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Non-linear dynamic state-space network modeling for decoding neurodegeneration

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Neural Regeneration Research 2024年第9期19卷 1879-1880页

作者： Venkata C.chirumamilla chi wang ip Martin Reich Robert Peach Jens Volkmann Bahman Nasseroleslami Muthuraman Muthuraman Prenatal Pediatrics Institute Children’s National HospitalWashingtonDCUSA Neural Engineering with Signal Analytics and Artificial Intelligence Department of NeurologyUniversity of WürzburgWürzburgGermany Academic Unit of Neurology Trinity Biomedical Sciences InstituteTrinity College DublinUniversity of DublinDublinIreland

Neurodegenerative disorders represent a pervasive global health challenge,yet therapeutic options remain conspicuously *** disorders are inherently dynamic processes within the central nervous system,unfolding across distinct sub-stages:initial structural neuronal alterations(sub-stage 1),functional impairment(sub-stage 2),and culminating in neuronal death(sub-stage 3).

关键词： alterations impairment dynamic

Pancreatic stent improves the success rate of needle-knife papillotomy in patients with difficult biliary cannulation

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World Journal of Gastroenterology 2025年第1期31卷 58-67页

作者： Mu-Hsien Lee Cheng-Hui Lin chi-Huan Wu Yung-Kuan Tsou Kai-Feng Sung Sheng-Fu wang Nai-Jen Liu Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital and Chang Gung University College of MedicineTaoyuan 33305Taiwan School of Medicine Chang Gung UniversityTaoyuan 33305Taiwan

BACKGROUND Needle-knife precut papillotomy(NKP)is typically performed ***,it remains unclear whether pancreatic stent(PS)placement can improve the outcomes of *** To explore whether PS placement improves the success rate of NKP in patients with difficult biliary *** This single-center retrospective study included 190 patients who underwent NKP between January 2017 and December 2021 after failed conventional biliary *** cases with incidental pancreatic duct cannulation during conventional biliary cannulation,the decision for pre-NKP PS placement was made at the endoscopist's *** primary outcome was the difference in the NKP success rate between patients with and without PS placement;the secondary outcome was the adverse event *** Among the 190 participants,82 received pre-NKP PS(PS-NKP group)whereas 108 did not[freehand or freehand NKP(FH-NKP)group].Post-NKP selective biliary cannulation was successful in 167(87.9%)patients,and the PS-NKP had a significantly higher success rate than the FH-NKP group(93.9%vs 83.3%,P=0.027).The overall adverse event rates were 7.3%and 11.1%in the PS-NKP and FH-NKP groups,respectively(P=0.493).A periampullary diverticulum(PAD)and significant intraoperative bleeding during NKP were independently associated with NKP failure;however,a pre-NKP PS was the only predictor of NKP *** the 44 participants with PADs,the PS-NKP group had a non-significantly higher NKP success rate than the FH-NKP group(87.5%and 65%,respectively;P=0.076).CONCLUSION PS significantly improved the success rate of NKP in patients with difficult biliary cannulation.

关键词： Difficult biliary cannulation Endoscopic retrograde cholangiopancreatography Needle-knife papillotomy Pancreatic stent Selective biliary cannulation

Structural stability of single-layered LaNi_4.25Al_0.75 film and its electro-chemical hydrogen-storage properties

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Rare Metals 2006年第5期25卷 543-548页

作者： wang Zhongmin chi Ying Vanessa Li ZHOU Huaiying Sammy Lap ip Chan SHI Liu Center of Material Science and Engineering Guilin University of Electronic Technology Guilin 541004 China School of Materials Science and Engineering University of New Sooth Wales Sydney NSW 2052 Australia Institute of Metal Research Chinese Academy of Sciences China

AB5-based hydrogen storage thin fdms （LaNi4.25Al0.75）, deposited on Cu substrate by dc magnetron sputtering were investigated in this study. X-ray diffraction （XRD） revealed that the microstructure of the layer was in crystal form. SEM and AFM analyses proved that the film appeared to be rather rough with numerous randomly sized pores of approximately 15-40 in nm diameter. Structural stability of the film was examined by the combined analyses of DSC, XRD, and SEM, which indicated that this film maintained its structural stability below 500 K or so, and a network structure was observed on the film after being heated at 700 K for 30 min. Electrochemical hydrogen-storage properties of the films were investigated by simulated battery tests. It was found that single-layered LaNi4.25A10.75 film exhibited electrochemical hydrogen-storage properties similar to typical AB5 alloys in bulk, and the maximum discharge capacity of the film was about 220 mAh/g. After 20 charge/discharge cycles, small needle-shaped aluminium oxide was formed on some fractions of the film surface.

