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Photonics Research 2018年第5期6卷 422-426页

作者： LIANG-YU WEI CHIN-WEI HSU CHI-WAI CHOW chien-hung yeh Department of Photonics and Institute of Electro-Optical Engineering Taiwan Chiao Tung UniversityHsinchu 30010China Department of Electronic Engineering The Chinese University of Hong KongSha TinHong KongChina Department of Photonics Feng Chia UniversityTaichung 40724China

We propose and experimentally demonstrate a recorded 1-m bidirectional 20.231-Gbit/s tricolor R/G/B laser diode(LD) based visible-light communication(VLC) system supporting signal remodulation. In the signal remodulation system, an LD source is not needed at the client side. The client reuses the downstream signal sent from the central office(CO) and remodulates it to produce the upstream signal. As the LD sources are located at the CO, the laser wavelength and temperature managements at the cost-sensitive client side are not *** is the first demonstration, to our knowledge, of a >20 Gbit∕s data rate tricolor R/G/B VLC signal transmission supporting upstream remodulation.

关键词： bidirectional signal remodulation visible-light communication system blue laser

Dynamic Gain-Clamped Amplifier with Backward-Injection of a Fabry-Perot Laser

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光学学报 2003年第S1期23卷 499-500页

作者： chien-hung yeh Chih-Yang Chen chien-Chung Lee Sien Chi Institute of Electro-Optical Engineering Chiao-Tung University 1001 Ta Hsueh Road Hsinchu Taiwan 300

We have been experimentally demonstrated an active control technique of dynamic gain-clamped spectra for theerbium-doped fiber amplifiers (EDFA's) by a backward-injected Fabry-Perot (F-P) laser into this EDFA. In addition, employing a short length erbium-doped fiber (EDF) that not cause any gain saturation for preamplification in front of this amplifier module, it can reduce the noise figure degradation and simultaneously achieve gain variation from 11.1 dB to 0.5 dB for 10 dB input power level change.

关键词： control technique fiber amplifiers noise figure input power

Integration of multiscale entropy and BASED scale of electroencephalography after adrenocorticotropic hormone therapy predict relapse of infantile spasms

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World Journal of Pediatrics 2022年第11期18卷 761-770页

作者： Lin Wan Chu-Ting Zhang Gang Zhu Jian Chen Xiu-Yu Shi Jing Wang Li-Ping Zou Bo Zhang Wen-Bin Shi chien-hung yeh Guang Yang Senior Department of Pediatrics Chinese PLA General HospitalBeijing100000China Department of Pediatrics the First Medical CentreChinese PLA General HospitalBeijingChina Medical School of Chinese People’s Liberation Army BeijingChina School of Information and Electronics Beijing Institute of TechnologyBeijing100081China The Second School of Clinical Medicine Southern Medical UniversityGuangzhouChina Department of Neurology and ICCTR Biostatistics and Research Design Center Boston Children’s HospitalHarvard Medical SchoolBostonMAUSA

Background Even though adrenocorticotropic hormone(ACTH)demonstrated powerful efficacy in the initially successful treatment of infantile spasms(IS),nearly half of patients have experienced a *** sought to investigate whether features of electroencephalogram(EEG)predict relapse in those IS patients without structural brain *** We retrospectively reviewed data from children with IS who achieved initial response after ACTH treatment,along with EEG recorded within the last two days of *** recurrence of epileptic spasms following treatment was tracked for 12 *** were categorized as either non-relapse or relapse *** clinical and EEG recordings were collected,burden of amplitudes and epileptiform discharges(BASED)score and multiscale entropy(MSE)were carefully explored for cross-group *** Forty-one patients were enrolled in the study,of which 26(63.4%)experienced a *** BASED score was significantly higher in the relapse *** in the non-relapse group was significantly lower than the relapse group in theγband but higher in the lower frequency range(δ,θ,α).Sensitivity and specificity were 85.71%and 92.31%,respectively,when combining MSE in theδ/γfrequency of the occipital region,plus BASED score were used to distinguish relapse from non-relapse *** BASED score and MSE of EEG after ACTH treatment could be used to predict relapse for IS patients without brain structural *** with BASED score≥3,MSE increased in higher frequency,and decreased in lower frequency had a high risk of relapse.

