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A Full CMOS Integration Including ISFET Microsensors and Interface Circuit for Biochemical Applications

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稀有金属材料与工程 2006年第S3期 443-446页

作者： Jinbao Wei~(1,2) Haigang Yang~(1*) Hongguang Sun~(1,2) Zengjin Lin~(1,2) Shanhong Xia~1 (1.The State Key Lab of Transducer Technology,Institute of Electronics,CAS,P.O.Box 2652,beijing 100080,china) (2.graduate university of the chinese academy of sciences,beijing 100039,china)

One of today's challenges is the integration of ISFETs in chemical and biochemical *** article presents a full integration of ISFET chip containing the ISFET/REFET(reference FET) pair,ISFET/REFET amplifiers,bias current generator,as well as a reference electrode structure,all integrated on the same chip based on CMOS *** sensor chip was fabricated in a standard 0.35μm CMOS process(Chartered Semiconductor,Singapore).The extra post processing steps have been developed and added for depositing ***,the pH response of the integrated sensor was measured with the interface circuit.

关键词： ISFET interface circuit integration and post processing

Ionogram inversion for MARSIS topside sounding

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Ionogram inversion for MARSIS topside sounding

中国地球物理学会第二十七届年会

作者： Xiuhong Han~(1,2) Weixing Wan~1 1.beijing National Observatory of Space Environment,Institute of Geology and Geophysics, chinese academy of sciences,beijing 100029,china 2.graduate university of chinese academy of sciences,beijing 100049, china

A technique of ionogram inversion is proposed to retrieve the electron density profile,Ne(h),of the Martian ionosphere from the topside ionogram measured by the Mars Advanced Radar for Subsurface and Ionosphere Sounding(MARSIS).The inversion technique is developed from Titheridge’s method by replacing the prior polynomials with the empirical orthogonal functions(EOFs),which are calculated from the historical N(h) observation by the radio occultation of the Mars Global Surveyor(MGS).The inversion technique is applied to the MARSIS ionograms and the results suggested that the EOF series in the real height expansion converges *** a few leading EOFs can represent the maximum possible fraction of the variability contained in the original ***,the technique can treat deformed ionograms,e.g.,ionograms without the ionospheric

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Mining and characterization of ubiquitin E3 ligases from the mouse genome

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Mining and characterization of ubiquitin E3 ligases from the...

“细胞活动生命活力”——中国细胞生物学学会全体会员代表大会暨第十二次学术大会

作者： Xiaojun Hou~1,Wei Zhang~(1,2),Chunsheng Han~1 1.State Key Laboratory of Reproductive Biology,Institute of Zoology,chinese academy of sciences,beijing 100101,china 2.graduate university of chinese academy of sciences,beijing 100039,china

Ubiquitin-mediated protein modification and degradation are believed to play important roles in mammalian *** our previous studies,we have identified several ubiquitin E3 Iigases that belong to the RING finger protein *** the present study,we first did a genome-wide mining of all potential mouse E3 Iigases,and identified those that are highly or specifically expressed in the *** a result,92 putative E3s belonging to the RING,U-box,and F-box subfamilies were discovered and 21 of them are abundantly expressed in the testis based on microarray expression *** selected 15 such genes for further characterization by examining their expression,cellular localization and E3 ligase activity. RT-PCR results showed that all the selected genes are predominately expressed in *** nuclear localization was observed in CHO and Hela cell *** addition,some novel proteins possess E3 ubiquitin ligase activity indicated by both in vivo and in vitro *** results indicated that large number of E3 Iigases are probably involved in *** will be important to identify their substrate in order to elucidate their molecular functions in spermatogenesis.

关键词： spermatogenesis Ubiquitination E3 ligase

Ribophorin II is a substrate of spermatid-specific E3 ligase RNF148

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Ribophorin II is a substrate of spermatid-specific E3 ligase...

