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太平洋战争前后英日殖民统治与马来亚独立建国运动

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世界历史 2018年第3期 36-56,158页

作者：陈中和马来西亚拉曼大学中华研究院

英国在其殖民统治期间对马来亚各个族群实施分而治之的政策。境内的非马来人被视为外来者,马来人被视为原住民而享有各种特殊的权利。太平洋战争爆发后,日本的殖民统治得到当地许多马来民族主义者的支持。日本殖民政府对马来亚社会分而... 详细信息

英国在其殖民统治期间对马来亚各个族群实施分而治之的政策。境内的非马来人被视为外来者,马来人被视为原住民而享有各种特殊的权利。太平洋战争爆发后,日本的殖民统治得到当地许多马来民族主义者的支持。日本殖民政府对马来亚社会分而治之的方针,以及亲日的马来民兵和华人领导的抗日军的对抗,激发了战后马来人和华人激烈的族群冲突。华人的积极抗日促进英国制定了马来亚联盟方案,认可华人在马来亚生根发展的权利,但也在战后激发马来人开展"民族大团结运动"。由于战争时期崛起的马来亚共产党在战后发动武装革命,英殖民政府积极扶持右派华人领袖和亲英的马来领袖来组织自治政府,并以宽松的条件开放公民权利于非马来人,以打击马共。此举加速了马来亚的独立进程,促进了一个多族群共治的新国家的诞生。

关键词：英属马来亚太平洋战争日本帝国主义马来亚人民抗日军巫统

Ultrasonic-Assisted Production of Biodiesel from Waste Frying Oil Using a Two-Step Catalyzing Process

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Journal of Sustainable Bioenergy Systems 2012年第4期2卷 117-121页

作者： chin-Chiuan Lin Ming-Chien Hsiao Peir-Horng Liao Department of Business Administration Kun-Shan University Tainan Taiwan Department of Environment Engineering Kun-Shan University Tainan Taiwan

This study proposed using waste frying oil rather than refined vegetable oil as an effective way to reduce the raw material cost of producing biodiesel. In addition, the ultrasonic-assisted two-step catalyzing Process was first adopted for the production of biodiesel from waste frying oil. The results show that the total reaction time was less than 50 min and the conversion rate of fatty acid methyl esters (FAMEs) achieved was 97.1%. Therefore, the ultrasonic-assisted two-step catalyzing process has a potential application in producing biodiesel from waste frying oil.

关键词： Ultrasonic Biodiesel Waste Frying Oil

Hybrid Dirac semimetal-based photodetector with efficient low-energy photon harvesting

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Light(Science & Applications) 2022年第3期11卷 107-116页

作者： Lin Wang Li Han Wanlong Guo Libo Zhang Chenyu Yao Zhiqingzi Chen Yulu Chen Cheng Guo Kaixuan Zhang Chia-Nung Kuo chin Shan Lue Antonio Politano Huaizhong Xing Mengjie Jiang Xianbin Yu Xiaoshuang Chen Wei Lu State Key Laboratory for Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of Sciences500 Yu-tian RoadShanghai 200083China Department of Optoelectronic Science and Engineering Donghua UniversityShanghai 201620China College of Physics and Optoelectronic Engineering Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesNo.1Sub-Lane XiangshanXihu DistrictHangzhou 310024China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China The 50th Research Institute of china Electronics Technology Group Shanghai 200331China Research Center for Intelligent Network Zhejiang LabHangzhou 311121China Department of Physics Cheng Kung University1 Ta-Hsueh Road70101 TainanTaiwanChina INSTM and Department of Physical and Chemical Sciences University of L’Aquilavia Vetoio67100 L’Aquila(AQ)Italy CNR-IMM Istituto per la Microelettronica e Microsistemi VIII strada 5I-95121 CataniaItaly