关键词： Burden of amplitudes and epileptiform discharges score Infantile spasms Multiscale entropy Prediction Relapse

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2010年台湾心脏病学会高血压管理指南

中华高血压杂志 2011年第1期19卷 9-23页

作者： Chern-En Chiang Tzung-Dau Wang Yi-Heng Li Tsung-Hsien Lin Kuo-Liong chien hung-I yeh Kou-Gi Shyu Wei-Chuen Tsai Ting-Hsing Chao Juey-Jen Hwang Fu-Tien Chiang Jyh-Hong Chen Unknown unit

高血压是心血管疾病和心血管死亡的重要危险因素。从2003年美国高血压预防、检测、评价和治疗全国联合委员会第7次报告（the seventh report of the joint national committee on prevention,detection,evaluation,and treatment of hig... 详细信息

关键词：欧洲心脏病学会高血压协会管理指南 prevention 心血管疾病台湾地区联合委员会危险因素

Microbial diversity of soil bacteria in agricultural field contaminated with heavy metals

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Journal of Environmental Sciences 2008年第3期20卷 359-363页

作者： chien Chihching KUO Yumei CHEN Changchieh hung Chunwei yeh Chihwei yeh Weijen Graduate School of Biotechnology and Bioengineering Yuan Ze University Chung-Li Taiwan 320 China Department of Occupational Safety and Health Chung Hwa University of Medical Technology Tainan Taiwan China

In this study we evaluated the bacterial diversity in a soil sample from a site next to a chemical industrial factory previously contaminated with heavy metals. Analysis of 16S rDNA sequences amplified from DNA directly extracted from the soil revealed 17 different bacterial types （genera and/or species）. They included Polyangium spp., Sphingomonas spp., Variovorax spp., Hafina spp., Clostridia, Acidobacteria, the enterics and some uncultured strains. Microbes able to tolerate high concentrations of cadmium （500μmol/L and above） were also isolated from the soil. These isolates included strains of Acinetobacter （strain CD06）, Enterobacter sp. （strains CD01, CD03, CD04 and CD08）（similar strains also identified in culture-independent approach） and a strain of Stenotrophomonas sp. The results indicated that the species identified from direct analysis of 16S rDNA of the soil can be quite different from those strains obtained from enrichment cultures and the microbial activities for heavy metal resistance might be more appropriately addressed by the actual isolates.

关键词： cadmium heavy metal heavy metal resistant microbial diversity soil bacteria

Re-evaluating the role of pelvic radiation in the age of modern precision medicine and systemic therapy

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World Journal of Clinical Oncology 2024年第1期15卷 1-4页

作者： Tao-Wei Ke Yu-Min Liao Sheng-Chi Chang Che-hung Lin William Tzu-Liang Chen Ji-An Liang Chun-Ru chien Department of Colorectal Surgery China Medical University HospitalTaichung 40402Taiwan School of Chinese Medicine College of Chinese MedicineChina Medical UniversityTaichung 40402Taiwan Division of Hematology and Oncology Department of Internal MedicineChina Medical University HospitalTaichung 40402Taiwan Department of Colorectal Surgery China Medical University Hsinchu HospitalHsinchu 30272Taiwan School of Medicine College of MedicineChina Medical UniversityTaichung 40402Taiwan Department of Radiation Oncology China Medical University HospitalTaichung 40402Taiwan

The efficacy of pelvic radiation in the management of locally advanced stage rectal cancer has come under scrutiny in the context of modern precision medicine and systemic therapy as evidenced by recent clinical trials such as FOWARC(J Clin Oncol 2019;37:3223-3233),NCT04165772(N Engl J Med 2022;386:2363-2376),and PROSPECT(N Engl J Med 2023;389:322-334).In this review,we comprehensively assess these pivotal trials and offer additional insights into the evolving role of pelvic radiation in contemporary oncology.