“细胞活动生命活力”——中国细胞生物学学会全体会员代表大会暨第十二次学术大会

作者： Wei Zhang~(1,2),Zhenyu Xiao~(1,2),Chunsheng Han~1 1.State Key Laboratory of Reproductive Biology,Institute of Zoology,chinese academy of sciences,beijing 100101,china 2.graduate university of chinese academy of sciences,beijing 100039,china

Ring finger proteins(RNFs) are a subfamily of zinc finger proteins and many of them function as ubiquitin ligases(E3s).Many RNFs are germ cell-specifically expressed and play important roles in spermatogenesis. Previously,we have shown that RNF133 is a testis-specific endoreticulum-associated *** this study,we show that another spermatid-specific gene Rnf148,located 5k-bp upstream of Rnfl33,also encodes an E3 with similar protein domains including a signal peptide,a protease-association domain,a transmembrane domain and a C3HC4 RING finger *** vitro assays showed that RNF148 worked with ubiquitin-conjugating enzymes(E2s) such as UbcH5b and UbcH7,which is involved in endoreticulum associated degradation(ERAD) ***148 co-localized with the reticulum-associated E2 MmUbc6, and co-immunoprecipitated with CD3-.which is a typical substrate in ERAD *** two-hybrid screening revealed that RNF148 physically interacts with ribophorin II(RPNII),which is a component of ***-immunoprecipitation and cycloheximide treatment experiments confirmed that RPNII is not only a partner but also a substrate of *** was highly expressed in spermatogonia and spermatocytes,in which RNF148 was *** negative correlation of the expression of RNF148 and RPNII in mouse testis implied that RPNII is targeted by RNF148 for degradation in *** RPNII is involved in the biosynthesis process of N-glycans on glycoproteins, which has been reported to play key roles in germ cell-Sertoli cell attachment,we propose that RNF148 may inhibit the synthesis of glycoproteins through the degradation of RPNII resulting in the dissociation of germ cell from Sertoli cells and their release into the seminiferous tubules.

关键词： RNF148 RPNII RING E3 ligase ubiquitination spermatogenesis

Study on the ecotourism model of ethnic areas in western Sichuan Province under the comprehensive tourism strategy:a case of Zoige County

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Ecological Economy 2008年第4期4卷 484-495页

作者： Li Bin Li Yu Dong Suocheng Institute of Geographic sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 P.R. China graduate university Chinese Academy of Sciences Beijing 100039 P. R. china

The ethnic areas of western Sichuan Province are characterized by complicated topography, seismic active zone, serious soil erosion, fragile eco-environment, low level of economy, and so on. Periphery regions and central regions appear in western Sichuan Province. The socioconomic development in the central regions is at high level, whereas the ethnic areas are generally at lower level. Moreover. the deterioration of the eco-environment has seriously restricted the development of traditional industries in the ethnic areas, and it is necessary to develop environment-friendly and resource-saving industries. The ethnic areas of western Sichuan Province are rich in tourism resources, and have the potentiality of developing ecotourism. Advantages＇ of tourism resources in the ethnic areas should be made full use of and ＂comprehensive tourism ＂ is the requirement of the characteristics and the status quo of the ethnic areas. The ＂comprehensive tourism development model ＂ has the functions of ecotourism on the key industry. Based on the demands and the interaction among different industries, the model cart accelerate the development of related-industries, such as eco-agrieulture, eco-industry, eco-tertiary industry, and so on. Through implementing the comprehensive tourism model, we can fully utilize the advantages of ethnic areas, and promote the rapid and sustainable growth of regional economy, and also the harmonious development of economy, environment and society.

关键词： Ethnic areas Comprehensive tourism Ecotourism Regional sustainable development

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Digital Ocean Oriented Data Processing and Information Service Systems

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Digital Ocean Oriented Data Processing and Information Servi...

第二十七届中国控制会议

作者： Wang Xiaomin 1,2,Zhang Xin 1,Chi Tianhe 1 1.Institute of Remote Sensing Applications,chinese academy of sciences,beijing 100101,P.R.china 2.graduate university of chinese academy of sciences,beijing 100039,P.R.china

Digital Ocean is one of important digital industries based on the concept of Digital *** a macro complex systematic engineering,the Digital Ocean is an ongoing task in *** mission of the Digital Ocean is to build an information system and develop methods for creating digital representations,or models,of ocean variables and *** gathering,processing,analyzing,visualizing and making data and information widely available,the Digital Ocean project can help provide integrated information on historical,current and future states of ocean and coastal *** paper analyzes data acquisition and information requirements of Digital *** on the analysis of the information needs,the data processing chain and methods of the Digital Ocean are brought *** then it presents two Digital Ocean oriented information service systems,one-stop portal based information services system for IOOS of Taiwan strait and 3-D globe based Digital Ocean prototype.

