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Cap polyposis: A rare cause of rectal bleeding in children

World Journal of Gastroenterology 2013年第26期19卷 4185-4191页

作者： Jia Hui Li May Ying Leong Kong Boo Phua Yee Low Ajmal Kader Veena Logarajah Lin Yin ong Joyce HY Chua Christina ong Gastroenterology Service Department of Pediatric Medicine KK Women's and Children's Hospital Department of Pathology KK Women's and Children's Hospital Department of Pediatric Surgery KK Hospital

AIM: To evaluate the clinicopathological features and treatment outcomes of cap polyposis in the pediatric population. METHODS: All pediatric patients with histologically proven diagnosis of cap polyposis were identified from our endoscopy and histology database over a 12 year period from 2000-2012 at our tertiary pediatric center, KK Women's and Children's Hospital in Singapore. The case records of these patients were retrospectively reviewed. The demographics, clinical course, laboratory results, endoscopic and histopathological features, treatments, and outcomes were analyzed. The study protocol was approved by the hospital institutional review board. The histological slides were reviewed by a pediatric histopathologist to confirm the diagnosis of cap polyposis. RESULTS: Eleven patients were diagnosed with cap polyposis. The median patient age was 13 years (range 5-17 years); the sample included 7 males and 4 females. All of the patients presented with bloody stools. Seven patients (63%) had constipation, while 4 patients (36%) had diarrhea. All of the patients underwent colonoscopy and polypectomies (excluding 1 patient who refused polypectomy). The macroscopic findings were of polypoid lesions covered by fibrinopurulent exudates with normal intervening mucosa. The rectum was the most common involvement site (n = 9, 82%), followed by the rectosigmoid colon (n = 3, 18%). Five (45%) patients had fewer than 5 polyps, and 6 patients (65%) had multiple polyps. Histological examination of these polyps showed surface ulcerations with a cap of fibrin inflammatory exudate. Four (80%) patients with fewer than 5 polyps had complete resolution of symptoms following the polypectomy. One patient who did not consent to the polypectomy had resolution of symptoms after being treated with sulphasalazine. All 6 patients with multiple polyps experienced recurrence of bloody stools on follow-up (mean = 28 mo). CONCLUSION: Cap polyposis is a rare and underrecognised cause of rectal b

关键词： Cap polyposis Polyps Rectal bleeding Pediatrics Inflammatory bowel disease

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AR-assisted robot welding programming

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Advances in Manufacturing 2020年第1期8卷 40-48页

作者： S.K.ong A.Y.C.Nee A.W.W.Yew N.K.Thanigaivel Department of Mechanical Engineering Faculty of EngineeringNational University of SingaporeSingapore

Robotic welding demands high accuracy and ***,robot programming is often a tedious and time-consuming process that requires expert *** paper presents an augmented reality assisted robot welding task programming(ARWP)system using a user-friendly augmented reality(AR)interface that simplifies and speeds up the programming of robotic welding *** ARWP system makes the programming of robot welding tasks more user-friendly and reduces the need for trained programmers and expertise in specific robotic *** AR interface simplifies the definition of a welding path as well as the welding gun orientation,and the system;the system can locate the welding seam of a workpiece quickly and generate a viable welding path based on the user *** developed system is integrated with the touch-sensing capability of welding robots in order to locate the welding path accurately based on the user input,for fillet *** system is applicable to other welding processes and methods of seam *** system implementation is described and evaluated with a case study.

关键词： Augmented reality(AR) Robot programming Welding Seam tracking

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The coronary computed tomography angiogram: from the basics to advanced interpretation

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Journal of Geriatric Cardiology 2006年第1期3卷 35-44页

作者： Tiong Kiam ong Stephan Achenbach Department of Cardiology Jalan Tun Ahmad Zaidi Adruce Kuching Sarawak 93586 Malaysia Department of Internal Medicine Ⅱ (Cardiology) University of Erlangen Nuremberg Germang

　　Introduction　　According to the WHO's World Health Report 2003, 1cardiovascular disease was responsible for 16.7 million deaths annually. As a result, it is now the leading cause of death in developed countries and in many developing countries. Detecting and preventing the progression of coronary artery disease is the target of many pharmaceutical, technological and other scientific programs today. Presently, the main diagnostic tool for evaluating coronary arteries is thc conventional coronary angiogram (CCA).……

