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Combined analysis of imaging tumor capsule with imaging tumor size guides the width of resection margin for solitary hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 551-558页

作者： Jia-Shuo Chao Qi Zhu De-Sheng Chen Gui-Ming Chen Xue-Qian Xie Ai-Qun Liu Sen-Lin Zhao hong-cheng sun Department of General Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of Radiology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghai 200032China

Background:The optimal width of resection margin(RM)for hepatocellular carcinoma(HCC)remains *** study aimed to investigate the value of imaging tumor capsule(ITC)and imaging tu-mor size(ITS)in guiding RM width for patients with ***:Patients who underwent hepatectomy for HCC in our center were retrospectively ***(complete/incomplete)and ITS(≤3 cm/>3 cm)were assessed by preoperative magnetic resonance imaging(MRI).Using subgroup analyses based on ITC and ITS,the impact of RM width[narrow RM(3 cm and complete ITC,the narrow RM group exhibited comparable RFS,OS,and incidence of RM recurrence with the wide RM group(P=0.606,0.916,and 0.649,respectively).However,in patients with ITS>3 cm and incomplete ITC,the wide RM group showed better RFS and OS and a lower incidence of RM recurrence compared with the narrow RM group(P=0.037,0.018,and 0.046,respectively).Conclusions:As MRI-based preoperative markers,conjoint analysis of ITC with ITS aids in determining RM width for solitary HCC *** RM is applicable in patients with ITS≤3 cm regardless of ITC status and in those with ITS>3 cm and complete *** RM is preferred in those with ITS>3 cm and incomplete ITC.

关键词： Hepatocellular carcinoma Resection Hepatectomy Magnetic resonance imaging Preoperative imaging

Semiunitary Transforrnation and Isospectral Hamiltonians in Arbitrary Dimensional Space

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Communications in Theoretical Physics 2001年第7期36卷 25-28页

作者： RUAN Dong WANG Xue-Jin HUANG Wei-cheng sun hong-Zhou Department of Physics Tsinghua University Beijing 100084 China The Key Laboratory of Quantum Information and Measurements of MOE Tsinghua University Beijing 100084 China Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator Lanzhou 730000 China Department of Electronic Engineering Tsinghua University Beijing 100084 China The Key Laboratory of Quantum Information and Measurements of MOE Tsinghua University Beijing 100084 China Institute of Applied Chemistry Xinjiang University Urumqi 830046 China Department of Physics Tsinghua University Beijing 100084 China Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator Lanzhou 730000 China

By means of the complex Clifford algebra, a new realization of multi-dimensional semiunitary transformation is put forward and then applied to studying the isospectrality of nonrelativistic Hamiltonians of multi-dimensional quantum mechanical systems, in which the generalized Pauli coupling interaction and spin-orbit coupling interaction appear naturally. Moreover, it is shown that the semiunitary operators, together with the Hamiltonian of quantum mechanical system, satisfy the polynomially-deformed angular momentum algebra.

关键词： semiunitary transformation, action-angle approach, isospectrality of Hamiltonians, deformed angular momentum algebra

Burden landscape of hepatobiliary and pancreatic cancers in Chinese young adults:30 years’overview and forecasted trends

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4177-4193页

作者： De-Sheng Chen Ze-Ping Chen Dong-Zi Zhu Lv-Xin Guan Qi Zhu Yi-Chao Lou Ze-Ping He Hao-Nan Chen hong-cheng sun Department of General Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of General Surgery Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Shenzhen Institute of Translational Medicine The First Affiliated Hospital of Shenzhen UniversityShenzhen 518035Guangdong ProvinceChina Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina

BACKGROUND Hepatobiliary and pancreatic(HBP)cancers impose a considerable burden on young populations(aged 15 to 49 years),resulting in a substantial number of new cases and fatalities each *** young populations,the HBP cancers shows extensive variance worldwide and the updated data in China is *** To investigate the current status,trends,projections,and underlying risk factors of HBP cancers among young populations in *** The Global Burden of Disease Study 2019 provided data on the annual incidence,mortality,disability-adjusted life years(DALYs),age-standardized incidence rate(ASIR),mortality rate(ASMR),and DALYs rate(ASDR)of HBP cancers in young Chinese adults between 1990 and *** trends were assessed using estimated annual percentage change and hierarchical ***-specific mortality and DALYs caused by various risks were analyzed across China and other regions,with future trends until 2035 projected using the Bayesian age-period-cohort *** From 1990 to 2019,incident cases,deaths,DALYs,ASIR,ASMR,and ASDR for liver cancer(LC)in young Chinese individuals decreased,classified into'significant decrease'***,cases of gallbladder and biliary tract cancer and pancreatic cancer rose,categorized as either'significant increase'or'minor increase'*** contribution of risk factors to mortality and DALYs for HBP tumors increased to varying *** lifestyle behaviors,such as tobacco control,weight management,alcohol moderation,and drug avoidance,could lower HBP cancers ***,except for LC in females,which is likely to initially decline slightly and then rise,the forecasting model predicted that the ASIR and ASMR for all HPB cancers subtypes by gender will increase among young *** HBP cancers burden among young adults in China is expected to increase until 2035,necessitating lifestyle interventions and targeted treatment strategies to mitigate the public health impact of these

关键词： Hepatobiliary and pancreatic cancers Burden landscape Young adults Projection China

Post-transplant infection improves outcome of hepatocellular carcinoma patients after orthotopic liver transplantation

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World Journal of Gastroenterology 2019年第37期25卷 5630-5640页

作者： Jia-Shuo Chao Sen-Lin Zhao Si-Wen Ou-yang Yong-Bing Qian Ai-Qun Liu Hua-Mei Tang Lin Zhong Zhi-Hai Peng Jun-Ming Xu hong-cheng sun Department of General Surgery Shanghai Organ Transplantat Medical CenterShanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200080China Department of Colorectal Surgery Fudan UniversityShanghai Cancer CenterShanghai 200032China Division of Critical Care Department of Liver SurgeryRenji HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200127China Department of Radiology Shanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200080China Department of Pathology Shanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200080China

BACKGROUND Tumor recurrence after orthotopic liver transplantation(OLT)remains a serious threat for long-term survival of the recipients with hepatocellular carcinoma(HCC),since very few factors or measures have shown impact on overcoming HCC recurrence after *** infection suppresses tumor recurrence and improves patient survival in lung cancer and malignant glioma probably via stimulating the immune ***-transplant infection(PTI),a common complication,is deemed to be harmful for the liver transplant recipients from a short-term ***,whether PTI inhibits HCC recurrence after OLT and prolongs the long-term survival of HCC patients needs to be *** To investigate the potential influence of PTI on the survival and tumor recurrence of patients with HCC after *** A total of 238 patients with HCC who underwent OLT between August 2002 and July 2016 at our center were retrospectively included and accordingly subdivided into a PTI group(53 patients)and a non-PTI group(185 patients).Univariate analyses,including the differences of overall survival(OS),recurrence-free survival(RFS),and post-recurrence survival(PRS),between the PTI and non-PTI subgroups as well as survival curve analysis were performed by the Kaplan-Meier method,and the differences were compared using the log rank *** variables with a P-value<0.1 in univariate analyses were included in the multivariate survival analysis by using a Cox proportional-hazards *** The 1-,3-,and 5-year OS and RFS rates of the whole cohort were 86.6%,69.0%,and 63.6%,and 75.7%,60.0%,and 57.3%,*** 1-,3-,and 5-year OS rates for the PTI patient group(96.0%,89.3%,and 74.0%)were significantly higher than those for the non-PTI group(84.0%,63.4%,and 60.2%)(P=0.033).The absence of PTI was an independent risk factor for dismal OS(relative risk[RR]=2.584,95%CI:1.226-5.449)and unfavorable RFS(RR=2.683,95%CI:1.335-5.390).Subgroup analyses revealed that PTI remark

关键词： Liver transplantation Liver cancer Infection Survival Tumor recurrence

Protective effect of icaritin on focal cerebral ischemic–reperfusion mice

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Chinese Herbal Medicines 2018年第1期10卷 40-45页

