检索结果-南通市图书馆

Orally administered BZL-s RNA-20 oligonucleotide targeting TLR4 effectively ameliorates acute lung injury in mice

Science China(Life Sciences) 2023年第7期66卷 1589-1599页

作者： Dandan Zhao Yuhao Qin Jiaqi Liu Kegong Tang Shuaiyao Lu Zirui Liu Yexuan Lin Cong Zhang Fengming Huang Jiahui Chang Chang Li Mingyao Tian Yiming Ma Xiaoyun Li Congzhao Zhou Xiao Li Xiaozhong Peng Ningyi Jin chengyu jiang State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical SciencesDepartment of BiochemistryPeking Union Medical CollegeBeijing 100005China Institute of Medical Biology Chinese Academy of Medical SciencesKunming 650031China Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences University of Science and Technology of ChinaHefei 230027China Changchun Veterinary Research Institute Chinese Academy of Agricultural SciencesChangchun 130122China

The global COVID-19 pandemic emerged at the end of December *** respiratory distress syndrome(ARDS)and acute lung injury(ALI)are common lethal outcomes of bacterial lipopolysaccharide(LPS),avian influenza virus,and SARS-Co ***-like receptor 4(TLR4)is a key target in the pathological pathway of ARDS and *** studies have reported that herbal small RNAs(s RNAs)are a functional medical ***-s RNA-20(Accession number:B59471456;Family ID:F2201.Q001979.B11)is a potent inhibitor of Toll-like receptor 4(TLR4)and pro-inflammatory ***,BZLs RNA-20 reduces intracellular levels of cytokines induced by lipoteichoic acid(LTA)and polyinosinic-polycytidylic acid(poly(I:C)).We found that BZL-s RNA-20 rescued the viability of cells infected with avian influenza H5N1,SARS-Co V-2,and several of its variants of concern(VOCs).Acute lung injury induced by LPS and SARS-Co V-2 in mice was significantly ameliorated by the oral medical decoctosome mimic(bencaosome;sphinganine(d22:0)+BZL-s RNA-20).Our findings suggest that BZLs RNA-20 could be a pan-anti-ARDS/ALI drug.

关键词： oligonucleotide drug herbal medicine ARDS/ALI SARS-CoV-2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fluctuating magnetic droplets immersed in a sea of quantum spin liquid

引用

The Innovation 2023年第5期4卷 33-40页

作者： Zihao Zhu Binglin Pan Linpeng Nie Jiamin Ni Yanxing Yang Changsheng Chen chengyu jiang Yeyu Huang Erjian Cheng Yunjie Yu Jianjian Miao Adrian D.Hilier Xianhui Chen Tao Wu Yi Zhou Shiyan Li Lei Shu State Key Laboratory of Surface Phys ics and Department of PhysicsFudan UniversityShanghai 200433China CAS Key Laboratory of Stronglycoupled Quantum Matter Physics Department of PhysicsUniversity of Science and Technology of ChinaHefeiAnhui 230026China Department of Physics the University of Hong KongHong KongChina ISIS Pulsed Neutron and Muon Source STFC Rutherford Appleton LaboratoryHarwell CampusDidcotOxfordshire 0X110QXUK Collaborative Innovation Center of Advanced Micr ostructures Nanjing 210093China CAS Center for Excellence in Superconducting Electronics(CENSE) Shanghai 200050China Institute of Physics and Beijing National Laboratory for Condensed Matter Physics Chinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory DongguanGuangdong 523808China Kavli Institute for Theoretical Sciences and CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190China Shanghai Research Center for Quantum Sciences Shanghai 201315China

