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Comparison of acute pneumonia caused by SARS-CoV-2 and other respiratory viruses in children:a retrospective multi-center cohort study during COVID-19 outbreak

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Military Medical Research 2021年第4期8卷 468-480页

作者： Guang-Li Ren Xian-Feng Wang Jun Xu Jun Li Qiong Meng Guo-Qiang Xie Bo Huang Wei-Chun Zhu Jing Lin cheng-He Tang Sheng Ye Zhuo Li Jie Zhu Zhen Tang Ming-Xin Ma Cong Xie Ying-Wen Wu Chen-Xi Liu Fang Yang Yu-Zong Zhou Ying zheng Shu-Ling Lan Jian-Feng Chen Feng Ye Yu He BenQing Wu Long Chen Si-Mao Fu cheng-zhong zheng Yuan Shi Department of Pediatrics General Hospital of Southern Theater Command of PLA111 Liuhua RoadYuexiu DistrictGuangzhou 510010GuangdongChina. Department of Pediatrics the Third People’s Hospital of ShenzhenShenzhen 518100GuangdongChina. Pediatric Intensive Care Unit Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430010China. Pediatric Intensive Care Unit Maternal and Child Health Hospital of HuangshiHuangshi 435000HubeiChina. Department of Pediatrics the Second People’s Hospital of Guangdong ProvinceGuangzhou 510317China. Department of Pediatrics the Third Affiliated Hospital of Zunyi Medical University(the First People’s Hospital of Zunyi)Guizhou 563000China. Department of Pediatrics the Eighth People’s Hospital of GuangzhouGuangzhou 510440China. Department of Pediatrics the First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100HenanChina. Pediatric Intensive Care Unit the Children’s Hospital Zhejiang University School of MedicineHangzhou 310000China. Department of Emergency/Critical Medicine Children’s Hospital of Nanjing Medical UniversityNanjing 210008China. Department of Pediatrics the Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260China. Department of Medical information date room General Hospital of Southern Theater Command of PLAGuangzhou 510010China. Department of Pediatrics the First Affiliated Hospital of Jinan UniversityGuangzhou 510632China. Department of Pediatrics Maternal and Child Health Hospital of YangjiangYangjiang 529500GuangdongChina. Department of Pediatrics Shenzhen Hospital Affiliated to the University of Chinese Academy of SciencesShenzhen 518107GuangdongChina. Department of Pediatrics Nanfang Hospital of Southern Medical UniversityGuangzhou 510515China. Department of Pediatrics Zhujiang Hospital of Southern Medical UniversityGuangzhou 510280China. Department of Pediatrics Military Hospital of 74 Group of PLAGuangzhou 510318China. Department of Neonatology

Background:Until January 18,2021,coronavirus disease-2019(COVID-19)has infected more than 93 million individuals and has caused a certain degree of *** pneumonia caused by common viruses such as respiratory syncytial virus,rhinovirus,human metapneumovirus,human bocavirus,and parainfluenza viruses have been more common in ***,the incidence of COVID-19 in children was significantly lower than that in *** purpose of this study was to describe the clinical manifestations,treatment and outcomes of COVID-19 in children compared with those of other sources of viral pneumonia diagnosed during the COVID-19 ***:Children with COVID-19 and viral pneumonia admitted to 20 hospitals were enrolled in this retrospective multi-center cohort study.A total of 64 children with COVID-19 were defined as the COVID-19 cohort,of which 40 children who developed pneumonia were defined as the COVID-19 pneumonia *** 284 children with pneumonia caused by other viruses were defined as the viral pneumonia *** epidemiologic,clinical,and laboratory findings were compared by Kolmogorov-Smirnov test,t-test,Mann-Whitney U test and Contingency table *** usage,immunotherapy,blood transfusion,and need for oxygen support were collected as the treatment ***,intensive care needs and symptomatic duration were collected as the outcome ***:Compared with the viral pneumonia cohort,children in the COVID-19 cohort were mostly exposed to family members confirmed to have COVID-19(53/64 vs.23/284),were of older median age(6.3 years vs.3.2 years),and had a higher proportion of ground-glass opacity(GGO)on computed tomography(18/40 vs.0/38,P<0.001).Children in the COVID-19 pneumonia cohort had a lower proportion of severe cases(1/40 vs.38/284,P=0.048),and lower cases with high fever(3/40 vs.167/284,P<0.001),requiring intensive care(1/40 vs.32/284,P<0.047)and with shorter symptomatic duration(median 5d vs.8d,P<0.001).The propor

关键词： Children Severe acute respiratory syndrome Coronavirus disease-2019 Viral pneumonia

Multi boron-doping effects in hard carbon toward enhanced sodium ion storage

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Journal of Energy Chemistry 2025年第1期100卷 730-738页

作者： Peng zheng Wang Zhou Ying Mo Biao zheng Miaomiao Han Qin zhong Wenwen Yang Peng Gao Lezhi Yang Jilei Liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute for Innovation Hunan University Changsha Research Institute of Mining & Metallurgy Co. LTD.

Hard carbon （HC） has been considered as promising anode material for sodium-ion batteries （SIBs）.The optimization of hard carbon’s microstructure and solid electrolyte interface （SEI） property are demonstrated effective in enhancing the Na+storage capability,however,a one-step regulation strategy to achieve simultaneous multi-scale structures optimization is highly ***,we have systematically investigated the effects of boron doping on hard carbon’s microstructure and interface chemistry.A variety of structure characterizations show that appropriate amount of boron doping can increase the size of closed pores via rearrangement of carbon layers with improved graphitization degree,which provides more Na+storage ***-situ Fourier transform infrared spectroscopy/electrochemical impedance spectroscopy （FTIR/EIS） and X-ray photoelectron spectroscopy （XPS） analysis demonstrate the presence of more BC3and less B–C–O structures that result in enhanced ion diffusion kinetics and the formation of inorganic rich and robust SEI,which leads to facilitated charge transfer and excellent rate *** a result,the hard carbon anode with optimized boron doping content exhibits enhanced rate and cycling *** general,this work unravels the critical role of boron doping in optimizing the pore structure,interface chemistry and diffusion kinetics of hard carbon,which enables rational design of sodium-ion battery anode with enhanced Na+storage performance.

关键词： X ray photoelectron spectroscopy

房价上涨对高新区企业研发投入的影响研究——基于31个国家高新区面板数据的实证分析

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华东经济管理 2020年第4期34卷 27-37页

作者：程正中夏恩君北京理工大学管理与经济学院北京100081 北方工业大学土木工程学院北京100144

文章基于31个大中城市国家高新区2007-2017年面板数据,实证研究了房价对高新区企业研发投入的影响,结果发现:房价上涨并没有显著抑制高新区企业研发投入,其影响存在异质性;沿海城市房价上涨对高新区企业研发投入抑制作用并不显著,内陆... 详细信息

文章基于31个大中城市国家高新区2007-2017年面板数据,实证研究了房价对高新区企业研发投入的影响,结果发现:房价上涨并没有显著抑制高新区企业研发投入,其影响存在异质性;沿海城市房价上涨对高新区企业研发投入抑制作用并不显著,内陆城市房价上涨显著抑制了高新区企业研发投入增长;房价上涨对高新区企业研发投入的影响与高新区发展水平有关;技术收入占比和人才占比能够正向调节房价上涨对高新区企业研发的负向影响。房价上涨会显著倒逼技术实力强、人才密度高、发展水平高的高新区企业增加研发投入;提高企业技术水平、增加人才投入可以更好地应对房价快速上涨带来的挑战;必须具备一定的人才和技术条件,房价上涨激发企业创新的倒逼机制才可能发生。

关键词：房价高新区研发投入倒逼效应实证分析

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基于国网2013标准单相智能电表硬件设计

中小企业管理与科技 2017年第19期1卷 189-190页

作者：程正忠惠州中城电子科技有限公司广东惠州516000

作者根据2013年的新标准电表新规范进行设计,实现单相智能电表的硬件电路设计,通过产品型式试验,通过国家电网的各项测试。

关键词：智能电表硬件单片机

单相智能电表载波和微功率无线模块互换性通信接口设计

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内燃机与配件 2017年第8期 34-36页

作者：程正忠惠州中城电子科技有限公司惠州516000

作者根据国家电网2013年智能电表新规范进行设计,实现单相智能电表的通信接口PLC模块和微功率无线模块可互换,以满足国家电网的需求。

关键词：智能电表通信规约通信接口

Specific CEA-producing colorectal carcinoma cell killing with recombinant adenoviral vector containing cytosine deaminase gene