关键词： hydrogen storage thin film magnetron sputtering structural stability electrochemical properties

Mechanism of metastasis by membrane type 1-matrix metalloproteinase in hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第40期11卷 6269-6276页

作者： Ying-chi ip Siu-Tim Cheung Ka-Ling Leung Sheung-Tat Fan Centre for the Study of Liver Disease and Department of Surgery

AIM To investigate the precise role of membrane type 1-matrix metalloproteinase （NTI-NNP） in hepatocellular carcinoma （HCC） metastasis. METHODS- Human HCC cells Hep3B with overexpression of MTT-MMP were established by stable transfection, and compared with control cells carrying the empty vector. Cells were examined in vivo for their differences in the metastatic ability of athymic nude mice, and analyzed in vito for their differences in invasion ability by invasion chamber coated with Matrigel, adhesion towards collagen I and migration through culture chamber. Cell proliferation and apoptosis in adherent and suspension status were evaluated by MTr and flow cytometry analysis. RESULTS We found that overexpression of MT1-MMP could increase intrahepatic metastasis in nude mice with orthotopic implantation of HCC cells （incidence of 100% [MT1-MMP transfectants] vs 40% [vector control transfectants], P〈0.05）. NT1-MMP could also enhance cell invasion through Natrigel （107.7 vs 39.3 cells/field, P〈0.001）, adhesion towards matrix （0.30 vs 0.12 absorbance unit at 540 nm, P〈0.001）, cell migration （89.3 vs 39.0 cells/field, P〈0.001）, and cell proliferation （24.3 vs 40.5 h/doubling, P〈0.001）. We also observed that NTI-NNP supported cell survival （71.4% vs 23.9%, P〈0.001） with reduced apoptosis （43.7% vs51.0%, P〈0.05） in an attachment-free environment. CONCLUSION： MT1-MMP overexpression could enhance metastasis. In addition to its active role in matrix degradation during tumor invasion, MT1-MMP enhances tumor cell survival upon challenge of detachment, which is important during metastasis when cells enter the circulation.

关键词： MT1-MMPIMMP14 Liver cancer Invasion Metastasis

Large scale current systems developed from substorm onset:Global MHD results

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Science china(Technological Sciences) 2018年第3期61卷 389-396页

作者： TANG BinBin wang chi State Key Laboratory of Space Weather National Space Science Center Chinese Academy of Sciences

We investigate the large-scale substorm current systems developed from its onset in an idealized substorm event simulated by global magnetohydrodynamic(MHD) models. Mainly three current systems(loops) are revealed:(1) the classical substorm current wedge, which is composed by the disputed cross-tail current in the magnetotail, the nightside westward electrojet in the high-latitude ionosphere and a pair of region 1 field-aligned currents(FAC);(2) the partial-ring current system, which is braced by two region 2 FACs; and(3) the meridional current system, which is formed by an equatorial radial current(outward/inward in the morning/evening sector), and region 1 and region 2 FACs at its two ends. The region 2 FAC connects with region 1 FAC by a latitudinal horizontal current at each morning/evening ionosphere to complete Loops 2 and 3. A quantitative study shows the significant enhancement of these current systems during the substorm expansion phase, while Loop 1 dominates, which can reach a magnitude of ~1 MA. Empirical relations among the ionospheric currents and the related magnetotail currents are established based on the simulation results, implying that the substonn current systems are not evolved locally or separately, but must be viewed from a global perspective. This knowledge of large-scale substorm current system would deepen our understanding of the substorm development and could be validated by observations in the future.