The search of quantum spin liquid(QSL),an exotic magnetic state with strongly fluctuating and highly entangled spins down to zero temperature,is a main theme in current condensed matter ***,there is no smoking gun evidence for deconfined spinons in any QSL candidate so *** disorders and competing exchange interactions may prevent the formation of an ideal QSL state on frustrated spin *** we report comprehensive and systematic measurements of the magnetic susceptibility,ultralow-temperature specific heat,muon spin relaxation(μSR),nuclear magnetic resonance(NMR),and thermal conductivity for NaYbSe2 single crystals,in which Yb3+ions with effective spin-1/2 form a perfect triangular *** these complementary techniques find no evidence of long-range magnetic order down to their respective base ***,specific heat,μSR,and NMR measurements suggest the coexistence of quasi-static and dynamic spins in *** scattering from these quasi-static spins may cause the absence of magnetic thermal ***,we propose a scenario of fluctuating ferrimagnetic droplets immersed in a sea of *** may be quite common on the way pursuing an ideal QSL,and provides a brand new platform to study how a QSL state survives impurities and coexists with other magnetically ordered states.

关键词： NMR immersed quantum

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Basic fibroblast growth factor protects against influenza A virus-induced acute lung injury by recruiting neutrophils

引用

Journal of Molecular Cell Biology 2018年第6期10卷 573-585页

作者： Keyu Wang Chengcai Lai Tieling Li Cheng Wang Wei Wang Bing Ni Changqing Bai Shaogeng Zhang Lina Han Hongjing Gu Zhongpeng Zhao Yueqiang Duan Xiaolan Yang Li Xing Lingna Zhao Shanshan Zhou Min Xia chengyu jiang Xiliang Wang Penghui Yang State Key Laboratory of Pathogens and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Chinese PLA General Hospital Beijing 100853China State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical SciencesBeijing 100005China Institute of Immunology Third Military Medical UniversityChongqing 400038China Beijing 307 Hospital of PLA Affiliated with the Chinese Academy of Medical Sciences Beijing 100070China Beijing 302 Hospital of PLA Beijing 100039China

Influenza virus (IAV)infection is a major cause of severe respiratory illness that affects almost every country in the *** infections result in respiratory illness and even acute lung injury and death,but the underlying mechanisms responsible for IAV pathogenesis have not yet been fully *** this study,the basic fibroblast growth factor 2 (FGF2)level was markedly increased in H1N1 virus-infected humans and ***2,which is predominately derived from epithelial cells,recruits and activates neutrophils via the FGFR2-PI3K-AKT-NFKB signaling ***2 depletion or knockout exacerbated influenzaassociated disease by impairing neutrophil recruitment and *** importantly,administration of the recombinant FGF2 protein significantly aUeviated the severity of IAV-induced lung injury and promoted the survival of IAV-infected *** on the results from experiments in which neutrophils were depleted and adoptively transferred,FGF2 protected mice against IAV , infection by recruiting ***,FGF2 plays a critical role in preventing IAV-induced lung injury,and FGF2 is a promising potential therapeutic target during IAV infection.

关键词： influenza H1N1 virus recombinant FGF2 protein neutrophil recruitment FGFR2-PI3K-AKT-NFκB signaling therapeutic target

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

制造信息资源粒度结构分析与编码技术研究

引用

西北工业大学学报 2007年第2期25卷 245-250页

作者：蒋建军王俊彪姜澄宇杨宾宏西北工业大学陕西西安710072

信息标准规范是制造业信息化的基础。文章采用粒度结构分析方法构建了基于粒度结构的制造信息资源组织模型。在该模型基础上,通过分析制造信息资源基于元数据的表达技术和多因素约束下的编码实现技术,采用面向对象的编码结构方案实现了... 详细信息

信息标准规范是制造业信息化的基础。文章采用粒度结构分析方法构建了基于粒度结构的制造信息资源组织模型。在该模型基础上,通过分析制造信息资源基于元数据的表达技术和多因素约束下的编码实现技术,采用面向对象的编码结构方案实现了制造信息资源表达方式的柔性统一。最后通过材料编码对所构建的模型进行了实例化。实践表明,制造信息资源粒度结构分析与编码技术能够很好地实现信息资源组织的规范化,为全生命周期产品研制模式下的信息资源规划提供了有效的手段。

