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Journal of Materials Science & Technology 2022年第17期112卷 291-300页

作者： Hongcan Chen Wei Xu Qun Luo Qian Li Yu Zhang Jingjing Wang Kuo-chih Chou State Key Laboratory of Advanced Special Steel&Shanghai Key Laboratory of Advanced Ferrometallurgy&School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China National Engineering Research Center for Magnesium Alloy Chongqing UniversityChongqing 400044China Ansteel Beijing Research Institute Co. LtdBeijing 102211China

Martensitic transformation is significant to strengthen steels,but its thermodynamic prediction is restricted to simple systems due to lacking multicomponent interaction *** driving forces of martensitic transformation can be divided into chemical and non-chemical driving *** magnetic parameters are carefully optimized because it affects the magnetic Gibbs free energy of austenite and ferrite,and have big impact on the chemical driving *** dilatational strain energy provides major contribution to non-chemical driving force,thus the integrated-models for dilatational coefficient are constructed in a wide composition and temperature range based on the experimental dilatational *** expands the scope of application of thermodynamic model and improved prediction accuracy of martensitic transformation temperature(M_(s)).The prediction error reaches 5.6%for Fe-C-X(X=Ni,Mn,Si,Cr)and6.5%for Fe-C-Mn-Si-X(X=Cr,Ni)steels.

关键词： Martensitic transformation Thermodynamics Dilatational strain energy Linear expansion coefficient Fe-C-X(X=Ni,Mn,Si,Cr)system

Experimental investigation and thermodynamic assessment of La-Y-Ni ternary system in Ni-rich corner

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Rare Metals 2023年第4期42卷 1316-1331页

作者： Sheng-Xiang Wu Li Wang Hui-Ping Yuan Qun Luo Qian Li Kuo-chih Chou State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou014030China State Key Laboratory of Advanced Special Steels Shanghai Key Laboratory of Advanced FerrometallurgySchool of Materials Science and EngineeringShanghai UniversityShanghai200444China GRIMAT Engineering Institute Co. Ltd.Beijing101407China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing400044China

La-Y-Ni alloys exhibit high discharge capacity due to the formation of AB_(3-3.8)-type(A=La,Y;B=Ni)intermetallic ***,the stable composition and temperature range for this type of phase are rarely reported,which restrains the development of La-Y-Ni hydrogen storage alloys with stable structure and high *** paper focuses on the phase equilibria of the La-Y-Ni ternary system in Ni-rich *** phase constitution,microstructure,and equilibrated composition were experimentally determined at 1273 and 1148 K using X-ray diffraction(XRD),scanning electron microscopy(SEM),and energy-dispersive spectroscopy(EDS).The solubilities of La and Y in the binary compounds were *** ternary compounds,3R-LaY_(2)Ni_(9)with the structure of PuNi3 type and La_(0.5)Y_(0.5)Ni_(5)with the structure of CaCu5 type,existed at both *** on the experimental data,the thermodynamic description of LaY-Ni system was assessed by Calculation of Phase Diagram *** calculated isothermal sections agree with the experimental *** thermodynamic database is helpful for the design of La-Y-Ni hydrogen storage alloys.

关键词： La-Y-Ni system Phase equilibria Calculation of Phase Diagram(CALPHAD) Isothermal section Phase transformation

Survival and comorbidities in lung cancer patients:Evidence from administrative claims data in Germany

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Oncology Research 2022年第4期30卷 173-185页

作者： DIEGO HERNANDEZ chih-YUAN CHENG KARLA HERNANDEZ-VILLAFUERTE MICHAEL SCHLANDER Division of Health Economics German Cancer Research Center(DKFZ)HeidelbergGermany Medical Faculty Mannheim Heidelberg UniversityMannheimGermany