关键词： Digital ocean Data processing Information service systems

More Entanglement,Less Reliability

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More Entanglement,Less Reliability

第三十届中国控制会议

作者： SONG Hong-Ting~(1,2),XI Zai-Rong~1 1.Key Laboratory of Systems and Control,Institute of Systems Science,academy of Mathematics and Systems Science,chinese academy of sciences,beijing 100190,P.R.china 2.graduate university of chinese academy of sciences,beijing 100039,P.R.china

＜正＞Entanglement of quantum states is a very important resource in quantum communication *** many special tasks,entanglement is found to be *** it is still a problem how to find the relationship between the amount of entanglement and the effect of doing the *** this work,we consider a particular task—trying to send a single classical bit as effective as possible through a noisy quantum channel and two transmissions through the channel are available as a *** two special channels—amplitude damping channel and two-Pauli channel,we separately establish the quantitative connections,and try to find whether the relationship is always monotonous,i.e.,the states with the larger entanglement necessarily result in the better ***,this is not *** the same time,we can get the optimal codes for the task using this method.

关键词： Entanglement Concurrence Two-Pauli Channel Optimal Codes

HSF2BP interacts with and changes the subcellular localization of BNC1

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HSF2BP interacts with and changes the subcellular localizati...

“细胞活动生命活力”——中国细胞生物学学会全体会员代表大会暨第十二次学术大会

作者： Yujian Wu~(1,2),Shang ying Liao~1,Xiuxia Wang~1,Chunsheng Han~1 1.State Key Laboratory of Reproductive Biology,Institute of Zoology,chinese academy of sciences,Bcijing 100101,china 2.graduate university of chinese academy of sciences,beijing 100039,china

Basonuclin(BNC1) is a zinc-finger type transcription factor abundantly expressed in the basal keratinocytes of stratified epithelium and the germ *** plays a pivotal role in spermatogenesis and *** further investigate the function of BNC1 in spermatogenesis,we screened murine testis cDNA expression library with a yeast two-hybrid system and identified HSF2BP as its binding partner. Their interaction was further confirmed by GST pull-down and co-immunoprecipitation *** expression of HSF2BP protein in 3T3 or 293 cells resulted in the transport of BNC1 from the nucleus to the *** a conclusion,HSF2BP probably regulates the transcription factor activity of BNC1 by physically interacting with and changing the subcellular localization of BNC1.

关键词： BNC1 HSF2BP spermatogenesis testis

多注速调管TM_(410)模同轴输出腔的研究

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微波学报 2010年第S1期26卷 431-433页

作者：韩慧鹏王勇张瑞中国科学院电子学研究所中国科学院高功率微波源与技术重点实验室北京100190 中国科学院研究生院北京100049

研究了多注速调管TM410模同轴输出腔中出现的外观品质因数高,模式频率间隔小以及工作模式场分布的均匀性差等问题,提出了一种设置短路杆和金属环的输出腔结构,从而改善了TM410模输出腔上述三个方面的性能。通过分析发现,适当设置短路杆... 详细信息

研究了多注速调管TM410模同轴输出腔中出现的外观品质因数高,模式频率间隔小以及工作模式场分布的均匀性差等问题,提出了一种设置短路杆和金属环的输出腔结构,从而改善了TM410模输出腔上述三个方面的性能。通过分析发现,适当设置短路杆和重入环不仅可以使外观品质因数降低,还可以改善工作模式的场分布;设置重入环还可以增大工作模式和邻近模式的频率间隔。利用CST-MWS软件,对X波段具有短路杆和金属环的多注速调管TM410模同轴输出腔进行了模拟计算,其工作模式(TM410模)的外观品质因数降低了42.7%(从540.4降至309.6),TM410模与邻近模式的频率间隔均达到了1.3GHz以上,工作模式的场分布也变得均匀。

关键词：多注速调管 TM310模光子晶体杂模抑制

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