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Effects of iron(hydr)oxides on the degradation of diethyl phthalate ester in heterogeneous(photo)-Fenton reactions

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Journal of Environmental Sciences 2019年第6期31卷 5-13页

作者： Wenjuan Shuai cheng Gu Guodong fang Dongmei zhou Juan Gao Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil Science Chinese Academy of Science University of Chinese Academy of Sciences State Key Laboratory of Pollution Control and Resource Reuse School of the Environment Nanjing University

This work studied the structural effects of hematite(α-Fe2 O3), 2-line ferrihydrite(HFO) and goethite(α-FeOOH) on diethyl phthalate ester(DEP) degradation. The results showed that the degradation of DEP was faster under 365 nm light irradiation than in the dark in the presence of iron(hydr)oxides. The apparent kinetic rates of DEP degradation followed the order HFO > goethite ≈ hematite in the dark and HFO > hematite > goethite under 365 nm light irradiation. Two pathways governed H2 O2 decomposition efficiency on iron(hydr)oxide surfaces:(1) forming UOH on inherent surface hydroxyl groups(Fe-OH) and(2) producing O2 and H2 O on the surface oxygen vacancies. X-ray photoelectron spectroscopy(XPS) analyses indicated that HFO not only has high Fe-OH content but also has high Vo content, resulting in its low H2 O2 utilization efficiency(η). DEP was degraded through hydrogen abstraction and deesterification, and the major products were(OH)2-DEP, mono-ethyl phthalate(MEP), OH-MEP,and phthalate acid(PA). The study is important in understanding the transformation of phthalate esters in top surface soils and surface waters under ultraviolet light.

关键词： Diethyl phthalate ester Iron(hydr)oxide Hydroxyl radical Heterogeneous Fenton reactions

The gut microbiome:implications for neurogenesis and neurological diseases

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Neural Regeneration Research 2022年第1期17卷 53-58页

作者： cheng Liu Shang-Yu Yang Long Wang fang zhou Department of Healthcare Administration College of Medical and Health ScienceAsia UniversityTaichungTaiwanChina Department of Anesthesiology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

There is an increasing recognition of the strong links between the gut microbiome and the brain,and there is persuasive evidence that the gut microbiome plays a role in a variety of physiological processes in the central nervous *** review summarizes findings that gut microbial composition alterations are linked to hippocampal neurogenesis,as well as the possible mechanisms of action;the existing literature suggests that microbiota influence neurogenic processes,which can result in neurological *** consider this evidence from the perspectives of neuroinflammation,microbial-derived metabolites,neurotrophins,and *** on the existing research,we propose that the administration of probiotics can normalize the gut *** could therefore also represent a promising treatment strategy to counteract neurological impairment.

关键词： gut microbiota microbial-derived metabolites microbiota-gut-brain axis neurogenesis neuroinflammation neurological diseases neurotrophins probiotics

Microstructure characterization and thermal properties of the waste-styrene-butadiene-rubber (WSBR)-modified petroleum-based mesophase asphalt

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Journal of Materials Science & Technology 2019年第5期35卷 852-857页

作者： Jingbo Hu Changqing fang Shisheng zhou Youliang cheng Hanzhi Han School of Mechanical and Precision Instrument Engineering Xi'an University of Technology Xi'an 710048 China Faculty of Printing. Packing Engineering and Digital Media Technology Xi'an University of Technology Xi'an 710048 China School of Information Technology and Equipment Engineering Xi'an University of Technology Xi'an 710048 China

In this work, waste-styrene-butadiene-rubber(WSBR)-modified petroleum-based mesophase asphalt was prepared through a co-carbonization process. The influence of contents of WSBR and carbonization temperature on the properties of mesophase asphalt was investigated. The chemical constituents,microstructure and thermal property of the samples were characterized. The results show that using WSBR as modifier can significantly promote the formation of mesophase. When the temperature is constant, the addition of WSBR results in more optically anisotropic crystal structure in the samples, and a better thermal stability. When the content of WSBR is invariable, with increasing temperature, the content of anisotropic structure in mesophase asphalt becomes higher and more uniform. The thermal stability of the samples is the best when WSBR content is 10 wt%.

关键词： Waste-styrene-butadiene-rubber Mesophase asphalt Thermal properties Microstructure

A New Discovery towards Novel Skeleton of Benzimidazole-Conjugated Pyrimidinones as Unique Effective Antibacterial Agents

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Chinese Journal of Chemistry 2022年第22期40卷 2642-2654页

作者： Xi Yang Rasheed Syed Bo fang cheng-He zhou Institute of Bioorganic&Medicinal Chemistry Key Laboratory of Applied Chemistry of Chongqing MunicipalitySchool of Chemistry and Chemical EngineeringSouthwest UniversityChongqing400715China College of Pharmacy National&Local Joint Engineering Research Center of Targeted and Innovative TherapeuticsChongqing Key Laboratoryof KinaseModulators as InnovativeMedicineChongqing University of Arts and SciencesChongqing 402160China

A class of new potential antibacterial agents with distinctive pyrimidinone benzimidazole skeleton was developed through nucleophilic substitution and Biginelli reaction starting from urea,ethyl 4-chloroacetoacetate and various *** target molecules exhibited strong antibacterial activities,especially pyrimidinone benzimidazole hybrid 9e possessed the strongest inhibitory effects on the growth of *** and *** with a lower MIC value of 1μg/mL than ***,compound 9e displayed strong antibiofilm capacity,low drug resistance and excellent biosafety toward human red blood *** research revealed that compound 9e could disrupt membrane integrity and cause leakage of cellular components such as proteins and nucleic ***,compound 9e could decrease lactate dehydrogenase activity,block cell metabolism and interact with DNA in an intercalation manner.