关键词： Radiotherapy Locally advanced stage rectal cancer Precision medicine Systemic therapy Clinical trial

Prognostic factors of early recurrence after complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

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World Journal of Clinical Cases 2024年第27期12卷 6057-6069页

作者： Chao-Yu Chen Tzu-Hao Huang Li-Wen Lee Jrhau Lung Yu-Che Ou chien-Hui hung Huei-Chieh Chuang Min-Chi Chen Ting-Yao Wang Department of Obstetrics and Gynecology Chang Gung Memorial HospitalChiayi 613Taiwan Graduate Institute of Clinical Medical Sciences College of MedicineChang Gung UniversityTaoyuan 333Taiwan Department of Early Childhood Care and Education Shu-Zen Junior College of Medicine and ManagementKaohsiung 821Taiwan Division of General Surgery Department of SurgeryChang Gung Memorial HospitalChiayi 613Taiwan Department of Diagnostic Radiology Chang Gung Memorial HospitalChiayi 613Taiwan College of Medicine Chang Gung UniversityTaoyuan 333Taiwan Department of Medical Research and Development Chang Gung Memorial HospitalChiayi 613Taiwan Department of Obstetrics and Gynecology Kaohsiung Chang Gung Memorial HospitalKaohsiung 833Taiwan Department of Anatomic Pathology Chang Gung Memorial HospitalChiayi 613Taiwan Department of Public Health Chang Gung UniversityTaoyuan 333Taiwan Division of Hematology and Oncology Department of Internal MedicineChang Gung Memorial HospitalChiayi 613Taiwan

BACKGROUND Although cytoreductive surgery(CRS)and hyperthermic intraperitoneal chemotherapy(HIPEC)offer the potential for long-term survival in peritoneal carcinomatosis,outcomes following CRS/HIPEC vary *** To identify the clinical factors associated with progression-free survival(PFS)after complete CRS/HIPEC in patients with colorectal/high-grade appendiceal,ovarian,and gastric *** We retrospectively evaluated the risk of recurrence within 1 year after CRS/HIPEC and its impact on overall survival(OS)in patients recruited between 2015 and *** regression models were used to assess the prognostic factors for the risk of recurrence within 1 ***–Meier survival curves and Cox proportional hazards models were used to evaluate the association between recurrence and *** Of the 80 enrolled patients,39 had an unfavorable PFS(12 was associated with a lower rate of achieving CC-0(P=0.027).The favorable PFS group had a significantly longer OS(median 81.7 mo vs 17.0 mo,P<0.001).CONCLUSION Achieving CC-0 was associated with a lower early recurrence rate and improved long-term *** study underscores the importance of selecting appropriate candidates for CRS/HIPEC to manage peritoneal carcinomatosis.

关键词： Peritoneal metastasis Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Predictor Recurrence

Mucosal patterns of Helicobacter pylori-related gastritis without atrophy in the gastric corpus using standard endoscopy

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World Journal of Gastroenterology 2010年第4期16卷 496-500页

作者： Shwu-Tzy Wu chien-Hua Chen yeh-Huang hung Tsung-Hsun Yang Vun-Siew Pang Yung-Hsiang yeh Department and Graduate Program of Bioindustrial Technology Dayeh UniversityChanghua County 51591TaiwanChina Division of Gastroenterology Department of Internal MedicineShow-Chwan Memorial HospitalChanghuaCity 500TaiwanChina Division of Gastroenterology Department of Internal MedicineChang Bing Show-Chwan Memorial HospitalChanghua County 505TaiwanChina

AIM:To identify the mucosal patterns of Helicobacter pylori(*** )-related gastritis in the gastric corpus using standard endoscopy and to evaluate their ***:A total of 112 consecutive patients underwent upper gastrointestinal *** endoscopists classified the endoscopic findings into 4 *** the second part of the study,90 images were shown to 3 endoscopists in order to evaluate the inter-observer and intra-observer variability in image ***:The mucosal patterns of the gastric bodywere categorized into 4 *** 1 pattern was defined as cleft-like appearance,type 2 as regular arrangement of red dots,type 3 pattern as the mosaic mucosal pattern and type 4 pattern as the mosaic pattern with a focal area of *** 1 and type 2 mucosal patterns were statistically significant in predicting *** status as compared with other mucosal types(χ 2 = 12.79 and 61.25 respectively,P < 0.01).Type 3 and type 4 mucosal patterns were statistically significant in predicting a ***-positive status as compared with other mucosal types(χ 2 = 21.22 and 11.02 respectively,P < 0.01).Furthermore,the sensitivity,specificity,positive and negative predictive values of type 3 plus type 4 patterns for predicting ***-positive gastric mucosa were 100%,86%,94%,and 100%,*** mean κ values for inter-and intra-observer agreement in assessing the various endoscopic patterns were 0.808(95% CI,0.678-0.938) and 0.826(95% CI,0.727-0.925) ***:Our study suggests that mucosal patterns in ***-infected gastric mucosa without atrophy can be reliably identified using standard endoscopy in the gastric corpus.

