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Anti-inflammatory effects of Solanum procumbens on a low dose complete Freund's adjuvant-induced arthritis rat model

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Asian Pacific Journal of Tropical Biomedicine 2023年第5期13卷 214-221页

作者： Xuan-Hai Do Trong Nghia Nguyen Thanh Chung dang Thi Thanh Mai Nguyen Trung Nhan Nguyen Van Nhat Truong Do Huu Tho Le Xuan Hai Nguyen Hoang Phu dang Giang-Linh Nguyen Dinh-Khanh Hoang Van-Quan Le Van-Mao Can Department of Practical and Experimental Surgery Vietnam Military Medical UniversityHanoi 10000Vietnam Department of Reconstructive and Microsurgery Craniofacial and Reconstructive Surgery CentreMilitary Central Hospital 108Hanoi 10000Vietnam Department of Anatomic Pathology Military Hospital 103Vietnam Military Medical UniversityHanoi 10000Vietnam Faculty of Chemistry University of ScienceVietnam National University Ho Chi Minh CityHo Chi Minh City 70000Vietnam Faculty of Medicine University of Medicine and PharmacyVietnam National UniversityHanoi 10000Vietnam Department of Ultrasound Imaging Diagnostics CentreMilitary Hospital 103Vietnam Military Medical UniversityHanoi 10000Vietnam Department of Functional Diagnostics Military Hospital 103Vietnam Military Medical UniversityHanoi 10000Vietnam Department of Pathophysiology Vietnam Military Medical UniversityHanoi 10000Vietnam

Objective:To investigate the anti-inflammatory and analgesic effects of Solanum procumbens on complete Freund’s adjuvantinduced arthritis rat ***:We isolated and identified five compounds in the ethanolsoluble Solanum procumbens extract(SP)with anti-inflammatory effects,including ursolic acid,β-sitosterol,hexadecanoic acid,cisvaccenic acid,and vanillic ***,we investigated the anti-inflammatory effects of SP on rheumatoid arthritis symptoms,including paw volumes,local temperatures,withdrawal latency,and mechanical withdrawal threshold at the hind paw and white blood cell(WBC)number from complete Freund’s adjuvant-induced arthritis rat ***:We have successfully established a complete Freund’s adjuvant-induced arthritis rat model at a low dose(1 mg/mL).SP extract significantly reduced paw volumes(P<0.05),prolonged withdrawal latencies(P<0.05),decreased local temperature,and increased the mechanical withdrawal threshold(P<0.05),but only SP extract at the dose of 300 mg/kg significantly decreased WBC ***:SP extract could be a potential medication candidate with anti-inflammatory effects for arthritis,but it requires further investigation into the mechanism of the SP and its effectiveness on other models as well as clinical trials.

关键词： Solanum procumbens Arthritis Anti-inflammation Complete Freund's adjuvant Rats

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Deep Learning Enabled Disease Diagnosis for Secure Internet of Medical Things

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Computers, Materials & Continua 2022年第10期73卷 965-979页

作者： Sultan Ahmad Shakir Khan Mohamed Fahad Al.Ajmi Ashit Kumar Dutta L.Minh dang Gyanendra Prasad Joshi Hyeonjoon Moon Department of Computer Science College of Computer Engineering and SciencesPrince Sattam Bin Abdulaziz UniversityAlkharj11942Saudi Arabia College of Computer and Information Sciences Imam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia College of Pharmacy King Saud UniversityRiyadh11451Saudi Arabia Department of Computer Science and Information System College of Applied SciencesAlMaarefa UniversityRiyadh11597Saudi Arabia Department of Information Technology FPT UniversityHo Chi Minh CityVietnam Department of Computer Science and Engineering Sejong UniversitySeoul05006Korea

