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Is there an anatomical endophenotype for neurodevelopmental disorders? A review of dual disorder anatomical likelihood estimation (ALE) meta-analyses of grey matter volumes

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Chinese Science Bulletin 2011年第32期56卷 3376-3381页

作者： MCALONAN Grainne M YU Kevin K CHAN Raymond C K CHUA Siew E cheung charlton Department of Psychiatry the University of Hong Kong State Key Laboratory for Brain and Cognitive Sciences the University of Hong Kong Neuropsychology and Applied Cognitive Neuroscience Laboratory Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences

The term "neurodevelopmental disorder" broadly encompasses conditions thought to arise early in development and includes schizophrenia, bipolar disorder and autism among others. These conditions share a number of genetic and environmental risk factors postulated to lead to common difficulties in socio-emotional processing, communication and cognitive function. The alternative position is that, while the same traits are affected across these conditions, the nature or direction in which they are modified may be distinct. MRI studies provide a rapidly expanding and rich database which we propose can be used to contribute to this debate. Anatomical likelihood estimation (ALE) is a method of meta-analysis applied to voxel-based MRI studies. We have adapted this method to explore the extent to which schizophrenia and bipolar disorder and schizophrenia and autism share a common brain structural phenotype. We will review this work here and discuss whether there is sufficient other evidence to justify a common framework for further research into the inter-relatedness of such conditions.

关键词：神经疾病似然估计审查工作解剖精神分裂症稳定质数进修

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Extensive brain structural network abnormality in first-episode treatment-naive patients with schizophrenia:Morphological and covariation study

Extensive brain structural network abnormality in first-epis...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Siew E Chua charlton cheung Grinne M.McAlonan Pak C Sham David A Collier Marco Picchioni Stefania Benetti Andrea Mechelli Nicolas Crossley Joseph P.Kambeitz Paul Allen Philip McGuire Department of Psychiatry The University of Hong KongPokfulamS.A.R.China MRC SGDP Centre Institute of PsychiatryKing's College LondonLondon SE5 8AFUK Division of Psychological Medicine and Psychiatry Section of NeuroimagingInstitute of PsychiatryKing's College LondonLondon SE5 8AFUK St Andrew's Academic Centre Institute of PsychiatryKing's College LondonNN1 5BG Department of Psychosis Study Institute of PsychiatryKing's College LondonLondon SE5 8AFUK

＜正＞Objective With a particular focus on putative cortico-striatal-thalamic-cortical（CSTC） networks current study aimed to explore robust gray matter volume（GMV） changes in non-medicated first-episode schizophrenia（FES） *** High-resolution T1-weighted images were obtained using 3.0 Tesla magnetic resonance imaging from 86 first-episode drug-naive schizophrenia patients and 86 healthy controls（CON）.Severity of symptoms in patients was evaluated by using Positive and Negative Syndrome Scale（PANSS）.Fourteen spherical region of interest （ROI） GMV in the CSTC loop were acquired after optimized voxel-based morphometry（VBM） *** of Spherical ROIs and corresponding correlation coefficients were compared between FES and CON *** associations of GMV with PANSS subscale score and symptom dimension scores were also *** GMV reduction was detected in bilateral hippocampus in FES group by VBM *** located in left inferior frontal gyrus（Brodmann’s area 47） and right thalamus（medial dosal nucleus） present GMV *** of ROIs revealed more extensive GMV loss and disassociation between *** Our study support that schizophrenia involves distributed rather than focal pathology and disordered *** analysis could make compensation to VBM and ROI method to uncover more subtle aberrations in regional correlation.

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在失代偿性肝硬化的HCV基因1型患者中,使用为期12周的雷迪帕韦/索磷布韦+利巴韦林(LDV/SOF+RBV):SOLAR-1和-2,与现实世界数据库进行比较

在失代偿性肝硬化的HCV基因1型患者中,使用为期12周的雷迪帕韦/索...

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第九届全国疑难及重症肝病大会

作者： Michael charlton Michelle C.M.cheung Michael Manns Nika Sajed Philip J.F.Troke James Spellman Amanda Copans Sarah Arterburn Diana M.Brainard William L.Irving HCV Research UK Graham R.Foster

背景:对于失代偿性肝硬化的HCV患者,在干扰素时代治疗方案选择有限,且预后不佳。最近,FDA根据SOLAR-1和-2批准了LDV/SOF+RBV可用于GT1的失代偿性肝硬化的患者。现实世界数据库在证实临床数据的普适性方面意义重要。本文中,对比了来自英...

背景:对于失代偿性肝硬化的HCV患者,在干扰素时代治疗方案选择有限,且预后不佳。最近,FDA根据SOLAR-1和-2批准了LDV/SOF+RBV可用于GT1的失代偿性肝硬化的患者。现实世界数据库在证实临床数据的普适性方面意义重要。本文中,对比了来自英国扩展准入项目(EAP)的现实世界数据和失代偿性肝硬化的HCV患者的临床试验数据。

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

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