Metabolic reprogramming in inflammaging and aging in T cells

作     者：Alessio Bevilacqua Ping-Chih Ho Fabien Franco Alessio Bevilacqua;Ping-Chih Ho;Fabien Franco

作者机构：Department of Fundamental OncologyUniversity of Lausanne1007 LausanneSwitzerland Ludwig Institute for Cancer ResearchUniversity of Lausanne1066 EpalingesSwitzerland 

出 版 物：《Life Metabolism》 (生命(代谢(英文))

年 卷 期：2023年第2卷第5期

页      面：17-24页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：P.C.H.was supported in part by the Helmut Horten Foundation the Anna Fuller Grant the Cancer Research Institute Llyod J.OLD STAR Investigator award the Melanoma Research Alliance Established Investigator Award Ludwig Cancer Research and the University of Lausanne 

主　　题：immunometabolism inflammaging T cells 

摘      要：Aging represents an emerging challenge for public health due to the declined immune responses against pathogens, weakened vaccination efficacy, and disturbed tissue homeostasis. Metabolic alterations in cellular and systemic levels are also known to be cardinal features of aging. Moreover, cellular metabolism has emerged to provide regulations to guide immune cell behavior via modulations on signaling cascades and epigenetic landscape, and the aberrant aging process in immune cells can lead to inflammaging, a chronic and low-grade inflammation that facilitates aging by perturbing homeostasis in tissues and organs. Here, we review how the metabolic program in T cells is influenced by the aging process and how aged T cells modulate inflammaging. In addition, we discuss the potential approaches to reverse or ameliorate aging by rewiring the metabolic programming of immune cells.