估的积极作用。非母语习得因为母语先天预设的障碍 ,以及语言学习的长时间、大跨度的特性 ,学习者保持恒久而强烈的兴趣显得特别重要。作为个人行为与心理... 详细信息

“兴趣”因素虽然属于个体的一种心理表征 ,但它在导致目标实现过程中有着不可低估的积极作用。非母语习得因为母语先天预设的障碍 ,以及语言学习的长时间、大跨度的特性 ,学习者保持恒久而强烈的兴趣显得特别重要。作为个人行为与心理活动 ,在教学中激发兴趣确实是困难的 ,但我们又必须设法去努力。本文通过对影响兴趣因素的相关条件的分析 ,归引出激发兴趣因素的一些途径。

关键词：非母语习得兴趣相关条件激发途径

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Stabilization of switched linear systems with bounded disturbances and unobservable switchings

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Science in china(Series F) 2007年第5期50卷 711-718页

作者： LIU feng School of Electronics and Information Engineeing Beijing Jiaotong University Beijing 100044 China

This paper studies the stabilization problem of switched linear systems with bounded disturbances. It is assumed that the system switches among an Infinite set of uniformly controllable linear systems, and that the switching signals are not observable, but the switching duration has a lower bound. It will be shown that by combining on-line adaptive estimation and control in the controller design, a feedback control law can be constructed which makes the switched linear system globally stable.

关键词： switched systems uniform controllability estimation stabilization

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Changes of Serotonin （5-HT）, 5-HT2A Receptor, and 5-HT Transporter in the Sprague-Dawley Rats of Depression, Myocardial Infarction and Myocardial Infarction Co-exist with Depression

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Chinese Medical Journal 2015年第14期128卷 1905-1909页

作者： Mei-Yan Liu Yan-Ping Ren Wan-lin Wei guo-Xiang Tian guo Li Department of Cardiology Beijing Anzhen Hospital Affiliated to Capital Medical University Beijing 100029 China Department of Geriatric-cardiovascular First Affiliated Hospital of Medical College Xi'an Shaanxi 710061 China Department of Cardiology Military General Hospital of Beijing PLA Beijing 100700 China Department of 4^th Cadres Ward Military General Hospital of Beijing PLA Beijing 100700 China

Background： To evaluate whether serotonin （5-HT）, 5-HT2A receptor （5-HT2AR）, and 5-HT transporter （serotonin transporter [SERT]） are associated with different disease states of depression, myocardial infarction （MI） and MI co-exist with depression in Sprague-Dawley rats. Methods： After established the animal model of four groups include control, depression, MI and MI with depression, we measured 5-HT, 5-HT2AR and SERT from serum and platelet lysate.Results： The serum concentration of 5-HT in depression rats decreased significantly compared with the control group （303.25 ± 9.99 vs. 352.98 ±13.73; P =0.000）, while that in MI group increased （381.78 ±14.17 vs. 352.98 ±13.73; P = 0.000）. However, the depression ＋ MI group had no change compared with control group （360.62 ±11.40 vs. 352.98 ±13.73; P = 0.036）. The changes of the platelet concentration of 5-HT in the depression, MI, and depression ＋ MI group were different from that of serum. The levels of 5-HT in above three groups were lower than that in the control group （380.40 ± 17.90, 387.75 ±22.28,246.40 ±18.99 vs. 500.29 ±20.91 ; P = 0.000）. The platelet lysate concentration of 5-HT2AR increased in depression group, MI group, and depression ＋ MI group compared with the control group （370.75 ±14.75,393.47 ±15.73,446.66 ±18.86 vs. 273.66 ±16.90; P= 0.000）. The serum and platelet concentration of SERT in the depression group, MI group and depression ＋ MI group were all increased compared with the control group （527.51 ±28.32, 602.02 ±23.32, 734.76 ±29.59 vs. 490.56 ±16.90; P 0,047, P = 0.000, P = 0.000 in each and 906.38 ±51.84, 897.33 ±60.34, 1030.17 ±58.73 vs. 708.62 ±51.15; P = 0.000 in each）. Conclusions： The concentration of 5-HT2AR in platelet lysate and SERT in serum and platelet may be involved in the pathway of MI with depression. Further studies should examine whether elevated 5-HT2AR and SERT may contribute to the biomarker in MI patients with depression.

关键词： 5-HT 5-HT2A Receptor Depression Myocardial Infarction, Serotonin Transporter

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数字技术赋能乡村生态产业:正值效应、现实梗阻及推进策略

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南海学刊 2024年第5期10卷 83-94页

作者：谯琳李娜锦州医科大学马克思主义学院辽宁锦州121001

积极发展乡村生态产业能够有效兼顾乡村产业发展和生态环境保护。数字技术正不断释放赋能潜力,为乡村生态产业发展带来新的生机。从数字技术支撑引领乡村产业生态化、生态产业化以及生态产业融合化三个角度分析数字技术赋能乡村生态产... 详细信息

积极发展乡村生态产业能够有效兼顾乡村产业发展和生态环境保护。数字技术正不断释放赋能潜力,为乡村生态产业发展带来新的生机。从数字技术支撑引领乡村产业生态化、生态产业化以及生态产业融合化三个角度分析数字技术赋能乡村生态产业的正值效应,发现乡村生态产业数字化过程中存在着基建迟滞、资金不足、人才短缺以及技术匮乏等现实梗阻,阻碍了乡村生态产业的发展。通过加强数字基础设施建设、加大资金支持、强化高质量人才供给以及推进数字技术支撑等方式,可以畅通数字技术赋能乡村生态产业的发展进路,进而助力乡村全面振兴行稳致远。

