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Enrichment of novel Tau isoform with altered biochemical properties in Alzheimer's disease

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Neural Regeneration Research 2023年第11期18卷 2397-2398页

作者： chin-tong ong Temasek Life Sciences Laboratory and Department of Biological SciencesNational University of SingaporeSingapore

Aberrant splicing in sporadic Alzheimer’s disease:Alzheimer’s disease (AD) is a progressive neurodegenerative disorder cha racterized by the presence of extracellular amyloid-β plaques and Tau-containing intracellular neurofib rilla ry tangles (Knopman et al.,2021).Cognitive decline in AD due to neuronal and synaptic loss is caused by the complex interplay between pathological amyloid-β and Tau species with the impaired innate clearance *** are two types of AD based on disease aetiology (Knopman et al.,2021).

关键词： Alzheimer impaired

Increased intron retention is linked to Alzheimer’s disease

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Neural Regeneration Research 2020年第2期15卷 259-260页

作者： chin-tong ong Swarnaseetha Adusumalli Temasek Life Sciences Laboratory Department of Biological Sciences National University of Singapore

Intron retention in aging and Alzheimer's disease (AD): AD is an age-related neurodegenerative disorder with pathological accumulation of amyloid plaque (Masters et al., 2015), which can be classified into familial and sporadic form. In familial AD, mutations in genes encoding either amyloid precursor protein or presenilin (PS1 and PS2) cause overproduction of amyloid-42 molecules and early onset of dementia.

关键词： retention Alzheimer's disease dementia

Regulation of aging by NELF-A and RNA polymerase Ⅱ elongation

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Neural Regeneration Research 2024年第7期19卷 1415-1416页

作者： chin-tong ong Zhen-Kai Ngian Temasek Life Sciences Laboratory and Department of Biological Sciences National University of SingaporeSingaporeSingapore Department of Genetics Harvard Medical SchoolBostonMAUSA Institute of Molecular and Cell Biology Agency for ScienceTechnology and ResearchSingaporeSingapore

Epigenetic regulation of aging:Aging is defined as the gradual decline of physiological function and cellular integrity,causing o rganismal vulnerability to age-onset diseases and *** in different animal models have l... 详细信息

关键词： aging twelve integrity

CDK5-mediated phosphorylation of CP190 may regulate locomotor activity in adult female Drosophila

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Journal of Genetics and Genomics 2018年第3期45卷 177-181页

作者： chin-tong ong Wei-Qi Lin Temasek Life Sciences Laboratory National University of Singapore Department of Biological Sciences National University of Singapore

The three-dimensional organization of the genome plays a crucial role in regulating gene expression patterns in metazoans（ong and Corces,2014）.The nuclear architectural proteins are known to facilitate the formation of topological domains within the genome through mediating inter-and intra-chromosomal *** vertebrate,CCCTC-binding factor（CTCF）is the main architectural protein that mediates long-range chromosomal interactions among its DNA binding sites through a process that is stabilized by cohesin （Parelho et al., 2008; Wendt et al., 2008）.

关键词： CP CDK5-mediated phosphorylation of CP190 may regulate locomotor activity in adult female Drosophila

Smart Semi-active PID-ACO control strategy for tower vibration reduction in Wind Turbines with MR damper

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Earthquake Engineering and Engineering Vibration 2019年第4期18卷 887-902页

作者： Mahmudur Rahman Zhi Chao ong Wen tong Chong Sabariah Julai Department of Mechanical Engineering Faculty of Engineering University of Malaya

Wind turbine technology is well known around the globe as an eco-friendly and eff ective renewable power source. However, this technology often faces reliability problems due to structural vibration. This study proposes a smart semi-active vibration control system using Magnetorheological (MR) dampers where feedback controllers are optimized with nature-inspired algorithms. Proportional integral derivative (PID) and Proportional integral (PI) controllers are designed to achieve the optimal desired force and current input for MR the damper. PID control parameters are optimized using an Ant colony optimization (ACO) algorithm. The eff ectiveness of the ACO algorithm is validated by comparing its performance with Ziegler-Nichols (Z-N) and particle swarm optimization (PSO). The placement of the MR damper on the tower is also investigated to ensure structural balance and optimal desired force from the MR damper. The simulation results show that the proposed semi-active PID-ACO control strategy can signifi cantly reduce vibration on the wind turbine tower under diff erent frequencies (i.e., 67%, 73%, 79% and 34.4% at 2 Hz, 3 Hz, 4.6 Hz and 6 Hz, respectively) and amplitudes (i.e. 50%, 58% and 67% for 50 N, 80 N, and 100 N, respectively). In this study, the simulation model is validated with an experimental study in terms of natural frequency, mode shape and uncontrolled response at the 1st mode. The proposed PID-ACO control strategy and optimal MR damper position is also implemented on a lab-scaled wind turbine tower model. The results show that the vibration reduction rate is 66% and 73% in the experimental and simulation study, respectively, at the 1st mode.

