Bioinspired 4D Printing Shape-Memory Polyurethane Rhinoplasty Prosthesis for Dynamic Aesthetic Adjustment
作者机构：Department of Plastic and Reconstructive SurgeryThe First Hospital of Jilin UniversityChangchun130021China Department of OrthopaedicsThe Second Hospital of Jilin UniversityChangchun130041China Key Laboratory of Bionic Engineering(Ministry of Education)Jilin UniversityChangchun130022China
出 版 物：《Journal of Bionic Engineering》 (仿生工程学报（英文版）)
年 卷 期：2024年第21卷第3期
页 面：1397-1411页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0802[工学-机械工程] 0836[工学-生物工程] 080201[工学-机械制造及其自动化]
基 金：financially supported by the talent reserve program of the first hospital of Jilin University(Grant Nos.JDYY-TRP-2024002) the National Natural Science Foundation of China(Grant Nos.82372391,82001971,82102358 and 82202698) Scientific Development Program of Jilin Province(Grant Nos.20200403088SF,20220204117YY,YDZJ202201ZYTS086,20200404202YY and 20200802008GH) Program of Jilin Provincial Health Department(Grant No.2020SC2T064 and 2020SC2T065) Project of"Medical+X"Interdisciplinary Innovation Team of Norman Bethune Health Science Center of Jilin University(Grant No.2022JBGS06) China Postdoctoral Science Foundation(Grant No.2021M701384) Bethune Plan of Jilin University(Grant No.2022B27,2022B03)
主 题：4D printing Shape memory polyurethane Rhinoplasty Self-deformation Dynamic aesthetic adjustment
摘 要：The disparity between the postoperative outcomes of rhinoplasty and the expected results frequently necessitates secondary or multiple surgeries as a compensatory measure,greatly diminishing patient ***,there is renewed optimism for addressing these challenges through the innovative realm of Four-Dimensional(4D)*** groundbreaking technology enables three-dimensional objects with shape-memory properties to undergo predictable transformations under specific external ***,implants crafted using 4D printing offer significant potential for dynamic *** by worms in our research,we harnessed 4D printing to fabricate a Shape-Memory Polyurethane(SMPU)for use as a nasal augmentation *** choice of SMPU was guided by its Glass Transition Temperature(Tg),which falls within the acceptable temperature range for the human *** attribute allowed for temperature-responsive intraoperative self-deformation and postoperative *** chosen animal model for experimentation was *** into account the anatomical structure of the rabbit nose,we designed and produced nasal augmentation prostheses with superior *** prostheses were then surgically implanted in a minimally invasive manner into the rabbit ***,they exhibited successful temperature-controlled in-surgery self-deformation according to the predetermined shape and non-invasive remodeling within a mere 9 days *** histological evaluations confirmed the practical viability of these prostheses in a living *** research findings posit that worm-inspired 4D-printed SMPU nasal prostheses hold significant promise for achieving dynamic aesthetic adjustments.
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