检索结果-南通市图书馆

Bioorthogonal microglia-inspired mesenchymal stem cell bioengineering system creates livable niches for enhancing ischemic stroke recovery via the hormesis

引用

Acta Pharmaceutica Sinica B 2024年第3期14卷 1412-1427页

作者： Jianpei Xu Yinzhe Sun Yang You Yuwen Zhang Dan Huang Songlei Zhou Yipu Liu Shiqiang Tong Fenfen Ma Qingxiang Song chengxiang dai Suke Li Jigang Lei Zhihua Wang Xiaoling Gao Jun Chen Shanghai Pudong Hospital&Department of Pharmaceutics School of PharmacyFudan UniversityShanghai 201203China Key Laboratory of Smart Drug Delivery Ministry of EducationSchool of PharmacyFudan UniversityShanghai 201203China Department of Pharmacology and Chemical Biology State Key Laboratory of Oncogenes and Related GenesShanghai Universities Collaborative Innovation Center for Translational MedicineShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Emergency Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China Institute of Science and Technology for Brain-Inspired Intelligence&Department of Neurology Fudan UniversityShanghai 201203China Department of Rehabilitation Medicine Huashan HospitalFudan UniversityShanghai 201203China Daxing Research Institute University of Science and Technology BeijingBiomedical Industry BaseZhongguancun Science and Technology ParkBeijing 102600China Cellular Biomedicine Group Inc. Shanghai 201210China

Mesenchymal stem cells(MSCs)experience substantial viability issues in the stroke infarct region,limiting their therapeutic efficacy and clinical *** levels of deadly reactive oxygen radicals(ROS)and proinflammatory cytokines(PC)in the infarct milieu kill transplanted MSCs,whereas low levels of beneficial ROS and PC stimulate and improve engrafted MSCs’*** on the intrinsic hormesis effects in cellular biology,we built a microglia-inspired MSC bioengineering system to transform detrimental high-level ROS and PC into vitality enhancers for strengthening MSC *** system is achieved by bioorthogonally arming metabolic glycoengineered MSCs with microglial membrane-coated nanoparticles and an antioxidative extracellular protective *** this system,extracellular ROSscavenging and PC-absorbing layers effectively buffer the deleterious effects and establish a microlivable niche at the level of a single MSC for ***,the infarct’s inanimate milieu is transformed at the tissue level into a new living niche to facilitate *** engineered MSCs achieved viability five times higher than natural MSCs at seven days after transplantation and exhibited a superior therapeutic effect for stroke recovery up to 28 *** vitality-augmented system demonstrates the potential to accelerate the clinical translation of MSC treatment and boost stroke recovery.

关键词： Ischemic stroke Mesenchymal stem cell Cell engineering Hormesis effect Bioorthogonal chemistry Microglia Reactive oxygen spices Proinflammatory cytokines

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sensitive determination of pheomelanin after 5-carboxyfluorescein succinimidyl ester precapillary derivatization and micellar electrokinetic capillary chromatography with laser-induced fluorescence detection

Sensitive determination of pheomelanin after 5-carboxyfluore...

引用

2008年中国微生物学会学术年会

作者： Jun dai,~*chengxiang Fang

The suitability of micellar electrokinetic capillary chromatography(MEKC) with laser-induced fluorescence(LIF) detection for the determination of pheomelanin in biological materials has been investigated.5-carboxyfluorescein succinimidyl ester was chosen as the labeling reagent to precapillary derivatize the two marker

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Large-sized bone defect repair by combining a decalcified bone matrix framework and bone regeneration units based on photo-crosslinkable osteogenic microgels

引用

Bioactive Materials 2022年第8期7卷 97-109页

作者： Junxiang Hao Baoshuai Bai Zheng Ci Jincheng Tang Guanhuai Hu chengxiang dai Mengyuan Yu Meng Li Wei Zhang Yixin Zhang Wenjie Ren Yujie Hua Guangdong Zhou Research Institute of Plastic Surgery Weifang Medical UniversityWeifangShandongChina Department of Plastic and Reconstructive Surgery Shanghai 9th People’s HospitalShanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Tissue EngineeringShanghaiChina National Tissue Engineering Center of China ShanghaiChina Institute of Regenerative Medicine and Orthopedics Institutes of Health Central PlainXinxiang Medical UniversityXinxiangHenanChina Cellular Biomedicine Group Inc.ShanghaiChina

Physiological repair of large-sized bone defects is great challenging in clinic due to a lack of ideal grafts suitable for bone *** bone matrix(DBM)is considered as an ideal bone regeneration scaffold,but low cell seeding efficiency and a poor osteoinductive microenvironment greatly restrict its application in large-sized bone *** address these problems,we proposed a novel strategy of bone regeneration units(BRUs)based on microgels produced by photo-crosslinkable and microfluidic techniques,containing both the osteogenic ingredient DBM and vascular endothelial growth factor(VEGF)for accurate biomimic of an osteoinductive *** physicochemical properties of microgels could be precisely controlled and the microgels effectively promoted adhesion,proliferation,and osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)in *** were successfully constructed by seeding BMSCs onto microgels,which achieved reliable bone regeneration in ***,by integrating the advantages of BRUs in bone regeneration and the advantages of DBM scaffolds in 3D morphology and mechanical strength,a BRU-loaded DBM framework successfully regenerated bone tissue with the desired 3D morphology and effectively repaired a large-sized bone defect of rabbit *** current study developed an ideal bone biomimetic microcarrier and provided a novel strategy for bone regeneration and large-sized bone defect repair.

关键词： Microgels Large-sized bone defect repair Bone regeneration units Photo-crosslinking Decalcified bone matrix

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Human adipose, placenta, and umbilical cord-derived mesenchymal stem cells ameliorate imiquimod-induced psoriatic mice via reducing T cells infiltration

引用

BIOCELL 2021年第3期45卷 537-546页

作者： JIGANG LEI ZHENYAO XU SUKE LI MENG LI ZHIKAI WANG PING LI JING WANG YINGLU CHEN X IAOLE SONG CHENGJIE REN MEIPING SHEN chengxiang dai Cellular Biomedicine Group Shanghai200233China Translational Medicine Center Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai200025China Shanghai Institute of Immunology Shanghai Jiaotong University School of MedicineShanghai200025China

Psoriasis is an autoimmune-related chronic inflammatory disease with an approximate prevalence of 2–3%around the world,involving increased keratinocyte ***,Th17 cells and IL-17 play critical roles in the pathogenesis of *** monoclonal antibodies against cytokines have been shown to have effectively immunosuppressive effects on human ***,there are still some patients that have no response to these *** patients have even serious side-effects which may affect their *** stem cells have the ability of immunosuppressive and anti-inflammatory effects,which may be an alternative therapy with more safety and efficacy for human ***,the underlying mechanisms by which the MSCs prevent or ameliorate psoriasis are still poorly ***,we first isolated and characterized human adipose,placenta,and umbilical cord-derived mesenchymal stem cells(haMSCs,hpMSCs,and huMSCs).After that,the animal model of imiquimod(IMQ)-induced psoriasis in C57BL/6 mice was *** investigated the impact of haMSCs,hpMSCs,and huMSCs on this model by H&E staining,immunohistochemistry staining,and quantitative real-time *** analysis showed that mice subcutaneously injected with these MSCs had a significantly decreased epidermal thickness,which was caused by obviously reduced hyper-proliferation of ***,our findings revealed that the infiltration of T cells to psoriatic lesions in IMQ-induced psoriasis mice was markedly downregulated by intradermal administration of haMSCs,hpMSCs,and huMSCs,***,the production of IL-17 from Th17 cells was reduced,which inhibits the proliferation of keratinocytes in lesioned skin of IMQ-induced psoriasis *** data suggest that haMSCs,hpMSCs,and huMSCs can inhibit the effects of proinflammatory Th17 cells on the development of psoriasis,which may be potential therapeutic candidates for skin inflammatory disease or other autoimmune

关键词： Mesenchymal stem cells Psoriasis T cells Skin inflammation Cell therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Correlation-Based Stochastic Model for Massive MIMO Channel

引用

China Communications 2024年第1期21卷 175-187页

作者： Yang Liu Gang Li chengxiang Wang National Mobile Communications Research Laboratory School of Information Science and EngineeringSoutheast UniversityNanjing 211189China School of Internet of Things Engineering Jiangnan UniversityWuxi 214122China Pervasive Communication Research Center Purple Mountain LaboratoriesNanjing 211111China

In this paper,the channel impulse response matrix(CIRM)can be expressed as a sum of couplings between the steering vectors at the base station(BS)and the eigenbases at the mobile station(MS).Nakagami distribution was used to describe the fading of the coupling between the steering vectors and the *** measurements were carried out to evaluate the performance of this proposed ***,the physical implications of this model were illustrated and the capacities are *** addition,the azimuthal power spectrum(APS)of several models was ***,the channel hardening effect was simulated and *** showed that the proposed model provides a better fit to the measured results than the other CBSM,i.e.,Weichselberger ***,the proposed model can provide better tradeoff between accuracy and complexity in channel *** CIRM model can be used for massive MIMO design in the future communication system design.

关键词： CBSM channel capacity channel hardening channel modeling massive MIMO

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clinical safety and efficacy of allogenic human adipose mesenchymal stromal cells-derived exosomes in patients with mild to moderate Alzheimer’s disease:a phaseⅠ/Ⅱclinical trial

引用

General Psychiatry 2023年第5期36卷 350-360页

作者： Xinyi Xie Qingxiang Song chengxiang dai Shishuang Cui Ran Tang Suke Li Jing Chang Ping Li Jintao Wang Jianping Li Chao Gao Hongzhuan Chen Shengdi Chen Rujing Ren Xiaoling Gao Gang Wang Department of Neurology and Institute of Neurology Shanghai Jiao Tong University Medical School Affiliated Ruijin HospitalShanghaiChina Department of Pharmacology and Chemical Biology State Key Laboratory of Oncogenes and Related GenesShanghai Universities Collaborative Innovation Center for Translational MedicineShanghai Jiao Tong University School of MedicineShanghaiChina Department of Regenerative Medicine Business Cellular Biomedicine GroupShanghaiChina Daxing Research Institute University of Science and TechnologyBeijingChina Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine ResearchShanghai University of Traditional Chinese MedicineShanghaiChina

Background There have been no effective treatments for slowing or reversing Alzheimer’s disease(AD)until *** preclinical evidence,including this study,suggests that mesenchymal stem cells-secreted exosomes(MSCs-Exos)have the potential to cure *** The first three-arm,drug-intervention,phase I/II clinical trial was conducted to explore the safety and efficacy of allogenic human adipose MSCs-Exos(ahaMSCs-Exos)in patients with mild to moderate *** The eligible subjects were assigned to one of three dosage groups,intranasally administrated with ahaMSCs-Exos two times per week for 12 weeks,and underwent follow-up visits at weeks 16,24,36 and *** No adverse events were *** the medium-dose arm,Alzheimer’s Disease Assessment Scale–Cognitive section(ADAS-cog)scores decreased by 2.33(1.19)and the basic version of Montreal Cognitive Assessment scores increased by 2.38(0.58)at week 12 compared with baseline levels,indicating improved cognitive ***,the ADAS-cog scores in the medium-dose arm decreased continuously by 3.98 points until week *** were no significant differences in altered amyloid or tau deposition among the three arms,but hippocampal volume shrank less in the medium-dose arm to some *** Intranasal administration of ahaMSCs-Exos was safe and well tolerated,and a dose of at least 4×10^(8)particles could be selected for further clinical trials.

关键词： clinical Alzheimer dosage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evolution of mechanical parameters of Shuangjiangkou granite under different loading cycles and stress paths

引用

Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1113-1126页

作者： Liangjie Gu Xia-Ting Feng Rui Kong chengxiang Yang Yuelin Xia Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang110819China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China

Surrounding rocks at different locations are generally subjected to different stress paths during the process of deep hard rock *** this study,to reveal the mechanical parameters of deep surrounding rock under different stress paths,a new cyclic loading and unloading test method for controlled true triaxial loading and unloading and principal stress direction interchange was proposed,and the evolution of mechanical parameters of Shuangjiangkou granite under different stress paths was studied,including the deformation modulus,elastic deformation increment ratios,fracture degree,cohesion and internal friction ***,stress path coefficient was defined to characterize different stress paths,and the functional relationships among the stress path coefficient,rock fracture degree difference coefficient,cohesion and internal friction angle were *** results show that during the true triaxial cyclic loading and unloading process,the deformation modulus and cohesion gradually decrease,while the internal friction angle gradually increases with increasing equivalent crack *** stress path coefficient is exponentially related to the rock fracture degree difference *** the stress path coefficient increases,the degrees of cohesion weakening and internal friction angle strengthening decrease *** cyclic loading and unloading under true triaxial principal stress direction interchange,the direction of crack development changes,and the deformation modulus increases,while the cohesion and internal friction angle decrease slightly,indicating that the principal stress direction interchange has a strengthening effect on the surrounding ***,the influences of the principal stress interchange direction on the stabilities of deep engineering excavation projects are discussed.

