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运动预处理联合骨髓间充质干细胞移植治疗大鼠心肌梗死

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中国组织工程研究 2025年第1期29卷 65-73页

作者：王治坤白少玄赵伟王晨宇郑州航空工业管理学院河南省郑州市450015 中国人民武装警察部队后勤学院天津市300309

背景:干细胞疗法在改善心肌梗死后心脏重构方面具有广阔前景,但心肌微环境改变影响干细胞疗效。运动预处理类似于缺血预处理,能够对心肌产生保护作用。然而,运动预处理与干细胞移植联合作用的效果与机制鲜有关注。目的:观察运动预处理... 详细信息

背景:干细胞疗法在改善心肌梗死后心脏重构方面具有广阔前景,但心肌微环境改变影响干细胞疗效。运动预处理类似于缺血预处理,能够对心肌产生保护作用。然而,运动预处理与干细胞移植联合作用的效果与机制鲜有关注。目的:观察运动预处理对心肌梗死大鼠骨髓间充质干细胞移植效果的影响,探讨局部炎症微环境在其中的作用机制。方法:80只雌性SD大鼠随机分为假手术组、模型组、移植组和联合组,每组20只。利用结扎冠状动脉左前降支的方法制作心肌梗死大鼠模型,假手术组仅穿线不结扎。移植组和联合组造模后于心肌内注射雄性大鼠来源骨髓间充质干细胞,此外,联合组在造模前还需进行8周跑台运动(即运动预处理)。干细胞移植后4周,采用递增负荷运动力竭实验测定运动能力,超声心动术测定心脏结构与功能,压力容积导管法检测左心室血液动力学,原位染色法进行心肌组织病理学观察并获取心肌胶原容积分数。干细胞移植后1,7 d和4周,采用定量反转录聚合酶链反应检测左心室促炎症因子(白细胞介素1β、白细胞介素6、肿瘤坏死因子α)、抗炎症因子(白细胞介素10)、Y染色体性别决定区和胚胎基因(心房钠尿肽、脑钠肽、β-肌球蛋白重链)m RNA表达量。结果与结论:(1)干细胞移植后4周:与假手术组比较,模型组运动能力、左心室射血分数降低(P 0.05)。与移植组比较,联合组上述各指标均进一步改善(P<0.05)。(2)干细胞移植后1,7d:与移植组比较,联合组Y染色体性别决定区m RNA表达量升高(P<0.05)。(3)相关分析显示,白细胞介素1β、白细胞介素6(除移植后1 d)、肿瘤坏死因子α与Y染色体性别决定区m RNA表达量呈负相关(P <0.05),白细胞介素10与Y染色体性别决定区m RNA表达量呈正相关(P <0.05)。结果表明:运动预处理能够增强骨髓间充质干细胞移植治疗心肌梗死大鼠的效果,表现为心脏重构得到抑制、心功能进一步提升,其机制与心肌炎症微环境改善促进骨髓间充质干细胞滞留和存活有关。

关键词：运动预处理心肌梗死骨髓间充质干细胞心脏重构炎症反应微环境

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Efficient privacy-preserving user authentication scheme with forward secrecy for industry 4.0

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Science China(Information Sciences) 2022年第1期65卷 192-206页

作者： chenyu wang Ding wang Guoai XU Debiao HE School of Cyber Security Beijing University of Posts and Telecommunications State Key Laboratory of Cryptology College of Cyber Science Nankai University Tianjin Key Laboratory of Network and Data Security Technology Nankai University School of Cyber Science and Engineering Wuhan University

