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巨噬细胞在血液透析用自体动静脉内瘘成熟与失功中的作用

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中国血液净化 2025年第1期24卷 54-57页

作者：邹佳乐迟雁青河北医科大学第三医院肾内科石家庄050051

炎症在自体动静脉内瘘(arteriovenous fistula,AVF)血管重塑的早期与晚期阶段均发挥着至关重要的调节作用。作为炎症反应中的重要免疫细胞之一,巨噬细胞具有在微环境中极化为炎症型(M1)和抗炎型(M2)等表型的能力。它们在炎症的发生、发... 详细信息

炎症在自体动静脉内瘘(arteriovenous fistula,AVF)血管重塑的早期与晚期阶段均发挥着至关重要的调节作用。作为炎症反应中的重要免疫细胞之一,巨噬细胞具有在微环境中极化为炎症型(M1)和抗炎型(M2)等表型的能力。它们在炎症的发生、发展和消退过程中扮演着关键角色,并在AVF经历手术创伤下及血流动力学改变、缺氧和高脂血症等环境下能发挥重要调控作用,影响AVF的成熟或失功。目前,一些免疫抑制剂和他汀类药物已被证实能够减少巨噬细胞的浸润,从而改善AVF的通畅性。因此,深入了解巨噬细胞在AVF血管重塑中的作用,同时寻找更有效的调控巨噬细胞的方法可能成为提高AVF成熟率和保持通畅性的新方向。

关键词：巨噬细胞自体动静脉内瘘炎症

A SIMULTANEOUS MULTI-PROBE DETECTION LABEL-FREE OPTICAL-RESOLUTION PHOTOACOUSTIC MICROSCOPY TECHNIQUE BASED ON MICROCAVITY TRANSDUCER

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Journal of Innovative Optical Health Sciences 2013年第3期6卷 108-113页

作者： YONGBO WU ZHILIE TANG yan chi LIRU WU School of Physics and Telecom Engineering South China Normal University Guangzhou 510006P.R.China Laboratory of Quantum Information Technology South China Normal University IMOTGuangzhou 510006P.R.China

We demonstrate the feasibility of simultancous multi-probe detection for an optcal-resolution photoacoustic microscopy(OR-PAM)***-P AM has elicited the attention of biomedical imaging researchers because of its optical absorption contrast and high spatial resolution with great imaging ***-PAM allows label-free and noninvasive imaging by maximizing the optical absorption of endogenous ***,given the inadequate absoption of some biomolcules,detection sensitivity at the same incident intensity requires *** this study,a modulated continuous wave with power density less than 3mW/cm^(2)(1/4 of the ANSI safety limit)excited the weak photoacoustic(PA)signals of biological cells.A microcavity traneducer is developed based on the bulk modulus of gas five orders of magnitude lower than that of solid;air pressure variation is inversely proportional to cavity volume at the same temperature *** that a PA wave expands in various directions,detecting PA signals from different positions and adding them together can increase detection sensitivity and signal-to-noise ***,we employ four detectors to acquire tiny PA signals *** results show that the developed OR-PAM system allows the label-free imaging of cells with weak optical absorption.

关键词： Multi-probe label free optical-resolution photoacoustic microscopy

Current status of associating liver partition with portal vein ligation for staged hepatectomy: Comparison with two-stage hepatectomy and strategies for better outcomes

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World Journal of Gastroenterology 2019年第43期25卷 6373-6385页

作者： Kin Pan Au Albert chi yan Chan Department of Surgery Queen Mary HospitalHong KongChina Department of Surgery and State Key Laboratory for Liver Research The University of Hong KongHong KongChina

Since its introduction in 2012,associating liver partition with portal vein ligation for staged hepatectomy(ALPPS)has significantly expanded the pool of candidates for liver *** offers patients with insufficient liver function a chance of a *** is most controversial when its high morbidity and mortality is *** mortality is usually a result of posthepatectomy liver failure and can be minimized with careful patient *** patients have limited reserve for tolerating the demanding *** with colorectal liver metastasis have normal liver and are ideal *** for cholangiocarcinoma is technically challenging and associated with fair *** with hepatocellular carcinoma have chronic liver disease and limited parenchymal ***,in selected patients with limited hepatic fibrosis satisfactory outcomes have been *** the inter-stage period,serum bilirubin and creatinine level and presence of surgical complication predict mortality after stage *** growth rate and hepatobiliary scintigraphy also guide the decision whether to postpone or omit stage II *** outcomes of ALPPS have been improved by a combination of technical *** patients with challenging anatomy,partial ALPPS potentially reduces morbidity,but remnant hypertrophy may compare unfavorably to a complete *** compared to conventional two-stage hepatectomy with portal vein embolization or portal vein ligation,ALPPS offers a higher resection rate for colorectal liver metastasis without increased morbidity or *** ALPPS has obvious theoretical oncological advantages over two-stage hepatectomy,the long-term outcomes are yet to be determined.