In recent times,Internet of Medical Things(IoMT)gained much attention in medical services and healthcare management *** healthcare sector generates massive volumes of data like personal details,historical medical data,hospitalization records,and discharging records,IoMT devices too evolved with potentials to handle such high quantities of *** and security of the data,gathered by IoMT gadgets,are major issues while transmitting or saving it in *** advancements made in Artificial Intelligence(AI)and encryption techniques find a way to handle massive quantities of medical data and achieve *** this view,the current study presents a new Optimal Privacy Preserving and Deep Learning(DL)-based Disease Diagnosis(OPPDL-DD)in IoMT ***,the proposed model enables IoMT devices to collect patient data which is then preprocessed to optimize *** order to decrease the computational difficulty during diagnosis,Radix Tree structure is *** addition,ElGamal public key cryptosystem with Rat Swarm Optimizer(EIG-RSO)is applied to encrypt the *** the transmission of encrypted data to cloud,respective decryption process occurs and the actual data gets ***,a hybridized methodology combining Gated Recurrent Unit(GRU)with Convolution Neural Network(CNN)is exploited as a classification model to diagnose the *** sets of simulations were conducted to highlight the performance of the proposed model on benchmark *** experimental outcomes ensure that the proposed model is superior to existing methods under different measures.

关键词： Internet of medical things privacy security encryption radix tree deep learning

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火热相关证候慢性失眠脉图特征研究

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西部中医药 2024年第2期37卷 65-68页

作者：党娇娇于艺雷洪涛袁霭凤张喜闪增郁宋军中国中医科学院医学实验中心北京100700

目的:对火热相关证候慢性失眠患者与正常人群的脉图模型及参数进行对比分析,以探寻火热相关证候慢性失眠的脉图特征。方法:应用高精度智能机械手中医脉诊信息采集分析系统,对16例火热相关证候慢性失眠患者与20例健康受试者的脉诊信息进... 详细信息

目的:对火热相关证候慢性失眠患者与正常人群的脉图模型及参数进行对比分析,以探寻火热相关证候慢性失眠的脉图特征。方法:应用高精度智能机械手中医脉诊信息采集分析系统,对16例火热相关证候慢性失眠患者与20例健康受试者的脉诊信息进行采集与分析。结果:两组人群的脉诊信息差异明显,参数拟合的分类判决结果正确区分率高达97%;在193个参数中共有19个参数参与了分类,包括5个脉位参数,4个时域参数,10个频域参数;双手6部脉图参数的贡献度比较,右关脉贡献最多,其次是右尺脉,左关脉贡献最少。结论:脉图参数可以将火热相关证候慢性失眠患者与正常人群进行区分,可将左手寸关尺、右关、右尺脉位沉、右尺脉位最沉作为火热相关证候慢性失眠的一个重要标志。运用脉诊仪进行诊脉客观可靠且特异性较高,能为慢性失眠的中医辨证从中医脉学角度提供客观参考依据。

关键词：失眠慢性火热证候脉图脉诊客观化

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广东鹅源多杀性巴氏杆菌的分离鉴定、耐药表型和耐药基因的检测及相关性分析

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中国预防兽医学报 2024年第2期46卷 121-127页

作者：苏文楠杨智灿张美琳钟嘉诚陈亦杏陈济铛张溢珊张济培佛山科学技术学院广东佛山528225 佛山天牧生物科技有限公司广东佛山528225

为了解广东地区鹅源多杀性巴氏杆菌(Pm)的流行情况、药物敏感性、耐药基因的携带情况以及耐药表型与耐药基因的相关性,本实验对2019年~2022年从广东地区采集的193份疑似感染Pm病鹅的心脏血液和肝脏组织划线接种于不同的培养基分离细菌,... 详细信息