Despite the considerable effort,fast and highly sensitive photodetection is not widely available at the low-photon-energy range(~meV)of the electromagnetic spectrum,owing to the challenging light funneling into small active areas with efficient conversion into an electrical ***,we provide an alternative strategy by efficiently integrating and manipulating at the nanoscale the optoelectronic properties of topological Dirac semimetal PtSe_(2)and its van der Waals ***,we realize strong plasmonic antenna coupling to semimetal states near the skin-depth regime(λ/10^(4)),featuring colossal photoresponse by in-plane symmetry *** observed spontaneous and polarization-sensitive photocurrent are correlated to strong coupling with the nonequilibrium states in PtSe_(2)Dirac semimetal,yielding efficient light absorption in the photon range below 1.24 meV with responsivity exceeding∼0.2 A/W and noise-equivalent power(NEP)less than~38 pW/Hz^(0.5),as well as superb ambient *** results pave the way to efficient engineering of a topological semimetal for high-speed and low-energy photon harvesting in areas such as biomedical imaging,remote sensing or security applications.

关键词： stability Dirac topological

为了生存还是为了生活?弱势创业者的行业选择

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南方经济 2023年第8期 134-152页

作者：朱虹明陈国福 chin Ho Kalson Hoi 唐炎钊重庆工商大学经济学院重庆市361005 厦门大学管理学院 Shanghai American School

弱势创业者是最需要帮助也最易被忽视的群体之一,其创业行业选择以路径依赖的方式塑造着新创企业的绩效潜力,关系着创业和个体幸福双重质量,是创业与民生领域的交叉课题。研究基于个人—环境匹配理论视角,探索“为了生活”的主动观下弱... 详细信息

弱势创业者是最需要帮助也最易被忽视的群体之一,其创业行业选择以路径依赖的方式塑造着新创企业的绩效潜力,关系着创业和个体幸福双重质量,是创业与民生领域的交叉课题。研究基于个人—环境匹配理论视角,探索“为了生活”的主动观下弱势创业者的行业选择机制及其作用的边界条件。基于中国劳动力动态调查(china Labor-force Dynamics Survey,CLDS)数据的实证分析发现:弱势创业者倾向于进入低门槛行业创业,其在低门槛行业创业能够感知到更高的经济满意度和生活选择自由度的提升;高层次需求将提升个人需求与环境供应的匹配度,进而增加其进入低门槛行业创业的可能性;而弱势创业者的过度自信所引发的环境要求与个人能力匹配度的感知偏差,将增加其进入高门槛行业创业的可能性。研究结论表明,弱势创业者进入低门槛行业是出于个人—环境匹配且能够实现幸福感提升的理性选择。这挑战了现有文献中弱势创业者因资源匮乏被迫进入低门槛创业的隐含假设以及弱势创业者在低门槛行业创业低绩效、低创新、低增长导致低价值的刻板认知。文章对指导弱势创业者的行业选择,推动实现包容性增长有启示意义。

关键词：弱势创业者行业选择低门槛创业高层次需求个人—环境匹配理论

High-resolution microendoscopy for esophageal cancer screening in china: A cost-effectiveness analysis

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World Journal of Gastroenterology 2015年第18期21卷 5513-5523页

作者： chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy Institute for Technology Assessment Massachusetts General Hospital Harvard Medical School Boston MA 02114 United States Gastrointestinal Unit Massa- chusetts General Hospital Department of Endoscopy Cancer Institute and Hospital Chinese Academy of Medical Sciences Department of Endoscopy The First Hospital of Jilin University Department of Pathology The Mount Sinai Medical Center Icahn School of Medicine Department of Pathology Cancer Institute and Hospital Chinese Academy of Medical Sciences Department of Bioengineering Rice University Baylor Global Initiatives and the Baylor Global Innovation Center Baylor College of Medicine

AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in ***:A decision analytic Markov model of ESCC was *** model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in *** 50-year-old individuals were followed until age 80 or *** compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an *** parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer *** states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and *** ESCC incidence transition rates were generated for the average-risk and high-risk *** in chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price ***:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY *** endoscopic screening was weakly *** the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per *** both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per ***-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s i