关键词： Associating liver partition with portal vein ligation for staged hepatectomy Two-stage hepatectomy Patient selection Surgical outcomes

Equivalent circuit model for the insulated core transformer

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Nuclear Science and Techniques 2016年第3期27卷 132-137页

作者： Bo yang Lei Cao Jun yang Sheng-chi yan Yi-Bin Tao china Electric Power Research Institute Nanjing 210003China State Key Laboratory of Advanced Electromagnetic Engineering and Technology Huazhong University of Science and TechnologyWuhan 430074China

The design of the insulated core transformer(ICT)needs to consider the flux leakage *** equivalent linear circuit model is proposed based on the principle of *** is composed by two types of leakage inductances:conventional leakage between windings and special leakage introduced mainly by the insulation *** values of leakage inductances depend on the dimensions of the core,gaps,or windings and the property of magnetic *** circuit allows for quantitatively evaluating influences of ICT internal parameters on its output *** winding self- and mutual inductance matrix is mathematically converted to derive the inductance *** an example,the leakage parameters of a sixstage two-dimensional(2D) ICT are calculated and analyzed.

关键词：等效电路模型变压器绝缘性能影响电感计算对偶原理等效线性磁性材料

Simultaneous portohepatic vein embolization a radiological:a short cut to associating liver partition and portal vein ligation for staged hepatectomy?

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 373-375页

作者： Ka Wing Ma Albert chi yan Chan Department of Surgery Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina

Insufficient future liver remnant(FLR)represented one of the most common contraindications for major hepatectomy as post-hepatectomy liver failure(PHLF)was associated with high mortality with no effective *** the description of portal vein embolization(PVE)by Makucchi in 1984(1),FLR volumetric modulation was made *** of PVE before major hepatectomy for patients with insufficient FLR(i.e.,<30%of estimated standard liver volume)had greatly improved resectability.

关键词： hepatectomy mortality liver

Combustion characteristics of tannery sludge and volatilization of heavy metals in combustion

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第7期11卷 530-537页

作者： Xu-guang JIANG Chun-yu LI Zhen-wei FEI Yong chi Jian-hua yan State Key Laboratory of Clean Energy Utilization Zhejiang University Hangzhou 310027 China

Incineration is considered one of the most readily available techniques for sewage sludge disposal, including tannery sludge, which often contains significant amounts of volatile heavy metals. The combustion characteristics and kinetic analysis of tannery sludge were investigated using thermogravimetric analysis (TGA) at a heating rate of 30 °C/min in 50–950 °C. In addition to confirming that tannery sludge has a high content of volatile material and ash, it was further discovered that almost all the zinc (Zn) in tannery sludge is volatilized at 900 °C. The degree of volatilization for heavy metals at 900 °C followed the order of Zn>Cd>Cu>Mn>Pb>Cr. Moreover, the volatilization of these heavy metals increased with temperature. It is thus concluded that, to avoid heavy metal volatization during incineration disposal, 800 °C is a reasonable incineration temperature.

关键词： Tannery sludge Combustion Heavy metal volatilization Thermogravimetric analysis (TGA) Combustion kinetics

Initial experience with stereotactic body radiotherapy for intrahepatic hepatocellular carcinoma recurrence after liver transplantation

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World Journal of Clinical Cases 2020年第13期8卷 2758-2768页

作者： Kin Pan Au chi Leung chiang Albert chi yan Chan Tan To Cheung Chung Mau Lo Kenneth Siu Ho Chok Department of Surgery Queen Mary HospitalThe University of Hong KongHong Kong 999077China Department of Clinical Oncology Queen Mary Hospitalthe University of Hong KongHong Kong 999077China