为了解广东地区鹅源多杀性巴氏杆菌(Pm)的流行情况、药物敏感性、耐药基因的携带情况以及耐药表型与耐药基因的相关性,本实验对2019年~2022年从广东地区采集的193份疑似感染Pm病鹅的心脏血液和肝脏组织划线接种于不同的培养基分离细菌,对分离菌纯化后采用PCR扩增分离菌的KMT1基因并测序,采用多重PCR扩增分离菌的5个荚膜基因及8个脂多糖基因,分析分离菌的荚膜分型与脂多糖(LPS)分型。结果显示分离到83株鹅源Pm,其中82株为荚膜A型,1株无法通过荚膜定型;LPS分型为L1型。采用K-B纸片扩散法检测分离菌的药物敏感性;通过PCR检测分离菌7类药物的15种耐药基因,包括β-内酰胺类(bla_(CTX-M)、bla_(TEM)、bla_(OXA))、氨基糖苷类(aadA1、aph(3’)Ila)、喹诺酮类(qnrA、qnrB、qnrS)、酰胺醇类(floR)、四环素类(tetM、tetX)、大环内酯类(ermF、ereD)、磺胺类(sul1、sul3)耐药基因。采用统计学软件SPSS22中的完全随机设计两样本率的卡方检验分析分离菌的耐药表型和相应耐药基因的相关性。药敏试验结果显示,83株鹅源Pm对多种药物敏感性较高,其中对喹诺酮类的环丙沙星和氧氟沙星、氨基糖苷类的丁胺卡那和大观霉素、β-内酰胺类的头孢曲松、磺胺类的复方新诺明、大环内酯类的阿奇霉素敏感的菌株占比均在63%以上;对氨基糖苷类的链霉素和卡那霉素耐药的菌株占比高于50%,对氨基糖苷类的新霉素和四环素类的四环素耐药的菌株分别占49.40%(41/83)和46.99%(39/83)。耐药基因的检测结果显示,分离菌检出耐药基因qnrB、sul3、blaTEM、aadA1、aph(3’)Ila、ereD、ermF、tetM、floR,检出率分别为9.63%(8/94)、27.71%(23/83)、28.92%(24/83)、48.19%(40/83)、14.46%(12/83)、49.40%(41/83)、3.61%(3/83)、1.20%(1/83)、32.53%(27/83),未检出耐药基因qnrA、qnrS、sul1、tetX、bla_(CTX-M)、bla_(OXA)。相关性分析结果显示,aadA1基因与Pm对新霉素、链霉素、卡那霉素、大观霉素的耐药性具有极显著的相关性(P<0.001);bla_(CTX-M)基因、floR基因分别与Pm对头孢拉定、氟苯尼考的耐药性具有显著相关性(P<0.05)。上述结果表明,广东地区鹅源Pm主要为A∶L1基因型,对多种药物敏感,耐药基因携带率不高,部分药物的耐药表型与耐药基因具有相关性。本研究为广东地区鹅源Pm病的监测和防治提供参考依据,为Pm耐药机制的研究奠定基础。

关键词：多杀性巴氏杆菌药物敏感性试验耐药基因

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Applying Molecular Breeding to Improve Soybean Rust Resistance in Vietnamese Elite Soybean

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American Journal of Plant Sciences 2013年第1期4卷 1-6页

作者： Tran dang Khanh Truong Quoc Anh Bui chi Buu Tran dang Xuan 2Institute of Agricultural Science for Southern Vietnam Ho Chi Minh City Vietnam Department of Molecular Biology Agricultural Genetics Institute Hanoi Vietnam Graduate School for International Development and Cooperation Hiroshima University Hiroshima Japan Institute of Agricultural Science for Southern Vietnam Ho Chi Minh City Vietnam

Soybean production in Vietnam has recently been threatened by the widespread dissemination of soybean rust (SBR) caused by the fungus Phakopsora pachyrhizi. Application of molecular breeding is considered as a feasible method to improve soybean rust resistance and minimize the adverse effects from overuse fungicides in this country. In this study, we have successfully applied molecular markers in a backcross breeding program to introgress the Rpp5 gene of SBR resistance into HL203, an elite Vietnamese soybean variety, from two donor lines of DT2000 and Stuart 99084B-28. The plants in BC4F1 generation had maximum contribution from the recurrent parents and retained SBR resistance gene.