关键词： Cost-effectiveness analysis Diagnostic imaging Endoscopy Esophageal squamous cell cancer Simulation disease model

当代马来西亚政教关系研究——以伊斯兰法律地位的变迁为视角

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南洋问题研究 2018年第1期 46-62页

作者：陈中和马来西亚拉曼大学中华研究院

在保障宗教自由的前提下,马来西亚在独立时立伊斯兰为官方宗教。惟马哈蒂尔统治时期通过大规模的伊斯兰化政策和伊斯兰法律体制的改革,大举提高了伊斯兰教的法律地位,其对国内穆斯林的日常生活形成严密的规范,也严重冲击马来西亚的世俗... 详细信息

在保障宗教自由的前提下,马来西亚在独立时立伊斯兰为官方宗教。惟马哈蒂尔统治时期通过大规模的伊斯兰化政策和伊斯兰法律体制的改革,大举提高了伊斯兰教的法律地位,其对国内穆斯林的日常生活形成严密的规范,也严重冲击马来西亚的世俗化体制。但是,实施日渐保守和严厉的伊斯兰规范使得宗教激进主义逐渐发展成为普及马来社会的意识形态,执政党巫统反而日渐受制于伊斯兰化的草根力量,近年来进一步向宗教激进主义靠拢。为今之计,马来苏丹、巫统开明的党领袖和元老、誓言维护世俗体制的其他政党领袖、开明的政府官僚和知识分子成为防止马来西亚世俗体制进一步变化的最后一道防线。

关键词：马来西亚伊斯兰法联邦宪法伊斯兰国巫统马哈蒂尔

Interaction of Immune System Protein with PEGylated and Un-PEGylated Polymeric Nanoparticles

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Advances in Nanoparticles 2017年第3期6卷 103-113页

作者： Matthewos Eshete Kayla Bailey Tuyen Duong Thanh Nguyen Santosh Aryal seong-O Choi Department of Chemistry Mississippi Valley State University Itta Bena MS USA Nanotechnology Innovation Center of Kansas State (NICKS) Kansas State University Manhattan KS USA Department of Chemistry Kansas State University Manhattan KS USA Department of Anatomy and Physiology Kansas State University Manhattan KS USA

Biodegradable Nanoparticles (NPs) are under intense investigation due to their potential application in targeted drug delivery. Upon their entry to the biological system, they encounter the immune system, which limits their availability at the intended site. Most importantly, the innate immune system is the one that acts as the first line of defense against foreign materials. It can be activated by collectin proteins which recognize the structural pattern of polysaccharide on the surface of microorganisms. NPs may interact with these proteins in a similar way, and the interaction may lead to beneficial outcomes in vaccine delivery. On the other hand, in targeted drug delivery, it is desirable for the NPs not to be recognized as foreign material as this may lead to their fast elimination from the system through mechanism such as opsonization. We investigated the interaction of PEGylated and un-PEGylated PLGA NPs with Recombinant Human Mannose-Binding Protein (HMBP) in an effort to understand the effect of surface modification on their binding to the protein. Results show that both PLGA-COOH and PLGA-PEG-NH2 bind to HMBP as studied using dynamic light scattering (DLS), fluoresce and UV-vis spectroscopy. However, their binding is shown to have different effect on the structure of the protein. Study done using fluorescence spectroscopy displayed a decrease in fluorescence emission of the protein upon binding to PLGA-COOH. On the other hand the fluorescence emission of the protein increased upon binding to the PLGA-PEG-NH2 indicating conformational changes in the protein structure.

关键词： Nanoparticles Mannose-Binding Protein Poly (L-Lactic-Co-Glycolic Acid) Nanoparticle Protein Interaction

Ophiobolin B inhibits proliferation of glioblastoma U87MG cells by inducing S phase arrest and caspase-dependent apoptosis

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Ophiobolin B inhibits proliferation of glioblastoma U87MG ce...

