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Gut microbiota and its implications in small bowel transplantation

Frontiers of Medicine 2018年第3期12卷 239-248页

作者： chenyang wang Qiurong Li Jieshou Li Research Institute of General Surgery Jinling Hospital Medical School Nanjing University Nanjing 210002 China

The gut microbiota is mainly composed of a diverse population of commensal bacterial species and plays a pivotal role in the maintenance of intestinal homeostasis, immune modulation and metabofism. The influence of the gut microbiota on solid organ transplantation has recently been recognized. In fact, several studies indicated that acute and chronic allograft rejection in small bowel transplantation （SBT） is closely associated with the alterations in microbial patterns in the gut. In this review, we focused on the recent findings regarding alterations in the microbiota following SBT and the potential roles of these alterations in the development of acute and chronic allograft rejection. We also reviewed important advances with respect to the interplays between the microbiota and host immune systems in SBT. Furthermore, we explored the potential of the gut microbiota as a microbial marker and/or therapeutic target for the predication and intervention of allografl rejection and chronic dysfunction. Given that current research on the gut microbiota has become increasingly sophisticated and comprehensive, large cohort studies employing metagenomic analysis and multivariate linkage should be designed for the characterization of host-microbe interaction and causality between microbiota alterations and clinical outcomes in SBT. The findings are expected to provide valuable insights into the role of gut microbiota in the development of allograft rejection and other transplant-related complications and introduce novel therapeutic targets and treatment approaches in clinical practice.

关键词： gut microbiota small bowel transplantation acute rejection chronic rejection mucosal immunity biomarker microbiota-targeted therapy

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Preventive and control system for the life cycle of a pandemic

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Journal of Safety Science and Resilience 2022年第4期3卷 321-329页

作者： chenyang wang Rui Ba Ranpeng wang Hui Zhang Department of Engineering Physics Tsinghua UniversityBeijing 100084China

Herein,a matching method for varied epidemic phase characteristics and appropriate strategies is presented,aiming at the complexities of the novel coronavirus disease 2019 pandemic and the hysteresis of *** classical diffusion dynamic models of the epidemic spread are ***,the Bass diffusion model is selected to study more characteristics of an epidemic,such as the diversities in regional internal and external infection ***,the classical division method vis-à-vis a pandemic life cycle is improved.A specific approach is proposed to portray more detailed characteristics of the pandemic by dividing it into more ***,a four-level epidemic prevention and control measure system is *** applicable phases and strategic effectiveness of each measure are integrated into the different phases of the pandemic life ***,the matching method is applied to analyze two cases of the spread of the outbreak in cities and significant *** findings provide a certain reference for the effectiveness of the matching method in the post-peak epidemic period.

关键词： Pandemic Life cycle Prevention and control system

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A Sub-100 mg Electromagnetically Driven Insect-inspired Flapping-wing Micro Robot Capable of Liftoff and Control Torques Modulation

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Journal of Bionic Engineering 2020年第6期17卷 1085-1095页

作者： chenyang wang Weiping Zhang Yang Zou Ran Meng Jiaxin Zhao Mingchen Wei National Key Laboratory of Science and Technology on Micro/Nano Fabrication School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Inspired by the unique,agile and efficient flapping flight of insects,we present a novel sub-100 mg,electromagnetically driven,tailless,flapping-wing micro *** robot utilizes two optimized electromagnetic actuators placed back to back to drive two wings separately,then kinematics of each wing can be independently controlled,which gives the robot the ability to generate all three control torques of pitch,roll and yaw for *** quantify the performance of the robot,a simplified aerodynamic model is used to estimate the generated lift and torques,and two customized test platforms for lift and torque measurement are built for this *** mean lift generated by the robot is measured to be proportional to the square of the input voltage *** three control torques are measured to be respectively proportional to three decoupled parameters of the control voltages,therefore the modulation of three control torques for the robot is independent,which is helpful for the further controlled *** these measured results fit well with the calculated results of the aerodynamic ***,with a total weight of 96 mg and a wingspan of 3.5 cm,this robot can generate sufficient lift to take off.

关键词： insect-inspired insect-scale micro robot FMAV electromagnetic actuation

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Effects of offshore artificial islands on beach stability of sandy shores:case study of Hongtang Bay,Hainan Province

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Frontiers of Earth Science 2022年第4期16卷 876-889页

作者： Songzhe LI Biao LV Yunping YANG Yanhua YANG chenyang wang State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China Key Laboratory of Engineering Sediment Tianjin Research Institute for Water Transport EngineeringMinistry of TransportTianjin 300456China

Artificial island-type reclamation often exerts certain impacts on near-shore sandy shoreline resources and coastal ecological *** relationship between artificial islands and offshore beach evolution has attracted considerable attention in coastal protection and engineering *** this study,we consider Hongtang Bay in Hainan Province,China,as the research *** adopted the Gao-Collins model to investigate the substrate transport trend in this sea area based on the analysis of the measured hydrologic and sediment *** shore section from Nanshanjiao to Hongtangling(Taling),including the flat and straight shore sections,is dominated by the lateral transport trend of the vertical *** near-shore water has a strong lateral sediment transport capacity,while the outer deep-water area exhibits a sediment transport trend consistent with the tidal current *** multi-year topographic data,the shoreline and seabed alterations in Hongtang Bay were analyzed,and the LITLINE beach evolution model was adopted to simulate the effects of three artificial island layouts with different island filling areas,offshore distances,and plan forms on the near-shore shoreline *** results obtained indicate that the artificial island arrangement with a large offshore distance and a small area has relatively substantial advantages,such as minimizing the adverse effects of artificial island implementation on the near-shore beach.