关键词： MPR from the basics to advanced interpretation The coronary computed tomography angiogram CTA MDCT oral MIP

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Point-to-face contact heterojunctions:Interfacial design of 0D nanomaterials on 2D g-C_(3)N_(4)towards photocatalytic energy applications

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Carbon Energy 2022年第5期4卷 665-730页

作者： Xin-Quan Tan Sue-Faye Ng Abdul Rahman Mohamed Wee-Jun ong School of Energy and Chemical Engineering Xiamen University MalaysiaSelangor Darul EhsanMalaysia Center of Excellence for NaNo Energy&Catalysis Technology(CONNECT) Xiamen University MalaysiaSelangor Darul EhsanMalaysia Low Carbon Economy(LCE)Research Group School of Chemical EngineeringUniversiti Sains MalaysiaNibong TebalPulau PinangMalaysia State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamenFujianChina Shenzhen Research Institute of Xiamen University ShenzhenGuangdongChina

Green energy generation is an indispensable task to concurrently resolve fossil fuel depletion and environmental issues to align with the global goals of achieving carbon ***,a process that transforms solar energy into clean fuels through a photocatalyst,represents a felicitous direction toward ***-rich metal-free graphitic carbon nitride(g-C_(3)N_(4))is profiled as an attractive photocatalyst due to its fascinating properties,including excellent chemical and thermal stability,moderate band gap,visible light-active nature,and ease of ***,the shortcomings of g-C_(3)N_(4)include fast charge recombination and limited surface-active sites,which adversely affect photocatalytic *** the modification strategies,point-to-face contact engineering of 2D g-C_(3)N_(4)with 0D nanomaterials represents an innovative and promising synergy owing to several intriguing attributes such as the high specific surface area,short effective charge-transfer pathways,and quantum confinement *** review introduces recent advances achieved in experimental and computational studies on the interfacial design of 0D nanostructures on 2D g-C_(3)N_(4)in the construction of point-to-face heterojunction ***,0D materials such as metals,metal oxides,metal sulfides,metal selenides,metal phosphides,and nonmetals on g-C_(3)N_(4)with different charge-transfer mechanisms are systematically discussed along with controllable synthesis *** applications of 0D/2D g-C_(3)N_(4)-based photocatalysts are focused on solar-to-energy conversion via the hydrogen evolution reaction,the CO_(2)reduction reaction,and the N2 reduction reaction to evaluate the photocatalyst activity and elucidate reaction ***,future perspectives for developing high-efficiency 0D/2D photocatalysts are proposed to explore potential emerging carbon nitride allotropes,large-scale production,machine learning integration,and multidiscipli

关键词： 0D/2D heterojunction charge-transfer mechanisms g-C_(3)N_(4)nanosheets heterojunction interface photocatalysis solar-to-energy conversion

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Optimizing biliary outcomes in living donor liver transplantation:Evolution towards standardization in a high-volume center

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Hepatobiliary & Pancreatic Diseases International 2020年第4期19卷 324-327页

作者： Tsan-Shiun Lin Jeffrey Samuel Co Chao-Long Chen Aldwin D.ong Liver Transplantation Center Department of SurgeryKaohsiung Chang Gung Memorial Hospital123 Ta-Pei RoadNiao SungKaohsiung 833TaiwanChina

Biliary complications have always been a dreaded cause of morbidity after living donor liver *** intrinsic variations in both graft and recipient biliary anatomy remain a significant factor to the difficulty of biliary reconstruction,our institution has taken advantage of its high volume of cases to critically review and evaluate modifiable operative risk factors,in particular,our surgical *** present herein,the evolution of our reconstructive biliary technique from conventional methods to our current standard of microsurgical biliary reconstruction for both graft and recipient *** this period of transition,our center has created a classification system for biliary reconstruction that decreased the biliary complication rates from 40.0%to 10.2%.