Human myoblast genome therapy

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Ki seong Eom Gil-Saeng Jeong Tae Young Kim Department of Neurosurgery College of MedicineWonkwang University College of Pharmacy Wonkwang University

*** Human glioblastoma is the most common primary malignant brain tumor that only weakly responsive to the current therapeutic ***,new therapeutic agents for treat this devastating disease are urgently *** are secondary metabolites of certain fungi belonging to the genera Bipolaris,Drechslera,Cephalosporium and *** sesterterpene-type compounds（C25） are characterized by a unique tricyclic chemical *** B（OPB） is a minor member of a class of phytotoxic metabolites and acts as an inhibitor of calmodulin action in calcium *** has a wide range of biochemical and pharmacological effects,including antitumor activities,but its mechanism of action is not clearly *** this study,we investigated that the relationship between the antiproliferative activities of berberine and the apoptotic pathway associated with its molecular mechanism of action in human glioblastoma U87MG *** and mathods The effect of berberine on cell viability was quantified using MTT *** cytometric analysis was used to measure the cellular DNA *** blot analysis was performed using primary antibodies against p21,p27,cyclin-dependent kinase（CDK）2,CDK4,cyclin B,cyclin A,cyclin E,Bcl-2,Bax,caspase-9,caspase-3,poly（ADPribose） polymerase（PARP）,and *** nuclei of U87MG cells were stained with DAPI in order to assess the degree of *** data shown are a summary of the results from at least three experiments and statistical evaluation of the results was performed by One-way analysis of variance（ANOVA）.*** OPB significantly decreased the cell viability of U87MG cells in a dose-dependent *** cytometry showed a dose dependent increase of S phase arrested after treatment with OPB in U87MG *** blot analysis showed that the OPB-induced S phase arrest was mediated through the increased expression of cyclin-dependent kinase inhibitor（CDKi） proteins（p21 and p27） a

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Journal of Geriatric Cardiology 2006年第3期3卷 135-151页

作者： Peter K Law Danlin M Law Eugene KW Sim Khawja H Haider Margarita N Vakhromeeva Ilia I Berishvili Leo A Bockeria Choong-chin Liew Cell Transplants Asia Ltd. Canada National University Medical Institutes National University of Singapore Singapore Department of Pathology and Laboratory Medicine University of Cincinnati Ohio USA Bakoulev Scientific Center for Cardiovascular Surgery Russian Academy of Medical Sciences Russia Bingham and Women's Hospital The Cardiovascular Genome Unit Harvard Medical School USA

Human Myoblast Genome Therapy (HMGT) is a platform technology of cell transplantation, nuclear transfer, and tissue engineering. Unlike stem cells, myoblasts are differentiated, immature cells destined to become muscles. Myoblasts cultured from satellite cells of adult muscle biopsies survive, develop, and function to revitalize degenerative muscles upon transplantation. Injection injury activates regeneration of host myofibers that fuse with the engrafted myoblasts, sharing their nuclei in a common gene pool of the syncytium. Thus, through nuclear transfer and complementation, the normal human genome can be transferred into muscles of patients with genetic disorders to achieve phenotype repair or disease prevention. Myoblasts are safe and efficient gene transfer vehicles endogenous to muscles that constitute 50% of body weight. Results of over 280 HMGT procedures on Duchenne Muscular Dystrophy (DMD) subjects in the past 15 years demonstrated absolute safety. Myoblast-injected DMD muscles showed improved histology. Strength increase at 18 months post-operatively averaged 123%. In another application of HMGT on ischemic cardiomyopathy, the first human myoblast transfer into porcine myocardium revealed that it was safe and effective. Clinical trials on approximately 220 severe cardiomyopathy patients in 15 countries showed a way to confirm these preliminary results. The future of HMGT is bright and exciting.

关键词： heart regeneration human genome therapy myoblasts