Lung cancer is the most common cancer type worldwide and has the highest and second highest mortality rate for men and women respectively in ***,the role of comorbid illnesses in lung cancer patient prognosis is still *** analyzed administrative claims data from one of the largest statutory health insurance(SHI)funds in Germany,covering close to 9 million people(11%of the national population);observation period was from 2005 to *** cancer patients and their concomitant diseases were identified by ICD-10-GM *** were classified according to the Charlson Comorbidity Index(CCI).Incidence,comorbidity prevalence and survival are estimated considering sex,age at diagnosis,and place of *** Meier curves with 95%confidence intervals were built in relation to common *** identified 70,698 lung cancer incident cases in the *** and survival figures are comparable to official statistics in *** prevalent comorbidities are chronic obstructive pulmonary disease(COPD)(36.7%),followed by peripheral vascular disease(PVD)(18.7%),diabetes without chronic complications(17.4%),congestive heart failure(CHF)(16.5%)and renal disease(14.7%).Relative to overall survival,lung cancer patients with CHF,cerebrovascular disease(CEVD)and renal disease are associated with largest drops in survival probabilities(9%or higher),while those with PVD and diabetes without chronic complications with moderate drops(7%or lower).The study showed a negative association between survival and most common comorbidities among lung cancer patients,based on a large sample for *** research needs to explore the individual effect of comorbidities disentangled from that of other patient characteristics such as cancer stage and histology.

关键词： Lung Cancer Comorbidities Survival Administrative data Statutory health insurance

A Deep Learning-Based Continuous Blood Pressure Measurement by Dual Photoplethysmography Signals

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Computers, Materials & Continua 2022年第2期70卷 2937-2952页

作者： chih-Ta Yen Sheng-Nan Chang Liao Jia-Xian Yi-Kai Huang Department of Electrical Engineering Taiwan Ocean UniversityKeelung202301Taiwan Department of Internal Medicine National Taiwan UniversityYun-Lin BranchDou-Liu640Taiwan Department of Electrical Engineering National Formosa UniversityYunlin632Taiwan

This study proposed a measurement platform for continuous blood pressure estimation based on dual photoplethysmography(PPG)sensors and a deep learning(DL)that can be used for continuous and rapid measurement of blood pressure and analysis of cardiovascular-related *** proposed platform measured the signal changes in PPG and converted them into physiological indicators,such as pulse transit time(PTT),pulse wave velocity(PWV),perfusion index(PI)and heart rate(HR);these indicators were then fed into the DL to calculate blood *** hardware of the experiment comprised 2 PPG components(i.e.,Raspberry Pi 3 Model B and analog-todigital converter[MCP3008]),which were connected using a serial peripheral *** DL algorithm converted the stable dual PPG signals acquired from the strictly standardized experimental process into various physiological indicators as input parameters and finally obtained the systolic blood pressure(SBP),diastolic blood pressure(DBP)and mean arterial pressure(MAP).To increase the robustness of the DL model,this study input data of 100 Asian participants into the training database,including those with and without cardiovascular disease,each with a proportion of approximately 50%.The experimental results revealed that the mean absolute error and standard deviation of SBP was 0.17±0.46 *** mean absolute error and standard deviation of DBP was 0.27±0.52 *** mean absolute error and standard deviation of MAP was 0.16±0.40 mmHg.

关键词： Deep learning(DL) blood pressure continuous non-invasive blood pressure measurement photoplethysmography(PGG)

Inter-Purchase Time Prediction Based on Deep Learning

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Computer Systems Science & Engineering 2022年第8期42卷 493-508页

作者： Ling-Jing Kao chih-Chou Chiu Yu-Fan Lin Heong Kam Weng Department of Business Management National Taipei University of TechnologyTaipei106Taiwan Digital Transformation Institute Institute for Information IndustryTaipei106Taiwan

Inter-purchase time is a critical factor for predicting customer *** the prediction accuracy can exploit consumer’s preference and allow businesses to learn about product or pricing plan weak points,operation issues,as well as customer expectations to proactively reduce reasons for *** remarkable progress has been made,classic statistical models are difficult to capture behavioral characteristics in transaction data because transaction data are dependent and short-,medium-,and long-term data are likely to interfere with each other *** from literature,this study proposed a hybrid inter-purchase time prediction model for customers of on-line ***,the analysis of differences in the purchase behavior of customers has been particularly *** integrated self-organizing map and Recurrent Neural Network technique is proposed to not only address the problem of purchase behavior but also improve the prediction accuracy of inter-purchase *** permutation importance method was used to identify crucial variables in the prediction model and to interpret customer purchase *** performance of the proposed method is evaluated by comparing the prediction with the results of three competing approaches on the transaction data provided by a leading e-retailer in *** study provides a valuable reference for marketing professionals to better understand and develop strategies to attract customers to shorten their inter-purchase times.