作者： cheng-hong sun li-hong pan jian yang jing-chun yao bing-bing li yu-jun tan gui-min zhang ying sun state key laboratory of generic manufacture technology of chinese traditional medicine linyi 276000china linyi key laboratory for immunopharmacology and immunotoxicology of natural medicine linyi 276000china center for new drug pharmacology lunan pharmaceutical group corporationlinyi 276000china

Objective： To investigate the protective effects of icaritin （ICT）, one of the active ingredients in Epimedii Folium, on mouse model of cerebral ischemia-reperfusion （I/R） in vivo. Methods： ICR mice were subjected to an I h transient middle cerebral artery occlusion （MCAO） and fol- lowed by 24 h of reperfusion. Neurological deficits, infarct volume, brain edema and survive rate were measured, respectively. The levels of brain IL-1β, TNF-a, ROS and DNA-binding activity of NF-KB p65 were measured by ELISA kits. The levels of malondialdehyde （MDA） and activities of superoxide dismu- tase （SOD） were detected by spectrophotometry, and the release of nitric oxide （NO） were detected by Griess kit. Results： ICT markedly reduced the neurological deficit scores, brain edema, infarct volume and increased the survival rate of the cerebral I/R mice. The expression of IL-Iβ, TNF-α, NO, MDA and DNA-binding activity of NF-KB p65 were significantly inhibited by ICT, while the activity of SOD were up-regulated at the same time. Conclusion： ICT possessed significant neuroprotective effects in cerebral I/R mice, which might be related to prevent neuroinflammatory and oxidative damage.

关键词： brain edema brain infarct icaritin focal cerebral ischemic-reperfusion neuroinflammation oxidative damage

利用DCMD模型生命表系统对“六普”数据中死亡漏报的估计

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人口研究 2018年第2期42卷 99-112页

作者：李成米红孙凌雪浙江大学公共管理学院浙江大学人口与发展研究所

低龄死亡概率和老龄死亡概率对估计0岁和60岁预期寿命有特殊意义,直接关系到计算结果的准确性,且涉及养老保险等一系列政策的制定。众多研究表明"六普"数据中低龄组与老龄组死亡数据存在明显漏报,并且给出了不同的修正方法以及相应的结... 详细信息

低龄死亡概率和老龄死亡概率对估计0岁和60岁预期寿命有特殊意义,直接关系到计算结果的准确性,且涉及养老保险等一系列政策的制定。众多研究表明"六普"数据中低龄组与老龄组死亡数据存在明显漏报,并且给出了不同的修正方法以及相应的结果。文章利用DCMD模型生命表系统,根据"六普"数据中60~75岁的分性别人口数计算出老龄死亡率,结合UNICEF的儿童死亡率和IHME的成人死亡率数据,对"六普"时期我国分性别的国民生命表进行重建,重新计算了0岁和60岁的预期寿命,并在此基础上估计了低龄组和老龄组死亡数据的漏报程度。结果表明,"六普"时期我国婴儿死亡率男性为16.41‰、女性为15.94‰,相应的漏报水平为77.3%和75.5%;老龄死亡概率(60~89岁)男性0.703、女性0.595,相应的漏报水平为2.3%和7.0%。

关键词：死亡漏报模型生命表死亡模式人口普查

制造业投入服务化对企业出口国内增加值的提升效应——基于中国制造业微观企业的经验研究

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中国工业经济 2017年第10期 62-80页

作者：许和连成丽红孙天阳湖南大学经济与贸易学院

服务化已成为全球制造业发展的重要趋势。本文基于2000—2010年中国工业企业数据库、中国海关进出口数据库和世界投入产出数据库(WIOD)的投入产出数据,测算了中国各制造行业的投入服务化程度,以及制造业企业的出口国内增加值率(DVAR),... 详细信息