关键词： Living donor liver transplantation Biliary reconstruction Microsurgical biliary reconstruction Biliary classification Biliary complications

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Ischaemic Monomelic Neuropathy in a Diabetic Patient after Brachio-Basilic Arteriovenous Fistula Creation

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Case Reports in Clinical Medicine 2016年第6期5卷 199-202页

作者： Nicholas B. Shannon Siew Ping Chng Chieh Suai Tan chin-Ann Johnny ong Duke-NUS Graduate Medical School Singapore City Singapore Singapore General Hospital Singapore City Singapore

Introduction: The number of people with diabetes is increasing in every country. Recent estimates put the prevalence at 8.3% of adults, with a predicted rise to 10.1 in 2035 [1]. Although less than 1% of patients with diabetes require definitive haemodialysis, this still represents a significant number who may require arteriovenous fistula creation. Presentation: We report a case of IMN occurring in a patient with end stage diabetic nephropathy following brachio-basilic arteriovenous fistula creation for chronic maintenance haemodialysis. Discussion: Ischaemicmonomelic neuropathy (IMN) has developed as a distinct clinical entity involving dysfunction of multiple peripheral nerves following vascular access. Symptom onset is usually immediate, and neurological symptoms are dominant, generally in the absence of significant clinical ischaemia. Acute neurological symptoms may be disabling and irreversible, but prompt ligation of arteriovenous fistula can prevent permanent disability. Conclusion: Ischaemicmonomelic neuropathy (IMN) is a rare but serious complication of vascular access for arteriovenous fistula for haemodialysis and should be considered in the differential diagnosis of hand dysfunction following such surgery. While the condition is not preventable or predictable, prompt recognition and treatment can lead to prevention of permanent disability.

关键词： Diabetes Vascular Neuropathy

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Effects of miR-219/miR-338 on microglia and astrocyte behaviors and astrocyte-oligodendrocyte precursor cell interactions

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Neural Regeneration Research 2020年第4期15卷 739-747页

作者： Lan Huong Nguyen William ong Kai Wang Mingfeng Wang Dean Nizetic Sing Yian Chew School of Chemical and Biomedical Engineering Nanyang Technological UniversitySingaporeSingapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore Blizard Institute Barts&The London School of MedicineQueen Mary University of LondonLondonUK NUS Synthetic Biology for Clinical and Technological Innovation(SynCTI) Life Sciences InstituteNational University of SingaporeSingapore

MiR-219 and miR-338(miR-219/miR-338)are oligodendrocyte-specific *** overexpression of these miRs in oligodendrocyte precursor cells promotes their differentiation and maturation into oligodendrocytes,which may enhance axonal remyelination after nerve injuries in the central nervous system(CNS).As such,the delivery of miR-219/miR-338 to the CNS to promote oligodendrocyte precursor cell differentiation,maturation and myelination could be a promising approach for nerve ***,nerve injuries in the CNS also involve other cell types,such as microglia and ***,we investigated the effects of miR-219/miR-338 treatment on microglia and astrocytes in vitro and in *** found that miR-219/miR-338 diminished microglial expression of pro-inflammatory cytokines and suppressed astrocyte *** addition,we showed that miR-219/miR-338 enhanced oligodendrocyte precursor cell differentiation and maturation in a scratch assay paradigm that re-created a nerve injury condition in ***,our results suggest miR-219/miR-338 as a promising treatment for axonal remyelination in the CNS following nerve *** experimental procedures were approved by the Institutional Animal Care and Use Committee(IACUC),Nanyang Technological University(approval No.A0309 and A0333)on April 27,2016 and October 8,2016.

关键词： central nervous system electrospinning gene silencing glia hydrogel myelination nanofibers oligodendroglial polycaprolactone spinal cord injury

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硅转化BALB/c-3T3细胞基因组DNA异常甲基化的研究

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中国职业医学 2003年第5期30卷 2-4页

作者：雷毅雄 Pius Joseph2 tong man ong 广州医学院预防医学教研室广州510182 Molecular Epidemiology Laboratory Toxicology and Molecular Biology BranchNational Institute for Occupational Safety and Health

目的　对硅转化细胞基因组DNA异常甲基化进行研究 ,探讨硅的表遗传致癌机制。方法　从结晶型硅 (Si)转化BALB/c 3T3细胞中提取基因组DNA ,经Mse1(甲基化非敏感性酶 )单独消化或Mse1和BstU1(甲基化敏感性酶 )联合消化 ,消化产物用甲基化... 详细信息