关键词： Rust Resistant Gene Soybean Marker Assisted Selection Molecular Marker

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Plasmonic enhancement and polarization dependence of nonlinear upconversion emissions from single gold nanorod@SiO_(2)@CaF2:Yb^(3+),Er^(3+)hybrid core–shell–satellite nanostructures

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Light(Science & Applications) 2016年第1期5卷 224-234页

作者： Jijun He Wei Zheng Filip Ligmajer chi-Fai Chan Zhiyong Bao Ka-Leung Wong Xueyuan Chen Jianhua Hao Jiyan Dai Siu-Fung Yu dang Yuan Lei Department of Applied Physics The Hong Kong Polytechnic UniversityHong KongChina Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002China Central European Institute of Technology Brno University of TechnologyBrno 61669Czech Republic Department of Chemistry Hong Kong Baptist UniversityHong KongChina

Lanthanide-doped upconversion nanocrystals(UCNCs)have recently become an attractive nonlinear fluorescence material for use in bioimaging because of their tunable spectral characteristics and exceptional *** materials are often introduced into the vicinity of UCNCs to increase their emission intensity by means of enlarging the absorption cross-section and accelerating the radiative decay ***,plasmonic nanostructures(e.g.,gold nanorods,GNRs)can also influence the polarization state of the UC fluorescence—an effect that is of fundamental importance for fluorescence polarization-based imaging methods yet has not been discussed *** study this effect,we synthesized GNR@SiO_(2)@CaF2:Yb^(3+),Er^(3+)hybrid core–shell–satellite nanostructures with precise control over the thickness of the SiO_(2) *** evaluated the shell thicknessdependent plasmonic enhancement of the emission intensity in ensemble and studied the plasmonic modulation of the emission polarization at the single-particle *** hybrid plasmonic UC nanostructures with an optimal shell thickness exhibit an improved bioimaging performance compared with bare UCNCs,and we observed a polarized nature of the light at both UC emission bands,which stems from the relationship between the excitation polarization and GNR *** used electrodynamic simulations combined with Förster resonance energy transfer theory to fully explain the observed *** results provide extensive insights into how the coherent interaction between the emission dipoles of UCNCs and the plasmonic dipoles of the GNR determines the emission polarization state in various situations and thus open the way to the accurate control of the UC emission anisotropy for a wide range of bioimaging and biosensing applications.

关键词： Förster resonance energy transfer gold nanorods lanthanide-doped upconversion nanocrystals plasmon-enhanced nonlinear fluorescence polarization modulation

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A Study on Hovering Control of Small Aerial Robot by Sensing Existing Floor Features

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自动化学报：英文版 2020年第4期7卷 1016-1025页

作者： chinthaka Premachandra dang Ngoc Hoang Thanh Tomotaka Kimura Hiroharu Kawanaka the Department of Electronic Engineering and Science Graduate School of EngineeringShibaura Institute of TechnologyTokyo 135-8548Japan the Department of Information Technology School of Business Information TechnologyUniversity of Economics Ho Chi Minh CityHue 530000Vietnam the Department of Intelligent Information Engineering Faculty of Science and EngineeringDoshisha UniversityKyoto 602-8580Japan the Department of Electrical and Electronic Engineering Faculty of EngineeringMie UniversityMie 514-8507Japan

Since precise self-position estimation is required for autonomous flight of aerial robots, there has been some studies on self-position estimation of indoor aerial robots. In this study, we tackle the self-position estimation problem by mounting a small downward-facing camera on the chassis of an aerial robot. We obtain robot position by sensing the features on the indoor *** this work, we used the vertex points(tile corners) where four tiles on a typical tiled floor connected, as an existing feature of the floor. Furthermore, a small lightweight microcontroller is mounted on the robot to perform image processing for the onboard camera. A lightweight image processing algorithm is developed. So, the real-time image processing could be performed by the microcontroller alone which leads to conduct on-board real time tile corner detection. Furthermore, same microcontroller performs control value calculation for flight commanding. The flight commands are implemented based on the detected tile corner information. The above mentioned all devices are mounted on an actual machine, and the effectiveness of the system was investigated.