关键词：数字技术乡村生态产业乡村生态产业数字化

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Ghrelin inhibits IKKβ/NF-κB activation and reduces pro-inflammatory cytokine production in pancreatic acinar AR42J cells treated with cerulein

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Hepatobiliary & Pancreatic Diseases International 2021年第4期20卷 366-375页

作者： Ren-Jie Chang Hui-lin Wang Meng-Bin Qin Zhi-Hai Liang Jia-Ping He Yu-Le Wei Hong-Zong Fu guo-Du Tang Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Department of Gastroenterology The First People’s Hospital of Nanning CityThe Fifth Affiliated Hospital of Guangxi Medical UniversityNanning 530022China Department of Chemotherapy Affiliated Tumor Hospital of Guangxi Medical UniversityNanning 530021China Department of Gastroenterology Second Affiliated Hospital of Guangxi Medical UniversityNanning 530007China Department of Gastroenterology Liuzhou General HospitalLiuzhou 545006China Department of Gastroenterology Guangxi International Zhuang Medical HospitalNanning 530001China

Background: Previous studies have provided conflicting results regarding whether the serum ghrelin concentration can reflect the severity of acute pancreatitis(AP). The present study examined the correlation between the serum ghrelin concentration and AP severity in animal models and investigated whether altered ghrelin expression in pancreatic acinar cells influences IKK β/NF-κ B signaling and pro-inflammatory cytokine production. Methods: Mild or severe AP was induced in rats by intraperitoneal injection of cerulein or retrograde cholangiopancreatic duct injection of sodium taurocholate, respectively. After successful model induction, serum ghrelin, tumor necrosis factor-α(TNF-α), and interleukin-6(IL-6) concentrations were determined by enzyme-linked immunosorbent assay, and IKK β/NF-κ B activation was assessed by immunohistochemistry. Subsequently, stable overexpression or knockdown of ghrelin in AR42 J cells was achieved by lentiviral transfection. After transfected cells and control cells were treated with cerulein for 24 h, the TNF-αand IL-1 β levels in the supernatants were determined by enzyme-linked immunosorbent assay, and the expression levels of p-p65, IKK β, and p-IKK β were detected by Western blotting. Results: In rat AP models, AP severity was correlated with increased IKK β/NF-κ B activation, proinflammatory cytokine production, and ghrelin secretion. The levels of pro-inflammatory cytokines TNF-αand IL-1 β as well as IKK β/NF-κ B signaling activity were increased upon knockdown of ghrelin in the AP acinar cell model and decreased with ghrelin overexpression. Conclusions: Serum ghrelin is related to the severity of AP. Ghrelin may play a protective role in the pathogenesis of AP by inhibiting the pro-inflammatory cytokines and the activation of the IKK β/NF-κ B signaling pathway.

关键词： Acute pancreatitis Ghrelin Inflammatory cytokine Acinar cells

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FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis

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Bone Research 2022年第4期10卷 726-740页

作者： Dong guo Chuangxin lin Yuheng Lu Hong Guan Weizhong Qi Hongbo Zhang Yan Shao Chun Zeng Rongkai Zhang Haiyan Zhang Xiaochun Bai Daozhang Cai Department of Joint Surgery Center for Orthopedic SurgeryThe Third Affiliated Hospital of Southern Medical UniversityGuangzhouChina Department of Orthopedics Orthopedic Hospital of Guangdong ProvinceAcademy of OrthopedicsGuangdong ProvinceThe Third Affiliated Hospital of Southern Medical UniversityGuangzhouChina The Third School of Clinical Medicine Southern Medical UniversityGuangzhouChina Guangdong Provincial Key laboratory of Bone and Joint Degeneration Diseases GuangzhouChina Department of Orthopedic Surgery Shantou Central HospitalAffiliated Shantou Hospital of Sun Yat-sen UniversityShantouChina State Key laboratory of Organ Failure Research Department of Cell BiologySouthern Medical University School of Basic Medical SciencesGuangzhouChina

Increasing evidence shows that adipokines play a vital role in the development of rheumatoid arthritis(RA).Fatty acid-binding protein 4(FABP4),a novel adipokine that regulates inflammation and angiogenesis,has been extensively studied in a variety of organs and ***,the effect of FABP4 on RA remains ***,we found that FABP4 expression was upregulated in synovial M1-polarized macrophages in *** increase in FABP4 promoted synovitis,angiogenesis,and cartilage degradation to exacerbate RA progression in vivo and in vitro,whereas BMS309403(a FABP4 inhibitor)and anagliptin(dipeptidyl peptidase 4 inhibitor)inhibited FABP4 expression in serum and synovial M1-polarized macrophages in mice to alleviate RA *** studies showed that constitutive activation of mammalian target of rapamycin complex 1(mTORC1)by TSC1 deletion specifically in the myeloid lineage regulated FABP4 expression in macrophages to exacerbate RA progression in *** contrast,inhibition of mTORC1 by ras homolog enriched in brain(Rheb1)disruption specifically in the myeloid lineage reduced FABP4 expression in macrophages to attenuate RA development in *** findings established an essential role of FABP4 that is secreted by M1-polarized macrophages in synovitis,angiogenesis,and cartilage degradation in ***309403 and anagliptin inhibited FABP4 expression in synovial M1-polarized macrophages to alleviate RA ***,FABP4 may represent a potential target for RA therapy.

关键词： angiogenesis inhibited synovitis

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