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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 308-314页

作者： Ka Wing Ma Albert chi yan Chan Kenneth Siu Ho Chok Wong Hoi She Tan To Cheung Wing chiu Dai James yan Yue Fung Chung Mau Lo Department of Surgery The University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina

Background:Hepatocellular carcinoma(HCC)with portal vein tumour thrombus(PVTT)signifies advanced disease,whether LT confers any survival superiority over resection remains ***:A propensity score matched(PSM)analysis of liver transplantation(LT)and liver resection(LR)for HCC with PVTT was ***:A consecutive series of 88 patients who received either LT(10 DDLTs and 3 LDLTs)or LR(n=75)respectively were *** PSM,the LT group has a higher MELD score(17.3 vs.7.8,Pching for serum AFP levels and tumour size,1-,3-and 5-year overall survival for LT were 81 ng/mL,3.9 cm,80%,70%and 70%and the corresponding rates for LR were 1,417 ng/mL,5.3 cm,51.8%,19,6%and 9.8%(P value=0.12,0.27 and 0.009 respectively).Conclusions:LT is associated with significantly better oncological outcomes in HCC patients with PVTT involving the lobar or segmental level.A modest expansion of selection criteria to include small HCC with segmental PVTT should be considered.

关键词： Liver transplantation(LT) portal vein tumour thrombus liver resection(LR)Submitted Aug 10,2019.Accepted for publication Oct 15,2019.

Impact of small-for-size liver grafts on medium-term and long-term graft survival in living donor liver transplantation: A meta-analysis

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World Journal of Gastroenterology 2019年第36期25卷 5559-5568页

作者： Ka Wing Ma Kelly Hiu ching Wong Albert chi yan Chan Tan To Cheung Wing chiu Dai James yan Yue Fung Wong Hoi She Chung Mau Lo Kenneth Siu Ho Chok Department of Surgery Queen Mary Hospital Hong Kong China Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China Department of Surgery The University of Hong Kong Hong Kong China Department of Medicine Queen Mary Hospital Hong Kong China

BACKGROUND Small-for-size grafts (SFSGs) in living donor liver transplantation (LDLT) could optimize donor postoperative outcomes and also expand the potential donor pool. Evidence on whether SFSGs would affect medium-term and long-term recipient graft survival is lacking. AIM To evaluate the impact of small-for-size liver grafts on medium-term and longterm graft survival in adult to adult LDLT. METHODS A systematic review and meta-analysis were performed by searching eligible studies published before January 24, 2019 on PubMed, EMBASE, and Web of Science databases. The primary outcomes were 3-year and 5-year graft survival. Incidence of small-for-size syndrome and short term mortality were also extracted. RESULTS This meta-analysis is reported according to the guidelines of the PRISMA 2009 Statement. Seven retrospective observational studies with a total of 1821 LDLT recipients were included in the meta-analysis. SFSG is associated with significantly poorer medium-term graft survival. The pooled odds ratio for 3-year graft survival was 1.58 [95% confidence interval 1.10-2.29, P = 0.014]. On the other hand, pooled results of the studies showed that SFSG had no significant discriminatory effect on 5-year graft survival with an odds ratio of 1.31 (95% confidence interval 0.87-1.97, P = 0.199). Furthermore, incidence of small-for-size syndrome detected in recipients of SFSG ranged from 0-11.4% in the included studies. CONCLUSION SFSG is associated with inferior medium-term but not long-term graft survival. Comparable long-term graft survival based on liver graft size shows that smaller grafts could be accepted for LDLT with appropriate flow modulatory measures. Close follow-up for graft function is warranted within 3 years after liver transplantation.

关键词： Living donor liver transplantation Small-for-size grafts Small-for-size syndrome Graft survival

Survival outcomes of liver transplantation for hepatocellular carcinoma in patients with normal, high and very high preoperative alpha-fetoprotein levels

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World Journal of Hepatology 2018年第2期10卷 308-318页

作者： Wong Hoi She Albert chi yan Chan Tan To Cheung Chung Mau Lo Kenneth Siu Ho Chok Department of Surgery University of Hong Kong Department of Surgery and State Key Laboratory for Liver Research University of Hong Kong

