Anti-inflammatory effects of Solanum procumbens on a low dose complete Freund's adjuvant-induced arthritis rat model

作     者：Xuan-Hai Do Trong Nghia Nguyen Thanh Chung Dang Thi Thanh Mai Nguyen Trung Nhan Nguyen Van Nhat Truong Do Huu Tho Le Xuan Hai Nguyen Hoang Phu Dang Giang-Linh Nguyen Dinh-Khanh Hoang Van-Quan Le Van-Mao Can Xuan-Hai Do;Trong Nghia Nguyen;Thanh Chung Dang;Thi Thanh Mai Nguyen;Trung Nhan Nguyen;Van Nhat Truong Do;Huu Tho Le;Xuan Hai Nguyen;Hoang Phu Dang;Giang-Linh Nguyen;Dinh-Khanh Hoang;Van-Quan Le;Van-Mao Can

作者机构：Department of Practical and Experimental SurgeryVietnam Military Medical UniversityHanoi 10000Vietnam Department of Reconstructive and MicrosurgeryCraniofacial and Reconstructive Surgery CentreMilitary Central Hospital 108Hanoi 10000Vietnam Department of Anatomic PathologyMilitary Hospital 103Vietnam Military Medical UniversityHanoi 10000Vietnam Faculty of ChemistryUniversity of ScienceVietnam National University Ho Chi Minh CityHo Chi Minh City 70000Vietnam Faculty of MedicineUniversity of Medicine and PharmacyVietnam National UniversityHanoi 10000Vietnam Department of UltrasoundImaging Diagnostics CentreMilitary Hospital 103Vietnam Military Medical UniversityHanoi 10000Vietnam Department of Functional DiagnosticsMilitary Hospital 103Vietnam Military Medical UniversityHanoi 10000Vietnam Department of PathophysiologyVietnam Military Medical UniversityHanoi 10000Vietnam 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2023年第13卷第5期

页      面：214-221页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by Military Hospital 103 Vietnam Military Medical University 

主　　题：Solanum procumbens Arthritis Anti-inflammation Complete Freund's adjuvant Rats 

摘      要：Objective:To investigate the anti-inflammatory and analgesic effects of Solanum procumbens on complete Freund’s adjuvantinduced arthritis rat ***:We isolated and identified five compounds in the ethanolsoluble Solanum procumbens extract(SP)with anti-inflammatory effects,including ursolic acid,β-sitosterol,hexadecanoic acid,cisvaccenic acid,and vanillic ***,we investigated the anti-inflammatory effects of SP on rheumatoid arthritis symptoms,including paw volumes,local temperatures,withdrawal latency,and mechanical withdrawal threshold at the hind paw and white blood cell(WBC)number from complete Freund’s adjuvant-induced arthritis rat ***:We have successfully established a complete Freund’s adjuvant-induced arthritis rat model at a low dose(1 mg/mL).SP extract significantly reduced paw volumes(P0.05),prolonged withdrawal latencies(P0.05),decreased local temperature,and increased the mechanical withdrawal threshold(P0.05),but only SP extract at the dose of 300 mg/kg significantly decreased WBC ***:SP extract could be a potential medication candidate with anti-inflammatory effects for arthritis,but it requires further investigation into the mechanism of the SP and its effectiveness on other models as well as clinical trials.