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World Journal of Gastroenterology 2002年第2期8卷 270-275页

作者： Li-Zong Shen Wen-Xi Wu Qiang Ding Yi-Bing Hua,Department of General Surgery,The First Affiliated Hospital of Nanjing Medical University,Nanjing,210029,Jiangsu Province,China De-Hua Xu zhong-cheng zheng Xin-Yuan Liu,Shanghai Institute of Biochemistry and Cell Biology,The Chinese Academy of Sciences,Shanghai,200031,China Kun Yao,Department of Microbiology and Immunology,Nanjing Medical University,Nanjing,210029,Jiangsu Province,China Department of General Surgery The First Affiliated Hospital of Nanjing Medical University 300 Guangzhou Road Nanjing 210029 Jiangsu Province China.

AIM: To kill CEA positive colorectal carcinoma cells specifically using the E coli cytosine deaminase (CD) suicide gene, a new replication-deficient recombinant adenoviral vector was constructed in which CD gene was controlled under CEA promoter and its in vitro cytotoxic effects were evaluated. METHODS: Shuttle plasmid containing CD gene and regulatory sequence of the CEA gene was constructed and recombined with the right arm of adenovirus genome DNA in 293 cell strain. Dot blotting and PCR were used to identify positive plaques. The purification of adenovirus was performed with ultra-concentration in CsCl step gradients and the titration was measured with plaque formation assay. Cytotoxic effects were assayed with MTT method, The fifty percent inhibition concentration (IC(50)) of 5-FC was calculated using a curve-fitting parameter. The human colorectal carcinoma cell line, which was CEA-producing, and the CEA-nonproducing Hela cell line were applied in cytological tests. An established recombinant adenovirus vector AdCMVCD, in which the CD gene was controlled under CMV promoter, was used as virus control. Quantitative results were expressed as the mean +/- SD of the mean. Statistical analysis was performed using ANOVA test. RESULTS: The desired recombinant adenovirus vector was named AdCEACD. The results of dot blotting and PCR showed that the recombinant adenovirus contained CEA promoter and CD gene. Virus titer was about 5.0 X 10(14)pfu/L(-1) after purification. The CEA-producing Lovo cells were sensitive to 5-FC and had the same cytotoxic effect after infection with AdCEACD and AdCMVCD (The IC(50) values of 5-FC in parent Lovo cells, Lovo cells infected with 100 M.O.I AdCEACD and Lovo cells infected with 10 M.O.I AdCMVCD were >15000, 216.5+/-38.1 and 128.8+/-25.4 micromol.L(-1), P<0.001, respectively), and the cytotoxicity of 5-FC increased accordingly when the m.o.i of adenoviruses were enhanced (The value of IC(50) of 5-FC was reduced to 27.9+/-4.2 micr

关键词： Gene Therapy Genetic Vectors Adenoviridae Animals Antimetabolites Bystander Effect Carcinoembryonic Antigen Cell Line Colorectal Neoplasms Cytosine Deaminase Flucytosine Hela Cells Humans Nucleoside Deaminases Promoter Regions (Genetics) Research Support, Non-U.S. Gov't Tumor Cells, Cultured

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加强园区协作,发展北京文化创意产业

科技与管理 2007年第4期9卷 20-22页

作者：程正中北方工业大学经济管理学院北京100041

制定创意产业发展规划,建设创意产业园区,重复建设、园区定位模糊的缺陷逐渐浮现。对比分析了北京和上海发展创意产业的优势和劣势,提出北京应该大力发展以文化为内容的创意产业。在园区建设上应结合园区的资源优势,选准重点领域和优势... 详细信息

制定创意产业发展规划,建设创意产业园区,重复建设、园区定位模糊的缺陷逐渐浮现。对比分析了北京和上海发展创意产业的优势和劣势,提出北京应该大力发展以文化为内容的创意产业。在园区建设上应结合园区的资源优势,选准重点领域和优势产业链环节,避免大而全小而全,促进北京创意产业聚集区的协调发展。