关键词：粒度结构制造信息资源元数据信息编码

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

引用

Science China(Life Sciences) 2020年第3期63卷 364-374页

作者： Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei Wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou chengyu jiang Lei Liu Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseaseShenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical SciencesDepartment of BiochemistryPeking Union Medical CollegeBeijing 100005China Institute of Microbiology Chinese Academy of SciencesBeijing 100101China Emergence Department Peking Union Medical College Hospital Beijing 100731China

The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other *** we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,*** 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 *** viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease ***,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung ***,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease ***,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung *** results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection.

关键词： 2019-nCoV AngiotensinⅡ ARDS

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

论城市排水防涝工程水文问题

引用

水利水电科技进展 2015年第1期35卷 42-48页

作者：芮孝芳蒋成煜陈清锦河海大学水文水资源学院江苏南京210098 北京世纪千府国际工程设计有限公司江苏分公司江苏南京210029

排水防涝工程是防治和减轻城市洪涝灾害的重要设施,其建设规模主要受到工程寿命期内雨洪变化规律、社会经济发展水平的制约。论述了城市雨洪变化的特点、洪涝灾害的成因和不同类型工程措施的防灾、减灾原理;阐述了致灾率、设计标准等概... 详细信息

排水防涝工程是防治和减轻城市洪涝灾害的重要设施,其建设规模主要受到工程寿命期内雨洪变化规律、社会经济发展水平的制约。论述了城市雨洪变化的特点、洪涝灾害的成因和不同类型工程措施的防灾、减灾原理;阐述了致灾率、设计标准等概念;提出了城市排水防涝工程规划、设计中的水文计算任务;讨论了城市设计暴雨所涉及的暴雨强度公式、设计暴雨雨型等问题以及由设计暴雨确定设计洪水的原理和方法。

关键词：城市水文问题排水防涝工程暴雨强度公式设计暴雨雨型产汇流计算

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

一种快速有效的薄壁件加工表面误差预测算法

引用

航空学报 2007年第5期28卷 1262-1267页

作者：康永刚王仲奇姜澄宇西北工业大学机电学院陕西西安710072

在切削力作用下,刀具/工件的变形是影响薄壁弱刚度件加工精度与质量的关键因素,快速有效地进行表面误差的预测是实现工艺参数优化及在线刀具路径补偿的前提。针对立铣加工过程,提出了一种考虑刀具/工件变形位置的快速柔性迭代算法,基于... 详细信息

在切削力作用下,刀具/工件的变形是影响薄壁弱刚度件加工精度与质量的关键因素,快速有效地进行表面误差的预测是实现工艺参数优化及在线刀具路径补偿的前提。针对立铣加工过程,提出了一种考虑刀具/工件变形位置的快速柔性迭代算法,基于此建立了薄壁件加工变形预测的有限元计算模型,并通过等效集中力作用位置的确定、模型分割及最小化网格重划方法进一步提高了模型的计算速度。通过刀具/工件的瞬时接触区域的限定算法、实际切深的修正算法、材料去除效应的模拟等关键技术更提高了模型的计算精度。以典型航空铝合金材料为对象,合理安排试验,并通过数值计算结果和试验数据的对比,表明该方法计算精度高,计算速度较文献方法提高了近2倍。

关键词：立铣薄壁件柔性迭代算法表面误差

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

靶向TLR4的口服寡核苷酸药物BZL-sRNA-20可有效缓解小鼠急性肺损伤

引用

中国科学：生命科学 2024年第7期54卷 1279-1291页

作者：赵丹丹秦宇豪刘佳齐汤克功鲁帅尧刘子睿林烨暄张聪黄凤鸣常佳慧李昌田明尧马一鸣李晓芸周丛照李霄彭小忠金宁一蒋澄宇中国医学科学院基础医学研究所&北京协和医学院基础学院生物化学与分子生物学系重大疾病共性机制研究全国重点实验室北京100005 中国医学科学院医学生物学研究所昆明650031 中国农业科学院长春兽医研究所长春130122 中国科学技术大学合肥微尺度物质科学国家研究中心合肥230027