关键词： Hovering control light weight algorithm development image processing self-position estimation small aerial robot tile corner sensing

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Surface molecular doping of all-inorganic perovskite using zethrenes molecules

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Nano Research 2019年第1期12卷 77-84页

作者： Arramel Hu Pan Aozhen Xie Songyan Hou Xinmao Yin chi Sin Tang Nguyen T.Hoa Muhammad D.Birowosuto Hong Wang Cuong dang Andrivo Rusydi Andrew T.S.Wee Jishan Wu Department of Physics National University of Singapore2 Science Drive 3Singapore 117542Singapore Centre for Advanced 2D Materials National University of SingaporeBlock S14Level 66 Science Drive 2Singapore 117546Singapore Department of Chemistry National University of Singapore3 Science Drive 3Singapore 117543Singapore CINTRA UMICNRS/NTU/THALES 3288 Research Techno Plaza50 Nanyang DriveLevel 6Border X BlockSingapore 637553Singapore School of Electrical and Electronic Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore Energy Research Institute@NTU(ERI@N) Nanyang Technological UniversityResearch Techno PlazaX-Frontier BlockLevel 550 Nanyang DriveSingapore 637553Singapore Singapore Synchrotron Light Source National University of Singapore5 Research LinkSingapore 1176033Singapore NUS Graduate School for Integrative Sciences and Engineering(NGS) National University of SingaporeSingapore 117456Singapore NUSNNI-NanoCore National University of SingaporeSingapore 117411Singapore Institute of Materials Research&Engineering(IMRE) Agency far ScienceTechnology and Research(A^*STAR)2 Fusionopolis WayInnovisSingapore 138634Singapore

We present an optical and photoelectron spectroscopic study to elucidate the interfacial electronic properties of organic-inorganic semiconductor heterojunctions formed in a kinetically blocked heptazethrene triisopropylsilyl ethynylene (HZ-TIPS) and its homologue,octazethrene (OZ-TIPS) on an all-inorganic perovskite cesium lead bromide (CsPbBr3) *** photoluminescence behavior of the underlying perovskites upon differing molecular doping conditions was *** turns out that the charge transfer dynamics of thermally-evaporated OZ-TIPS molecule exhibited a faster average lifetime than that of the HZ-TIPS case suggesting the importance of the biradical state in the former *** interfacial dipole was formed at the interface due to the competing interaction between the dispersion force of the bulky TIPS-substituent group and the attractive van der Waals interaction at the first few *** spectroscopy of the physisorbed HZ-TIPS shows chemical shifts,which indicates electron transfer from HZ-TIPS molecules to the CsPbBr3 perovskite single *** contrast,the adsorbed OZ-TIPS molecular layer on CsPbBr3 demonstrates the opposite trend indicating a hole transfer *** average molecular orientation as determined by near edge X-ray absorption fine structure (NEXAFS) suggests that the HZ-TIPS molecular plane is generally lifted with respect to the perovskite *** suggest that the nature of the closed-shell electronic ground state of HZ-TIPS could contribute to the formation of interfacial dipole at the molecule/perovskite interface.

关键词： zethrene photoelectron spectroscopy perovskite near edge X-ray absorption fine structure and molecular doping

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Prognosis of HER2 over-expressing gastric cancer patients with liver metastasis

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World Journal of Gastroenterology 2012年第19期18卷 2402-2407页

作者： Hai-Zhen dang Yang Yu Shun-Chang Jiao Department of Medical Oncology GeneralHospital of the People＇s Liberation Army Beijing 100853 Chi}aa Department of Traditional chinese Medicine FirstHospital Affiliated to the General Hospital of the People＇s Libera-tion Army Beijing 100048 China Yang Yu Department of Traditional Chinese Medicine FirstHospital Affiliated to the General Hospital of the People＇s Libera-tion Army Beijing 100048 China Department of Medical Oncology GeneralHospital of the People＇s Liberation Army Beijing 100853 China