Industry 4.0, which combines information technology, network and industrial production, is expected to have a tremendous impact on our daily lives. In such a complex and security-critical system with resource-constrained sensor nodes, the design of a secure user authentication scheme for preventing real-time data from unauthorized access is full of challenges, and the main crux lies in how to realize the important property of forward secrecy. Existing schemes either fail to achieve forward secrecy or achieve forward secrecy with high computation cost on sensor nodes. Besides, they often fail to conform to the development trend of industry 4.0 systems where a cloud center is necessary to help intelligent decision-making and alleviate computation and storage pressure. Therefore, in this paper, we propose an efficient privacy-preserving user authentication scheme with forward secrecy for industry 4.0, and formally prove its security in the random oracle model. Compared with previous schemes, it has three advantages:(1) all eleven state-of-the-art criteria are achieved;(2) its computation cost on sensor nodes is comparable to those insecure schemes that employ only symmetric cryptographic algorithms, and is superior to those that also use asymmetric cryptographic algorithms;(3) it takes the advantage of the computation and storage capabilities of the cloud center to achieve user anonymity and the resistance to offline dictionary attack without performing any asymmetric cryptographic algorithms on gateways. Our computation cost on gateways is the smallest among all state-of-the-art relevant schemes for comparison.

关键词： industry 4.0 wireless sensor networks password authentication forward secrecy offline dictionary attack

Prediction and Regulation of Delamination at Flexible Film/Finite-Thickness-Substrate Structure Interfaces

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Acta Mechanica Solida Sinica 2024年第2期37卷 238-251页

作者： Yutang Zhou Yunlong Xu Haoran Gong chenyu wang Department of Engineering Mechanics Northwestern Polytechnical UniversityXi’an710072China School of Instrumentation Science and Opto-Electronics Engineering Beihang UniversityBeijing100191China

Regulating the surface instability of thin film/substrate structures has been successfully applied to prepare new ductile electronic ***,such electronic devices need to be subjected to external loads during operation,which can easily induce delamination of the thin-film electronic device from the *** study aims to investigate the instability characteristics of hard films on flexible substrate surfaces from theoretical analysis and numerical simulation *** finite-thickness substrates,this paper establishes theoretical models for pure bending,bent wrinkle,partial delamination,and total delamination buckling of film/substrate structures based on the nonlinear Euler–Bernoulli beam theory and the principle of minimum energy;then the effects of material and geometric parameters of the structure,interfacial adhesion strength,and pre-strain on the evolutionary path of the four patterns are *** study results show that:the greater Young’s modulus of the substrate is,the larger the parameter region where partial delamination of the film/substrate structure occurs,and the smaller the parameter region where bent wrinkle *** varying Young’s modulus,thickness of the film and substrate,interfacial adhesion coefficient,and pre-strain,the buckling pattern of the structure can be predicted and *** parametric design intervals for each pattern are summarized in the phase *** results of this paper provide theoretical support for the design and reliability evaluation of flexible electronic devices.

关键词： Thin film/finite-thickness-substrate structure Delamination Surface instability Pattern evolution

Enhancing the robustness of object detection via 6G vehicular edge computing

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Digital Communications and Networks 2022年第6期8卷 923-931页

作者： Chen Chen Guorun Yao chenyu wang Sotirios Goudos Shaohua Wan School of Telecommunication Engineering Xidian UniversityXi'an710071China Department of Physics ELEDIA@AUTHAristotle University of Thessaloniki54124ThessalonikiGreece Shenzhen Institute for Advanced Study University of Electronic Science and Technology of ChinaShenzhen518110China

Academic and industrial communities have been paying significant attention to the 6th Generation (6G) wireless communication systems after the commercial deployment of 5G cellular communications. Among the emerging technologies, Vehicular Edge Computing (VEC) can provide essential assurance for the robustness of Artificial Intelligence (AI) algorithms to be used in the 6G systems. Therefore, in this paper, a strategy for enhancing the robustness of AI model deployment using 6G-VEC is proposed, taking the object detection task as an example. This strategy includes two stages: model stabilization and model adaptation. In the former, the state-of-the-art methods are appended to the model to improve its robustness. In the latter, two targeted compression methods are implemented, namely model parameter pruning and knowledge distillation, which result in a trade-off between model performance and runtime resources. Numerical results indicate that the proposed strategy can be smoothly deployed in the onboard edge terminals, where the introduced trade-off outperforms the other strategies available.