AIM To investigate the impact of alpha-fetoprotein(AFP) on long-term recurrence rate and overall survival and we also aimed to define the level of AFP leading to a higher risk of disease recurrence and affecting patient *** Data of adult patients who received liver transplant(LT) for hepatocellular carcinoma(HCC) at our hospital from January 2000 to December 2013 were reviewed. Reviewed data included demographic characteristics, preoperative AFP level, operative details, follow-up details, and survival outcomes. Patients were mostly listed for LT based on Milan or UCSF criteria. For the purpose of this study, normal AFP level was defined as AFP value < 10 ng/m L, high AFP level was defined as AFP value ≥ 10 to < 400 ng/m L, and very highAFP level was defined as AFP ≥ 400 ng/m L. The patients were divided into these 3 groups accordingly. Survival rates were plotted as Kaplan-Meier curves and compared by log-rank analysis. Continuous variables were expressed as median(interquartile range). Categorical variables were compared by Spearman's test. Discriminative analysis was used to define the lowest value of AFP that could affect the overall survival in study population. Statistical significance was defined by a P value of < *** Totally 250 adult patients underwent LT for HCC in the study period. Eight-four of them received deceaseddonor LT and 166 had living-donor LT. The patients were divided into 3 groups: Group A, AFP < 10 ng/m L(n = 83); Group B, AFP ≥ 10 to < 400 ng/m L(n = 131); Group C, AFP ≥ 400 ng/m L(n = 36). The commonest etiology was hepatitis-B-related cirrhosis. The Model for End-stage Liver Disease scores in these groups were similar(median, 13 vs 13 vs 12; P = 0.745). The time to operation in Group A was longer(median, 94 vs 31 vs 35 d; P = 0.001). The groups were similar in hospital mortality(P = 0.626) and postoperative complication(P = 0.702). Pathology of explants showed that the 3 groups had similar numbers of tumor nodules, b

关键词： Alpha-fetoprotein Liver transplantation Recurrence Survival

New antibacterial depsidones from an ant-derived fungus Spiromastix ***-1

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chinese Journal of Natural Medicines 2022年第8期20卷 627-632页

作者： GUO Zhi-Kai HU Wen-Yong ZHAO Li-Xing CHEN yan-chi LI Sui-Jun CHENG Ping GE Hui-Ming TAN Ren-Xiang JIAO Rui-Hua State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesSchool of Life SciencesNanjing UniversityNanjing 210093China Hainan Key Laboratory of Tropical Microbe Resources Institute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural SciencesHaikou 571101China Yunnan Key Laboratory of Vaccine Research&Development on Severe Infectious Diseases Institute of Medical BiologyChinese Academy of Medical SciencesKunming 650118China Yunnan Institute of Microbiology Yunnan UniversityKunming 650091China

Six new(1–6)and seven known depsidones(7–13)were isolated from the culture of an ant(Monomorium chinensis)-derived fungus Spiromastix *** structures were elucidated by extensive spectroscopic analysis including high resolution MS,1D and 2D NMR *** new bromide depsidones were obtained through supplementing potassium bromide in the fermentation medium of Spiromastix *** isolated compounds showed various bioactivities against the tested phytopathogenic ***,new bromide compound 4,named spiromastixone S,exhibited the strongest activity against Xanthomonas oryzae *** with a MIC value of 5.2μmol·^L(−1).

关键词： Fungus Spiromastix sp Depsidones Phytopathogenic bacteria Antibacterial

生成式人工智能大模型全球治理的理论证成与初步构想

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中国科技论坛 2024年第5期 140-148页

作者：严驰同济大学法学院上海200092

生成式人工智能作为人工智能领域重要技术分支,不仅起到驱动数字经济变革和推进产业智能化升级的正面效应,也引发若干新型社会问题和国家安全风险,生成式人工智能大模型全球治理的提出正当其时。欧盟作为数字时代中美之外“第三极”力量... 详细信息

生成式人工智能作为人工智能领域重要技术分支,不仅起到驱动数字经济变革和推进产业智能化升级的正面效应,也引发若干新型社会问题和国家安全风险,生成式人工智能大模型全球治理的提出正当其时。欧盟作为数字时代中美之外“第三极”力量,在全球数字治理规则构建中发挥重要作用。生成式人工智能大模型全球治理应秉承“网络空间命运共同体”理念,先行设计合理的技术规制方案,利用《数字市场法》中的“守门人”制度,防范和化解模型运营商潜在的垄断风险,从技术角度将生成式人工智能大模型视为《数字服务法》中的“在线搜索引擎”,为构建更具体的生成式人工智能大模型全球治理方案奠定基础。

关键词：生成式人工智能全球治理数字霸权网络空间命运共同体搜索引擎

Performance Evaluation of Enterprise Knowledge Management based on Multiple Attribute Group Decision Making

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中国管理信息化 2009年第15期12卷 84-87页

作者： LIU yan- chi GUO Hong - wei School of Economics and Management University of Science and Technology Beijing Beijing 100083 P. R. China

Given that the classical performance evaluation models can not deal with the group decision making problems since they simply average the index,we propose an enterprise knowledge management evaluation model based on multiple attribute group decision making (MAGDM). Find the differences between Ordered Weighted Averaging (OWA) and methods for uncertain decision making. Also,analyze the multiple attribute group decision making process and implement the algorithm. Finally,apply the method on performance evaluation of four enterprises and make sensitivity analysis towards the evaluation results.

