Enrichment of novel Tau isoform with altered biochemical properties in Alzheimer's disease

作     者：Chin-Tong Ong Chin-Tong Ong

作者机构：Temasek Life Sciences Laboratoryand Department of Biological SciencesNational University of SingaporeSingapore 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第11期

页      面：2397-2398页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100203[医学-老年医学] 10[医学] 

基　　金：supported by core funding provided by Temasek Life Sciences Laboratory (to CTO) 

主　　题：Alzheimer impaired 

摘      要：Aberrant splicing in sporadic Alzheimer’s disease:Alzheimer’s disease (AD) is a progressive neurodegenerative disorder cha racterized by the presence of extracellular amyloid-β plaques and Tau-containing intracellular neurofib rilla ry tangles (Knopman et al.,2021).Cognitive decline in AD due to neuronal and synaptic loss is caused by the complex interplay between pathological amyloid-β and Tau species with the impaired innate clearance *** are two types of AD based on disease aetiology (Knopman et al.,2021).