关键词： 6G Vehicular edge computing Object detection Feature fusion Model compression Model deployment

Bioinspired 4D Printing Shape-Memory Polyurethane Rhinoplasty Prosthesis for Dynamic Aesthetic Adjustment

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Journal of Bionic Engineering 2024年第3期21卷 1397-1411页

作者： Jiaqi Liu Guiwei Li He Liu Jincheng wang Hui wang Xue Gao Qingping Liu chenyu wang Department of Plastic and Reconstructive Surgery The First Hospital of Jilin UniversityChangchun130021China Department of Orthopaedics The Second Hospital of Jilin UniversityChangchun130041China Key Laboratory of Bionic Engineering(Ministry of Education) Jilin UniversityChangchun130022China

The disparity between the postoperative outcomes of rhinoplasty and the expected results frequently necessitates secondary or multiple surgeries as a compensatory measure,greatly diminishing patient ***,there is renewed optimism for addressing these challenges through the innovative realm of Four-Dimensional(4D)*** groundbreaking technology enables three-dimensional objects with shape-memory properties to undergo predictable transformations under specific external ***,implants crafted using 4D printing offer significant potential for dynamic *** by worms in our research,we harnessed 4D printing to fabricate a Shape-Memory Polyurethane(SMPU)for use as a nasal augmentation *** choice of SMPU was guided by its Glass Transition Temperature(Tg),which falls within the acceptable temperature range for the human *** attribute allowed for temperature-responsive intraoperative self-deformation and postoperative *** chosen animal model for experimentation was *** into account the anatomical structure of the rabbit nose,we designed and produced nasal augmentation prostheses with superior *** prostheses were then surgically implanted in a minimally invasive manner into the rabbit ***,they exhibited successful temperature-controlled in-surgery self-deformation according to the predetermined shape and non-invasive remodeling within a mere 9 days *** histological evaluations confirmed the practical viability of these prostheses in a living *** research findings posit that worm-inspired 4D-printed SMPU nasal prostheses hold significant promise for achieving dynamic aesthetic adjustments.

关键词： 4D printing Shape memory polyurethane Rhinoplasty Self-deformation Dynamic aesthetic adjustment

Study on in situ stress testing method based on Kaiser effect of acoustic emission and COMSOL simulation

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Frontiers of Earth Science 2023年第3期17卷 818-831页

作者： chenyu wang Dongming ZHANG Shujian LI Yu CHEN Chongyang wang Kangde REN State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400044China School of Resources and Safety Engineering Chongqing UniversityChongqing 400044China Yunnan Phosphate Chemical Group Co. Ltd.Kunming 650600China National Engineering and Technology Research Center for Development and Utilization of Phosphate Resources Kunming 650600China

In situ stress testing can improve the safety and efficiency of coal *** the Kaiser effect point is vital for in situ stress calculations;however,the in situ stress calculation is limited by the rock sampling ***,the Kaiser effect point identification theory is established and applied to the Xuyong Coal *** compression and acoustic emission experiments were carried out on sandstone with 6 sampling ***,COMSOL simulation is applied to study the in situ stress distribution in the coal mine to verify the calculation *** results are as follows.1)The failure mode of non-bedded and vertical-bedded rocks is primarily tensile shear failure with obvious brittleness in mechanical and acoustic emission *** slip along the bedding plane is the primary failure mode of inclined-bedded *** take-off points exist in the AE count curve.2)The Kaiser point identification method based on the variation of AE count curve parametersΔti andτi can effectively calculate the in situ *** to the numerical value of Kaiser point and sampling direction,the in situ stress of the conveyor roadway in the Xuyong Coal Mine was calculated asσ1=22.81 MPa,σ2=10.87 MPa andσ3=6.14 MPa.3)By the COMSOL simulation study,it was found that a stress concentration zone of 16.13 MPa exists near the two sides *** with the Kaiser effect method,the deviation rates of the three-direction principal stress calculated by COMSOL were all less than 5%.This verifies that the in situ stress calculation by Kaiser effect in this study can be applied to the Xuyong Coal Mine.