关键词： magnetospheric physics substorm current system magnetohydrodynamic(MHD) simulation

New Chains of Space Weather Monitoring Stations in china

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Bulletin of the chinese Academy of Sciences 2013年第1期27卷 35-40页

作者： wang chi Center for Space Science and Applied Research Chinese Academy of Sciences China State Key Laboratory of Space Weather China chinese Meridian Project China

To develop an understanding of near-Earth space’s response to solar activities and to eventually enhance the success of space weather predictions, it is crucial to make synergetic observations of the entire environment from the Sun to the Earth as a system. Since the beginning of the space era, direct observations by satellites have become a much needed means toward this end. However,

关键词：空间天气监测站卫星地面接收站中国观测卫星地面观测太阳活动近地空间

Electrochemical performance of aluminum niobium oxide as anode for lithium-ion batteries

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Rare Metals 2016年第3期35卷 256-261页

作者： Qi wang Fu-chi wang Xing-wang Cheng School of Material Science and Engineering Beijing Institute of Technology

AlNbO_4,as lithium-ion batteries（LIBs） anode,has a high theoretical capacity of 291.5 m Ah g^-***,AlNbO_4 anode materials were synthesized through a simple solid-state *** structure,morphology and electrochemical performances of AlNbO4 anode were systematically *** results show that AlNbO4 is monoclinic with C2/m space *** scanning electron microscopy（SEM） and transmission electron microscopy（TEM） characterizations reveal the AlNbO_4 particles with the size of 100 nm^–2 *** a lithium-ion batteries anode,AlNbO4 delivers a high reversible capacity and good rate *** discharge capacity is as high as 151.0 m Ah g^-1 after 50 charge and discharge cycles at 0.1 C corresponding to capacity retention of 90.7 %.When the current density increases to 5.0C,AlNbO4 anode displays reversible discharge capacity of 73.6 m Ah g^-1 at the50 th cycle.

关键词： Aluminum niobium oxide Electrochemical performance Anode Lithium-ion batteries

ANTI-DIFFUSIVE FINITE DIFFERENCE WENO METHODS FOR SHALLOW WATER WITH TRANSPORT OF POLLUTANT

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Journal of Computational Mathematics 2006年第3期24卷 239-251页

作者： Zhengfu Xu chi-wang Shu Department of Mathematics Pennsylvania State University University Park PA 16802 USA Division of Applied Mathematics Brown University Providence Rhode Island 02912 USA

In this paper we further explore and apply our recent anti-diffusive flux corrected high order finite difference WENO schemes for conservation laws [18] to compute the SaintVenant system of shallow water equations with pollutant propagation, which is described by a transport equation. The motivation is that the high order anti-diffusive WENO scheme for conservation laws produces sharp resolution of contact discontinuities while keeping high order accuracy for the approximation in the smooth region of the solution. The application of the anti-diffusive high order WENO scheme to the Saint-Venant system of shallow water equations with transport of pollutant achieves high resolution

关键词： Anti-diffusive flux correction Sharpening contact discontinuity High order accuracy Finite difference WENO scheme Saint-Venant system of shallow water Transport of pollutant.

Preface: Frontiers in Astrophysics(Ⅱ)——A special issue dedicated to the 20th anniversary of RAA(2001–2020)

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Research in Astronomy and Astrophysics 2020年第10期20卷 157-159页

作者： Jingxiu wang Wing-Huen ip University of chinese Academy of Sciences Beijing 100049 National Astronomical Observatories Chinese Academy of SciencesBeijing 100101 Institute of Astronomy “National”Central UniversityZhongliTaoyuan 32049

On the arrival of the 20 th anniversary of the journal,Research in Astronomy and Astrophysics(RAA),we see rapid progress in the frontiers of astronomy and *** celebrate the birth and growth of RAA,a special issue consisting of 11 invited reviews from more than 30 authors,mainly from china,has been *** is the second volume of the special issues entitled Frontiers in Astrophysics published in *** publication aims at evaluating the current status and key progress in some frontier areas of astronomy and astrophysics with a spirit of guiding future studies.

关键词： galaxies:statistics Galaxy:structure stars:binaries,black holes planetary systems Sun:CMEs,filaments,magnetic fields astronomical instrumentation,methods and techniques