关键词： Purchasing behavior e-commerce inter-purchase time self-organizing map recurrent neural network

Metabolic reprogramming in inflammaging and aging in T cells

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Life Metabolism 2023年第5期2卷 17-24页

作者： Alessio Bevilacqua Ping-chih Ho Fabien Franco Department of Fundamental Oncology University of Lausanne1007 LausanneSwitzerland Ludwig Institute for Cancer Research University of Lausanne1066 EpalingesSwitzerland

Aging represents an emerging challenge for public health due to the declined immune responses against pathogens, weakened vaccination efficacy, and disturbed tissue homeostasis. Metabolic alterations in cellular and systemic levels are also known to be cardinal features of aging. Moreover, cellular metabolism has emerged to provide regulations to guide immune cell behavior via modulations on signaling cascades and epigenetic landscape, and the aberrant aging process in immune cells can lead to inflammaging, a chronic and low-grade inflammation that facilitates aging by perturbing homeostasis in tissues and organs. Here, we review how the metabolic program in T cells is influenced by the aging process and how aged T cells modulate inflammaging. In addition, we discuss the potential approaches to reverse or ameliorate aging by rewiring the metabolic programming of immune cells.

关键词： immunometabolism inflammaging T cells

Asian Horseshoe Crab Bycatch in Intertidal Zones of the Northern Beibu Gulf:Suggestions for Conservation Management

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Journal of Ocean University of China 2022年第3期21卷 611-621页

作者： WANG Chun-chieh CHEN Ruifang YANG Xin WEN Yulong KUANG Yang ZHANG Ce ZHU Junhua KWAN Kit Yue Guangxi Key Laboratory of Marine Environmental Science Guangxi Beibu Gulf Marine Research CenterGuangxi Academy of SciencesNanning530007China Guangxi Key Laboratory of Beibu Gulf Marine Biodiversity Conservation College of Marine SciencesBeibu Gulf UniversityQinzhou535011China

Bycatch poses a severe challenge to global fishery *** studies have focused on marine megafauna bycatch,research on relevant issues regarding invertebrates is limited,particularly for the threatened horseshoe *** this study,the distribution of fishing gears and the bycatch intensity of Asian horseshoe crabs in the intertidal zones of the northern Beibu Gulf that harbors the most abundant juvenile Asian horseshoe crabs populations in China were *** intertidal nursery habitats for Tachypleus tridentatus and Carcinoscorpius rotundicauda were surveyed from May to July in 2021.A transect that crossed the tidal creeks and tidal flats between the high tide embankment/vegetation and low tide line of a given habitat was surveyed during the ebb *** type,number,and GPS of fishing gears were recorded when sighted,and the number and prosomal width of each horseshoe crab species were *** intensities differed among habitats,ranging from 0.3 to 18.4 and 1.2 to 22.7 individuals per kilometer of transect for *** and ***,*** the three identified fishing gear types,ground cages and stick net sets caused a stronger bycatch pressure on these two *** *** bycatch and *** bycatch were large individuals in late juvenile and adult ***,the ground cages and stick net sets along/near the tidal creeks,mangrove fringe,and low tide line should be regulated and removed to ensure the functionality of the intertidal zone as the spawning corridor and nursery habitat of Asian horseshoe crabs.

关键词： Tachypleus tridentatus Carcinoscorpius rotundicauda ground cage stick net tidal creek mangrove low tide line spawning corridor

Treatment of portal hypertension

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World Journal of Gastroenterology 2012年第11期18卷 1166-1175页

作者： Khurram Bari Guadalupe Garcia-tsao Section of Digestive Diseases Yale University School of MedicineNew HavenCT and VA-Connecticut Healthcare SystemWest HavenCT 06520United States