关键词： offshore artificial island stability analysis beach evolution Hongtang Bay Hainan

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Rethinking the urban resilience:Extension and connotation

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Journal of Safety Science and Resilience 2022年第4期3卷 398-403页

作者： Rui Ba chenyang wang Luyao Kou Xiaojing Guo Hui Zhang School of National Security People’s Public Security University of ChinaBeijing100038China Institute of Public Safety Research Tsinghua UniversityBeijing100084China

In recent years,urban resilience has attracted increasing attention from researchers and managers from the international community at the national,regional,and urban *** multi-dimensional and cross-disciplinary investigations,campaigns,and outlines have significantly promoted the development goal of re-silience in cities ***,the existing definitions and interpretations of urban resilience still call for a more comprehensive,systematic,and exhaustive analysis as urbanization accelerates and the complex risks of various safety events *** this end,we rethink the extension and connotation of urban resilience based on a review and analysis of critical hotspots,realistic demand,and development trends.A conceptual classification with three aspects and three typical tiers of urban resilience is proposed,which further promotes a new definition and interpretation by incorporating the resilience extension of urban *** addition,the six-dimensional characteristics are extracted to furnish the urban resilience connotation,and four-stage improvement measures are introduced *** addition,the newly developed urban resilience is applied to a case analysis of a large-scale disaster,which demonstrates the necessity and significance of this *** new extension and connotation investigation will be helpful for the improvement and implementation of urban resilience,thereby guiding the construction of resilient cities.

关键词： Urban resilience Infrastructure Social units Complex systems

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A many-body dissipative particle dynamics with energy conservation study of droplets icing on microstructure surfaces

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Advances in Aerodynamics 2021年第1期3卷 610-622页

作者： chenyang wang Xiao Wu Pengfei Hao Feng He Xiwen Zhang Department of Engineering Mechanics Tsinghua UniversityBeijing 100084China

Droplets icing has important applications in real *** icing process of droplets on microstructure is explored based on the MDPDE method in this ***,the correctness of the heat transfer model was verified by one-dimensional heat conduction simulation,and then the feasibility of the phase change model was verified by investigating the icing process of *** influence of cold surface temperature,droplet volume and contact angle on freezing time of droplets was discussed,and it was found that the temperature of cold surfaces had a greater effect on *** finally explored the influence of different microstructure surfaces on the icing of droplets,and results showed that the presence of microstructures greatly enhanced the anti-icing effect of the *** our research,the contact angle is a relatively large factor affecting the icing of *** addition,it was discovered that the droplet had the strongest ability to delay freezing on the surface of triangle microstructures with a contact angle of 157.1°.

关键词： MDPDE Droplet freezing Microstructure Anti-icing

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The response of intestinal stem cells and epithelium after alemtuzumab administration

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Cellular & Molecular Immunology 2011年第4期8卷 325-332页

作者： Qiurong Li Qiang Zhang chenyang wang Shaojun Jiang Ning Li Jieshou Li Department of Surgery Jinling HospitalNanjing University School of MedicineNanjingChina Department of Pathology Jinling HospitalNanjingChina

Qiurong Li1,Qiang Zhang1,chenyang wang1,Shaojun Jiang2,Ning Li1,Jieshou Li1 Intestinal stem cells may have important roles in the maintenance of epithelial integrity during tissue *** is a humanized anti-CD52 lymphocytic antibody that is increasingly being used to induce immunosuppression;intestinal barrier function is impaired during treatment with *** investigated the response of intestinal stem cells to epithelial damage resulting from alemtuzumab *** epithelial cell loss and abnormal Paneth cell morphology were found following a single dose of *** animals receiving alemtuzumab exhibited increased apoptosis in the villi 3 days after alemtuzumab treatment and in the crypt on day 9,but apoptosis was scarce on day *** assessed expression of Musashi-1-and Lgr5-positive stem cells following alemtuzumab *** numbers of cells staining positive for both Musashi-1 and Lgr5 were found in the stem cell zone after alemtuzumab treatment for 3 and 9 *** data indicated that the epithelial cells were injured following alemtuzumab treatment,with the associated expansion of intestinal stem *** alemtuzumab treatment for 35 days,the numbers of intestinal epithelial cells and intestinal stem cells returned to *** study suggests that alemtuzumab treatment induced the increase in stem cells,resulting in the availability of more enterocytes for repair.