目的　对硅转化细胞基因组DNA异常甲基化进行研究 ,探讨硅的表遗传致癌机制。方法　从结晶型硅 (Si)转化BALB/c 3T3细胞中提取基因组DNA ,经Mse1(甲基化非敏感性酶 )单独消化或Mse1和BstU1(甲基化敏感性酶 )联合消化 ,消化产物用甲基化敏感性内切酶指纹法 (MSRF)进行分析 ,差异显示出异常甲基化基因片段 ,进一步将异常甲基化DNA片段亚克隆和序列测定 ,再与基因文库中的基因进行类比分析。结果　发现硅转化细胞存在 6条异常甲基化DNA(其中 1条为高甲基化 ,5条有低甲基化现象 ) ,序列测定显示这些异常甲基化基因片段似乎来源于一些RNA转录和蛋白质翻译等基因家族。结论　DNA异常甲基化会导致基因表达激活或抑制 ,因此硅转化细胞基因组某些功能基因DNA异常甲基化导致的异常表达。

关键词：硅转化细胞 DNA甲基化基因

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Point-of-care ultrasound identification of pneumatosis intestinalis associated with Henoch-Schönlein purpura gastrointestinal involvement:A case report

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World Journal of Emergency Medicine 2021年第1期12卷 76-78页

作者： Sek Wan Tan Vigil James Aswin Warier Gene Yong-kwang ong Children’s Emergency KK Women’s and Children’s Hospital229899Singapore

Dear editor,Henoch-Schönlein purpura (HSP) is the commonestvasculitis in children, typically affecting children agedthree to ten years.[1] It is a multi-systemic vasculitismediated by type III hypersensitivity with deposition ofimmunoglobulin. An immune complex-mediated vasculitisaffects small vessels of the skin, joints, kidneys, andgastrointestinal (GI) tracts. HSP is usually a self-limitingcondition and resolves within six to eight weeks.[1]

关键词： gastrointestinal involvement Sch

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Assessment of left ventricular ejection fraction: comparison of two dimensional echocardiography, cardiac magnetic resonance imaging and 64-row multi-detector computed tomography

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Journal of Geriatric Cardiology 2006年第1期3卷 2-8页

作者： Chee Khoon LIEW Rapaee ANNUAR Tiong Kiam ong Sze Piaw chin Tobias Seyfarth Yean Yip Fong Choon Kiat ANG Houng Bang LIEW Kui Hian SIM Department of Cardiology Sarawak General Hospital Sarawak Malaysia University Malaysia Sarawak Siemens Cardiac Solutions Erlangen Germany Department of Cardiology Sarawak General Hospital SarawakMalaysia

Objectives To compare left ventricular ejection fraction (LVEF) determined from 64-row multi-detector computed tomography (64-row MDCT) with those determined from two dimensional echocardiography (2D echo) and cardiac magnetic resonance imaging (CMR). Methods Thirty-two patients with coronary artery disease underwent trans-thoracic 2D echo, CMR and contrast-enhanced 64-row MDCT for assessment of LVEF within 48 hours of each other. 64-row MDCT LVEF was derived using the Syngo Circulation software; CMR LVEF was by Area Length Ejection Fraction (ALEF) and Simpson method and 2D echo LVEF by Simpson *** The LVEF was 49.13 ± 15.91% by 2D echo, 50.72 ± 16.55% (ALEF method) and 47.65 ± 16.58%(Simpson method) by CMR and 50.00 ± 15.93% by 64-row MDCT. LVEF measurements by 64-row MDCT correlated well with LVEF measured with CMR using either the ALEF method (Pearson correlation r = 0.94, P ＜0.01) or Simpson method (r = 0.92, P＜0.01). It also correlated well with LVEF measured using 2D echo (r = 0.80, P ＜ 0.01). Conclusion LVEF measurements by 64-row MDCT correlated well with LVEF measured by CMR and 2D echo. The correlation between 64-row MDCT and CMR was better than the correlation between 2D echo with CMR. Standard data set from a 64-row MDCT coronary study can be reliably used to calculate the LVEF.

关键词： ejection fraction echocardiography magnetic resonance imaging computed tomography

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