关键词：文化创意高科技园区服务平台

Spontaneous Orientation Polarization of Anisotropic Equivalent Dipoles Harnessed by Entropy Engineering for Ultra‑Thin Electromagnetic Wave Absorber

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Nano-Micro Letters 2025年第1期17卷 424-438页

作者： Honghan Wang Xinyu Xiao Shangru Zhai Chuang Xue Guangping zheng Deqing Zhang Renchao Che Junye cheng Liaoning Key Lab of Lignocellulose Chemistry and BioMaterials Liaoning Collaborative Innovation Center for Lignocellulosic BiorefinerySchool of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian 116034People’s Republic of China School of Life Science and Biotechnology Dalian University of TechnologyDalian 116024People’s Republic of China Department of Mechanical Engineering Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077People’s Republic of China School of Materials Science and Engineering Qiqihar UniversityQiqihar 161006People’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Department of Materials Science Shenzhen MSU-BIT UniversityShenzhen 517182People’s Republic of China

The synthesis of carbon supporter/nanoscale high-entropy alloys(HEAs)electromagnetic response composites by carbothermal shock method has been identified as an advanced strategy for the collaborative competition engineering of conductive/dielectric *** migration modes within HEAs as manipulated by the electronegativity,valence electron configurations and molar proportions of constituent elements determine the steady state and efficiency of equivalent ***,enlightened by skin-like effect,a reformative carbothermal shock method using carbonized cellulose paper(CCP)as carbon supporter is used to preserve the oxygencontaining functional groups(O·)of carbonized cellulose fibers(CCF).Nucleation of HEAs and construction of emblematic shell-core CCF/HEAs heterointerfaces are inextricably linked to carbon metabolism induced by O·.Meanwhile,the electron migration mode of switchable electronrich sites promotes the orientation polarization of anisotropic equivalent *** virtue of the reinforcement strategy,CCP/HEAs composite prepared by 35%molar ratio of Mn element(CCP/HEAs-Mn_(2.15))achieves efficient electromagnetic wave(EMW)absorption of−51.35 dB at an ultra-thin thickness of 1.03 *** mechanisms of the resulting dielectric properties of HEAs-based EMW absorbing materials are elucidated by combining theoretical calculations with experimental characterizations,which provide theoretical bases and feasible strategies for the simulation and practical application of electromagnetic functional devices(e.g.,ultra-wideband bandpass filter).

关键词： High-entropy alloys Carbothermal shock Switchable electron migration modes Emblematic shell-core heterointerfaces Ultra-thin thickness

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镀锌机组带钢表面拉矫色差的分析及改进

钢铁研究学报 2017年第9期29卷 739-748页

作者：杨杰程正中胡琦汪磊川张战果付愚中国地质大学(武汉)机械与电子信息学院湖北武汉430074 武钢股份有限公司冷轧薄板厂湖北武汉430083 湘潭医卫职业技术学院湖南湘潭411100

冷轧镀锌机组的带钢在拉矫过程中,拉矫机机辊和带钢上成组出现宽度约为100mm的明暗相间色差条纹。为了减轻色差影响,结合带钢拉矫的力学基本理论,通过微观的角度对色差机理进行了研究,并采用Solidworks软件对拉矫设备进行了1∶1的实体... 详细信息

冷轧镀锌机组的带钢在拉矫过程中,拉矫机机辊和带钢上成组出现宽度约为100mm的明暗相间色差条纹。为了减轻色差影响,结合带钢拉矫的力学基本理论,通过微观的角度对色差机理进行了研究,并采用Solidworks软件对拉矫设备进行了1∶1的实体模型建立。然后基于实际生产工况,采用ANSYS/Workbench软件对带钢拉矫过程进行建模优化并进行了全面的有限元数值模拟分析,确定了镀锌带钢拉矫色差的主要成因机理。最后,采用Workbench的目标驱动优化组件,以带钢表面应力分布最均匀化为目标,对支承辊辊组的结构分布以及带钢拉矫工艺参数进行了优化设计及对比验证分析,优化后带钢表面的应力分布最大差值降低了69.77%。最终提出了镀锌机组拉矫色差缺陷的改善与控制策略。

关键词：拉矫机带钢色差微观分析有限元分析优化