关键词： alemtuzumab intestinal stem cells intestinal stem cell marker Musashi-1 Lgr5

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Facile and rapid fabrication of a novel 3D-printable,visible light-crosslinkable and bioactive polythiourethane for large-to-massive rotator cuff tendon repair

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Bioactive Materials 2024年第7期37卷 439-458页

作者： Xu Zhang Ke Li chenyang wang Ying Rao Rocky STuan Dan Michelle wang Dai Fei Elmer Ker Institute for Tissue Engineering and Regenerative Medicine The Chinese University of Hong KongNew TerritoriesHong Kong SARChina School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongNew TerritoriesHong Kong SARChina Center for Neuromusculoskeletal Restorative Medicine Hong Kong Science ParkHong Kong SARChina Ministry of Education Key Laboratory for Regenerative Medicine School of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongNew TerritoriesHong Kong SARChina Department of Orthopaedics and Traumatology Faculty of MedicineThe Chinese University of Hong KongNew TerritoriesHong Kong SARChina

Facile and rapid 3D fabrication of strong,bioactive materials can address challenges that impede repair of large-to-massive rotator cuff tears including personalized grafts,limited mechanical support,and inadequate tissue ***,we developed a facile and rapid methodology that generates visible light-crosslinkable polythiourethane(PHT)pre-polymer resin(~30 min at room temperature),yielding 3D-printable scaffolds with tendon-like mechanical attributes capable of delivering tenogenic bioactive *** vivo characterization confirmed successful fabrication,robust human supraspinatus tendon(SST)-like tensile properties(strength:23 MPa,modulus:459 MPa,at least 10,000 physiological loading cycles without failure),excellent suture retention(8.62-fold lower than acellular dermal matrix(ADM)-based clinical graft),slow degradation,and controlled release of fibroblast growth factor-2(FGF-2)and transforming growth factor-β3(TGF-β3).In vitro studies showed cytocompatibility and growth factor-mediated tenogenic-like differentiation of mesenchymal stem *** vivo studies demonstrated biocompatibility(3-week mouse subcutaneous implantation)and ability of growth factor-containing scaffolds to notably regenerate at least 1-cm of tendon with native-like biomechanical attributes as uninjured shoulder(8-week,large-to-massive 1-cm gap rabbit rotator cuff injury).This study demonstrates use of a 3D-printable,strong,and bioactive material to provide mechanical support and pro-regenerative cues for challenging injuries such as large-to-massive rotator cuff tears.

关键词： Photo-crosslinkable biomaterials Polyurethane Click reactions 3D-printing Growth factors Rotator cuff tendon tissue engineering

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Total phenolic, flavonoid content, and antioxidant activity of flour, noodles, and steamed bread made from different colored wheat grains by three milling methods

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The Crop Journal 2015年第4期3卷 328-334页

作者： Yaoguang Li Dongyun Ma Dexiang Sun chenyang wang Jian Zhang Yingxin Xie Tiancai Guo Agronomy College National Engineering Research Center for Wheat Henan Agricultural University The Collaborative Innovation Center of Henan Food Crops Henan Agricultural University Institute of Food Science and Technology Henan Agricultural University

The objective of this study was to evaluate the effects of wheat variety, food processing, and milling method on antioxidant properties. Black wheat variety Heibaoshi 1 had the highest total phenolic content(659.8 μg gallic acid equivalents g-1), total flavonoid content(319.3 μg rutin equivalents g-1), and antioxidant activity, whereas light purple wheat variety Shandongzimai 1 had the lowest total flavonoid content(236.2 μg rutin equivalents g-1) and antioxidant activity. Whole wheat flour and partially debranned grain flour had significantly higher total phenolic contents, total flavonoid contents, and antioxidant activity than refined flour(P < 0.05). Compared with flour, total phenolic contents, total flavonoid contents and antioxidant activity decreased in noodles and steamed bread, whereas noodles had slightly higher total phenolic and flavonoid content than steamed bread. Antioxidant activities(by ferric reducing ability of plasma assay) of steamed bread made from whole wheat flour, partially debranned grain flour, and refined flour were 23.5%, 21.1%, and 31.6% lower, respectively, than the corresponding values of flour. These results suggested that black whole wheat flour and partially debranned grain flour are beneficial to human health.

关键词： Total phenolic content Total flavonoid content Milling method Antioxidant activity Colored wheat

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Liquid metal catalyst for ammonia synthesis at low pressure

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Science China Materials 2024年

作者： Ziyue Zeng chenyang wang Lei Fu College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072China2The Institute for Advanced StudiesWuhan University

Liquid metal (LM) has attracted immense interest as a novel catalyst in the past few years for its distinctive physicochemical properties,encompassing superior electrical and thermal conductivities,as well as exceptional fluidity characteristics at low temperatures[1].In contrast to conventional solid heterogeneous catalysts,the fluidic characteristics of liquid metal catalysts enhance the interaction between catalysts and reactants,boosting mass transfer at the reaction ***,the atoms in liquid metal catalysts are characterized by vigorous thermal motion,and their surfaces are rich in free electrons,which confer higher catalytic activity[2].The liquid environ-

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