2019年12月底,新型冠状病毒病(coronavirus disease 2019,COVID-19)开始流行.急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)和急性肺损伤(acute lung injury,ALI)是由细菌脂多糖(lipopolysaccharide,LPS)、禽流感病毒和新型冠状病毒(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)等引发的高致死疾病.Toll样受体4(Toll-like receptor 4,TLR4)是ARDS和ALI病理通路中的关键靶点.草药小RNA(small RNA,sRNA)已被报道是草药药效的重要成分之一.本研究发现,半枝莲来源的小核酸BZL-sRNA-20(检索号:B59471456;ID:F2201.Q001979.B11)是TLR4及促炎细胞因子的有效抑制剂,可下调细菌脂磷壁酸(lipoteichoic acid,LTA)和聚肌苷酸-聚胞苷酸(Poly(I:C))引发上升的促炎细胞因子水平,并能挽救禽流感病毒H5N1,SARSCoV-2及其多种变异株感染所致的细胞死亡.此外,口服本草体(bencaosome):(鞘氨醇(d22:0)+BZL-sRNA-20)可缓解LPS与SARS-CoV-2诱导的小鼠急性肺损伤.本研究结果表明,半枝莲来源的BZL-sRNA-20可能是一种广谱治疗ARDS/ALI的寡核苷酸药物.

关键词：寡核苷酸药物中草药 ARDS/ALI SARS-CoV-2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury

引用

National Science Review 2020年第6期7卷 1003-1011页

作者： Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang Wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li DANDan Zhao Shunwang Li Shuguang Tan Zhaoqin Wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu chengyu jiang Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious Disease State Key Discipline of Infectious Disease Shenzhen Third People's Hospital Second Hospital Affiliated to Southern University of Science and Technology Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences University of Science and Technology of China The State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Department of Biochemistry Peking Union Medical College The NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChina CDC The NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention China CDC

A recent outbreak of pneumonia in Wuhan, China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19). We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen, China. To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V, we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients. Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy *** cytokines were linked to 2019-nCoV loads. Fifteen cytokines, namely M-CSF, IL-10, IFN-α2,IL-17, IL-4, IP-10, IL-7, IL-1 ra, G-CSF, IL-12, IFN-γ, IL-1α, IL-2, HGF and PDGF-BB, were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics. Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines, some of which could be potential biomarkers of disease severity of 2019-n Co V infections. These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease. Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized.

关键词： 2019-nCoV COVID-19 cytokine storm IP-10 IL-17

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

一种新的运动检测及轮廓追踪方法

引用

武汉大学学报（信息科学版） 2005年第8期30卷 723-727页

作者：吕常魁姜澄宇王宁生南京航空航天大学CIMS工程研究中心南京市御道街29号210016

构建了基于块区域二阶矩比的三帧差分运动检测模型,应用文献[1]中的核密度估计模型来滤除其中的非运动区域,并采用支持向量聚类实现多目标检测。给出了运动物体轮廓快速追踪的RW算法,该算法不必考虑检测区域内部的细节问题,能够充分利... 详细信息

构建了基于块区域二阶矩比的三帧差分运动检测模型,应用文献[1]中的核密度估计模型来滤除其中的非运动区域,并采用支持向量聚类实现多目标检测。给出了运动物体轮廓快速追踪的RW算法,该算法不必考虑检测区域内部的细节问题,能够充分利用所检测到的边缘信息,比较符合人眼对轮廓的搜索习惯。最后给出了实验结果。

关键词：运动检测轮廓追踪时间差分颜色矩滚轮算法

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：