关键词：知识管理 OWA MAGDM 决策

数字时代网络游戏出版管理的现实问题与困境突破

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出版与印刷 2023年第1期 24-32页

作者：严驰武汉理工大学法学与人文社会学院

为实现网络游戏产业的高质量发展,助力数字经济建设,文章通过对我国网络游戏出版管理现状的分析,指出我国的网络游戏出版管理尚存在管理体系不清晰、法律规制滞后、审批程序繁琐、属地化进展缓慢等现实问题。提出完善网络游戏出版管理... 详细信息

为实现网络游戏产业的高质量发展,助力数字经济建设,文章通过对我国网络游戏出版管理现状的分析,指出我国的网络游戏出版管理尚存在管理体系不清晰、法律规制滞后、审批程序繁琐、属地化进展缓慢等现实问题。提出完善网络游戏出版管理的对策建议:设立网络游戏出版管理双层审核制度;完善法律规定,建立分级制度;探索出海发行,传播中华文化;拓宽发展形式,探索影游结合。

关键词：数字时代网络游戏出版管理

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水溶性ZnO量子点制备及其光学性质

高等学校化学学报 2007年第12期28卷 2246-2251页

作者：庄稼迟燕华刘猛西南石油大学材料科学与工程学院成都610500 西南科技大学化学系绵阳621002

利用3-巯丙基三乙氧基硅烷对ZnO进行表面修饰后沉积SiO2,制备出水溶性SiO2包覆ZnO的量子点.与直接采用正硅酸乙酯沉积包覆SiO2的ZnO量子点相比,362 nm处的激子荧光发射峰的强度提高了将近4倍.由于表面引入了巯基官能团,量子点的水溶性... 详细信息

利用3-巯丙基三乙氧基硅烷对ZnO进行表面修饰后沉积SiO2,制备出水溶性SiO2包覆ZnO的量子点.与直接采用正硅酸乙酯沉积包覆SiO2的ZnO量子点相比,362 nm处的激子荧光发射峰的强度提高了将近4倍.由于表面引入了巯基官能团,量子点的水溶性明显提高,稳定性增强,即使在较高的盐浓度下也不会团聚.通过改变条件,制备出了发光波长在420 nm的蓝色荧光量子点.

关键词：氧化锌水溶性量子点表面包覆光学性质

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达旦黄与牛血清白蛋白结合的热力学研究

光谱学与光谱分析 2006年第11期26卷 2097-2100页

作者：毕欣颖迟燕华西南科技大学化学系四川绵阳621010

采用荧光光谱法和紫外-可见吸收光谱法研究了达旦黄(TY)与牛血清白蛋白(BSA)结合反应的特征。实验发现:TY对BSA有较强的荧光猝灭作用,根据荧光猝灭数据,由Stern-Volmer方程和Line weav-er-Burk双倒数方程得到了反应的结合常数和热力学参... 详细信息

采用荧光光谱法和紫外-可见吸收光谱法研究了达旦黄(TY)与牛血清白蛋白(BSA)结合反应的特征。实验发现:TY对BSA有较强的荧光猝灭作用,根据荧光猝灭数据,由Stern-Volmer方程和Line weav-er-Burk双倒数方程得到了反应的结合常数和热力学参数,并由此推出了结合反应的主要作用力类型。在此基础上依据F rster非辐射能量转移机理,探讨了TY与BSA相互结合时,给体-受体间的距离和能量转移效率。从而证实了该结合作用为单一静态猝灭过程,并阐明了其猝灭机制是通过能量转移产生的。

关键词：达旦黄牛血清白蛋白荧光光谱法结合反应热力学参数

动态规划法在搜索加筋土坡最危险滑动面的应用

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水利学报 2005年第1期36卷 77-82,88页

作者：严驰孙训海冯艺天津大学建筑工程学院天津300072

本文采用非线性有限元法计算加筋土坡的应力场和位移场,依据剪应力法定义的安全系数,应用动态规划法搜索土坡的最危险滑动面。根据计算结果,对比了加筋前后土坡应力场和位移场的变化,分析了加筋对土坡侧向位移和最危险滑动面的影响。指... 详细信息

本文采用非线性有限元法计算加筋土坡的应力场和位移场,依据剪应力法定义的安全系数,应用动态规划法搜索土坡的最危险滑动面。根据计算结果,对比了加筋前后土坡应力场和位移场的变化,分析了加筋对土坡侧向位移和最危险滑动面的影响。指出因加筋材料承担了部分剪应力,约束了土体的侧向位移,从而减小了土中的水平应力,扩散了剪应力,增大了土坡的安全系数。同时,计算分析了加筋材料摆放位置不同时,对土坡抗滑能力的影响效果。提出当将加筋材料贯穿于土中塑性区时,加筋效果最明显。对于较弱地基的土坡,筋材放置在坡底,有利于坡身荷载在地基土中的应力扩散,对限制地基土的侧向位移,提高土坡的安全系数有明显的效果。

关键词：非线性有限元法加筋土坡应力场和位移场塑性区动态规划法安全系数