关键词： Pyrimidinone Benzimidazole Antibacterial Resistance Membrane

Discovery of primary lung cancer following resection of rectal cancer lung metastasis:A case report

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World Journal of Clinical Oncology 2025年第2期16卷 173-179页

作者： Fei-Yan zhou fang-Hua Song Zhen-Hao cheng Sen Wu Department of Oncology II Xinhua HospitalDalian UniversityDalian 116000Liaoning ProvinceChina

BACKGROUND Colorectal cancer(CRC)ranks high among the most common types of malignant *** primary cause of cancer-related mortality is metastasis,with lung metastases accounting for 32.9%of all cases of metastatic CRC(MCRC).However,cases of MCRC in the lungs,which present concurrently with primary peripheral lung adenocarcinoma,are exceptionally *** SUMMARY This report describes the case of a 52-year-old female patient who,following a colonoscopy,was diagnosed with moderately differentiated adenocarcinoma based on rectal mucosal biopsy findings.A preoperative chest computed tomography scan revealed a ground-glass nodule in the right lung and a small nodule(approximately 0.6 cm in diameter)in the extramural basal segment of the left lower lobe,which suggested multiple lung metastases from rectal *** treatment and follow-up led to a diagnosis of rectal cancer with left lung metastasis and peripheral adenocarcinoma of the lower lobe of the right *** This case report describes the therapeutic journey of a patient with lung metastasis from rectal cancer in addition to primary peripheral adenocarcinoma,thus underscoring the critical roles of multidisciplinary collaboration,personalized treatment strategies,and comprehensive patient rehabilitation guidance.

关键词： Rectal cancer Metastatic lung cancer Peripheral lung adenocarcinoma Double primary cancer Case report

Optimal Path Embedding in the Exchanged Crossed Cube

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Journal of Computer Science & Technology 2017年第3期32卷 618-629页

作者： Dong-fang zhou Jian-Xi Fan cheng-Kuan Lin Bao-Lei cheng Jing-Ya zhou Zhao Liu School of Computer Science and Technology Soochow University Suzhou 215006 China Collaborative Innovation Center of Novel Software Technology and Industrialization Nanjing University Nanjing 210000 China

The （s＋t＋1）-dimensional exchanged crossed cube, denoted as ECQ（s, t）, combines the strong points of the exchanged hypercube and the crossed cube. It has been proven that ECQ（s, t） has more attractive properties than other variations of the fundamental hypercube in terms of fewer edges, lower cost factor and smaller diameter. In this paper, we study the embedding of paths of distinct lengths between any two different vertices in ECQ（s, t）. We prove the result in ECQ（s, t）： if s≥3, t≥3, for any two different vertices, all paths whose lengths are between max{9,「s＋1/2」＋「t＋1/2＋4}and 2s＋t＋1？1 can be embedded between the two vertices with dilation 1. Note that the diameter of ECQ（s, t） is「s＋1/2 」＋「t＋1/2 」＋2. The obtained result is optimal in the sense that the dilations of path embeddings are all 1. The result reveals the fact that ECQ（s, t） preserves the path embedding capability to a large extent, while it only has about one half edges of CQn.

关键词： interconnection network exchanged crossed cube path embedding parallel computing system

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang Zhi-cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

Comprehensive treatment of a functional pancreatic neuroendocrine tumor with multifocal liver metastases

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Chinese Journal of Cancer Research 2014年第4期26卷 501-506页

作者： Wei Wang Sharvesh Raj Seeruttun cheng fang Zhiwei zhou Department of Gastric and Pancreatic Surgery Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine

A 64-year-old man was admitted to the Sun Yat-Sen University Cancer Center with chief complaints of recurrent abdominal pain and diarrhea for about 3 years and with a history of surgical repair for intestinal perforation owing to stress ulcer. Positron emission tomography （PET）/computed tomography （CT） demonstrated a primary tumor on the pancreatic tail with multifocal liver metastases. Pathological and immunohistochemistry staining revealed the lesion to be a pancreatic neuroendocrine tumor （pNET）. According to the latest World Health Organization （WHO, 2013） classification, the tumor was classified as stage IV fimctional G1 pNET. After referral to the multidisciplinary treatment board （MDT）, the patient was started on periodic dose of omeprazole, somatostatin analogues and Interferon α （IFNα） and had scanning follow-ups. Based upon the imaging results, CT-guided radioactive iodine-125 （1251） seeds implantation therapy, radiofrequency ablation therapy （RFA） or microwave ablation technique were chosen for the treatment of the primary tumor. Transarterial chemoembolization （TACE）, RFA and microwave ablation techniques were decided upon for liver metastases. The patient showed beneficial response to the treatment with clinically manageable low-grade side effects and attained partial remission （RECIST criteria） with a good quality of life.

关键词： Pancreatic neuroendocrine tumor (pNET) functional liver metastases multidisciplinary team prognosis

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang zhou Yuan-Yan Huang Ding-Yue Shang Ying Chen Meng Tian cheng-Yu Jin Xin Lu Bing-Chun Yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology