A SIMULTANEOUS MULTI-PROBE DETECTION LABEL-FREE OPTICAL-RESOLUTION PHOTOACOUSTIC MICROSCOPY TECHNIQUE BASED ON MICROCAVITY TRANSDUCER

作     者：YONGBO WU ZHILIE TANG YAN CHI LIRU WU 

作者机构：School of Physics and Telecom EngineeringSouth China Normal University Guangzhou 510006P.R.China Laboratory of Quantum Information TechnologySouth China Normal University IMOTGuangzhou 510006P.R.China 

出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)

年 卷 期：2013年第6卷第3期

页      面：108-113页

核心收录：

学科分类：070207[理学-光学] 07[理学] 08[工学] 0803[工学-光学工程] 0702[理学-物理学] 

基　　金：supported by the National Natural Science Foundation of China(Grant No.61178086) Science and Technology Program of Guangzhou,China(Grant No.2012J4300138) Foundation for Distinguished Young Talents in South China Normal University,China.(Grant No.2012KJ010) 

主　　题：Multi-probe label free optical-resolution photoacoustic microscopy 

摘      要：We demonstrate the feasibility of simultancous multi-probe detection for an optcal-resolution photoacoustic microscopy(OR-PAM)***-P AM has elicited the attention of biomedical imaging researchers because of its optical absorption contrast and high spatial resolution with great imaging ***-PAM allows label-free and noninvasive imaging by maximizing the optical absorption of endogenous ***,given the inadequate absoption of some biomolcules,detection sensitivity at the same incident intensity requires *** this study,a modulated continuous wave with power density less than 3mW/cm^(2)(1/4 of the ANSI safety limit)excited the weak photoacoustic(PA)signals of biological cells.A microcavity traneducer is developed based on the bulk modulus of gas five orders of magnitude lower than that of solid;air pressure variation is inversely proportional to cavity volume at the same temperature *** that a PA wave expands in various directions,detecting PA signals from different positions and adding them together can increase detection sensitivity and signal-to-noise ***,we employ four detectors to acquire tiny PA signals *** results show that the developed OR-PAM system allows the label-free imaging of cells with weak optical absorption.