关键词： Gastric mucosa Helicobacter pylori Gastritis Digestive system diagnostic techniques Endoscopy

Role of body mass index in colon cancer patients in Taiwan

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World Journal of Gastroenterology 2012年第31期18卷 4191-4198页

作者： Chih-chien Chin Yi-hung Kuo chien-Yuh yeh Jinn-Shiun Chen Reiping Tang Chung-Rong Changchien Jeng-Yi Wang Wen-Shih Huang Division of Colon and Rectal Surgery Department of SurgeryChang Gung Memorial HospitalChiayi 613Taiwan Graduate Institute of Clinical Medical Science College of MedicineChang Gung UniversityTaoyuan 333Taiwan Division of Colon and Rectal Surgery Department of SurgeryChang Gung Memorial HospitalLinko 333Taiwan

AIM： To determine the effect of body mass index （BMI） on the characteristics and overall outcome of colon cancer in Taiwan. METHODS： From January 1995 to July 2003, 2138 patients with colon cancer were enrolled in this study. BMI categories （in kg/m2） were established according to the classification of the Department of Health of Tai- wan. Postoperative morbidities and mortality, and survival analysis including overall survival （OS）, disease- free survival （DFS）, and cancer-specific survival （CSS） were compared across the BMI categories.27 kg/m2） patients. Being female, apparently anemic, hypoalbuminemic, and having body weight loss was more likely among underweight patients than among the other patients （P 〈 0.001）. Underweight patients had higher mortality rate （P = 0.00.7） and lower OS （P 〈 0.001） and DFS （P = 0.002） than the other pa- tients. OS and DFS did not differ significantly between normal-weight, overweight, and obese patients, while CSS did not differ significantly with the BMI category. CONCLUSION： In Taiwan, BMI does not significantly affect colon-CSS. Underweight patients had a higher rate of surgical mortality and a worse OS and DFS than the other patients. Obesity does not predict a worse survival.

关键词： Body mass index Colon cancer Survival IVlorbidity Outcome

Injury-induced rapid activation of MAPK signaling in dechorionated eggs and larvae of the silkworm Bombyx mori

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Insect Science 2017年第2期24卷 248-258页

作者： Shi-Hong Gu chien-hung Chen Department of Biology National Museum of Natural Science Taichung Taiwan China Chung Hwa University of Medical Technol-ogy Tainan County Taiwan China

Previous study showed that diapause in Bombyx mori eggs can be ter- minated by dechorionation and that activation in the mitogen-activated protein kinase （MAPK）/extracellular signal-regulated kinase （ERK） in dechorionated cultured eggs is involved in diapause termination. In the present study, the possible mechanism underlying activation of ERK upon dechorionation was further investigated. Results showed that me- chanical injury of diapause eggs without medium incubation also resulted in rapid increase in the phospho-ERK levels and that injury increased the phospho-ERK levels at different stages of both diapause eggs and eggs in which diapause initiation was prevented by HC1. Effects of anaerobiosis on dechorionation-stimulated phospho-ERK levels showed that the mechanical injury itself but not the dramatic increase in oxygen uptake upon injury is in- volved in a rapid activation of ERK. Chemical anaerobiosis on dechorionation-stimulated phospho-ERK levels and the in vivo effect of anaerobiosis showed that the supply of oxygen also plays a role in ERK signaling. In addition, injury induced the phosphory- lation of c-jun N-terminal kinases （JNKs） and p38 kinase, components of two parallel MAPK pathways. A kinase assay showed a dramatic increase in .INK kinase activity in egg lysates upon injury. When newly hatched first instar larvae were injured, an increase in the phospho-ERK levels similar to that in dechorionated eggs was observed. From the results, we hypothesize that the injury-induced rapid activation of MAPK signaling, which serves as a natural signal for embryonic development, is related to diapause termination in dechorionated eggs.

关键词： Bombyx mori dechorionation embryonic diapause ERK phosphorylation injury MAPK