关键词： ant colony optimization fi nite diff erence method magnetorheological damper PID-ACO controller semiactive control system identifi cation wind turbine tower

Biomarkers in Barrett's esophagus and esophageal adenocarcinoma:Predictors of progression and prognosis

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World Journal of Gastroenterology 2010年第45期16卷 5669-5681页

作者： chin-Ann J ong Pierre Lao-Sirieix Rebecca C Fitzgerald MRC Cancer Cell Unit Hutchison-MRC Research CentreCambridgeCB20XZUnited Kingdom

Barrett’s esophagus is a well-known premalignant lesion of the lower esophagus that is characterized by intestinal metaplasia of the squamous epithelium. It is clinically important due to the increased risk (0.5% per annum) of progression to esophageal adenocarcinoma (EA), which has a poor outcome unless diagnosed early. The current clinical management of Barrett’s esophagus is hampered by the lack of accurate predictors of progression. In addition, when patients develop EA, the current staging modalities are limited in stratifying patients into different prognostic groups in order to guide the optimal therapy for an individual patient. Biomarkers have the potential to improve radically the clinical management of patients with Barrett’s esophagus and EA but have not yet entered mainstream clinical practice. This is in contrast to other cancers like breast and prostate for which biomarkers are utilized routinely to inform clinical decisions. This review aims to highlight the most promising predictive and prognostic biomarkers in Barrett’s esophagus and EA and to discuss what is required to move the field forward towards clinical application.

关键词： Barrett’s esophagus Esophageal adenocar cinoma Esophageal dysplasia Prognosis

A Review of Graphene Oxide Crosslinking as Enhanced Corrosion Shield Application

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Journal of Renewable Materials 2023年第6期11卷 2745-2770页

作者： Nurul Anis Athirah Ab Aziz chin Wei Lai Boon Hoong ong Nanotechnology&Catalysis Research Centre Institute for Advanced StudiesUniversity of MalayaKuala Lumpur50603Malaysia

Nowadays,corrosion is not only undesirable,but it also has a significant influence on the industrial sectors and technical innovations that have demand for *** global economic damage is expected to reach$2.5 trillion,equivalent to more than 3.4%of the world’s GDP in *** is linked with significant financial harm,manufacturing pollution,and safety *** electrochemical process primarily induces metal corrosion at the metalelectrolyte interface region,caused by steel oxidation and the reduction of oxygen,protons,and ***,organic and epoxy coatings can be applied as protective ***,it can prevent metal corrosion in various fields due to its unique properties,like the ability to manage its curing process over a long *** review paper focuses on improving the physicomechanical properties of modified graphene oxide(GO)coating by attaching a polymer,epoxy resin(EP).Moreover,we reviewed recent achievements for different methods in minimizing a corrosion ***,we considered the modification of epoxy resin using the curing agent as a bridge to the polymer to strengthen the functionalization of nanocomposites during the ***,we discussed the relationship between the modified GO/EP anticorrosive coating and physicomechanical properties since it is currently being questioned and remains *** a result,extensive studies on the mechanism of synthesis of the modified GO/EP anticorrosive coating were highlighted.

关键词： Corrosion anticorrosive graphene polymer epoxy resins

Lateral displacement of soft ground under vacuum pressure and surcharge load

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Frontiers of Structural and Civil Engineering 2011年第2期5卷 239-248页

作者： chin-Yee ong Jin-Chun CHAI Department of Civil Engineering and Architecture Saga UniversitySaga 840-8502Japan

Surcharge load(*** fill)will induce settlement and outward lateral displacement,while vacuum pressure will induce settlement and inward lateral displacement of a ***,combination of surcharge load and vacuum pressure can reduce or minimize the lateral *** large scale model(length:1.50 m,width:~0.62 m,height:0.85 m)tests and finite element analyses(FEA)were conducted to investigate the main influencing factors on lateral displacement of a soft clayey ground under the combination of vacuum pressure and surcharge *** the conditions investigated,the results indicate that the outward lateral displacement increases with the increase of the ratio of surcharge load to vacuum pressure(RL)and the loading rate of the surcharge load(LR).Also,it is shown that for a given RL and LR condition,lateral displacement reduces with the increase of the initial undrained shear strength(Su)of the *** predict the lateral displacement of a ground under the combination of surcharge load and vacuum pressure,the loading conditions in terms of RL and LR,and Su value of the ground have to be considered.

关键词： vacuum consolidation lateral displacement PVD finite element analysis surcharge load

Guest Editorial:Special issue on advances in representation learning for computer vision

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 1-3页

作者： Andrew Beng Jin Teoh Thian Song ong Kian Ming Lim chin Poo Lee Electrical and Electronic Engineering Department Yonsei UniversitySeoulSouth Korea Faculty of Information Science and Technology Multimedia UniversityMelakaMalaysia

Deep learning has been a catalyst for a transformative revo-lution in machine learning and computer vision in the past *** these research domains,methods grounded in deep learning have exhibited exceptional performance across a spectrum of *** success of deep learning methods can be attributed to their capability to derive potent representations from data,integral for a myriad of downstream *** representations encapsulate the intrinsic structure,fea-tures,or latent variables characterising the underlying statistics of visual *** these achievements,the challenge per-sists in effectively conducting representation learning of visual data with deep models,particularly when confronted with vast and noisy *** special issue is a dedicated platform for researchers worldwide to disseminate their latest,high-quality articles,aiming to enhance readers'comprehension of the principles,limitations,and diverse applications of repre-sentation learning in computer vision.

关键词： spite computer representation