关键词： Coal Mine uniaxial compression acoustic emission COMSOL simulation

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Understanding the forces acting in self-assembly and the implications for constructing three-dimensional （3D） supercrystals

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Nano Research 2015年第8期8卷 2445-2466页

作者： chenyu wang1 Carrie Siu Jun Zhang Jiye Fang Department of Chemistry State University of New York at Binghamton Binghamton New York 13902 USA Materials Science and Engineering Program State University of New York at Binghamton Binghamton New York 13902 USA State Key Laboratory of Heavy Oil Processing College of Chemical Engineering China University of Petroleum Qingdao 266580 China

The assembly of nanocrystals into ordered structures called supercrystals or superstructures has become a pivotal frontier owing to numerous useful applications such as correlating the arrangements of atoms in macroscopic crystals and tuning the collective properties to meet the demands of various applications. In this article, recent progress in the preparation of three-dimensional superlattices of nanocrystals is outlined, with a particular emphasis on the driving forces and evolutionary routes beyond orderly assembly. First, the leading or repulsive forces that internally and externally govern the formation of three-dimensional supercrystals are systematically identified and discussed with respect to their origins and functions in three-dimensional self-organization. Then a synoptic introduction of commonly applied means of nanocrystal self-assembly based on growth scenarios such as droplet evaporation and a liquid/liquid interface is presented with specific cases and detailed analyses. Finally, the existing challenges and prospects for this field are briefly highlighted.

关键词： interparticle forces superlattices supercrystals three-dimensional self-assembly

A V2V Emergent Message Dissemination Scheme for 6G-Oriented Vehicular Networks

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Chinese Journal of Electronics 2023年第6期32卷 1179-1191页

作者： CHEN Chen wang chenyu CONG Li XIAO Ming PEI Qingqi School of Telecommunication Engineering Xidian University The State Grid Jilin Province Electric Power Company Limited Information Communication Company KTH Royal Institute of Technology

To ensure traffic safety and improve traffic efficiency, vehicular networks come up with multiple types of messages for safety and efficiency applications. In sixth-generation(6G) systems, these messages should be timely and error-free disseminated through vehicle-to-vehicle(V2V) communication to ensure traffic safety and efficiency. V2V supports direct communication between two vehicle user equipments, regardless of whether a base station is involved. We propose a packet delivery ratio(PDR)-based message dissemination scheme(PDR-MD) between V2V in 6G-oriented vehicular networks to select relay vehicles when broadcasting emergent messages. This scheme grasps the balance between vehicle distance and PDR so as to reduce transmission delay while ensuring reliable PDR. We compared the PDR-MD scheme with other probabilistic broadcasting schemes. The experimental results show that the PDRMD protocol can maintain close to 95% and above PDR in transmitting emergent messages, and the transfer rate stays below 40%.

关键词： 6G mobile communication Protocols Urban areas Vehicular ad hoc networks Broadcasting Probabilistic logic Safety

Current knowledge of Krüppel-like factor 5 and vascular remodeling: providing insights for therapeutic strategies

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Journal of Molecular Cell Biology 2021年第2期13卷 79-90页

作者： Ziyan Xie Junye Chen chenyu wang Jiahao Zhang Yanxiang Wu Xiaowei Yan Department of Cardiology Peking Union Medical College HospitalPeking Union Medical College&Chinese Academy of Medical SciencesBeijing 100730China Department of Vascular Surgery Peking Union Medical College HospitalPeking Union Medical College&Chinese Academy of Medical SciencesBeijing 100730China

Vascular remodeling is a pathological basis of various disorders. Therefore, it is necessary to understand the occurrence, prevention, and treatment of vascular remodeling. Krüppel-like factor 5 (KLF5) has been identified as a significant factor in cardiovascular diseases during the last two decades. This review provides a mechanism network of function and regulation of KLF5 in vascular remodeling based on newly published data and gives a summary of its potential therapeutic applications. KLF5 modulates numerous biological processes, which play essential parts in the development of vascular remodeling, such as cell proliferation, phenotype switch, extracellular matrix deposition, inflammation, and angiogenesis by altering downstream genes and signaling pathways. Considering its essential functions, KLF5 could be developed as a potent therapeutic target in vascular disorders.

关键词： Krüppel-like factor 5(KLF5) vascular remodeling inflammation angiogenesis drug development microRNA