Portal hypertension is the main complication of cirrhosis and is defined as an hepatic venous pressure gradient(HVPG) of more than 5 *** significant portal hypertension is defined as HVPG of 10 mmHg or *** of gastroesophageal varices and variceal hemorrhage are the most direct consequence of portal *** the last decades significant advancements in the field have led to standard treatment *** clinical recommendations have evolved mostly as a result of randomized controlled trials and consensus conferences among experts where existing evidence has been reviewed and future goals for research and practice guidelines have been *** of varices/variceal hemorrhage is based on the clinical stage of portal *** specific treatment has shown to prevent the formation of *** of first variceal hemorrhage depends on the size/characteristics of *** patients with small varices and high risk of bleeding,nonselective b-blockers are recommended,while patients with medium/large varices can be treated with either b-blockers or esophageal band *** of care for acute variceal hemorrhage consists of vasoactive drugs,endoscopic band ligation and antibiotics *** intrahepatic portosystemic shunt(TIPS) is reserved for those who fail standard of care or for patients who are likely to fail("early TIPS").Prevention of recurrent variceal hemorrhage consists of the combination of b-blockers and endoscopic band ligation.

关键词：治疗方案高压受体阻滞剂静脉曲张临床意义毫米汞柱 TIPS 压力梯度

Uncovering Hidden Fiduciaries in South Korean Private Law

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Contemporary Social Sciences 2022年第2期7卷 137-155页

作者： Ying-chieh Wu School of Law Seoul National University.

This article attempts to extend the list of fiduciary relationship by unlocking some of the hidden fiduciaries in other areas of South Korean private *** reason for this is as *** exact label of“fiduciary relationship”may not be widely used,but the underlying mechanisms can be found in many other legal relationships under South Korean private *** the clarification of the types of fiduciary relationship,even though it may not be complete,we can come to understand when the fiduciary duty(or the duty of loyalty)and remedies for its breach should be *** article shows us that the following should be considered to be fiduciary relationships in addition to trustees and company directors:agents,mandataries,parents and adult guardians,executors of inheritance,commission agents,and *** must be stressed that the list is not yet *** is always the possibility for a new candidate being added to the *** cases must be treated alike,for certainty,systematic consistency,and legal stability are vital for any legal system.

关键词： fiduciary loyalty no-conflict rule no-profit rule mandate

Epigallocatechin-3-gallate exerts antihypertensive effects and improves endothelial function in spontaneously hypertensive rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第7期13卷 287-295页

作者： Yucinda YY Khor Siew-Keah Lee Dharmani Devi M Wei chih Ling Department of Pre-clinical Sciences M.Kandiah Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanSelangorMalaysia Department of Pharmacology Faculty of MedicineUniversiti MalayaKuala LumpurMalaysia

Objective:To investigate the effect of epigallocatechin-3-gallate(EGCG)on endothelial dysfunction in spontaneously hypertensive rats(SHR).Methods:Wistar-Kyoto(WKY)rats and SHR were divided into four groups;WKY control,SHR control and SHR treated with EGCG(50 mg/kg/day)or losartan(10 mg/kg/day).The treatment was given daily for 4 weeks by oral gavage and the blood pressure was monitored by tail-cuff method every 3 *** endothelium-dependent relaxations were assessed in isolated phenylephrine-precontracted aortic rings at the end of *** vascular levels of reactive oxygen species,nitric oxide,tetrahydrobiopterin,and cyclic guanosine monophosphate were also ***,the expression of angiotensinⅡtype 1(AT_(1))receptor protein was ***:The systolic blood pressure was significantly decreased in SHR treated with *** impaired endothelium-dependent relaxation was significantly improved in aortic ring isolated from the EGCG-treated SHR *** also significantly increased the levels of nitric oxide,tetrahydrobiopterin,and cyclic guanosine monophosphate,while decreasing the level of reactive oxygen species and the protein expression of AT_(1)receptor in ***:EGCG attenuates endothelial dysfunction in SHR by decreasing oxidative stress and increasing vascular nitric oxide bioavailability,which may be modulated partly by inhibition of vascular AT_(1)*** increase in endothelium-dependent relaxation may contribute to a decrease in blood pressure in hypertensive animals.

关键词： Epigallocatechin-3-gallate Vascular protection Antihypertension Tetrahydrobiopterin Cyclic guanosine monophosphate Angiotensin typeⅠreceptor Spontaneously hypertensive rats