BACKGROUND Graft hepatocellular carcinoma(HCC)recurrence after liver transplant is more frequently *** hepatectomy is technically challenging and is associated with high *** body radiation therapy(SBRT)has been shown to be safe and effective for the treatment of primary ***,its role in HCC recurrence in a liver graft remains *** To evaluate the safety and efficacy of SBRT for the treatment of graft HCC recurrence after liver *** A retrospective study was *** 2012 to 2018,6 patients with intrahepatic HCC recurrence after liver transplant were treated with SBRT at Queen Mary Hospital,the University of Hong *** primary outcome was time to overall disease progression and secondary outcomes were time to local progression and best local response,as assessed with the Modified response Evaluation Criteria for Solid Tumours *** were monitored for treatment related toxicities and graft *** A total of 9 treatment courses were given for 13 *** median tumour size was 2.3 cm(range 0.7-3.6 cm).Two(22%)patients had inferior vena cava tumour *** best local treatment response was:5(55%)complete response,1(11%)partial response and 3(33%)stable *** a median follow up duration of 15.5 mo,no local progression or mortality was yet *** median time to overall disease progression was 6.5 *** were 6 regional progression in the liver graft(67%)and 2 distant progression in the lung(22%).There was no grade 3 or above toxicity and there was no graft dysfunction after *** SBRT appears to be safe in this *** progression is the mode of failure.

关键词： Stereotactic body radiotherapy Hepatocellular carcinoma Liver transplantation Recurrence Radiosurgery Outcomes

Study on pyrolysis and gasification of wood in MSW

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Journal of Environmental Sciences 2006年第2期18卷 407-415页

作者： NI Ming-jiang XIAO Gang chi Yong yan Jian-hua MIAO Qi ZHU Wen-li CEN Ke-fa Institute for Thermal Power Engineering State Key Laboratory of Clean Energy Utilization Zhejiang University Hangzhou 310027 China

In order to develop municipal solid waste（MSW） pyrolysis/gasification and melting technology with low emission and high efficiency, it was planed that all the main components in MSW and some typical kinds of MSW were pyrolyzed/gasified to propose an expert system for raw MSW. In this paper, wood, which was a prevalent component in MSW, was pyrolyzed and gasified in fluidized-bed reactors at different apparent excess air ratios （EARs）, temperatures and fluidizing velocities. For pyrolysis, with tem- perature increasing from 400℃ to 700℃, the yield of pyrolysis char decreased while that of pyrolysis gas increased （in this paper respectively from 28% to 20% and from 10% to 35%）, and when temperature was 500℃, the yield of pyrolysis tar reached the highest, up to 38% in this paper. It was the optimum for gasification when temperature was 600℃ and apparent EAR was 0.4. Under the experimental conditions of this paper, gasification efficiency achieved 73%, lower heat value（LHV） reached 5800 kJ/（Nm^3） and yield of syngas was 2.01 Nm^3/kg. Lower fluidizing velocity was useful to upgrade gasification efficiency and LHV of syngas for wood gasification. Based on the results, the reactive courses and mechanism were analyzed respectively for wood pyrolysis and gasification.

关键词： wood pyrolysis gasification municipal solid waste(MSW)

An ethanolic extract of Bailian(Radix Ampelopsis Japonicae):demonstration of colorectal cancer treatment efficacy via inhibition of β-catenin signaling in vitro

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Journal of Traditional chinese Medicine 2019年第3期39卷 339-345页

作者： Su Tao Wang Xinning Li Chunyu Bai Jingxuan chi-yan Cheng Fu Xiuqiong Li Ting Yu Zhiling Consun chinese Medicines Research Centre for Renal Diseases School of Chinese Medicine Hong Kong Baptist University Kowloon Tong Hong Kong 999077 China HKBU Shenzhen Research Institute and Continuing Education Shenzhen 518001 China Centre for Cancer and Inflammation Research School of Chinese Medicine Hong Kong Baptist University Hong Kong999077 China

OBJECTIVE:To investigate the underlying mechanism of Bailian (Radix Ampelopsis Japonicae,BL) extract action on colorectal cancer (CRC).METHODS:We explored the involvement of β-catenin signaling on the anti-CRC effects of an BL ethanolic extract (BLE) in cell models by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay,immunofluorescent staining,luciferase assay,Western blot analysis and real-time quantitative polymerase chain reaction ***-CRC compounds were quantified by high performance liquid ***:The contents of gallic acid,catechin,and epicatechin in the BLE were 0.23,1.25,and 0.18 g/kg,***-mediated cytotoxic and apoptotic effects were accompanied by lowered β-catenin/Tcf transcriptional activity,reduced β-catenin nuclear localization,and downregulated protein and mRNA levels of both β-catenin and molecules regulated by β-***:The mechanism underpinning the anti-CRC effects of BLE may involve inhibition of β-catenin *** studies are necessary to establish the role of β-catenin signaling in the action of BLE-mediated anti-CRC effects.

关键词： Bailian (Radix Ampelopsis Japonicae) Colorectal neoplasms Beta Catenin Cytotoxins Apoptosis