AIM:To study the risk factors for liver metastasis and the prognosis in patients with human epidermal growth factor receptor 2(HER2) over-expressing gastric cancer(GC).METHODS:A total of 84 GC patients recruited from the General Hospital of the People's Liberation Army(PLA) between 2003 and 2010 were randomly enrolled in this ***2 expression was detected by immunohistochemistry in 84 GC patients with liver *** study group consisted of 66 men and 18 women,with an average age of 54 years(range:19-74 years).Liver metastasis was diagnosed by magnetic resonance imaging or computed *** were followed-up and predictive factors of liver metastasis were ***:The median follow-up period was 47 mo(range:6-85 mo).The characteristics of 35(25.7%) patients with HER2 over-expression of liver metastatic GC are ***2 over-expression was detected in 23 out of 49(46.9%) patients with intestinal GC,and 9 out of 35(25.7%) patients with diffuse GC.29 out of 59(49.2%) patients aged < 60 years were HER2positive,while 8 out of 25(32%) patients aged ≥ 60 were HER2-positive;a significant difference(P < 0.05).Univariate analysis(log-rank test) showed that HER2 over-expression,sex,Lauren classification,differentiation and disease-free interval were correlated with poor survival(P < 0.05).Survival analysis with a survival curve showed that HER2 over-expression was significantly relevant,with a reduced survival time in GC patients with liver metastases(P < 0.01).2-year survival was not associated with the patient's age.A diseasefree survival longer than 12 mo has a significant association with extended overall survival(OS) in GC patients with liver *** median survival time after the diagnosis of liver metastases was 18 mo [95% confidence interval(CI):9.07-26.94] among HER2 positive GC patients with liver *** comparison,for 49(69.4%) out of 84 HER2 negative patients with liver metastatic GC,the median survival time was 47 m

关键词：过度表达患者肝癌胃癌预后表皮生长因子受体免疫组化检测平均存活时间

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Deep Learning Based Optimal Multimodal Fusion Framework for Intrusion Detection Systems for Healthcare Data

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Computers, Materials & Continua 2021年第3期66卷 2555-2571页

作者： Phong Thanh Nguyen Vy dang Bich Huynh Khoa dang Vo Phuong Thanh Phan Mohamed Elhoseny Dac-Nhuong Le Department of Project Management Ho Chi Minh City Open UniversityHo Chi Minh City700000Vietnam Department of Learning Material Ho Chi Minh City Open UniversityHo Chi Minh City700000Vietnam Faculty of Computers and Information Mansoura UniversityDakahlia Governorate35516Egypt Institute of Research and Development Duy Tan UniversityDanang550000Vietnam Faculty of Information Technology Duy Tan UniversityDanang550000Vietnam

Data fusion is a multidisciplinary research area that involves different *** is used to attain minimum detection error probability and maximum reliability with the help of data retrieved from multiple healthcare *** generation of huge quantity of data from medical devices resulted in the formation of big data during which data fusion techniques become *** medical data is a crucial issue of exponentially-pacing computing world and can be achieved by Intrusion Detection Systems(IDS).In this regard,since singularmodality is not adequate to attain high detection rate,there is a need exists to merge diverse techniques using decision-based multimodal fusion *** this view,this research article presents a new multimodal fusion-based IDS to secure the healthcare data using *** proposed model involves decision-based fusion model which has different processes such as initialization,pre-processing,Feature Selection(FS)and multimodal classification for effective detection of *** FS process,a chaotic Butterfly Optimization(BO)algorithmcalled CBOA is *** the classic BO algorithm offers effective exploration,it fails in achieving faster *** order to overcome this,i.e.,to improve the convergence rate,this research work modifies the required parameters of BO algorithm using chaos ***,to detect intrusions,multimodal classifier is applied by incorporating three Deep Learning(DL)-based classification ***,the concepts like Hadoop MapReduce and Spark were also utilized in this study to achieve faster computation of big data in parallel computation *** validate the outcome of the presented model,a series of experimentations was performed using the benchmark NSLKDDCup99 Dataset *** proposed model demonstrated its effective results on the applied dataset by offering the maximum accuracy of 99.21%,precision of 98.93%and detection rate of 99.59%.The results assured the betterm

关键词： Big data data fusion deep learning intrusion detection bio-inspired algorithm spark

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