关键词： Triaxial cyclic loading and unloading test Stress path Deformation modulus and elastic deformation increment ratios Fracture degree Cohesion and internal friction angle

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Artificial Intelligence Based Multi-Scenario mmWave Channel Modeling for Intelligent High-Speed Train Communications

引用

China Communications 2024年第3期21卷 260-272页

作者： Zhang Mengjiao Liu Yu Huang Jie He Ruisi Zhang Jingfan Yu Chongyang Wang chengxiang School of Microelectronics Shandong UniversityJinan 250101China The State Key Laboratory of Rail Traffic Control and Safety Beijing Jiaotong UniversityBeijing 100044China The National Mobile Communications Research Laboratory School of Information Science and EngineeringSoutheast UniversityNanjing 210096China The Purple Mountain Laboratories Nanjing 211111China

A large amount of mobile data from growing high-speed train(HST)users makes intelligent HST communications enter the era of big *** corresponding artificial intelligence(AI)based HST channel modeling becomes a *** paper provides AI based channel characteristic prediction and scenario classification model for millimeter wave(mmWave)HST ***,the ray tracing method verified by measurement data is applied to reconstruct four representative HST *** setting the positions of transmitter(Tx),receiver(Rx),and other parameters,the multi-scenarios wireless channel big data is ***,based on the obtained channel database,radial basis function neural network(RBF-NN)and back propagation neural network(BP-NN)are trained for channel characteristic prediction and scenario ***,the channel characteristic prediction and scenario classification capabilities of the network are evaluated by calculating the root mean square error(RMSE).The results show that RBF-NN can generally achieve better performance than BP-NN,and is more applicable to prediction of HST scenarios.

关键词： artificial intelligence channel characteristic prediction HST channel millimeter wave scenario classification

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Micro-nanoarchitectonic of aluminum-hydrogel propellant with static stability and dynamic rheology

引用

Frontiers of Chemical Science and Engineering 2024年第4期18卷 87-96页

作者： Huiyan Guo Huaiyu Li Hongzhi Zhang Lun Pan chengxiang Shi Kang Xue Xiangwen Zhang Ji-Jun Zou Key Laboratory for Advanced Fuel and Propellant of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

The aluminum-water system is a promising propellant due to high energy and low signal characteristics,and the gel form is easier to store and *** this work,hydrogels of water and aluminum particles were prepared using the low-molecular-weight gellant *** various physical properties of gel systems,including the water loss rate,phase transition temperature,and centrifugal stability at different gellant and aluminum contents,were *** properties were assessed through shear thinning tests,thixotropy tests,strain sweep analysis,and frequency sweep *** microstructure of the gel was obtained through scanning electron microscopy *** results show that the aluminum-hydrogel network structure is composed of micron-scale aluminum and agarose nanosheets,and the unique micro-nanostructure endows the gel with excellent mechanical strength and thermal stability,which improve with increasing gellant and aluminum ***,the gel with 2% agarose and 20% aluminum had the best performance;the storage modulus reached 90647 Pa,which was within the linear viscoelastic region,and the maximum withstand pressure was 111.2 kPa,which was 118.8% greater than that of the pure ***,the gel demonstrates remarkable shear thinning behavior and can undergo gel-sol transformation upon shearing or heating to exceeding 114℃.

关键词： aluminum-water propellant gelled propellant rheological property mechanical strength

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Photoinduced transposed Paternò-Büchi reaction for effective synthesis of high-performance jet fuel

引用

Chinese Journal of Chemical Engineering 2024年第3期67卷 39-48页

作者： Jinxiu Hu Xianlong Liu Yi Liu Kang Xue chengxiang Shi Xiangwen Zhang Li Wang Ji-Jun Zou Lun Pan Key Laboratory for Green Chemical Technology of the Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China Zhejiang Institute of Tianjin University Ningbo 315201China Collaborative Innovative Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China

High-energy-density fuels are important for volume-limited aerospace vehicles,but the increase in fuel energy density always leads to poor cryogenic ***,we investigated the transposed Paternò-Büchi reaction of biomass cyclic ketone and cyclic alkene to synthesize a new kind of alkyl-substituted polycyclic hydrocarbon fuel with high energy density and good cryogenic *** triplet-energy-quenching results and phosphorescent emission spectra reveal the sensitization mechanism of the reaction,including photosensitizer excitation,triplettriplet energy transfer,cyclization,and relaxation,and the possible reaction path was revealed by the density functional theory(DFT)*** reaction conditions of photosensitizer type and addition,molar ratio of substrates,reaction temperature,and incident light intensity were optimized,with the target product yield achieving 65.5%.Moreover,the reaction dynamics of the reaction rate versus the light intensity are *** the hydrogenation-deoxygenation reaction,three fuels with a high density of 0.864-0.938 g·ml^(-1) and a low freezing point of<-55℃ are *** work provides a benign and effective approach to synthesize high-performance fuels.

关键词： High-energy-density fuel Transposed Patern-oeBüchi reaction Kinetics Bioenergy Photochemistry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：