Extensive brain structural network abnormality in first-episode treatment-naive patients with schizophrenia:Morphological and covariation study
作者单位：Department of PsychiatryThe University of Hong KongPokfulamS.A.R.China MRC SGDP CentreInstitute of PsychiatryKing's College LondonLondon SE5 8AFUK Division of Psychological Medicine and PsychiatrySection of NeuroimagingInstitute of PsychiatryKing's College LondonLondon SE5 8AFUK St Andrew's Academic CentreInstitute of PsychiatryKing's College LondonNN1 5BG Department of Psychosis StudyInstitute of PsychiatryKing's College LondonLondon SE5 8AFUK
会议名称：《中国神经科学学会第九届全国学术会议暨第五次会员代表大会》
会议日期：2011年
学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学]
摘 要：正Objective With a particular focus on putative cortico-striatal-thalamic-cortical（CSTC） networks current study aimed to explore robust gray matter volume（GMV） changes in non-medicated first-episode schizophrenia（FES） *** High-resolution T1-weighted images were obtained using 3.0 Tesla magnetic resonance imaging from 86 first-episode drug-naive schizophrenia patients and 86 healthy controls（CON）.Severity of symptoms in patients was evaluated by using Positive and Negative Syndrome Scale（PANSS）.Fourteen spherical region of interest （ROI） GMV in the CSTC loop were acquired after optimized voxel-based morphometry（VBM） *** of Spherical ROIs and corresponding correlation coefficients were compared between FES and CON *** associations of GMV with PANSS subscale score and symptom dimension scores were also *** GMV reduction was detected in bilateral hippocampus in FES group by VBM *** located in left inferior frontal gyrus（Brodmann’s area 47） and right thalamus（medial dosal nucleus） present GMV *** of ROIs revealed more extensive GMV loss and disassociation between *** Our study support that schizophrenia involves distributed rather than focal pathology and disordered *** analysis could make compensation to VBM and ROI method to uncover more subtle aberrations in regional correlation.