服务化已成为全球制造业发展的重要趋势。本文基于2000—2010年中国工业企业数据库、中国海关进出口数据库和世界投入产出数据库(WIOD)的投入产出数据,测算了中国各制造行业的投入服务化程度,以及制造业企业的出口国内增加值率(DVAR),并实证检验制造业投入服务化对企业出口国内增加值率的影响及作用机制。研究发现:总体来看,中国制造业投入服务化与企业出口DVAR之间呈U型关系,这主要是因为投入服务化对不同贸易类型企业的影响存在差异,其中对一般贸易企业出口DVAR的影响显著为正,而对加工贸易和混合贸易企业出口DVAR产生U型影响效应;制造业投入服务化对企业出口DVAR的影响具有明显异质性,依赖于企业贸易类型、技术水平、所在地区、所有制类型及服务要素投入特点;影响机制检验表明,成本降低和技术创新是制造业投入服务化提升企业出口DVAR的可能渠道;市场化进程和服务业开放程度较高的地区或行业,制造业投入服务化将显著促进企业出口DVAR提升。本文研究结论对于中国发展服务型制造和企业出口转型升级具有重要的政策启示。

关键词：制造业投入服务化出口国内增加值企业异质性

Magnetron sputtered nickel oxide with suppressed interfacial defect states for efficient inverted perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 348-355页

作者： Guoqiang Ma Qin Tan Zhaoning Li Jingwei Xiu Jiafeng Wang Tianle cheng Dong He Qiang sun Xuhang Ma Francesco Lamberti Zhubing He Department of Materials Science and Engineering Institute of Innovative Materials (I2M) Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG)Southern University of Science and Technology (SUSTech) Core Research Facilities Southern University of Science and Technology Department of Chemical Sciences Department of Industrial Engineering University of Padova

Widely used spin-coated nickle oxide （NiOx） based perovskite solar cells often suffer from severe interfacial reactions between the NiOxand adjacent perovskite layers due to surface defect states,which inherently impair device performance in a long-term view,even with surface molecule *** this study,we developed high-quality magnetron-sputtered NiOxthin films through detailed process optimization,and compared systematically sputtered and spin-coated NiOxthin film surfaces from materials to *** sputtered NiOxfilms exhibit improved crystallinity,smoother surfaces,and significantly reduced Ni3+or Ni vacancies compared to their spin-coated ***,the interface between the perovskite and sputtered NiOxfilm shows a substantially reduced density of defect *** solar cells （PSCs） fabricated with our optimally sputtered NiOxfilms achieved a high power conversion efficiency （PCE） of up to 19.93%and demonstrated enhanced stability,maintaining 86.2% efficiency during 500 h of maximum power point tracking under one standard sun ***,with the surface modification using (4-(2,7-dibromo-9,9-dimethylacridin-10（9H）-yl)butyl)p hosphonic acid （DMAcPA）,the device PCE was further promoted to 23.07%,which is the highest value reported for sputtered NiOxbased PSCs so far.

关键词： Nickle oxide Magnetron sputter Defect Stability Perovskite solar cell

A cellulose-based lithium-ion battery separator with regulated ionic transport and high thermal stability for extreme environments

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Nano Research 2025年第1期18卷 315-322页

作者： Kun-Peng Yang Song Xie Zi-Meng Han Hao-cheng Liu Chong-Han Yin Wen-Bin sun Zhang-Chi Ling Huai-Bin Yang De-Han Li Qing-Fang Guan Shu-hong Yu Department of Chemistry New Cornerstone Science LaboratoryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

Separators play a critical role in lithium-ion ***,the restrictions of thermal stability and inferior electrical performance in commercial polyolefin separators significantly limit their applications under harsh ***,we report a cellulose-assisted self-assembly strategy to construct a cellulose-based separator massively and *** an ultrahigh ionic conductivity in electrolytes of 3.7 mS·cm^(-1) and the ability to regulate ion transport,the obtained separator is a promising alternative for high-performance lithium-ion *** addition,integrated with high thermal stability,the cellulose-based separator endows batteries with high safety at high temperatures,greatly expanding the application scenarios of energy storage devices in extreme environments.

关键词： lithium-ion batteries bio-inspired materials battery separators cellulose nanofiber ultrahigh ionic conductivity high safety